{"id":"https://openalex.org/W2912783011","doi":"https://doi.org/10.1021/acs.jcim.8b00697","title":"DeepDDG: Predicting the Stability Change of Protein Point Mutations Using Neural Networks","display_name":"DeepDDG: Predicting the Stability Change of Protein Point Mutations Using Neural Networks","publication_year":2019,"publication_date":"2019-02-14","ids":{"openalex":"https://openalex.org/W2912783011","doi":"https://doi.org/10.1021/acs.jcim.8b00697","mag":"2912783011","pmid":"https://pubmed.ncbi.nlm.nih.gov/30759982"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.8b00697","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.8b00697","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058353324","display_name":"Huali Cao","orcid":null},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huali Cao","raw_affiliation_strings":["Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100613544","display_name":"Jingxue Wang","orcid":"https://orcid.org/0000-0001-6705-815X"},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingxue Wang","raw_affiliation_strings":["Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078156121","display_name":"Liping He","orcid":"https://orcid.org/0000-0003-2818-393X"},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liping He","raw_affiliation_strings":["Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101708276","display_name":"Yifei Qi","orcid":"https://orcid.org/0000-0003-2853-7910"},"institutions":[{"id":"https://openalex.org/I258800397","display_name":"New York University Shanghai","ror":"https://ror.org/02vpsdb40","country_code":"CN","type":"education","lineage":["https://openalex.org/I258800397","https://openalex.org/I57206974"]},{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yifei Qi","raw_affiliation_strings":["NYU-ECNU Center\rfor Computational Chemistry at NYU Shanghai, Shanghai 200062, China","Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China","NYU-ECNU Center for Computational Chemistry at NYU Shanghai, Shanghai 200062, China"],"raw_orcid":"https://orcid.org/0000-0003-2853-7910","affiliations":[{"raw_affiliation_string":"NYU-ECNU Center\rfor Computational Chemistry at NYU Shanghai, Shanghai 200062, China","institution_ids":["https://openalex.org/I258800397"]},{"raw_affiliation_string":"Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China","institution_ids":["https://openalex.org/I66867065"]},{"raw_affiliation_string":"NYU-ECNU Center for Computational Chemistry at NYU Shanghai, Shanghai 200062, China","institution_ids":["https://openalex.org/I258800397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045389074","display_name":"John Z. H. Zhang","orcid":"https://orcid.org/0000-0003-4612-1863"},"institutions":[{"id":"https://openalex.org/I258800397","display_name":"New York University Shanghai","ror":"https://ror.org/02vpsdb40","country_code":"CN","type":"education","lineage":["https://openalex.org/I258800397","https://openalex.org/I57206974"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"John Z. Zhang","raw_affiliation_strings":["Department of Chemistry, New York University, New York, New York 10003, United States","NYU-ECNU Center\rfor Computational Chemistry at NYU Shanghai, Shanghai 200062, China","Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China","NYU-ECNU Center for Computational Chemistry at NYU Shanghai, Shanghai 200062, China"],"raw_orcid":"https://orcid.org/0000-0003-4612-1863","affiliations":[{"raw_affiliation_string":"Department of Chemistry, New York University, New York, New York 10003, United States","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"NYU-ECNU Center\rfor Computational Chemistry at NYU Shanghai, Shanghai 200062, China","institution_ids":["https://openalex.org/I258800397"]},{"raw_affiliation_string":"Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China","institution_ids":["https://openalex.org/I66867065"]},{"raw_affiliation_string":"NYU-ECNU Center for Computational Chemistry at NYU Shanghai, Shanghai 200062, China","institution_ids":["https://openalex.org/I258800397"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045389074","https://openalex.org/A5101708276"],"corresponding_institution_ids":["https://openalex.org/I258800397","https://openalex.org/I57206974","https://openalex.org/I66867065"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":8.073,"has_fulltext":false,"cited_by_count":264,"citation_normalized_percentile":{"value":0.98464485,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"59","issue":"4","first_page":"1508","last_page":"1514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10260","display_name":"Software Engineering Research","score":0.9836999773979187,"subfield":{"id":"https://openalex.org/subfields/1710","display_name":"Information Systems"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9678999781608582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.7327526211738586},{"id":"https://openalex.org/keywords/accessible-surface-area","display_name":"Accessible surface area","score":0.7001006603240967},{"id":"https://openalex.org/keywords/missense-mutation","display_name":"Missense mutation","score":0.5996685028076172},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.5864307880401611},{"id":"https://openalex.org/keywords/surface-protein","display_name":"Surface protein","score":0.5207400321960449},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5200021862983704},{"id":"https://openalex.org/keywords/point-mutation","display_name":"Point mutation","score":0.5075441598892212},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5029863715171814},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"Protein engineering","score":0.4759007394313812},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4578075110912323},{"id":"https://openalex.org/keywords/correlation-coefficient","display_name":"Correlation coefficient","score":0.4270510971546173},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.41356784105300903},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.402370810508728},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3472898006439209},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3356359601020813},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.24139541387557983},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2288089394569397},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14794921875},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11545133590698242}],"concepts":[{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.7327526211738586},{"id":"https://openalex.org/C11072593","wikidata":"https://www.wikidata.org/wiki/Q3622068","display_name":"Accessible surface area","level":2,"score":0.7001006603240967},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.5996685028076172},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.5864307880401611},{"id":"https://openalex.org/C3019232848","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Surface protein","level":2,"score":0.5207400321960449},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5200021862983704},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.5075441598892212},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5029863715171814},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.4759007394313812},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4578075110912323},{"id":"https://openalex.org/C2780092901","wikidata":"https://www.wikidata.org/wiki/Q3433612","display_name":"Correlation coefficient","level":2,"score":0.4270510971546173},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.41356784105300903},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.402370810508728},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3472898006439209},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3356359601020813},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24139541387557983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2288089394569397},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14794921875},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11545133590698242},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044366","descriptor_name":"Transition Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044366","descriptor_name":"Transition Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044366","descriptor_name":"Transition Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.8b00697","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.8b00697","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:30759982","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30759982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2549171466","display_name":null,"funder_award_id":"2.01701070005e+31","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G427857027","display_name":null,"funder_award_id":"91753103","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5409335327","display_name":null,"funder_award_id":"31700646","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6393484340","display_name":null,"funder_award_id":"2016YFA0501700","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G7561748701","display_name":null,"funder_award_id":"21433004","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320309290","display_name":"New York University","ror":"https://ror.org/0190ak572"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1596947964","https://openalex.org/W2004510362","https://openalex.org/W2023490488","https://openalex.org/W2031553026","https://openalex.org/W2051210555","https://openalex.org/W2051628563","https://openalex.org/W2060588922","https://openalex.org/W2064488723","https://openalex.org/W2065283382","https://openalex.org/W2099524123","https://openalex.org/W2103459989","https://openalex.org/W2108101947","https://openalex.org/W2113710405","https://openalex.org/W2120819598","https://openalex.org/W2121519777","https://openalex.org/W2125677968","https://openalex.org/W2130590409","https://openalex.org/W2132540199","https://openalex.org/W2133312664","https://openalex.org/W2136513422","https://openalex.org/W2141920771","https://openalex.org/W2149580316","https://openalex.org/W2150854591","https://openalex.org/W2160784118","https://openalex.org/W2162870223","https://openalex.org/W2172034373","https://openalex.org/W2189911347","https://openalex.org/W2234529989","https://openalex.org/W2262896633","https://openalex.org/W2414282720","https://openalex.org/W2428593791","https://openalex.org/W2560705618","https://openalex.org/W2582187633","https://openalex.org/W2583907533","https://openalex.org/W2592275197","https://openalex.org/W2604306554","https://openalex.org/W2648949596","https://openalex.org/W2749454133","https://openalex.org/W2785273668","https://openalex.org/W2794503008","https://openalex.org/W2801491392","https://openalex.org/W2916078022","https://openalex.org/W2919115771","https://openalex.org/W2949867299","https://openalex.org/W2963457143","https://openalex.org/W2964307930","https://openalex.org/W3104705366","https://openalex.org/W3105389349"],"related_works":["https://openalex.org/W2997189992","https://openalex.org/W2400735452","https://openalex.org/W2117747873","https://openalex.org/W4293775601","https://openalex.org/W4210539014","https://openalex.org/W2112391609","https://openalex.org/W2427197815","https://openalex.org/W2018392691","https://openalex.org/W2984454404","https://openalex.org/W2131628961"],"abstract_inverted_index":{"Accurately":[0],"predicting":[1],"changes":[2,39],"in":[3,23,35,40],"protein":[4,12,118,133],"stability":[5,42],"due":[6,45],"to":[7,46,66,124,141],"mutations":[8,22],"is":[9,101,113,138],"important":[10,104],"for":[11,15,33,74,127],"engineering":[13,131],"and":[14,63,130],"understanding":[16],"the":[17,36,41,87,92,98,102,109,114],"functional":[18],"consequences":[19],"of":[20,38,43,72,86,97,117,132],"missense":[21],"proteins.":[24],"We":[25,120],"have":[26],"developed":[27],"DeepDDG,":[28],"a":[29,68],"neural":[30,50,136],"network-based":[31],"method,":[32],"use":[34],"prediction":[37],"proteins":[44],"point":[47],"mutations.":[48],"The":[49,135],"network":[51,137],"was":[52,64],"trained":[53],"on":[54],"more":[55],"than":[56],"5700":[57],"manually":[58],"curated":[59],"experimental":[60],"data":[61],"points":[62],"able":[65],"obtain":[67],"Pearson":[69],"correlation":[70],"coefficient":[71],"0.48-0.56":[73],"three":[75],"independent":[76],"test":[77],"sets,":[78],"which":[79,106],"outperformed":[80],"11":[81],"other":[82],"methods.":[83],"Detailed":[84],"analysis":[85],"input":[88],"features":[89],"shows":[90],"that":[91,108],"solvent":[93],"accessible":[94],"surface":[95],"area":[96,112],"mutated":[99],"residue":[100],"most":[103],"feature,":[105],"suggests":[107],"buried":[110],"hydrophobic":[111],"major":[115],"determinant":[116],"stability.":[119,134],"expect":[121],"this":[122],"method":[123],"be":[125],"useful":[126],"large-scale":[128],"design":[129],"freely":[139],"available":[140],"academic":[142],"users":[143],"at":[144],"http://protein.org.cn/ddg.html":[145],".":[146]},"counts_by_year":[{"year":2026,"cited_by_count":26},{"year":2025,"cited_by_count":40},{"year":2024,"cited_by_count":52},{"year":2023,"cited_by_count":40},{"year":2022,"cited_by_count":50},{"year":2021,"cited_by_count":31},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":2}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}