{"id":"https://openalex.org/W2786654671","doi":"https://doi.org/10.1021/acs.jcim.7b00606","title":"Partner-Specific Prediction of Protein-Dimer Stability from Unbound Structure of Monomer","display_name":"Partner-Specific Prediction of Protein-Dimer Stability from Unbound Structure of Monomer","publication_year":2018,"publication_date":"2018-02-14","ids":{"openalex":"https://openalex.org/W2786654671","doi":"https://doi.org/10.1021/acs.jcim.7b00606","mag":"2786654671","pmid":"https://pubmed.ncbi.nlm.nih.gov/29444397"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.7b00606","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.7b00606","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016441738","display_name":"Hamid Hadi\u2010Alijanvand","orcid":"https://orcid.org/0000-0001-8289-2214"},"institutions":[{"id":"https://openalex.org/I161028277","display_name":"Institute for Advanced Studies in Basic Sciences","ror":"https://ror.org/00bzsst90","country_code":"IR","type":"education","lineage":["https://openalex.org/I161028277"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Hamid Hadi-Alijanvand","raw_affiliation_strings":["Department of Biological Sciences, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, 45137-66731, Iran"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, 45137-66731, Iran","institution_ids":["https://openalex.org/I161028277"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084800440","display_name":"Maryam Rouhani","orcid":"https://orcid.org/0000-0003-2094-6568"},"institutions":[{"id":"https://openalex.org/I161028277","display_name":"Institute for Advanced Studies in Basic Sciences","ror":"https://ror.org/00bzsst90","country_code":"IR","type":"education","lineage":["https://openalex.org/I161028277"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Maryam Rouhani","raw_affiliation_strings":["Department of Biological Sciences, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, 45137-66731, Iran"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, 45137-66731, Iran","institution_ids":["https://openalex.org/I161028277"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016441738"],"corresponding_institution_ids":["https://openalex.org/I161028277"],"apc_list":null,"apc_paid":null,"fwci":0.2758,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.55085832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"58","issue":"3","first_page":"733","last_page":"745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dimer","display_name":"Dimer","score":0.7212735414505005},{"id":"https://openalex.org/keywords/monomer","display_name":"Monomer","score":0.6870768070220947},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.664941132068634},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.5079591870307922},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.43821343779563904},{"id":"https://openalex.org/keywords/protein-stability","display_name":"Protein stability","score":0.410762757062912},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.24005934596061707},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.20688343048095703},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.15004315972328186},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10243460536003113},{"id":"https://openalex.org/keywords/polymer","display_name":"Polymer","score":0.08034306764602661},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.07458722591400146},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.06555697321891785}],"concepts":[{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.7212735414505005},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.6870768070220947},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.664941132068634},{"id":"https://openalex.org/C2779519742","wikidata":"https://www.wikidata.org/wiki/Q198526","display_name":"D-dimer","level":2,"score":0.5079591870307922},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.43821343779563904},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.410762757062912},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24005934596061707},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20688343048095703},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15004315972328186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10243460536003113},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.08034306764602661},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.07458722591400146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06555697321891785}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.7b00606","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.7b00606","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:29444397","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29444397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.5099999904632568,"id":"https://metadata.un.org/sdg/10"},{"display_name":"Peace, Justice and strong institutions","score":0.49000000953674316,"id":"https://metadata.un.org/sdg/16"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324498","display_name":"Institute for Advanced Studies in Basic Sciences","ror":"https://ror.org/00bzsst90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W429766147","https://openalex.org/W1030883578","https://openalex.org/W1480376833","https://openalex.org/W1562938704","https://openalex.org/W1831050183","https://openalex.org/W1912982817","https://openalex.org/W1915490970","https://openalex.org/W1925045229","https://openalex.org/W1932911413","https://openalex.org/W1948562438","https://openalex.org/W2006617902","https://openalex.org/W2010485601","https://openalex.org/W2010612779","https://openalex.org/W2018459521","https://openalex.org/W2018776225","https://openalex.org/W2020604568","https://openalex.org/W2023490488","https://openalex.org/W2029667189","https://openalex.org/W2035503835","https://openalex.org/W2040488623","https://openalex.org/W2043699100","https://openalex.org/W2047468595","https://openalex.org/W2056392803","https://openalex.org/W2059446387","https://openalex.org/W2059885812","https://openalex.org/W2066962978","https://openalex.org/W2069003002","https://openalex.org/W2081681829","https://openalex.org/W2090683446","https://openalex.org/W2091710329","https://openalex.org/W2095521702","https://openalex.org/W2102201073","https://openalex.org/W2105012577","https://openalex.org/W2107996913","https://openalex.org/W2115161731","https://openalex.org/W2115788253","https://openalex.org/W2127771490","https://openalex.org/W2153255725","https://openalex.org/W2158100564","https://openalex.org/W2158698691","https://openalex.org/W2160690759","https://openalex.org/W2162259397","https://openalex.org/W2165179864","https://openalex.org/W2170505850","https://openalex.org/W2180749449","https://openalex.org/W2265800909","https://openalex.org/W2269993545","https://openalex.org/W2316431065","https://openalex.org/W2335043154","https://openalex.org/W2341018731","https://openalex.org/W2512372054","https://openalex.org/W2545226903","https://openalex.org/W2750193626","https://openalex.org/W4210719442"],"related_works":["https://openalex.org/W1975231683","https://openalex.org/W3208974412","https://openalex.org/W2953251415","https://openalex.org/W2092889823","https://openalex.org/W2126853599","https://openalex.org/W894066805","https://openalex.org/W1972220625","https://openalex.org/W2127915608","https://openalex.org/W2407990031","https://openalex.org/W2171778099"],"abstract_inverted_index":{"Protein":[0],"complexes":[1],"play":[2],"deterministic":[3],"roles":[4],"in":[5,8,68,158],"live":[6],"entities":[7],"sensing,":[9],"compiling,":[10],"controlling,":[11],"and":[12,16,43,71,110,137,166],"responding":[13],"to":[14,35,154,185],"external":[15],"internal":[17],"stimuli.":[18],"Thermodynamic":[19],"stability":[20,32,64,80,157,188],"is":[21,182],"an":[22],"important":[23],"property":[24],"of":[25,39,46,65,77,88,104,113,122,133,143,151,164,169,190],"protein":[26,40,47,66,91,115,125,171],"complexes;":[27],"having":[28],"knowledge":[29,82],"about":[30,83,140],"complex":[31,79],"helps":[33],"us":[34],"understand":[36],"the":[37,44,63,84,89,108,123,130,138,141,144,149,187,191],"basics":[38],"assembly-related":[41],"diseases":[42],"mechanism":[45],"assembly":[48],"clearly.":[49],"Enormous":[50],"protein-protein":[51],"interactions,":[52],"detected":[53],"by":[54,106,176],"high-throughput":[55],"methods,":[56],"necessitate":[57],"finding":[58],"fast":[59],"methods":[60,76],"for":[61,99],"predicting":[62,78,100],"assemblies":[67],"a":[69,96,114,119,159,170],"quantitative":[70],"qualitative":[72],"manner.":[73,161],"The":[74,127,162],"existing":[75],"need":[81],"three-dimensional":[85],"(3D)":[86],"structure":[87,132],"intended":[90,145,192],"complex.":[92,126],"Here,":[93],"we":[94],"introduce":[95],"new":[97],"method":[98,128],"dissociation":[101],"free":[102],"energy":[103],"subunits":[105],"analyzing":[107],"structural":[109,165],"topological":[111,167],"properties":[112,168],"binding":[116,146,172],"patch":[117,173],"on":[118,148],"single":[120],"subunit":[121,136,153],"desired":[124],"needs":[129],"3D":[131],"just":[134],"one":[135],"information":[139],"position":[142],"site":[147],"surface":[150],"that":[152],"predict":[155,186],"dimer":[156,193],"classwise":[160],"patterns":[163],"are":[174],"decoded":[175],"recurrence":[177],"quantification":[178],"analysis.":[179],"Nonparametric":[180],"discrimination":[181],"then":[183],"utilized":[184],"class":[189],"with":[194],"accuracy":[195],"greater":[196],"than":[197],"85%.":[198]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}