{"id":"https://openalex.org/W2980042847","doi":"https://doi.org/10.1021/acs.jcim.9b00642","title":"Molecular Mechanism of S1P Binding and Activation of the S1P<sub>1</sub> Receptor","display_name":"Molecular Mechanism of S1P Binding and Activation of the S1P<sub>1</sub> Receptor","publication_year":2019,"publication_date":"2019-10-07","ids":{"openalex":"https://openalex.org/W2980042847","doi":"https://doi.org/10.1021/acs.jcim.9b00642","mag":"2980042847","pmid":"https://pubmed.ncbi.nlm.nih.gov/31589433"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.9b00642","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00642","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000094065","display_name":"Zhenyan Jiang","orcid":"https://orcid.org/0000-0003-4594-7065"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyan Jiang","raw_affiliation_strings":["Department of Pharmacology, College of Basic Medical Sciences \u00a0and\u00a0 School of Pharmaceutical Sciences, Jilin University, Changchun, 130021, China"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Basic Medical Sciences \u00a0and\u00a0 School of Pharmaceutical Sciences, Jilin University, Changchun, 130021, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102957254","display_name":"Hansi Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hansi Zhang","raw_affiliation_strings":["Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China","institution_ids":["https://openalex.org/I194450716"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102957254"],"corresponding_institution_ids":["https://openalex.org/I194450716"],"apc_list":null,"apc_paid":null,"fwci":1.1081,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.77579237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"59","issue":"10","first_page":"4402","last_page":"4412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.657263457775116},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.6364753246307373},{"id":"https://openalex.org/keywords/sphingosine-1-phosphate-receptor","display_name":"Sphingosine-1-phosphate receptor","score":0.6300856471061707},{"id":"https://openalex.org/keywords/sphingosine","display_name":"Sphingosine","score":0.5733879804611206},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.5539165139198303},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5414578318595886},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.5191478133201599},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor","display_name":"G protein-coupled receptor","score":0.514588475227356},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.47303956747055054},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.4397764801979065},{"id":"https://openalex.org/keywords/sphingosine-kinase","display_name":"Sphingosine kinase","score":0.4220123589038849},{"id":"https://openalex.org/keywords/sphingosine-1-phosphate","display_name":"Sphingosine-1-phosphate","score":0.39390358328819275},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3474867343902588},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2679852843284607},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2653350830078125},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.08941203355789185}],"concepts":[{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.657263457775116},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6364753246307373},{"id":"https://openalex.org/C2776549689","wikidata":"https://www.wikidata.org/wiki/Q24782485","display_name":"Sphingosine-1-phosphate receptor","level":5,"score":0.6300856471061707},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.5733879804611206},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5539165139198303},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5414578318595886},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5191478133201599},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.514588475227356},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.47303956747055054},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4397764801979065},{"id":"https://openalex.org/C2777700496","wikidata":"https://www.wikidata.org/wiki/Q7576797","display_name":"Sphingosine kinase","level":5,"score":0.4220123589038849},{"id":"https://openalex.org/C2776596873","wikidata":"https://www.wikidata.org/wiki/Q418267","display_name":"Sphingosine-1-phosphate","level":4,"score":0.39390358328819275},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3474867343902588},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2679852843284607},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2653350830078125},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.08941203355789185}],"mesh":[{"descriptor_ui":"D000081025","descriptor_name":"Sphingosine-1-Phosphate Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000081025","descriptor_name":"Sphingosine-1-Phosphate Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000081025","descriptor_name":"Sphingosine-1-Phosphate Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000081025","descriptor_name":"Sphingosine-1-Phosphate Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000081025","descriptor_name":"Sphingosine-1-Phosphate Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000081025","descriptor_name":"Sphingosine-1-Phosphate Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.9b00642","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00642","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:31589433","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31589433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","score":0.5,"display_name":"Clean water and sanitation"}],"awards":[{"id":"https://openalex.org/G602931257","display_name":null,"funder_award_id":"JJKH20180109KJ","funder_id":"https://openalex.org/F4320326270","funder_display_name":"Education Department of Jilin Province"},{"id":"https://openalex.org/G6761372761","display_name":null,"funder_award_id":"JJKH20180179KJ","funder_id":"https://openalex.org/F4320326270","funder_display_name":"Education Department of Jilin Province"},{"id":"https://openalex.org/G8838626745","display_name":null,"funder_award_id":"2015219","funder_id":"https://openalex.org/F4320322300","funder_display_name":"Jilin University"},{"id":"https://openalex.org/G8987067172","display_name":null,"funder_award_id":"20190103098JH","funder_id":"https://openalex.org/F4320322174","funder_display_name":"People's Government of Jilin Province"}],"funders":[{"id":"https://openalex.org/F4320322174","display_name":"People's Government of Jilin Province","ror":"https://ror.org/02fzqav45"},{"id":"https://openalex.org/F4320322300","display_name":"Jilin University","ror":"https://ror.org/00js3aw79"},{"id":"https://openalex.org/F4320326270","display_name":"Education Department of Jilin Province","ror":"https://ror.org/05782e512"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W87981432","https://openalex.org/W1135792216","https://openalex.org/W1762981263","https://openalex.org/W1763096406","https://openalex.org/W1833104430","https://openalex.org/W1880336884","https://openalex.org/W1966078827","https://openalex.org/W1970613671","https://openalex.org/W1973892716","https://openalex.org/W1975032814","https://openalex.org/W1981956283","https://openalex.org/W1989971979","https://openalex.org/W1990803922","https://openalex.org/W1991794210","https://openalex.org/W1997340548","https://openalex.org/W2010648389","https://openalex.org/W2015627491","https://openalex.org/W2017128003","https://openalex.org/W2017196167","https://openalex.org/W2020288705","https://openalex.org/W2020350280","https://openalex.org/W2020579993","https://openalex.org/W2023277555","https://openalex.org/W2027736570","https://openalex.org/W2028645925","https://openalex.org/W2032506769","https://openalex.org/W2034705994","https://openalex.org/W2035266068","https://openalex.org/W2038422963","https://openalex.org/W2040758907","https://openalex.org/W2047567287","https://openalex.org/W2049617698","https://openalex.org/W2051106500","https://openalex.org/W2052091241","https://openalex.org/W2059551149","https://openalex.org/W2067174909","https://openalex.org/W2073765675","https://openalex.org/W2074473216","https://openalex.org/W2081645999","https://openalex.org/W2081693079","https://openalex.org/W2085381168","https://openalex.org/W2086836468","https://openalex.org/W2090977730","https://openalex.org/W2092686571","https://openalex.org/W2100729071","https://openalex.org/W2102308000","https://openalex.org/W2102513649","https://openalex.org/W2104477830","https://openalex.org/W2109254532","https://openalex.org/W2109849823","https://openalex.org/W2116949924","https://openalex.org/W2117003397","https://openalex.org/W2128572087","https://openalex.org/W2140820106","https://openalex.org/W2142409978","https://openalex.org/W2143185831","https://openalex.org/W2145360779","https://openalex.org/W2149963584","https://openalex.org/W2161605421","https://openalex.org/W2167857702","https://openalex.org/W2172084755","https://openalex.org/W2186676367","https://openalex.org/W2289177473","https://openalex.org/W2314292783","https://openalex.org/W2327174080","https://openalex.org/W2487106858","https://openalex.org/W2603879734","https://openalex.org/W2613379785","https://openalex.org/W2726859623","https://openalex.org/W4243281200"],"related_works":["https://openalex.org/W2312748819","https://openalex.org/W2382839978","https://openalex.org/W4213393391","https://openalex.org/W2050798169","https://openalex.org/W3025791184","https://openalex.org/W2771682211","https://openalex.org/W3174148303","https://openalex.org/W2962348518","https://openalex.org/W2746133014","https://openalex.org/W4214954782"],"abstract_inverted_index":{"Sphingosine-1-phosphate":[0],"(S1P)":[1],"is":[2,24,141,153,163,199,237],"a":[3,12,17,227],"lipidic":[4],"mediator":[5],"in":[6,33,148,178,187,203,223],"mammals":[7],"that":[8,108,211,236],"functions":[9],"either":[10],"as":[11,16],"second":[13],"messenger":[14],"or":[15],"ligand.":[18],"In":[19],"the":[20,64,68,73,91,102,112,121,127,144,149,172,179,188,204,207,219,224,232],"latter":[21],"case,":[22],"it":[23,36],"transported":[25],"by":[26,165],"its":[27],"HDL-associated":[28],"apoM":[29],"carrier":[30],"and":[31,45,104,137,197],"circulated":[32],"blood":[34],"where":[35],"binds":[37],"to":[38,78,84],"specific":[39],"S1P":[40,50,94,109,131,135,147,162],"receptors":[41],"on":[42],"cell":[43],"membranes":[44],"induces":[46],"downstream":[47],"reactions.":[48],"Although":[49],"signaling":[51],"pathways":[52],"are":[53,60],"essential":[54],"for":[55,143],"many":[56],"biological":[57],"processes,":[58],"they":[59],"poorly":[61],"understood":[62],"at":[63,101],"molecular":[65,80,88,229],"level.":[66],"Here,":[67],"solved":[69],"crystal":[70],"structures":[71],"of":[72,93,120,126,146,161,181,191,206,218,231],"S1P<sub>1</sub>":[74],"receptor":[75,113,128,166,225],"were":[76],"used":[77],"evaluate":[79],"dynamics":[81],"(MD)":[82],"simulations":[83,98],"generate":[85],"greater":[86],"detailed":[87,228],"insights":[89],"into":[90],"mechanism":[92],"signaling.":[95],"The":[96,158,193],"MD":[97],"provided":[99],"observations":[100],"coarse-grained":[103],"atomic":[105],"levels":[106],"indicating":[107],"may":[110],"access":[111],"binding":[114,150,160,209],"pocket":[115,210],"directly":[116],"from":[117],"solvents.":[118],"Lifting":[119],"bulky":[122],"N-terminal":[123],"cap":[124],"region":[125,190],"precedes":[129],"initial":[130],"binding.":[132,215,241],"Glu121<sup>3.29</sup>":[133],"guides":[134],"penetration,":[136],"together":[138],"with":[139,155],"Arg292<sup>7.34</sup>":[140],"responsible":[142],"stabilization":[145],"pocket,":[151],"which":[152],"consistent":[154],"experimental":[156],"predictions.":[157],"complete":[159],"followed":[164],"activation,":[167],"wherein":[168],"Trp269<sup>6.48</sup>":[169],"moves":[170],"toward":[171],"transmembrane":[173],"helix":[174],"(TM)":[175],"7,":[176],"resulting":[177,202],"formation":[180],"an":[182],"enhanced":[183],"hydrogen":[184],"bond":[185],"network":[186,222,235],"lower":[189],"TM7.":[192],"distance":[194],"between":[195],"TM3":[196],"TM6":[198],"subsequently":[200],"increased,":[201],"opening":[205],"intracellular":[208],"enables":[212],"G":[213],"protein":[214],"Further":[216],"analysis":[217],"force":[220],"distribution":[221],"yielded":[226],"understanding":[230],"signal":[233],"transmission":[234],"activated":[238],"upon":[239],"agonist":[240]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}