{"id":"https://openalex.org/W2804583760","doi":"https://doi.org/10.1021/acs.jcim.8b00125","title":"Cheminformatic Insight into the Differences between Terrestrial and Marine Originated Natural Products","display_name":"Cheminformatic Insight into the Differences between Terrestrial and Marine Originated Natural Products","publication_year":2018,"publication_date":"2018-05-24","ids":{"openalex":"https://openalex.org/W2804583760","doi":"https://doi.org/10.1021/acs.jcim.8b00125","mag":"2804583760","pmid":"https://pubmed.ncbi.nlm.nih.gov/29792805"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.8b00125","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.8b00125","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103175701","display_name":"Jun Shang","orcid":"https://orcid.org/0000-0003-4569-4758"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Shang","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China","State Key Lab of CAD&CG, Zhejiang University, Hangzhou, Zhejiang 310058, China","State Key Laboratory of Agricultural Microbiology and Agricultural Bioinformatics, Key Laboratory of Hubei Province, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China"],"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"State Key Lab of CAD&CG, Zhejiang University, Hangzhou, Zhejiang 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"State Key Laboratory of Agricultural Microbiology and Agricultural Bioinformatics, Key Laboratory of Hubei Province, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101105007","display_name":"Ben Hu","orcid":"https://orcid.org/0009-0001-7648-5695"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ben Hu","raw_affiliation_strings":["State Key Laboratory of Agricultural Microbiology and Agricultural Bioinformatics, Key Laboratory of Hubei Province, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Agricultural Microbiology and Agricultural Bioinformatics, Key Laboratory of Hubei Province, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100643054","display_name":"Junmei Wang","orcid":"https://orcid.org/0000-0002-9607-8229"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junmei Wang","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"],"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100755257","display_name":"Feng Zhu","orcid":"https://orcid.org/0000-0001-8069-0053"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Zhu","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China"],"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100624617","display_name":"Yu Kang","orcid":"https://orcid.org/0000-0002-0999-8802"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Kang","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China"],"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380698","display_name":"Dan Li","orcid":"https://orcid.org/0000-0002-1264-5952"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Li","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China"],"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011434518","display_name":"Huiyong Sun","orcid":"https://orcid.org/0000-0002-7107-7481"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiyong Sun","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China"],"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081833384","display_name":"Kong De","orcid":"https://orcid.org/0000-0003-0744-116X"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"De-Xin Kong","raw_affiliation_strings":["State Key Laboratory of Agricultural Microbiology and Agricultural Bioinformatics, Key Laboratory of Hubei Province, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Agricultural Microbiology and Agricultural Bioinformatics, Key Laboratory of Hubei Province, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028525523","display_name":"Tingjun Hou","orcid":"https://orcid.org/0000-0001-7227-2580"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tingjun Hou","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China","State Key Lab of CAD&CG, Zhejiang University, Hangzhou, Zhejiang 310058, China"],"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"State Key Lab of CAD&CG, Zhejiang University, Hangzhou, Zhejiang 310058, China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5028525523","https://openalex.org/A5081833384"],"corresponding_institution_ids":["https://openalex.org/I204823248","https://openalex.org/I76130692"],"apc_list":null,"apc_paid":null,"fwci":5.7182,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.96686955,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"58","issue":"6","first_page":"1182","last_page":"1193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.9909999966621399,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural","display_name":"Natural (archaeology)","score":0.6514211297035217},{"id":"https://openalex.org/keywords/environmental-science","display_name":"Environmental science","score":0.39421167969703674},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23696687817573547},{"id":"https://openalex.org/keywords/paleontology","display_name":"Paleontology","score":0.13078570365905762}],"concepts":[{"id":"https://openalex.org/C2776608160","wikidata":"https://www.wikidata.org/wiki/Q4785462","display_name":"Natural (archaeology)","level":2,"score":0.6514211297035217},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.39421167969703674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23696687817573547},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.13078570365905762}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054879","descriptor_name":"Halogenation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054879","descriptor_name":"Halogenation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054879","descriptor_name":"Halogenation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059001","descriptor_name":"Aquatic Organisms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D059001","descriptor_name":"Aquatic Organisms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D059001","descriptor_name":"Aquatic Organisms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jcim.8b00125","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.8b00125","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:29792805","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29792805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:oceanrep.geomar.de:48024","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400264","display_name":"Helmholtz Centre for Ocean Research Kiel (GEOMAR)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I34403800","host_organization_name":"GEOMAR Helmholtz Centre for Ocean Research Kiel","host_organization_lineage":["https://openalex.org/I34403800"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"    Journal of Chemical Information and Modeling, 58  (6).   pp. 1182-1193.   ","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.8899999856948853}],"awards":[{"id":"https://openalex.org/G2260806423","display_name":null,"funder_award_id":"21575128","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6661147074","display_name":null,"funder_award_id":"2016YFA0501701","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G6876550061","display_name":null,"funder_award_id":"R01-GM079383","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7516209925","display_name":null,"funder_award_id":"R21-GM097617","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7991011545","display_name":null,"funder_award_id":"81773632","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8163957757","display_name":null,"funder_award_id":"2016YFB0201700","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1969921890","https://openalex.org/W1971327393","https://openalex.org/W1976595010","https://openalex.org/W1984017257","https://openalex.org/W1987612487","https://openalex.org/W1991286793","https://openalex.org/W1992018931","https://openalex.org/W1992716708","https://openalex.org/W1993605104","https://openalex.org/W1999683540","https://openalex.org/W2005688310","https://openalex.org/W2008525757","https://openalex.org/W2022125914","https://openalex.org/W2030211802","https://openalex.org/W2041620837","https://openalex.org/W2046594601","https://openalex.org/W2048782427","https://openalex.org/W2055715156","https://openalex.org/W2060531713","https://openalex.org/W2060759403","https://openalex.org/W2064073012","https://openalex.org/W2073486971","https://openalex.org/W2077483199","https://openalex.org/W2079108916","https://openalex.org/W2088226047","https://openalex.org/W2088997692","https://openalex.org/W2093265335","https://openalex.org/W2100536115","https://openalex.org/W2106588364","https://openalex.org/W2112664428","https://openalex.org/W2124679671","https://openalex.org/W2126662293","https://openalex.org/W2129682066","https://openalex.org/W2130839195","https://openalex.org/W2133707654","https://openalex.org/W2133920756","https://openalex.org/W2139857335","https://openalex.org/W2140715421","https://openalex.org/W2162398229","https://openalex.org/W2162603056","https://openalex.org/W2167061733","https://openalex.org/W2168052206","https://openalex.org/W2168775915","https://openalex.org/W2185500533","https://openalex.org/W2204695023","https://openalex.org/W2220807183","https://openalex.org/W2272547341","https://openalex.org/W2297812176","https://openalex.org/W2332082155","https://openalex.org/W2332439340","https://openalex.org/W2402635743","https://openalex.org/W2503701046","https://openalex.org/W2562257444","https://openalex.org/W2564843018","https://openalex.org/W2566670795","https://openalex.org/W2584342683","https://openalex.org/W2605908560","https://openalex.org/W2916094824","https://openalex.org/W2924170992","https://openalex.org/W4206110330","https://openalex.org/W4242372416","https://openalex.org/W4294120837"],"related_works":["https://openalex.org/W4283262748","https://openalex.org/W2502773048","https://openalex.org/W4252362398","https://openalex.org/W48866389","https://openalex.org/W2117651364","https://openalex.org/W3112533414","https://openalex.org/W2490481324","https://openalex.org/W1979668694","https://openalex.org/W4312662746","https://openalex.org/W2364036969"],"abstract_inverted_index":{"This":[0],"is":[1,26],"a":[2,21,150],"new":[3],"golden":[4],"age":[5],"for":[6],"drug":[7,238,241,244],"discovery":[8,245],"based":[9],"on":[10],"natural":[11,35,40,62],"products":[12,36,41,63],"derived":[13],"from":[14,68,88,198],"both":[15],"marine":[16,34],"and":[17,38,55,64,79,94,102,116,120,146,155,166,185,192,211,227],"terrestrial":[18,39],"sources.":[19],"Herein,":[20],"straightforward":[22],"but":[23],"important":[24,50],"question":[25],"\"what":[27],"are":[28,80,213,217],"the":[29,49,58,69,89,139,160,176,179,196,199],"major":[30],"structural":[31,53],"differences":[32,67],"between":[33,153],"(MNPs)":[37],"(TNPs)?\"":[42],"To":[43],"answer":[44],"this":[45],"question,":[46],"we":[47],"analyzed":[48],"physicochemical":[51],"properties,":[52],"features,":[54],"drug-likeness":[56,202],"of":[57,61,71,91,138,159,178],"two":[59],"types":[60],"discussed":[65],"their":[66],"perspective":[70,90],"evolution.":[72],"In":[73],"general,":[74],"MNPs":[75,96,110,126,145,154,210,216,226],"have":[76,112,233],"lower":[77],"solubility":[78],"often":[81,167,186],"larger":[82],"than":[83,135,221],"TNPs.":[84,136,156,222],"On":[85],"average,":[86],"particularly":[87],"unique":[92],"fragments":[93],"scaffolds,":[95],"usually":[97],"possess":[98],"more":[99,113,131,188,219],"long":[100],"chains":[101],"large":[103],"rings,":[104,174],"especially":[105],"8-":[106],"to":[107,163,172,182,236],"10-membered":[108,173],"rings.":[109],"also":[111,148],"nitrogen":[114],"atoms":[115],"halogens,":[117],"notably":[118],"bromines,":[119],"fewer":[121],"oxygen":[122],"atoms,":[123],"suggesting":[124],"that":[125,206,225],"may":[127],"be":[128,164,183,237],"synthesized":[129],"by":[130],"diverse":[132],"biosynthetic":[133],"pathways":[134],"Analysis":[137],"frequently":[140],"occurring":[141],"Murcko":[142],"frameworks":[143],"in":[144,209,243],"TNPS":[147],"reveals":[149],"striking":[151],"difference":[152],"The":[157],"scaffolds":[158,177,232],"former":[161],"tend":[162,181],"longer":[165],"contain":[168],"ester":[169],"bonds":[170],"connected":[171],"while":[175],"latter":[180],"shorter":[184],"bear":[187],"stable":[189],"ring":[190],"systems":[191],"bond":[193],"types.":[194],"Besides,":[195],"prediction":[197],"na\u00efve":[200],"Bayesian":[201],"classification":[203],"model":[204],"suggests":[205],"most":[207],"compounds":[208],"TNPs":[212,228],"drug-like,":[214],"although":[215],"slightly":[218],"drug-like":[220,231],"We":[223],"believe":[224],"with":[229],"novel":[230],"great":[234],"potential":[235],"leads":[239],"or":[240],"candidates":[242],"campaigns.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}