{"id":"https://openalex.org/W2914605563","doi":"https://doi.org/10.1021/acs.jcim.8b00957","title":"Structural Features and Energetics of the Periplasmic Entrance Opening of the Outer Membrane Channel TolC Revealed by Molecular Dynamics Simulation and Markov State Model Analysis","display_name":"Structural Features and Energetics of the Periplasmic Entrance Opening of the Outer Membrane Channel TolC Revealed by Molecular Dynamics Simulation and Markov State Model Analysis","publication_year":2019,"publication_date":"2019-02-15","ids":{"openalex":"https://openalex.org/W2914605563","doi":"https://doi.org/10.1021/acs.jcim.8b00957","mag":"2914605563","pmid":"https://pubmed.ncbi.nlm.nih.gov/30768264"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.8b00957","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.8b00957","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002073070","display_name":"Jingwei Weng","orcid":"https://orcid.org/0000-0002-4639-7600"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingwei Weng","raw_affiliation_strings":["Department of Chemistry, Institute of Biomedical Sciences and Multiscale Research Institute of Complex Systems, Fudan University, Shanghai, China 200433"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Institute of Biomedical Sciences and Multiscale Research Institute of Complex Systems, Fudan University, Shanghai, China 200433","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039234406","display_name":"Wenning Wang","orcid":"https://orcid.org/0000-0002-8712-0536"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenning Wang","raw_affiliation_strings":["Department of Chemistry, Institute of Biomedical Sciences and Multiscale Research Institute of Complex Systems, Fudan University, Shanghai, China 200433"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Institute of Biomedical Sciences and Multiscale Research Institute of Complex Systems, Fudan University, Shanghai, China 200433","institution_ids":["https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039234406"],"corresponding_institution_ids":["https://openalex.org/I24943067"],"apc_list":null,"apc_paid":null,"fwci":0.4262,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.6062907,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"59","issue":"5","first_page":"2359","last_page":"2366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/periplasmic-space","display_name":"Periplasmic space","score":0.8665897846221924},{"id":"https://openalex.org/keywords/energetics","display_name":"Energetics","score":0.7393243312835693},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.7018697261810303},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.611744225025177},{"id":"https://openalex.org/keywords/chemical-physics","display_name":"Chemical physics","score":0.5363641381263733},{"id":"https://openalex.org/keywords/bacterial-outer-membrane","display_name":"Bacterial outer membrane","score":0.5223734974861145},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5113391280174255},{"id":"https://openalex.org/keywords/markov-chain","display_name":"Markov chain","score":0.5093570947647095},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.5043207406997681},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4784391224384308},{"id":"https://openalex.org/keywords/channel","display_name":"Channel (broadcasting)","score":0.4542243778705597},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.4319014549255371},{"id":"https://openalex.org/keywords/markov-model","display_name":"Markov model","score":0.42667126655578613},{"id":"https://openalex.org/keywords/state","display_name":"State (computer science)","score":0.411197692155838},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.36672329902648926},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.3250211477279663},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.3221983313560486},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.31876862049102783},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.2440873682498932},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.21589058637619019},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19138610363006592},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1351291537284851}],"concepts":[{"id":"https://openalex.org/C201663137","wikidata":"https://www.wikidata.org/wiki/Q21198990","display_name":"Periplasmic space","level":4,"score":0.8665897846221924},{"id":"https://openalex.org/C97514900","wikidata":"https://www.wikidata.org/wiki/Q719597","display_name":"Energetics","level":2,"score":0.7393243312835693},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.7018697261810303},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.611744225025177},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.5363641381263733},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.5223734974861145},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5113391280174255},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.5093570947647095},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.5043207406997681},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4784391224384308},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.4542243778705597},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4319014549255371},{"id":"https://openalex.org/C163836022","wikidata":"https://www.wikidata.org/wiki/Q6771326","display_name":"Markov model","level":3,"score":0.42667126655578613},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.411197692155838},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.36672329902648926},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.3250211477279663},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.3221983313560486},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.31876862049102783},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.2440873682498932},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21589058637619019},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19138610363006592},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1351291537284851},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019897","descriptor_name":"Periplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019897","descriptor_name":"Periplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019897","descriptor_name":"Periplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.8b00957","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.8b00957","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:30768264","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30768264","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1562478425","display_name":null,"funder_award_id":"21473034","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2355594566","display_name":null,"funder_award_id":"2016YFA0501702","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G6401300148","display_name":null,"funder_award_id":"21877017","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7206280582","display_name":null,"funder_award_id":"21773038","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W360967467","https://openalex.org/W1503309822","https://openalex.org/W1544313346","https://openalex.org/W1729750927","https://openalex.org/W1892148740","https://openalex.org/W1937264217","https://openalex.org/W1944808330","https://openalex.org/W1966078827","https://openalex.org/W1969903391","https://openalex.org/W1976499671","https://openalex.org/W1977486075","https://openalex.org/W1978607920","https://openalex.org/W1981889785","https://openalex.org/W1983806833","https://openalex.org/W1990593157","https://openalex.org/W1992764122","https://openalex.org/W1999099977","https://openalex.org/W2014445318","https://openalex.org/W2019432740","https://openalex.org/W2021927242","https://openalex.org/W2029667189","https://openalex.org/W2032226429","https://openalex.org/W2035266068","https://openalex.org/W2037752797","https://openalex.org/W2040867797","https://openalex.org/W2043901383","https://openalex.org/W2049859919","https://openalex.org/W2049862828","https://openalex.org/W2053348581","https://openalex.org/W2061558163","https://openalex.org/W2066795144","https://openalex.org/W2067174909","https://openalex.org/W2075243501","https://openalex.org/W2076233570","https://openalex.org/W2085213650","https://openalex.org/W2091127706","https://openalex.org/W2099407940","https://openalex.org/W2103945336","https://openalex.org/W2111339528","https://openalex.org/W2123032774","https://openalex.org/W2128572087","https://openalex.org/W2141064673","https://openalex.org/W2143095073","https://openalex.org/W2151800393","https://openalex.org/W2168240189","https://openalex.org/W2170458297","https://openalex.org/W2172084755","https://openalex.org/W2265218244","https://openalex.org/W2268723910","https://openalex.org/W2327586557","https://openalex.org/W2337942016","https://openalex.org/W2416405911","https://openalex.org/W2440453788","https://openalex.org/W2580371295","https://openalex.org/W2597700712","https://openalex.org/W2614889529","https://openalex.org/W2902980859"],"related_works":["https://openalex.org/W2035118599","https://openalex.org/W2177070127","https://openalex.org/W1566092905","https://openalex.org/W2137745451","https://openalex.org/W2099486582","https://openalex.org/W2745981626","https://openalex.org/W2355766117","https://openalex.org/W3159422309","https://openalex.org/W1907957509","https://openalex.org/W1967946321"],"abstract_inverted_index":{"TolC":[0,32,167],"is":[1,15,38,109],"a":[2,17,72,102],"channel":[3,136],"protein":[4],"responsible":[5],"for":[6,129],"substrate":[7,46],"translocation":[8,47],"across":[9],"the":[10,20,35,42,50,55,87,90,97,117,135,141],"outer":[11],"membrane,":[12],"and":[13,108,131,140],"it":[14],"also":[16,169],"part":[18],"of":[19,31,63,78,89,93,96,113,124,162,165,173],"tripartite":[21,178],"multidrug":[22],"efflux":[23,179],"pumps":[24],"in":[25,41,101,105,149,177],"Gram-negative":[26],"bacteria.":[27],"The":[28],"crystal":[29],"structure":[30],"shows":[33],"that":[34],"periplasmic":[36,57,98],"entrance":[37,51,58,99],"tightly":[39],"closed":[40],"resting":[43],"state,":[44],"while":[45],"definitely":[48],"requires":[49],"to":[52,60],"open.":[53],"How":[54],"occluded":[56],"opens":[59],"allow":[61],"passage":[62],"substrates":[64],"remains":[65],"elusive.":[66],"In":[67],"this":[68],"work,":[69],"we":[70],"constructed":[71],"Markov":[73],"state":[74,176],"model":[75],"from":[76,146],"swarms":[77],"all-atom":[79],"molecular":[80],"dynamics":[81,164],"(MD)":[82],"simulation":[83],"trajectories,":[84],"which":[85,147],"delineates":[86],"energetics":[88],"conformational":[91,163],"changes":[92],"TolC.":[94],"Opening":[95],"results":[100,156],"monotonic":[103],"increase":[104],"free":[106],"energy":[107],"accompanied":[110],"by":[111],"disruption":[112],"interprotomer":[114],"interactions,":[115],"whereas":[116],"intraprotomer":[118],"interactions":[119],"remain":[120],"intact.":[121],"Multi-ion":[122],"potential":[123],"mean":[125],"force":[126],"(PMF)":[127],"profiles":[128],"Na<sup>+</sup>":[130],"Cl<sup>-</sup>":[132],"permeation":[133],"along":[134],"have":[137],"been":[138],"calculated,":[139],"cation/anion":[142],"permeability":[143],"ratio":[144],"derived":[145],"are":[148],"good":[150],"agreement":[151],"with":[152],"electrophysiological":[153],"experiments.":[154],"These":[155],"not":[157],"only":[158],"deepen":[159],"our":[160],"understanding":[161],"isolated":[166],"but":[168],"provide":[170],"valuable":[171],"vision":[172],"its":[174],"functioning":[175],"pumps.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
