{"id":"https://openalex.org/W2969330232","doi":"https://doi.org/10.1021/acs.jcim.9b00365","title":"EK-DRD: A Comprehensive Database for Drug Repositioning Inspired by Experimental Knowledge","display_name":"EK-DRD: A Comprehensive Database for Drug Repositioning Inspired by Experimental Knowledge","publication_year":2019,"publication_date":"2019-08-21","ids":{"openalex":"https://openalex.org/W2969330232","doi":"https://doi.org/10.1021/acs.jcim.9b00365","mag":"2969330232","pmid":"https://pubmed.ncbi.nlm.nih.gov/31433187"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.9b00365","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00365","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079284081","display_name":"Chongze Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chongze Zhao","raw_affiliation_strings":["Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China"],"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101755730","display_name":"Xi Dai","orcid":"https://orcid.org/0000-0002-8964-793X"},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Dai","raw_affiliation_strings":["Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China"],"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103076965","display_name":"Yecheng Li","orcid":"https://orcid.org/0000-0003-3578-3714"},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yecheng Li","raw_affiliation_strings":["Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China"],"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101667379","display_name":"Qingqing Guo","orcid":"https://orcid.org/0000-0003-2863-805X"},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingqing Guo","raw_affiliation_strings":["Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China"],"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434782","display_name":"Jianhua Zhang","orcid":"https://orcid.org/0009-0008-8751-0834"},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianhua Zhang","raw_affiliation_strings":["Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China"],"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403795","display_name":"Xiaotong Zhang","orcid":"https://orcid.org/0000-0001-7600-7231"},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaotong Zhang","raw_affiliation_strings":["Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China"],"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100398640","display_name":"Ling Wang","orcid":"https://orcid.org/0000-0003-2141-4272"},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ling Wang","raw_affiliation_strings":["Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China"],"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China","institution_ids":["https://openalex.org/I90610280"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100398640"],"corresponding_institution_ids":["https://openalex.org/I90610280"],"apc_list":null,"apc_paid":null,"fwci":0.7759,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.7483933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"59","issue":"9","first_page":"3619","last_page":"3624"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9796000123023987,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.8037931323051453},{"id":"https://openalex.org/keywords/chembl","display_name":"chEMBL","score":0.6302867531776428},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6300125122070312},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.611761212348938},{"id":"https://openalex.org/keywords/resource","display_name":"Resource (disambiguation)","score":0.5800266265869141},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5447912216186523},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.5372004508972168},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.43592309951782227},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.41825783252716064},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.4129413962364197},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.38193994760513306},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.3642919659614563},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.26497942209243774},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.23399749398231506},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13962486386299133},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.13854768872261047}],"concepts":[{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.8037931323051453},{"id":"https://openalex.org/C63222358","wikidata":"https://www.wikidata.org/wiki/Q6120337","display_name":"chEMBL","level":3,"score":0.6302867531776428},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6300125122070312},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.611761212348938},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.5800266265869141},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5447912216186523},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.5372004508972168},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.43592309951782227},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.41825783252716064},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.4129413962364197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38193994760513306},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.3642919659614563},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26497942209243774},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23399749398231506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13962486386299133},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.13854768872261047},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051188","descriptor_name":"Knowledge Bases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051188","descriptor_name":"Knowledge Bases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051188","descriptor_name":"Knowledge Bases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D062313","descriptor_name":"Databases, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062313","descriptor_name":"Databases, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062313","descriptor_name":"Databases, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.9b00365","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00365","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:31433187","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31433187","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1329528192","display_name":null,"funder_award_id":"2018ZD37","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G4902922151","display_name":null,"funder_award_id":"2016A030310421","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320321106","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1968779484","https://openalex.org/W1973106804","https://openalex.org/W1975875968","https://openalex.org/W1984084871","https://openalex.org/W1985270532","https://openalex.org/W2009081245","https://openalex.org/W2018518196","https://openalex.org/W2028279608","https://openalex.org/W2029124536","https://openalex.org/W2049988693","https://openalex.org/W2055043387","https://openalex.org/W2062941476","https://openalex.org/W2065812641","https://openalex.org/W2077004593","https://openalex.org/W2080754816","https://openalex.org/W2093313266","https://openalex.org/W2118423035","https://openalex.org/W2138512826","https://openalex.org/W2169678694","https://openalex.org/W2176184837","https://openalex.org/W2204230050","https://openalex.org/W2204695023","https://openalex.org/W2210241103","https://openalex.org/W2227583040","https://openalex.org/W2273267066","https://openalex.org/W2291177112","https://openalex.org/W2514790758","https://openalex.org/W2544136853","https://openalex.org/W2559588208","https://openalex.org/W2612436700","https://openalex.org/W2660983679","https://openalex.org/W2739999456","https://openalex.org/W2757363103","https://openalex.org/W2762358889","https://openalex.org/W2764184942","https://openalex.org/W2772508026","https://openalex.org/W2774596167","https://openalex.org/W2802693280","https://openalex.org/W2826750344"],"related_works":["https://openalex.org/W2800402488","https://openalex.org/W3087749121","https://openalex.org/W4233725430","https://openalex.org/W3010058077","https://openalex.org/W2920569584","https://openalex.org/W2951512731","https://openalex.org/W2046431380","https://openalex.org/W4392354878","https://openalex.org/W4321254242","https://openalex.org/W4385760073"],"abstract_inverted_index":{"Drug":[0,94],"repositioning,":[1],"or":[2,154],"the":[3,25,30,35,58,91,168],"identification":[4],"of":[5,29,37,57,60,68,177],"new":[6,89],"indications":[7],"for":[8,64,116],"approved":[9],"therapeutic":[10],"drugs,":[11,181],"has":[12,44],"gained":[13],"substantial":[14],"traction":[15],"with":[16,158],"both":[17],"academics":[18],"and":[19,27,34,101,119,144,162,185,193,200],"pharmaceutical":[20],"companies":[21],"because":[22,56],"it":[23],"reduces":[24],"cost":[26],"duration":[28],"drug":[31,70,113,169],"development":[32],"pipeline":[33],"likelihood":[36],"unforeseen":[38],"adverse":[39],"events.":[40],"To":[41,82],"date":[42],"there":[43],"not":[45],"been":[46],"a":[47,61,88,175],"systematic":[48],"effort":[49],"to":[50,73,167],"identify":[51],"such":[52],"opportunities,":[53],"in":[54],"part":[55],"lack":[59],"comprehensive":[62],"resource":[63],"an":[65],"enormous":[66],"amount":[67],"unsystematic":[69],"repositioning":[71,114,152,183],"information":[72],"support":[74],"scientists":[75],"who":[76],"could":[77],"benefit":[78],"from":[79],"this":[80,84],"endeavor.":[81],"address":[83],"challenge,":[85],"we":[86],"developed":[87],"database,":[90],"Experimental":[92],"Knowledge-Based":[93],"Repositioning":[95],"Database":[96],"(EK-DRD),":[97],"by":[98],"using":[99,130],"text":[100],"data":[102],"mining":[103],"as":[104,106],"well":[105],"manual":[107],"curation.":[108],"EK-DRD":[109,204],"contains":[110],"experimentally":[111],"validated":[112],"annotation":[115],"1861":[117],"FDA-approved":[118],"102":[120],"withdrawn":[121],"small-molecule":[122],"drugs.":[123],"Annotation":[124],"was":[125],"done":[126],"at":[127,208],"four":[128],"levels":[129],"30":[131],"944":[132],"target":[133,155],"assay":[134,138,142],"records,":[135,139,143],"3999":[136],"cell":[137],"585":[140],"organism":[141],"8889":[145],"clinical":[146],"trial":[147],"records.":[148],"Additionally,":[149],"approximately":[150],"1799":[151],"protein":[153],"sequences":[156],"coupled":[157],"856":[159],"related":[160,186],"diseases":[161],"1332":[163],"pathways":[164],"are":[165],"linked":[166],"entries.":[170],"Our":[171],"web-based":[172],"software":[173],"displays":[174],"network":[176],"integrative":[178],"relationships":[179],"between":[180],"their":[182],"targets,":[184],"diseases.":[187],"The":[188],"database":[189],"is":[190,205],"fully":[191],"searchable":[192],"supports":[194],"extensive":[195],"text,":[196],"sequence,":[197],"chemical":[198],"structure,":[199],"relational":[201],"query":[202],"searches.":[203],"freely":[206],"accessible":[207],"http://www.idruglab.com/drd/index.php":[209],".":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}