{"id":"https://openalex.org/W2887519731","doi":"https://doi.org/10.1021/acs.jcim.8b00146","title":"Node-Weighted Amino Acid Network Strategy for Characterization and Identification of Protein Functional Residues","display_name":"Node-Weighted Amino Acid Network Strategy for Characterization and Identification of Protein Functional Residues","publication_year":2018,"publication_date":"2018-08-14","ids":{"openalex":"https://openalex.org/W2887519731","doi":"https://doi.org/10.1021/acs.jcim.8b00146","mag":"2887519731","pmid":"https://pubmed.ncbi.nlm.nih.gov/30107728"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.8b00146","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.8b00146","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002678361","display_name":"Wenying Yan","orcid":"https://orcid.org/0000-0001-5016-575X"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenying Yan","raw_affiliation_strings":["Center for systems biology, Soochow University, Suzhou 215006, China"],"affiliations":[{"raw_affiliation_string":"Center for systems biology, Soochow University, Suzhou 215006, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101617943","display_name":"Guang Hu","orcid":"https://orcid.org/0000-0002-8754-1541"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guang Hu","raw_affiliation_strings":["Center for systems biology, Soochow University, Suzhou 215006, China"],"affiliations":[{"raw_affiliation_string":"Center for systems biology, Soochow University, Suzhou 215006, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045167053","display_name":"Zhongjie Liang","orcid":"https://orcid.org/0000-0003-0763-5407"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongjie Liang","raw_affiliation_strings":["Center for systems biology, Soochow University, Suzhou 215006, China"],"affiliations":[{"raw_affiliation_string":"Center for systems biology, Soochow University, Suzhou 215006, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078556234","display_name":"Jianhong Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianhong Zhou","raw_affiliation_strings":["Center for systems biology, Soochow University, Suzhou 215006, China"],"affiliations":[{"raw_affiliation_string":"Center for systems biology, Soochow University, Suzhou 215006, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100397381","display_name":"Yang Yang","orcid":"https://orcid.org/0000-0001-5720-773X"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Yang","raw_affiliation_strings":["School of computer science and technology, Soochow University, Suzhou 215006, China"],"affiliations":[{"raw_affiliation_string":"School of computer science and technology, Soochow University, Suzhou 215006, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100401009","display_name":"Jiajia Chen","orcid":"https://orcid.org/0000-0003-3659-0658"},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajia Chen","raw_affiliation_strings":["School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou 215011, China"],"affiliations":[{"raw_affiliation_string":"School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou 215011, China","institution_ids":["https://openalex.org/I308837"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081095213","display_name":"Bairong Shen","orcid":"https://orcid.org/0000-0003-2899-1531"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bairong Shen","raw_affiliation_strings":["Center for systems biology, Soochow University, Suzhou 215006, China"],"affiliations":[{"raw_affiliation_string":"Center for systems biology, Soochow University, Suzhou 215006, China","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5081095213"],"corresponding_institution_ids":["https://openalex.org/I3923682"],"apc_list":null,"apc_paid":null,"fwci":0.7424,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.70635291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"58","issue":"9","first_page":"2024","last_page":"2032"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6945058107376099},{"id":"https://openalex.org/keywords/node","display_name":"Node (physics)","score":0.590045154094696},{"id":"https://openalex.org/keywords/characterization","display_name":"Characterization (materials science)","score":0.5781804919242859},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5265522003173828},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.49533572793006897},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.45282846689224243},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41366127133369446},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.36021143198013306},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2723595201969147},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.11419552564620972},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.08301621675491333},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.07988181710243225},{"id":"https://openalex.org/keywords/botany","display_name":"Botany","score":0.07420656085014343}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6945058107376099},{"id":"https://openalex.org/C62611344","wikidata":"https://www.wikidata.org/wiki/Q1062658","display_name":"Node (physics)","level":2,"score":0.590045154094696},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.5781804919242859},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5265522003173828},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.49533572793006897},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45282846689224243},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41366127133369446},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36021143198013306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2723595201969147},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.11419552564620972},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.08301621675491333},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07988181710243225},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.07420656085014343},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.8b00146","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.8b00146","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:30107728","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30107728","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.7400000095367432,"display_name":"Affordable and clean energy"}],"awards":[{"id":"https://openalex.org/G6223480252","display_name":null,"funder_award_id":"61602332","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6987374417","display_name":null,"funder_award_id":"31400712","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7271893892","display_name":null,"funder_award_id":"14KJB520035","funder_id":"https://openalex.org/F4320321605","funder_display_name":"Government of Jiangsu Province"},{"id":"https://openalex.org/G7349633688","display_name":null,"funder_award_id":"91530320","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8880520401","display_name":null,"funder_award_id":"31600671","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320324775","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W1731081199","https://openalex.org/W1819481941","https://openalex.org/W1967293793","https://openalex.org/W1969909621","https://openalex.org/W1971195826","https://openalex.org/W1972221499","https://openalex.org/W1981122373","https://openalex.org/W1982874561","https://openalex.org/W1986719264","https://openalex.org/W1986795645","https://openalex.org/W1987819535","https://openalex.org/W1989181256","https://openalex.org/W1990320360","https://openalex.org/W1990460499","https://openalex.org/W1991605720","https://openalex.org/W1996446367","https://openalex.org/W1998053010","https://openalex.org/W2000747101","https://openalex.org/W2008708467","https://openalex.org/W2014731953","https://openalex.org/W2025630031","https://openalex.org/W2031291897","https://openalex.org/W2038324414","https://openalex.org/W2048917743","https://openalex.org/W2073746700","https://openalex.org/W2075155374","https://openalex.org/W2077349723","https://openalex.org/W2092810439","https://openalex.org/W2097944242","https://openalex.org/W2098914939","https://openalex.org/W2105316179","https://openalex.org/W2114868131","https://openalex.org/W2122854841","https://openalex.org/W2124676068","https://openalex.org/W2125299915","https://openalex.org/W2128393152","https://openalex.org/W2130479394","https://openalex.org/W2130809031","https://openalex.org/W2132886170","https://openalex.org/W2133350649","https://openalex.org/W2136224545","https://openalex.org/W2137974866","https://openalex.org/W2140239055","https://openalex.org/W2140687507","https://openalex.org/W2141624700","https://openalex.org/W2141960720","https://openalex.org/W2142025713","https://openalex.org/W2143887102","https://openalex.org/W2144391203","https://openalex.org/W2145126338","https://openalex.org/W2147526198","https://openalex.org/W2150192011","https://openalex.org/W2154319440","https://openalex.org/W2157122545","https://openalex.org/W2157605186","https://openalex.org/W2157735020","https://openalex.org/W2159093475","https://openalex.org/W2160975112","https://openalex.org/W2168164063","https://openalex.org/W2170317338","https://openalex.org/W2175309784","https://openalex.org/W2177124199","https://openalex.org/W2288665025","https://openalex.org/W2290562923","https://openalex.org/W2325343629","https://openalex.org/W2325652290","https://openalex.org/W2345718491","https://openalex.org/W2395425574","https://openalex.org/W2519777545","https://openalex.org/W2523926726","https://openalex.org/W2533967599","https://openalex.org/W2609293186","https://openalex.org/W2777899362","https://openalex.org/W2777941847","https://openalex.org/W2792363117","https://openalex.org/W2795011345","https://openalex.org/W3098217834"],"related_works":["https://openalex.org/W3107994849","https://openalex.org/W4247143848","https://openalex.org/W2009883749","https://openalex.org/W2735573198","https://openalex.org/W29442446","https://openalex.org/W2193237397","https://openalex.org/W330727063","https://openalex.org/W2896904446","https://openalex.org/W1483407203","https://openalex.org/W2084679820"],"abstract_inverted_index":{"The":[0,15,135,177],"study":[1],"of":[2,38,53,59,84,110,133],"functional":[3,186],"residues":[4,139],"(FRs)":[5],"is":[6,192],"essential":[7],"for":[8,25,160,166,174,195],"understanding":[9],"protein":[10],"functions":[11],"and":[12,40,80,91,107,114,149,169,198],"biological":[13],"processes.":[14],"amino":[16,42,55,72,112],"acid":[17,56,73],"network":[18,76,155],"(AAN)":[19],"has":[20],"become":[21],"an":[22],"emerging":[23],"paradigm":[24],"studying":[26],"FRs":[27,118,148],"during":[28],"the":[29,36,45,48,51,70,111,117,120],"past":[30],"decade.":[31],"Current":[32],"AAN":[33,46,67],"models":[34],"ignore":[35],"heterogeneity":[37],"nodes":[39,100],"treat":[41],"acids":[43,113],"in":[44],"as":[47],"same.":[49],"However,":[50],"properties":[52,109],"each":[54,131],"node":[57],"are":[58,144],"fundamental":[60],"importance.":[61],"We":[62,94,123],"here":[63],"proposed":[64,178],"a":[65],"node-weighted":[66,71],"strategy":[68,179],"termed":[69],"contact":[74],"energy":[75],"(NACEN)":[77],"to":[78,129,184],"characterize":[79],"predict":[81],"three":[82],"types":[83],"FRs,":[85],"namely,":[86],"hot":[87],"spots,":[88],"catalytic":[89],"residues,":[90],"allosteric":[92,175],"residues.":[93],"first":[95],"constructed":[96],"NACENs":[97],"with":[98,119,141,153],"their":[99],"weighted":[101],"based":[102],"on":[103],"structural,":[104],"sequence,":[105],"physicochemical,":[106],"dynamical":[108],"then":[115],"characterized":[116,140],"NACEN":[121,142,162,196],"parameters.":[122],"finally":[124],"built":[125],"machine":[126],"learning":[127],"predictors":[128],"identify":[130],"type":[132],"FR.":[134],"results":[136],"revealed":[137],"that":[138],"parameters":[143],"more":[145],"distinguishable":[146],"between":[147],"non-FRs":[150],"than":[151],"those":[152],"unweighted":[154],"ones.":[156],"With":[157],"few":[158],"features":[159],"classification,":[161],"yields":[163],"comparable":[164],"performance":[165],"FR":[167],"identification":[168],"provides":[170],"residue":[171,187],"level":[172],"prediction":[173],"regulation.":[176],"can":[180],"be":[181],"easily":[182],"implemented":[183],"other":[185],"identification.":[188],"An":[189],"R":[190],"package":[191],"also":[193],"provided":[194],"construction":[197],"analysis":[199],"at":[200],"http://sysbio.suda.edu.cn/NACEN/index.html":[201],".":[202]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}