{"id":"https://openalex.org/W2892456649","doi":"https://doi.org/10.1021/acs.jcim.8b00414","title":"Machine Learning Classification and Structure\u2013Functional Analysis of Cancer Mutations Reveal Unique Dynamic and Network Signatures of Driver Sites in Oncogenes and Tumor Suppressor Genes","display_name":"Machine Learning Classification and Structure\u2013Functional Analysis of Cancer Mutations Reveal Unique Dynamic and Network Signatures of Driver Sites in Oncogenes and Tumor Suppressor Genes","publication_year":2018,"publication_date":"2018-09-25","ids":{"openalex":"https://openalex.org/W2892456649","doi":"https://doi.org/10.1021/acs.jcim.8b00414","mag":"2892456649","pmid":"https://pubmed.ncbi.nlm.nih.gov/30253099"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.8b00414","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.8b00414","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052539028","display_name":"Steve Agajanian","orcid":null},"institutions":[{"id":"https://openalex.org/I185071736","display_name":"Chapman University","ror":"https://ror.org/0452jzg20","country_code":"US","type":"education","lineage":["https://openalex.org/I185071736"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Agajanian","raw_affiliation_strings":["Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University\rDrive, Orange, California 92866, United States","Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California 92866, United States"],"affiliations":[{"raw_affiliation_string":"Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University\rDrive, Orange, California 92866, United States","institution_ids":["https://openalex.org/I185071736"]},{"raw_affiliation_string":"Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California 92866, United States","institution_ids":["https://openalex.org/I185071736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085209894","display_name":"Oluyemi Odeyemi","orcid":null},"institutions":[{"id":"https://openalex.org/I185071736","display_name":"Chapman University","ror":"https://ror.org/0452jzg20","country_code":"US","type":"education","lineage":["https://openalex.org/I185071736"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oluyemi Odeyemi","raw_affiliation_strings":["Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University\rDrive, Orange, California 92866, United States","Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California 92866, United States"],"affiliations":[{"raw_affiliation_string":"Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University\rDrive, Orange, California 92866, United States","institution_ids":["https://openalex.org/I185071736"]},{"raw_affiliation_string":"Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California 92866, United States","institution_ids":["https://openalex.org/I185071736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083877251","display_name":"Nathaniel Bischoff","orcid":null},"institutions":[{"id":"https://openalex.org/I185071736","display_name":"Chapman University","ror":"https://ror.org/0452jzg20","country_code":"US","type":"education","lineage":["https://openalex.org/I185071736"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel Bischoff","raw_affiliation_strings":["Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University\rDrive, Orange, California 92866, United States","Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California 92866, United States"],"affiliations":[{"raw_affiliation_string":"Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University\rDrive, Orange, California 92866, United States","institution_ids":["https://openalex.org/I185071736"]},{"raw_affiliation_string":"Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California 92866, United States","institution_ids":["https://openalex.org/I185071736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110603012","display_name":"Simrath Ratra","orcid":null},"institutions":[{"id":"https://openalex.org/I185071736","display_name":"Chapman University","ror":"https://ror.org/0452jzg20","country_code":"US","type":"education","lineage":["https://openalex.org/I185071736"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simrath Ratra","raw_affiliation_strings":["Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University\rDrive, Orange, California 92866, United States","Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California 92866, United States"],"affiliations":[{"raw_affiliation_string":"Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University\rDrive, Orange, California 92866, United States","institution_ids":["https://openalex.org/I185071736"]},{"raw_affiliation_string":"Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California 92866, United States","institution_ids":["https://openalex.org/I185071736"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031922505","display_name":"Gennady M. Verkhivker","orcid":"https://orcid.org/0000-0002-4507-4471"},"institutions":[{"id":"https://openalex.org/I185071736","display_name":"Chapman University","ror":"https://ror.org/0452jzg20","country_code":"US","type":"education","lineage":["https://openalex.org/I185071736"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gennady M. Verkhivker","raw_affiliation_strings":["Chapman University, School of Pharmacy, Irvine, California 92618, United States","Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University\rDrive, Orange, California 92866, United States","Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California 92866, United States"],"affiliations":[{"raw_affiliation_string":"Chapman University, School of Pharmacy, Irvine, California 92618, United States","institution_ids":["https://openalex.org/I185071736"]},{"raw_affiliation_string":"Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University\rDrive, Orange, California 92866, United States","institution_ids":["https://openalex.org/I185071736"]},{"raw_affiliation_string":"Graduate Program in Computational and Data Sciences, Department of Computational Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California 92866, United States","institution_ids":["https://openalex.org/I185071736"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5031922505"],"corresponding_institution_ids":["https://openalex.org/I185071736"],"apc_list":null,"apc_paid":null,"fwci":1.1031,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.7755594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"58","issue":"10","first_page":"2131","last_page":"2150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6270948052406311},{"id":"https://openalex.org/keywords/suppressor","display_name":"Suppressor","score":0.6139447093009949},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5038554072380066},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5023677349090576},{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.4472014307975769},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.42718786001205444},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.42619121074676514},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.40210410952568054},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3655845522880554},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3625379800796509},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3206586241722107}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6270948052406311},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.6139447093009949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5038554072380066},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5023677349090576},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.4472014307975769},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42718786001205444},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.42619121074676514},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40210410952568054},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3655845522880554},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3625379800796509},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3206586241722107}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.8b00414","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.8b00414","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:30253099","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30253099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","score":0.47999998927116394,"id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":115,"referenced_works":["https://openalex.org/W1529921298","https://openalex.org/W1833133328","https://openalex.org/W1854233595","https://openalex.org/W1875037981","https://openalex.org/W1880949099","https://openalex.org/W1956577542","https://openalex.org/W1967940883","https://openalex.org/W1968324646","https://openalex.org/W1969292035","https://openalex.org/W1976815080","https://openalex.org/W1982874561","https://openalex.org/W1987507232","https://openalex.org/W1989458006","https://openalex.org/W1991166678","https://openalex.org/W2004474495","https://openalex.org/W2005272471","https://openalex.org/W2009720434","https://openalex.org/W2011941471","https://openalex.org/W2015631955","https://openalex.org/W2018189081","https://openalex.org/W2023568503","https://openalex.org/W2026263500","https://openalex.org/W2027041600","https://openalex.org/W2038473742","https://openalex.org/W2039482819","https://openalex.org/W2044433401","https://openalex.org/W2044573154","https://openalex.org/W2049449785","https://openalex.org/W2057590120","https://openalex.org/W2059145105","https://openalex.org/W2064626957","https://openalex.org/W2072572998","https://openalex.org/W2073201685","https://openalex.org/W2076357933","https://openalex.org/W2080601747","https://openalex.org/W2086072858","https://openalex.org/W2087588809","https://openalex.org/W2089335658","https://openalex.org/W2090038231","https://openalex.org/W2090264443","https://openalex.org/W2099057076","https://openalex.org/W2099224719","https://openalex.org/W2101234009","https://openalex.org/W2101412130","https://openalex.org/W2102140136","https://openalex.org/W2102859097","https://openalex.org/W2104283848","https://openalex.org/W2111326065","https://openalex.org/W2114029728","https://openalex.org/W2114843025","https://openalex.org/W2117098110","https://openalex.org/W2118151336","https://openalex.org/W2118527670","https://openalex.org/W2120627772","https://openalex.org/W2121637291","https://openalex.org/W2121695889","https://openalex.org/W2121906867","https://openalex.org/W2129172946","https://openalex.org/W2129952088","https://openalex.org/W2134508297","https://openalex.org/W2135784953","https://openalex.org/W2137284086","https://openalex.org/W2137886330","https://openalex.org/W2140620049","https://openalex.org/W2143185848","https://openalex.org/W2145187337","https://openalex.org/W2149441684","https://openalex.org/W2155845523","https://openalex.org/W2158485828","https://openalex.org/W2159082261","https://openalex.org/W2160995259","https://openalex.org/W2161162779","https://openalex.org/W2163188200","https://openalex.org/W2163641424","https://openalex.org/W2168348146","https://openalex.org/W2172467208","https://openalex.org/W2178323482","https://openalex.org/W2196516240","https://openalex.org/W2198606573","https://openalex.org/W2214916291","https://openalex.org/W2272037513","https://openalex.org/W2288771987","https://openalex.org/W2309952608","https://openalex.org/W2311607323","https://openalex.org/W2331480251","https://openalex.org/W2344185956","https://openalex.org/W2345718491","https://openalex.org/W2439991713","https://openalex.org/W2474819416","https://openalex.org/W2502949459","https://openalex.org/W2506497981","https://openalex.org/W2521967673","https://openalex.org/W2555711097","https://openalex.org/W2564018391","https://openalex.org/W2565848986","https://openalex.org/W2566578012","https://openalex.org/W2577347274","https://openalex.org/W2582236637","https://openalex.org/W2611387862","https://openalex.org/W2611545926","https://openalex.org/W2623410148","https://openalex.org/W2666241239","https://openalex.org/W2724571272","https://openalex.org/W2753588101","https://openalex.org/W2757281736","https://openalex.org/W2765668980","https://openalex.org/W2790516087","https://openalex.org/W2794135466","https://openalex.org/W2794804602","https://openalex.org/W2795068716","https://openalex.org/W2795941120","https://openalex.org/W2796408191","https://openalex.org/W3100171530","https://openalex.org/W4238448376","https://openalex.org/W4240237951"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W2888392564","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W4390569940","https://openalex.org/W4361193272","https://openalex.org/W2963326959","https://openalex.org/W4388685194","https://openalex.org/W1986582023","https://openalex.org/W2966829450"],"abstract_inverted_index":{"In":[0],"this":[1,240],"study,":[2],"we":[3,46,89,122,158,242],"developed":[4],"two":[5],"cancer-specific":[6,109],"machine":[7,69,125],"learning":[8,70,126],"classifiers":[9],"for":[10,244],"prediction":[11],"of":[12,25,59,94,101,108,119,131,149,165,211,219,235,249],"driver":[13,120,133,156,171,182,213,252],"mutations":[14,28,134,172,183,229,253],"in":[15,57,67,135,173,184,198,266],"cancer-associated":[16],"genes":[17,187],"that":[18,49,161,194,225,254],"were":[19],"validated":[20,27],"on":[21,239],"canonical":[22],"data":[23,36,83],"sets":[24],"functionally":[26,226],"and":[29,42,62,79,97,112,139,146,153,202,262],"applied":[30],"to":[31],"a":[32,54,232,247],"large":[33],"cancer":[34,60,132,212,228,268],"genomics":[35],"set.":[37],"By":[38,143,207],"examining":[39,144],"sequence,":[40],"structure,":[41,259],"ensemble-based":[43],"integrated":[44],"features,":[45],"have":[47,90,123,159],"shown":[48,160],"evolutionary":[50],"conservation":[51],"scores":[52],"play":[53],"critical":[55],"role":[56],"classification":[58,110],"drivers":[61],"provide":[63],"the":[64,68,92,99,106,154,162,220],"strongest":[65],"signal":[66],"prediction.":[71],"Through":[72],"extensive":[73],"comparative":[74],"analysis":[75,130],"with":[76,128],"structure-functional":[77,129],"experiments":[78],"multicenter":[80],"mutational":[81,151],"calling":[82],"from":[84],"Pan":[85],"Cancer":[86],"Atlas":[87],"studies,":[88],"demonstrated":[91],"robustness":[93],"our":[95,215],"models":[96,111],"addressed":[98],"validity":[100],"computational":[102],"predictions.":[103],"To":[104],"address":[105],"interpretability":[107],"obtain":[113],"novel":[114,250],"insights":[115],"about":[116],"molecular":[117,209],"signatures":[118,148,210],"mutations,":[121,157,214],"complemented":[124],"predictions":[127],"several":[136],"important":[137,267],"oncogenes":[138,174],"tumor":[140,185],"suppressor":[141,186],"genes.":[142,269],"structural":[145],"dynamic":[147],"known":[150],"hotspots":[152],"predicted":[155],"greater":[163],"flexibility":[164],"specific":[166],"functional":[167],"regions":[168],"targeted":[169],"by":[170,257],"may":[175,230],"facilitate":[176],"activating":[177],"conformational":[178],"changes,":[179],"while":[180],"loss-of-function":[181],"can":[188,255],"preferentially":[189],"target":[190],"structurally":[191],"rigid":[192],"positions":[193],"mediate":[195],"allosteric":[196,263],"communications":[197],"residue":[199],"interaction":[200,264],"networks":[201,265],"modulate":[203],"protein":[204],"binding":[205],"interfaces.":[206],"revealing":[208],"results":[216],"highlighted":[217],"limitations":[218],"binary":[221],"driver/passenger":[222],"classification,":[223],"suggesting":[224],"relevant":[227],"span":[231],"continuum":[233],"spectrum":[234],"driverlike":[236],"effects.":[237],"Based":[238],"analysis,":[241],"propose":[243],"experimental":[245],"testing":[246],"group":[248],"potential":[251],"act":[256],"altering":[258],"global":[260],"dynamics,":[261]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}