{"id":"https://openalex.org/W2942891342","doi":"https://doi.org/10.1021/acs.jcim.9b00156","title":"Movements of the Substrate-Binding Clamp of Cypemycin Decarboxylase CypD","display_name":"Movements of the Substrate-Binding Clamp of Cypemycin Decarboxylase CypD","publication_year":2019,"publication_date":"2019-04-29","ids":{"openalex":"https://openalex.org/W2942891342","doi":"https://doi.org/10.1021/acs.jcim.9b00156","mag":"2942891342","pmid":"https://pubmed.ncbi.nlm.nih.gov/31033286"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.9b00156","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00156","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101907377","display_name":"Lei Liu","orcid":"https://orcid.org/0000-0002-8680-1209"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I3130456415","display_name":"Mianyang Normal University","ror":"https://ror.org/02rka3n91","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130456415"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Liu","raw_affiliation_strings":["College of Life Science & Biotechnology, Mianyang Normal University, Mianyang 621000, P. R. China","Department of Chemistry, Fudan University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science & Biotechnology, Mianyang Normal University, Mianyang 621000, P. R. China","institution_ids":["https://openalex.org/I3130456415"]},{"raw_affiliation_string":"Department of Chemistry, Fudan University, Shanghai 200433, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056471340","display_name":"Stephen Chan","orcid":"https://orcid.org/0000-0001-8865-6618"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Stephen Chan","raw_affiliation_strings":["Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China","institution_ids":["https://openalex.org/I4210145761","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027543525","display_name":"Tianlu Mo","orcid":null},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianlu Mo","raw_affiliation_strings":["Department of Chemistry, Fudan University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Fudan University, Shanghai 200433, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100608631","display_name":"Wei Ding","orcid":"https://orcid.org/0000-0003-4368-8215"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Ding","raw_affiliation_strings":["State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076097117","display_name":"Shaoning Yu","orcid":"https://orcid.org/0000-0002-5153-9829"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaoning Yu","raw_affiliation_strings":["Department of Chemistry, Fudan University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Fudan University, Shanghai 200433, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360362","display_name":"Qi Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qi Zhang","raw_affiliation_strings":["Department of Chemistry, Fudan University, Shanghai 200433, China"],"raw_orcid":"https://orcid.org/0000-0002-8135-2221","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Fudan University, Shanghai 200433, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022513985","display_name":"Shuguang Yuan","orcid":"https://orcid.org/0000-0001-9858-4742"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH","CN"],"is_corresponding":true,"raw_author_name":"Shuguang Yuan","raw_affiliation_strings":["Laboratory of Physical Chemistry of Polymers and Membranes, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH B3 495 (B\u00e2timent CH) Station 6, Lausanne CH-1015, Switzerland","Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"],"raw_orcid":"https://orcid.org/0000-0001-9858-4742","affiliations":[{"raw_affiliation_string":"Laboratory of Physical Chemistry of Polymers and Membranes, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH B3 495 (B\u00e2timent CH) Station 6, Lausanne CH-1015, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China","institution_ids":["https://openalex.org/I4210145761","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5022513985","https://openalex.org/A5100360362"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I24943067","https://openalex.org/I4210145761","https://openalex.org/I5124864"],"apc_list":null,"apc_paid":null,"fwci":1.3876,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.79984088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"59","issue":"6","first_page":"2924","last_page":"2929"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.9793999791145325,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.970300018787384,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substrate","display_name":"Substrate (aquarium)","score":0.5960655808448792},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5654372572898865},{"id":"https://openalex.org/keywords/decarboxylation","display_name":"Decarboxylation","score":0.5233002305030823},{"id":"https://openalex.org/keywords/cysteine","display_name":"Cysteine","score":0.5100036859512329},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.46101653575897217},{"id":"https://openalex.org/keywords/flavin-group","display_name":"Flavin group","score":0.4595377445220947},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.4594680964946747},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.4322489798069},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3974422514438629},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.32557016611099243},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.3210362195968628},{"id":"https://openalex.org/keywords/catalysis","display_name":"Catalysis","score":0.21125152707099915},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1727832853794098}],"concepts":[{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5960655808448792},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5654372572898865},{"id":"https://openalex.org/C2780595602","wikidata":"https://www.wikidata.org/wiki/Q898436","display_name":"Decarboxylation","level":3,"score":0.5233002305030823},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.5100036859512329},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.46101653575897217},{"id":"https://openalex.org/C33093398","wikidata":"https://www.wikidata.org/wiki/Q174337","display_name":"Flavin group","level":3,"score":0.4595377445220947},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4594680964946747},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4322489798069},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3974422514438629},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32557016611099243},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3210362195968628},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.21125152707099915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1727832853794098},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001430","descriptor_name":"Bacteriocins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001430","descriptor_name":"Bacteriocins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001430","descriptor_name":"Bacteriocins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002262","descriptor_name":"Carboxy-Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002262","descriptor_name":"Carboxy-Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002262","descriptor_name":"Carboxy-Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002262","descriptor_name":"Carboxy-Lyases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002262","descriptor_name":"Carboxy-Lyases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002262","descriptor_name":"Carboxy-Lyases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009068","descriptor_name":"Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009068","descriptor_name":"Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009068","descriptor_name":"Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.9b00156","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00156","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:31033286","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31033286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1731867471","display_name":null,"funder_award_id":"2016YFA0501302","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G3214837932","display_name":"\u86cb\u767d\u78f7\u9178\u5316\u9176\u81ea\u6211\u6291\u5236\u7ed3\u6784\u57df\u53ca\u5176\u4e0e\u514d\u75ab\u6291\u5236\u836f\u7269\u7684\u4f5c\u7528\u673a\u5236\u7814\u7a76","funder_award_id":"31470786","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3239239561","display_name":null,"funder_award_id":"31600398","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3514866892","display_name":"\u65b0\u578bsactipeptide\u7684\u53d1\u73b0\u53ca\u751f\u7269\u5408\u6210\u673a\u5236\u7814\u7a76","funder_award_id":"31670060","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6308746262","display_name":null,"funder_award_id":"18YFF0212501","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1867876960","https://openalex.org/W1968438069","https://openalex.org/W1984718726","https://openalex.org/W2028181978","https://openalex.org/W2083122789","https://openalex.org/W2087480493","https://openalex.org/W2091584330","https://openalex.org/W2121400889","https://openalex.org/W2125427536","https://openalex.org/W2132328461","https://openalex.org/W2142696585","https://openalex.org/W2147228798","https://openalex.org/W2162854463","https://openalex.org/W2292301738","https://openalex.org/W2318259697","https://openalex.org/W2326298341","https://openalex.org/W2592527354","https://openalex.org/W2607829678","https://openalex.org/W2743239503","https://openalex.org/W2755025259","https://openalex.org/W2768059482","https://openalex.org/W2794743485","https://openalex.org/W2892078448","https://openalex.org/W2901730017","https://openalex.org/W2914003568","https://openalex.org/W2914908944"],"related_works":["https://openalex.org/W1984955493","https://openalex.org/W1987685202","https://openalex.org/W4390393178","https://openalex.org/W4239503938","https://openalex.org/W2952699752","https://openalex.org/W3043940973","https://openalex.org/W2082898637","https://openalex.org/W2367949257","https://openalex.org/W2080368264","https://openalex.org/W123440712"],"abstract_inverted_index":{"Linaridins":[0],"are":[1,171],"a":[2,57,73,132,136,145],"small":[3],"but":[4],"growing":[5],"class":[6,22],"of":[7,36,45,70,75,87,117,124,158],"natural":[8],"products":[9],"belonging":[10],"to":[11,135],"the":[12,37,46,66,83,94,102,118,125,128,155],"ribosomally":[13],"synthesized":[14],"and":[15,51,77,98,109,144,154,185,190,195],"post-translationally":[16],"modified":[17],"peptide":[18,48],"(RiPP)":[19],"superfamily.":[20],"The":[21,148],"A":[23],"linaridins,":[24],"exemplified":[25],"by":[26,56,72],"cypemycin,":[27],"possess":[28],"an":[29,42,161],"unusual":[30],"S-[(":[31],"Z)-2-aminovinyl]-d-cysteine":[32],"(AviCys)":[33],"residue.":[34],"Formation":[35],"AviCys":[38],"in":[39,164,174,198],"cypemycin":[40],"requires":[41],"oxidative":[43],"decarboxylation":[44],"precursor":[47],"C-terminal":[49],"Cys,":[50],"this":[52,62,175],"reaction":[53],"is":[54],"catalyzed":[55],"flavin-dependent":[58,187],"decarboxylase":[59],"CypD.":[60],"In":[61],"work,":[63],"we":[64],"investigate":[65],"molecular":[67,106],"recognition":[68],"processes":[69],"CypD":[71,88,184],"combination":[74],"computational":[76],"biochemical":[78],"analysis.":[79],"We":[80],"show":[81],"that":[82,115],"substrate":[84,95,119,159,166],"binding":[85,116],"clamp":[86,130],"undergoes":[89],"dramatic":[90],"fluctuation,":[91],"mediating":[92,165],"both":[93],"entrance":[96],"into":[97,183],"product":[99],"release":[100],"from":[101,131],"catalytic":[103],"pocket.":[104],"Extensive":[105],"dynamic":[107],"simulations":[108],"Fourier":[110],"transform":[111],"IR":[112],"analyses":[113],"indicated":[114],"induces":[120],"substantial":[121],"structural":[122],"change":[123],"enzyme,":[126],"converting":[127],"substrate-binding":[129],"random":[133],"loop":[134],"more":[137],"ordered":[138],"structure":[139],"comprising":[140],"two":[141],"\u03b2":[142,146],"sheets":[143],"turn.":[147],"salt":[149],"bridge":[150],"between":[151],"Arg159":[152],"guanine":[153],"Cys":[156,188],"carboxylate":[157],"plays":[160],"important":[162,173,180],"role":[163],"binding,":[167],"while":[168],"hydrophobic":[169],"interactions":[170],"also":[172],"process.":[176],"These":[177],"results":[178],"provide":[179],"mechanistic":[181],"insights":[182],"other":[186],"decarboxylases,":[189],"could":[191],"facilitate":[192],"future":[193],"biosynthetic":[194],"bioengineering":[196],"efforts":[197],"studying":[199],"AviCys-containing":[200],"RiPPs.":[201]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1}],"updated_date":"2026-06-06T09:05:17.133730","created_date":"2025-10-10T00:00:00"}