{"id":"https://openalex.org/W2944825169","doi":"https://doi.org/10.1021/acs.jcim.9b00298","title":"Understanding Ligand Binding Selectivity in a Prototypical GPCR Family","display_name":"Understanding Ligand Binding Selectivity in a Prototypical GPCR Family","publication_year":2019,"publication_date":"2019-05-24","ids":{"openalex":"https://openalex.org/W2944825169","doi":"https://doi.org/10.1021/acs.jcim.9b00298","mag":"2944825169","pmid":"https://pubmed.ncbi.nlm.nih.gov/31125224"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.9b00298","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00298","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.9b00298","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.9b00298","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056562007","display_name":"Giulio Mattedi","orcid":"https://orcid.org/0000-0002-7290-694X"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Giulio Mattedi","raw_affiliation_strings":["Department of Chemistry, University College London, London WC1E 6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University College London, London WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081526659","display_name":"Francesca Deflorian","orcid":"https://orcid.org/0000-0002-8904-4645"},"institutions":[{"id":"https://openalex.org/I4210147697","display_name":"Heptares Therapeutics (United Kingdom)","ror":"https://ror.org/051fk5x88","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210147697"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Francesca Deflorian","raw_affiliation_strings":["Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom","institution_ids":["https://openalex.org/I4210147697"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107412290","display_name":"Jonathan S. Mason","orcid":null},"institutions":[{"id":"https://openalex.org/I4210147697","display_name":"Heptares Therapeutics (United Kingdom)","ror":"https://ror.org/051fk5x88","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210147697"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan S. Mason","raw_affiliation_strings":["Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom","institution_ids":["https://openalex.org/I4210147697"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020226245","display_name":"Chris de Graaf","orcid":"https://orcid.org/0000-0002-1226-2150"},"institutions":[{"id":"https://openalex.org/I4210147697","display_name":"Heptares Therapeutics (United Kingdom)","ror":"https://ror.org/051fk5x88","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210147697"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris de Graaf","raw_affiliation_strings":["Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom","institution_ids":["https://openalex.org/I4210147697"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023053470","display_name":"Francesco Luigi Gervasio","orcid":"https://orcid.org/0000-0003-4831-5039"},"institutions":[{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Francesco L. Gervasio","raw_affiliation_strings":["Department of Chemistry, University College London, London WC1E 6BT, United Kingdom","Institute of Structural and Molecular Biology, University College London, London WC1E 6BT, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-4831-5039","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University College London, London WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, University College London, London WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5023053470","https://openalex.org/A5056562007"],"corresponding_institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":1.7088,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.8468857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"59","issue":"6","first_page":"2830","last_page":"2836"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-receptor","display_name":"G protein-coupled receptor","score":0.7714077234268188},{"id":"https://openalex.org/keywords/adenosine-receptor","display_name":"Adenosine receptor","score":0.5916057229042053},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.5726116895675659},{"id":"https://openalex.org/keywords/subfamily","display_name":"Subfamily","score":0.5267093777656555},{"id":"https://openalex.org/keywords/functional-selectivity","display_name":"Functional selectivity","score":0.5133758783340454},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.5015439987182617},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49692586064338684},{"id":"https://openalex.org/keywords/adenosine","display_name":"Adenosine","score":0.48297563195228577},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.45669063925743103},{"id":"https://openalex.org/keywords/structural-similarity","display_name":"Structural similarity","score":0.44167301058769226},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4314758777618408},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3247159719467163},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.25942403078079224},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16844937205314636},{"id":"https://openalex.org/keywords/agonist","display_name":"Agonist","score":0.07209563255310059}],"concepts":[{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.7714077234268188},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.5916057229042053},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5726116895675659},{"id":"https://openalex.org/C50929876","wikidata":"https://www.wikidata.org/wiki/Q164280","display_name":"Subfamily","level":3,"score":0.5267093777656555},{"id":"https://openalex.org/C43587935","wikidata":"https://www.wikidata.org/wiki/Q1258877","display_name":"Functional selectivity","level":4,"score":0.5133758783340454},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5015439987182617},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49692586064338684},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.48297563195228577},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45669063925743103},{"id":"https://openalex.org/C139489369","wikidata":"https://www.wikidata.org/wiki/Q770846","display_name":"Structural similarity","level":2,"score":0.44167301058769226},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4314758777618408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3247159719467163},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25942403078079224},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16844937205314636},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.07209563255310059}],"mesh":[{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.jcim.9b00298","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00298","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.9b00298","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:31125224","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31125224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10075766","is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10075766/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"   Journal of Chemical Information and Modeling       (2019)     (In press).  ","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7007187","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7007187","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acs.jcim.9b00298","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00298","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.9b00298","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.550000011920929}],"awards":[{"id":"https://openalex.org/G3702480926","display_name":null,"funder_award_id":"EP/P011306/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7393843935","display_name":"EPSRC Flagship Software - BioSimSpace: A shared space for the community development of biomolecular simulation workflows","funder_award_id":"EP/P022138/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7941732191","display_name":null,"funder_award_id":"EP/P022138/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8454717748","display_name":"Efficient modelling and validation of cryptic protein binding sites for drug discovery","funder_award_id":"EP/P011306/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8947107902","display_name":null,"funder_award_id":"EP/L000253/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2944825169.pdf"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W428850520","https://openalex.org/W1031578623","https://openalex.org/W1607931568","https://openalex.org/W1676635233","https://openalex.org/W1833104430","https://openalex.org/W1969111000","https://openalex.org/W1975391500","https://openalex.org/W1975740938","https://openalex.org/W1985598247","https://openalex.org/W1989146783","https://openalex.org/W2000655486","https://openalex.org/W2001996470","https://openalex.org/W2039399096","https://openalex.org/W2040809566","https://openalex.org/W2049617698","https://openalex.org/W2057806291","https://openalex.org/W2075205895","https://openalex.org/W2077684756","https://openalex.org/W2080653934","https://openalex.org/W2095596429","https://openalex.org/W2142322475","https://openalex.org/W2145991947","https://openalex.org/W2146411229","https://openalex.org/W2147993766","https://openalex.org/W2149655632","https://openalex.org/W2168634451","https://openalex.org/W2280969907","https://openalex.org/W2314730640","https://openalex.org/W2352978152","https://openalex.org/W2404280981","https://openalex.org/W2439566903","https://openalex.org/W2594829311","https://openalex.org/W2609589855","https://openalex.org/W2736015721","https://openalex.org/W2774484667","https://openalex.org/W2809171792"],"related_works":["https://openalex.org/W2075796864","https://openalex.org/W2794568828","https://openalex.org/W2013049584","https://openalex.org/W2130619870","https://openalex.org/W2811177568","https://openalex.org/W3016345108","https://openalex.org/W2561886516","https://openalex.org/W2021722027","https://openalex.org/W3146713902","https://openalex.org/W1986341934"],"abstract_inverted_index":{"adenosine":[0],"receptors.":[1],"Our":[2],"model":[3],"shows":[4],"how":[5],"small":[6],"differences":[7],"in":[8,13],"the":[9,14,18],"binding":[10],"pocket":[11],"and":[12],"water":[15],"network":[16],"around":[17],"ligand":[19],"can":[20],"be":[21],"leveraged":[22],"to":[23],"achieve":[24],"selectivity.":[25]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":9}],"updated_date":"2026-05-22T06:13:13.366637","created_date":"2025-10-10T00:00:00"}
