{"id":"https://openalex.org/W2808959079","doi":"https://doi.org/10.1021/acs.jcim.8b00217","title":"QM/MM Studies of Dph5 \u2013 A Promiscuous Methyltransferase in the Eukaryotic Biosynthetic Pathway of Diphthamide","display_name":"QM/MM Studies of Dph5 \u2013 A Promiscuous Methyltransferase in the Eukaryotic Biosynthetic Pathway of Diphthamide","publication_year":2018,"publication_date":"2018-06-21","ids":{"openalex":"https://openalex.org/W2808959079","doi":"https://doi.org/10.1021/acs.jcim.8b00217","mag":"2808959079","pmid":"https://pubmed.ncbi.nlm.nih.gov/29927239"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.8b00217","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.8b00217","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059480698","display_name":"Johanna H\u00f6rberg","orcid":"https://orcid.org/0009-0006-7256-3859"},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Johanna H\u00f6rberg","raw_affiliation_strings":["Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30 G\u00f6teborg, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003995168","display_name":"Patricia Saenz\u2010M\u00e9ndez","orcid":"https://orcid.org/0000-0002-6711-4972"},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Patricia Saenz-Mendez","raw_affiliation_strings":["Computational Chemistry and Biology Group, Facultad de Qu\u00edmica, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay"],"affiliations":[{"raw_affiliation_string":"Computational Chemistry and Biology Group, Facultad de Qu\u00edmica, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001315059","display_name":"Leif A. Eriksson","orcid":"https://orcid.org/0000-0001-5654-3109"},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Leif A. Eriksson","raw_affiliation_strings":["Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30 G\u00f6teborg, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001315059"],"corresponding_institution_ids":["https://openalex.org/I881427289"],"apc_list":null,"apc_paid":null,"fwci":0.6727,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.70630455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"58","issue":"7","first_page":"1406","last_page":"1414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12858","display_name":"Plant Disease Resistance and Genetics","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.6829777956008911},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.5945627689361572},{"id":"https://openalex.org/keywords/methyltransferase","display_name":"Methyltransferase","score":0.5148943662643433},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.5018384456634521},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5000934600830078},{"id":"https://openalex.org/keywords/active-site","display_name":"Active site","score":0.4832899868488312},{"id":"https://openalex.org/keywords/histidine","display_name":"Histidine","score":0.47624969482421875},{"id":"https://openalex.org/keywords/biosynthesis","display_name":"Biosynthesis","score":0.4406864643096924},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.4359997808933258},{"id":"https://openalex.org/keywords/molecular-mechanics","display_name":"Molecular mechanics","score":0.4326384663581848},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.377720445394516},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.28681978583335876},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.2666904330253601},{"id":"https://openalex.org/keywords/yeast","display_name":"Yeast","score":0.14938542246818542},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.10638836026191711},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.10156795382499695}],"concepts":[{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6829777956008911},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5945627689361572},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.5148943662643433},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.5018384456634521},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5000934600830078},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.4832899868488312},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.47624969482421875},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.4406864643096924},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.4359997808933258},{"id":"https://openalex.org/C25057246","wikidata":"https://www.wikidata.org/wiki/Q1344441","display_name":"Molecular mechanics","level":3,"score":0.4326384663581848},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.377720445394516},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.28681978583335876},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2666904330253601},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.14938542246818542},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.10638836026191711},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.10156795382499695},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020652","descriptor_name":"Peptide Elongation Factor 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020652","descriptor_name":"Peptide Elongation Factor 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020652","descriptor_name":"Peptide Elongation Factor 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053898","descriptor_name":"Biosynthetic Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053898","descriptor_name":"Biosynthetic Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053898","descriptor_name":"Biosynthetic Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.8b00217","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.8b00217","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:29927239","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29927239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.6399999856948853}],"awards":[{"id":"https://openalex.org/G122947616","display_name":null,"funder_award_id":"2014-3914","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1896254721","https://openalex.org/W1964126019","https://openalex.org/W1964535362","https://openalex.org/W1966078827","https://openalex.org/W1967633180","https://openalex.org/W1994261442","https://openalex.org/W2002501900","https://openalex.org/W2003433740","https://openalex.org/W2005393891","https://openalex.org/W2011495938","https://openalex.org/W2033870792","https://openalex.org/W2034270556","https://openalex.org/W2047280630","https://openalex.org/W2049557754","https://openalex.org/W2065917802","https://openalex.org/W2074986801","https://openalex.org/W2091711066","https://openalex.org/W2100071542","https://openalex.org/W2102993309","https://openalex.org/W2103880092","https://openalex.org/W2132629607","https://openalex.org/W2151460035","https://openalex.org/W2154587122","https://openalex.org/W2154792548","https://openalex.org/W2168592521","https://openalex.org/W2171783362","https://openalex.org/W2324850324","https://openalex.org/W2950772389","https://openalex.org/W4246356731"],"related_works":["https://openalex.org/W2049444949","https://openalex.org/W4316690323","https://openalex.org/W1976691753","https://openalex.org/W2414729539","https://openalex.org/W2317280338","https://openalex.org/W1971868198","https://openalex.org/W2089104969","https://openalex.org/W1991900549","https://openalex.org/W2004834660","https://openalex.org/W2378227601"],"abstract_inverted_index":{"Eukaryotic":[0],"diphthine":[1,19,174],"synthase,":[2],"Dph5,":[3,72],"is":[4],"a":[5,37,91,103,109,131,140,144,151,162],"promiscuous":[6],"methyltransferase":[7],"that":[8,97],"catalyzes":[9],"an":[10],"extraordinary":[11],"N,":[12],"O-tetramethylation":[13],"of":[14,29,43,53,71,100,123,173],"2-(3-carboxy-3-aminopropyl)-l-histidine":[15],"(ACP)":[16],"to":[17,67,78,89,143,175,185],"yield":[18],"methyl":[20,152],"ester":[21],"(DTM).":[22],"These":[23],"are":[24],"intermediates":[25],"in":[26,61],"the":[27,30,44,51,69,80,98,114,118,124,157,170,177,181],"biosynthesis":[28],"post-translationally":[31],"modified":[32],"histidine":[33],"residue":[34,41,147],"diphthamide":[35],"(DTA),":[36],"unique":[38],"and":[39,75,83],"essential":[40],"part":[42],"eukaryotic":[45],"elongation":[46],"factor":[47],"2":[48],"(eEF2).":[49],"Herein,":[50],"promiscuity":[52],"Saccharomyces":[54],"cerevisiae":[55],"Dph5":[56],"has":[57],"been":[58],"studied":[59],"with":[60,108,166],"silico":[62],"approaches,":[63],"including":[64],"homology":[65],"modeling":[66],"provide":[68],"structure":[70],"protein-protein":[73],"docking":[74],"molecular":[76],"dynamics":[77],"construct":[79],"Dph5-eEF2":[81],"complex,":[82],"quantum":[84],"mechanics/molecular":[85],"mechanics":[86],"(QM/MM)":[87],"calculations":[88,95,129],"outline":[90],"plausible":[92],"mechanism.":[93],"The":[94],"show":[96],"methylation":[99,111,183],"ACP":[101],"follows":[102],"typical":[104],"S<sub>N</sub>2":[105],"mechanism,":[106,133],"initiating":[107],"complete":[110],"(trimethylation)":[112],"at":[113],"N-position,":[115],"followed":[116,149],"by":[117,150],"single":[119],"O-methylation.":[120],"For":[121],"each":[122],"three":[125],"N-methylation":[126],"reactions,":[127],"our":[128],"support":[130],"stepwise":[132],"which":[134,168],"first":[135],"involve":[136],"proton":[137],"transfer":[138],"through":[139],"bridging":[141],"water":[142],"conserved":[145],"aspartate":[146],"D165,":[148,167],"transfer.":[153],"Once":[154],"fully":[155],"methylated,":[156],"trimethyl":[158],"amino":[159],"group":[160,172],"forms":[161],"weak":[163],"electrostatic":[164],"interaction":[165],"allows":[169],"carboxylate":[171],"attain":[176],"right":[178],"orientation":[179],"for":[180],"final":[182],"step":[184],"be":[186],"accomplished.":[187]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
