{"id":"https://openalex.org/W2913355937","doi":"https://doi.org/10.1021/acs.jcim.9b00006","title":"Characterization of Differential Dynamics, Specificity, and Allostery of Lipoxygenase Family Members","display_name":"Characterization of Differential Dynamics, Specificity, and Allostery of Lipoxygenase Family Members","publication_year":2019,"publication_date":"2019-02-14","ids":{"openalex":"https://openalex.org/W2913355937","doi":"https://doi.org/10.1021/acs.jcim.9b00006","mag":"2913355937","pmid":"https://pubmed.ncbi.nlm.nih.gov/30762363"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.9b00006","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00006","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"publisher-specific-oa","license_id":"https://openalex.org/licenses/publisher-specific-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6541894","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040279016","display_name":"Karolina Mikulska\u2010Ruminska","orcid":"https://orcid.org/0000-0001-7227-5503"},"institutions":[{"id":"https://openalex.org/I4210086947","display_name":"Institute of Physics","ror":"https://ror.org/000sfad56","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210086947","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]}],"countries":["PL","US"],"is_corresponding":true,"raw_author_name":"Karolina Mikulska-Ruminska","raw_affiliation_strings":["Institute of Physics, Department of Biophysics and Medical Physics, Nicolaus Copernicus University, 87-100 Torun, Poland","Departments of Computational and System Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States"],"affiliations":[{"raw_affiliation_string":"Institute of Physics, Department of Biophysics and Medical Physics, Nicolaus Copernicus University, 87-100 Torun, Poland","institution_ids":["https://openalex.org/I4210086947","https://openalex.org/I3019271933"]},{"raw_affiliation_string":"Departments of Computational and System Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010544263","display_name":"Indira H. Shrivastava","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Indira Shrivastava","raw_affiliation_strings":["Departments of Computational and System Biology \u00a0and\u00a0 Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States"],"affiliations":[{"raw_affiliation_string":"Departments of Computational and System Biology \u00a0and\u00a0 Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076809288","display_name":"James Krieger","orcid":"https://orcid.org/0000-0001-6194-6244"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Krieger","raw_affiliation_strings":["Departments of Computational and System Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States"],"affiliations":[{"raw_affiliation_string":"Departments of Computational and System Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042499227","display_name":"She Zhang","orcid":"https://orcid.org/0000-0001-9265-4498"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"She Zhang","raw_affiliation_strings":["Departments of Computational and System Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States"],"affiliations":[{"raw_affiliation_string":"Departments of Computational and System Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101457676","display_name":"Hongchun Li","orcid":"https://orcid.org/0000-0002-3446-2962"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongchun Li","raw_affiliation_strings":["Departments of Computational and System Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States"],"affiliations":[{"raw_affiliation_string":"Departments of Computational and System Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061593498","display_name":"H\u00fclya Bay\u0131r","orcid":"https://orcid.org/0000-0003-2361-4120"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H\u00fclya Bay\u0131r","raw_affiliation_strings":["Environmental and Occupational Health \u00a0and\u00a0 Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States"],"affiliations":[{"raw_affiliation_string":"Environmental and Occupational Health \u00a0and\u00a0 Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062793362","display_name":"Sally E. Wenzel","orcid":"https://orcid.org/0000-0002-4242-0164"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sally E. Wenzel","raw_affiliation_strings":["Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States"],"affiliations":[{"raw_affiliation_string":"Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019267575","display_name":"Andrew P. VanDemark","orcid":"https://orcid.org/0000-0003-3424-4831"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew P. VanDemark","raw_affiliation_strings":["Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States"],"affiliations":[{"raw_affiliation_string":"Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049450190","display_name":"Valerian E. Kagan","orcid":"https://orcid.org/0000-0002-7245-1885"},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Valerian E. Kagan","raw_affiliation_strings":["Laboratory of Navigational Redox Lipidomics, I M Sechenov Moscow State Medical University, Moskva 119146, Russia"],"affiliations":[{"raw_affiliation_string":"Laboratory of Navigational Redox Lipidomics, I M Sechenov Moscow State Medical University, Moskva 119146, Russia","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081814496","display_name":"\u0130vet Bahar","orcid":"https://orcid.org/0000-0001-9959-4176"},"institutions":[{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ivet Bahar","raw_affiliation_strings":["Mol & Cell Cancer Biology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania 15232, United States","Departments of Computational and System Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States"],"affiliations":[{"raw_affiliation_string":"Mol & Cell Cancer Biology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania 15232, United States","institution_ids":["https://openalex.org/I4210128526"]},{"raw_affiliation_string":"Departments of Computational and System Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5040279016","https://openalex.org/A5081814496"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I3019271933","https://openalex.org/I4210086947","https://openalex.org/I4210128526"],"apc_list":null,"apc_paid":null,"fwci":4.4586,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.9494449,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"59","issue":"5","first_page":"2496","last_page":"2508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9807999730110168,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9807999730110168,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9699000120162964,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9685999751091003,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"Allosteric regulation","score":0.9187880754470825},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.642133355140686},{"id":"https://openalex.org/keywords/allosteric-enzyme","display_name":"Allosteric enzyme","score":0.5350822806358337},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.522650957107544},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4572943449020386},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.4447833299636841},{"id":"https://openalex.org/keywords/protein-family","display_name":"Protein family","score":0.43201589584350586},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"Substrate specificity","score":0.42803704738616943},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.4230378270149231},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3935871422290802},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.36572566628456116},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.24637728929519653},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.183026522397995},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.09344184398651123}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.9187880754470825},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.642133355140686},{"id":"https://openalex.org/C109964505","wikidata":"https://www.wikidata.org/wiki/Q3321436","display_name":"Allosteric enzyme","level":4,"score":0.5350822806358337},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.522650957107544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4572943449020386},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4447833299636841},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.43201589584350586},{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.42803704738616943},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.4230378270149231},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3935871422290802},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36572566628456116},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24637728929519653},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.183026522397995},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.09344184398651123}],"mesh":[{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008084","descriptor_name":"Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008084","descriptor_name":"Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008084","descriptor_name":"Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008084","descriptor_name":"Lipoxygenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008084","descriptor_name":"Lipoxygenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008084","descriptor_name":"Lipoxygenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009068","descriptor_name":"Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009068","descriptor_name":"Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009068","descriptor_name":"Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jcim.9b00006","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00006","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"publisher-specific-oa","license_id":"https://openalex.org/licenses/publisher-specific-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:30762363","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30762363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:6541894","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6541894","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6541894","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6541894","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"},"sustainable_development_goals":[{"score":0.44999998807907104,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G2194122157","display_name":null,"funder_award_id":"U19 AI068021","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5207768667","display_name":null,"funder_award_id":"P41 GM103712","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7515960544","display_name":null,"funder_award_id":"P30 DA035788","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1105693001","https://openalex.org/W1964942556","https://openalex.org/W1967165515","https://openalex.org/W1975207791","https://openalex.org/W1979937246","https://openalex.org/W1986743126","https://openalex.org/W1987774535","https://openalex.org/W1991514431","https://openalex.org/W1996960217","https://openalex.org/W2008057379","https://openalex.org/W2012673800","https://openalex.org/W2013253738","https://openalex.org/W2018748094","https://openalex.org/W2029667189","https://openalex.org/W2030517878","https://openalex.org/W2033058272","https://openalex.org/W2043949885","https://openalex.org/W2043980528","https://openalex.org/W2048855990","https://openalex.org/W2048910851","https://openalex.org/W2050333027","https://openalex.org/W2050975341","https://openalex.org/W2052612332","https://openalex.org/W2060665868","https://openalex.org/W2074203890","https://openalex.org/W2082779257","https://openalex.org/W2083120667","https://openalex.org/W2085347260","https://openalex.org/W2088718376","https://openalex.org/W2096602558","https://openalex.org/W2097504850","https://openalex.org/W2101941602","https://openalex.org/W2102725267","https://openalex.org/W2103388612","https://openalex.org/W2103693942","https://openalex.org/W2104512614","https://openalex.org/W2106393249","https://openalex.org/W2115928493","https://openalex.org/W2122020349","https://openalex.org/W2124483575","https://openalex.org/W2129280925","https://openalex.org/W2130479394","https://openalex.org/W2132926880","https://openalex.org/W2140616220","https://openalex.org/W2142595184","https://openalex.org/W2150981663","https://openalex.org/W2151595894","https://openalex.org/W2153255725","https://openalex.org/W2159884214","https://openalex.org/W2160975112","https://openalex.org/W2166245415","https://openalex.org/W2168798454","https://openalex.org/W2169076235","https://openalex.org/W2171537755","https://openalex.org/W2176487670","https://openalex.org/W2203570694","https://openalex.org/W2218941725","https://openalex.org/W2223938323","https://openalex.org/W2224056471","https://openalex.org/W2309892786","https://openalex.org/W2336330109","https://openalex.org/W2395063887","https://openalex.org/W2430188761","https://openalex.org/W2483488371","https://openalex.org/W2544136853","https://openalex.org/W2610329791","https://openalex.org/W2728165287","https://openalex.org/W2747815474","https://openalex.org/W2759112714","https://openalex.org/W2780195914","https://openalex.org/W2799633991","https://openalex.org/W2889334945","https://openalex.org/W2890744142","https://openalex.org/W2905449420","https://openalex.org/W2951184823","https://openalex.org/W3106205370"],"related_works":["https://openalex.org/W2049682677","https://openalex.org/W2034301964","https://openalex.org/W2463850709","https://openalex.org/W2751232480","https://openalex.org/W4220959342","https://openalex.org/W3164888202","https://openalex.org/W1982170406","https://openalex.org/W2333603516","https://openalex.org/W2088091011","https://openalex.org/W4231759675"],"abstract_inverted_index":{"Accurate":[0],"modeling":[1],"of":[2,5,19,29,32,41,53,63,75,81,94,103],"structural":[3],"dynamics":[4,102],"proteins":[6],"and":[7,25,50,71,84,86,107,125],"their":[8],"differentiation":[9,109],"across":[10],"different":[11],"species":[12],"can":[13],"help":[14],"us":[15],"understand":[16],"generic":[17],"mechanisms":[18],"function":[20],"shared":[21],"by":[22],"family":[23,40,106],"members":[24],"the":[26,30,39,48,67,100,104],"molecular":[27],"basis":[28],"specificity":[31],"individual":[33],"members.":[34],"We":[35,58],"focused":[36],"here":[37],"on":[38],"lipoxygenases,":[42],"enzymes":[43,77],"that":[44,117],"catalyze":[45],"lipid":[46],"oxidation,":[47],"mammalian":[49],"bacterial":[51],"structures":[52],"which":[54],"have":[55],"been":[56],"elucidated.":[57],"present":[59],"a":[60,79,91],"systematic":[61],"method":[62],"approach":[64],"for":[65],"characterizing":[66],"sequence,":[68],"structure,":[69],"dynamics,":[70],"allosteric":[72,126],"signaling":[73],"properties":[74],"these":[76],"using":[78],"combination":[80],"structure-based":[82],"models":[83],"methods":[85],"bioinformatics":[87],"tools":[88],"applied":[89],"to":[90,121],"data":[92],"set":[93],"88":[95],"structures.":[96],"The":[97],"analysis":[98],"elucidates":[99],"signature":[101],"lipoxygenase":[105],"its":[108,119],"among":[110],"members,":[111],"as":[112,114],"well":[113],"key":[115],"sites":[116],"enable":[118],"adaptation":[120],"specific":[122],"substrate":[123],"binding":[124],"activity.":[127]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
