{"id":"https://openalex.org/W2974098637","doi":"https://doi.org/10.1021/acs.jcim.9b00243","title":"Scaffold-Based Analytics: Enabling Hit-to-Lead Decisions by Visualizing Chemical Series Linked across Large Datasets","display_name":"Scaffold-Based Analytics: Enabling Hit-to-Lead Decisions by Visualizing Chemical Series Linked across Large Datasets","publication_year":2019,"publication_date":"2019-09-18","ids":{"openalex":"https://openalex.org/W2974098637","doi":"https://doi.org/10.1021/acs.jcim.9b00243","mag":"2974098637","pmid":"https://pubmed.ncbi.nlm.nih.gov/31532656"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.9b00243","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00243","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052974651","display_name":"Deepak Bandyopadhyay","orcid":"https://orcid.org/0000-0002-8747-369X"},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Deepak Bandyopadhyay","raw_affiliation_strings":["GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, United States"],"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081115546","display_name":"Constantine Kreatsoulas","orcid":"https://orcid.org/0000-0002-3654-8209"},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Constantine Kreatsoulas","raw_affiliation_strings":["GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, United States"],"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056808437","display_name":"Pat Brady","orcid":null},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pat G. Brady","raw_affiliation_strings":["GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, United States"],"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047028744","display_name":"J. Gregory Boyer","orcid":null},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Boyer","raw_affiliation_strings":["GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, United States"],"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100899625","display_name":"Zangdong He","orcid":null},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zangdong He","raw_affiliation_strings":["GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, United States"],"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003546706","display_name":"Genaro S. Scavello","orcid":null},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Genaro Scavello","raw_affiliation_strings":["GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, United States"],"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046883846","display_name":"Tyler Peryea","orcid":"https://orcid.org/0000-0002-5388-9750"},"institutions":[{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler Peryea","raw_affiliation_strings":["National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, Maryland 20850, United States"],"affiliations":[{"raw_affiliation_string":"National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, Maryland 20850, United States","institution_ids":["https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061786031","display_name":"Ajit Jadhav","orcid":"https://orcid.org/0000-0001-7955-1451"},"institutions":[{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ajit Jadhav","raw_affiliation_strings":["National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, Maryland 20850, United States"],"affiliations":[{"raw_affiliation_string":"National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, Maryland 20850, United States","institution_ids":["https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061179559","display_name":"\u00d0\u1eafc-Trung Nguy\u1ec5n","orcid":"https://orcid.org/0000-0003-2591-9948"},"institutions":[{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dac-Trung Nguyen","raw_affiliation_strings":["National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, Maryland 20850, United States"],"affiliations":[{"raw_affiliation_string":"National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, Maryland 20850, United States","institution_ids":["https://openalex.org/I4210148682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069062997","display_name":"Rajarshi Guha","orcid":"https://orcid.org/0000-0001-7403-8819"},"institutions":[{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rajarshi Guha","raw_affiliation_strings":["National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, Maryland 20850, United States"],"affiliations":[{"raw_affiliation_string":"National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, Maryland 20850, United States","institution_ids":["https://openalex.org/I4210148682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5052974651","https://openalex.org/A5061179559","https://openalex.org/A5069062997"],"corresponding_institution_ids":["https://openalex.org/I4210114143","https://openalex.org/I4210148682"],"apc_list":null,"apc_paid":null,"fwci":1.9961,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.88056372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"59","issue":"11","first_page":"4880","last_page":"4892"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13083","display_name":"Advanced Text Analysis Techniques","score":0.9724000096321106,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lead","display_name":"Lead (geology)","score":0.670846700668335},{"id":"https://openalex.org/keywords/analytics","display_name":"Analytics","score":0.6531616449356079},{"id":"https://openalex.org/keywords/series","display_name":"Series (stratigraphy)","score":0.5554184913635254},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5440281629562378},{"id":"https://openalex.org/keywords/scaffold","display_name":"Scaffold","score":0.48414096236228943},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.38398075103759766},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.147109717130661},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10076448321342468}],"concepts":[{"id":"https://openalex.org/C2777093003","wikidata":"https://www.wikidata.org/wiki/Q6508345","display_name":"Lead (geology)","level":2,"score":0.670846700668335},{"id":"https://openalex.org/C79158427","wikidata":"https://www.wikidata.org/wiki/Q485396","display_name":"Analytics","level":2,"score":0.6531616449356079},{"id":"https://openalex.org/C143724316","wikidata":"https://www.wikidata.org/wiki/Q312468","display_name":"Series (stratigraphy)","level":2,"score":0.5554184913635254},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5440281629562378},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.48414096236228943},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.38398075103759766},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.147109717130661},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10076448321342468},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017143","descriptor_name":"Fuzzy Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017143","descriptor_name":"Fuzzy Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017143","descriptor_name":"Fuzzy Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.9b00243","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00243","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:31532656","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31532656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W134574290","https://openalex.org/W1966388665","https://openalex.org/W1968753037","https://openalex.org/W1978116785","https://openalex.org/W1978229532","https://openalex.org/W1979189217","https://openalex.org/W1984596955","https://openalex.org/W1989012153","https://openalex.org/W1991286793","https://openalex.org/W1999360250","https://openalex.org/W2003932717","https://openalex.org/W2011430131","https://openalex.org/W2020195882","https://openalex.org/W2022625706","https://openalex.org/W2027393938","https://openalex.org/W2031441006","https://openalex.org/W2043814498","https://openalex.org/W2048080607","https://openalex.org/W2050190889","https://openalex.org/W2058397078","https://openalex.org/W2060531713","https://openalex.org/W2062671889","https://openalex.org/W2077645025","https://openalex.org/W2078295062","https://openalex.org/W2090631504","https://openalex.org/W2125109129","https://openalex.org/W2155741020","https://openalex.org/W2213138713","https://openalex.org/W2268755124","https://openalex.org/W2503383968","https://openalex.org/W2704666864","https://openalex.org/W2930082324"],"related_works":["https://openalex.org/W4255463199","https://openalex.org/W4281691423","https://openalex.org/W2411039299","https://openalex.org/W1856410221","https://openalex.org/W2081717811","https://openalex.org/W2695162732","https://openalex.org/W2884765235","https://openalex.org/W2318949977","https://openalex.org/W2351880312","https://openalex.org/W4390482427"],"abstract_inverted_index":{"We":[0,35,153],"present":[1],"a":[2,38,43,106,138,172,214],"method":[3],"for":[4],"visualizing":[5],"and":[6,18,72,93,108,142,159,163,167,181,190,204,211],"navigating":[7],"large":[8,107,189],"screening":[9,54,192],"datasets":[10,76],"while":[11],"also":[12],"taking":[13],"into":[14],"account":[15],"their":[16,161],"activities":[17],"properties.":[19],"Our":[20],"approach":[21,46],"is":[22,111],"to":[23,42,57,96,121,127,197,217],"annotate":[24],"the":[25,49,53,59,79,146,206],"data":[26,73],"with":[27,178],"all":[28,115,128],"possible":[29,120],"scaffolds":[30,117],"contained":[31],"within":[32],"each":[33],"molecule.":[34],"have":[36],"developed":[37],"Spotfire":[39,173],"visualization,":[40],"coupled":[41],"fuzzy":[44,179],"clustering":[45,180],"based":[47],"on":[48],"scaffold":[50,70,80,132,156],"decomposition":[51],"of":[52,99,105,140,148,150,171,188,208],"deck,":[55],"used":[56,175],"drive":[58],"hit":[60,110],"triage":[61],"process.":[62],"Progression":[63],"decisions":[64],"can":[65],"be":[66],"made":[67],"using":[68],"aggregate":[69],"parameters":[71],"from":[74],"multiple":[75,100],"merged":[77],"at":[78,145],"level.":[81],"This":[82,131,194],"visualization":[83,174],"reveals":[84],"overlaps":[85],"that":[86],"help":[87],"prioritize":[88],"hits,":[89],"highlight":[90],"tractable":[91],"series,":[92],"posit":[94],"ways":[95],"combine":[97],"aspects":[98],"hits.":[101,130],"The":[102,169],"structure-activity":[103],"relationship":[104],"complex":[109],"automatically":[112],"mapped":[113],"onto":[114],"constituent":[116],"making":[118],"it":[119],"navigate,":[122],"via":[123],"any":[124],"shared":[125],"scaffold,":[126],"related":[129,202],"\"walking\"":[133],"helps":[134],"address":[135],"bias":[136],"toward":[137],"handful":[139],"potent":[141],"ligand-efficient":[143],"molecules":[144,203],"expense":[147],"coverage":[149],"chemical":[151],"space.":[152],"consider":[154],"two":[155],"generation":[157],"methods":[158],"explored":[160],"similarities":[162],"differences":[164],"both":[165],"qualitatively":[166],"quantitatively.":[168],"workflow":[170],"in":[176,213],"combination":[177],"structure":[182],"annotation":[183],"provides":[184],"an":[185],"intuitive":[186],"view":[187],"diverse":[191],"datasets.":[193],"allows":[195],"teams":[196],"effortlessly":[198],"navigate":[199],"between":[200],"structurally":[201],"enriches":[205],"population":[207],"leads":[209],"considered":[210],"progressed":[212],"manner":[215],"complementary":[216],"established":[218],"approaches.":[219]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
