{"id":"https://openalex.org/W2809697843","doi":"https://doi.org/10.1021/acs.jcim.7b00475","title":"A Machine Learning Approach for Predicting HIV Reverse Transcriptase Mutation Susceptibility of Biologically Active Compounds","display_name":"A Machine Learning Approach for Predicting HIV Reverse Transcriptase Mutation Susceptibility of Biologically Active Compounds","publication_year":2018,"publication_date":"2018-06-28","ids":{"openalex":"https://openalex.org/W2809697843","doi":"https://doi.org/10.1021/acs.jcim.7b00475","mag":"2809697843","pmid":"https://pubmed.ncbi.nlm.nih.gov/29953819"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.7b00475","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.7b00475","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005493387","display_name":"Thomas M. Kaiser","orcid":"https://orcid.org/0000-0001-5174-9183"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas M. Kaiser","raw_affiliation_strings":["Department of Chemistry, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046396153","display_name":"Pieter B. Burger","orcid":"https://orcid.org/0000-0003-0272-1111"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pieter B. Burger","raw_affiliation_strings":["Department of Chemistry, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States","Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, 280 Calhoun St., MSC 141, Charleston, South Carolina 29425-1410, United States"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, 280 Calhoun St., MSC 141, Charleston, South Carolina 29425-1410, United States","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008825536","display_name":"Christopher J. Butch","orcid":"https://orcid.org/0000-0003-3112-0470"},"institutions":[{"id":"https://openalex.org/I4210111488","display_name":"Life Science Institute","ror":"https://ror.org/01yeyd808","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210111488"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Christopher J. Butch","raw_affiliation_strings":["Department of Chemistry, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States","Earth-Life Science Institute, Tokyo Institute of Technology, 2-12-1-IE-1 Ookayam, Meguro-ku, Tokyo 152-8550, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Earth-Life Science Institute, Tokyo Institute of Technology, 2-12-1-IE-1 Ookayam, Meguro-ku, Tokyo 152-8550, Japan","institution_ids":["https://openalex.org/I4210111488","https://openalex.org/I114531698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040477247","display_name":"Stephen C. Pelly","orcid":"https://orcid.org/0000-0001-5930-4939"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen C. Pelly","raw_affiliation_strings":["Department of Chemistry, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032077625","display_name":"Dennis C. Liotta","orcid":null},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dennis C. Liotta","raw_affiliation_strings":["Department of Chemistry, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5005493387","https://openalex.org/A5032077625"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":null,"apc_paid":null,"fwci":2.0194,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.88363304,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"58","issue":"8","first_page":"1544","last_page":"1552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reverse-transcriptase","display_name":"Reverse transcriptase","score":0.8592729568481445},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.7024224400520325},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.6424469351768494},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.6115623116493225},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5548676252365112},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5095527172088623},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.4846092164516449},{"id":"https://openalex.org/keywords/bayes-theorem","display_name":"Bayes' theorem","score":0.4699699282646179},{"id":"https://openalex.org/keywords/hiv-drug-resistance","display_name":"HIV drug resistance","score":0.4639456272125244},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4400627017021179},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39600658416748047},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"Antiretroviral therapy","score":0.38168829679489136},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.34879958629608154},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3374333381652832},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.30015766620635986},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.2552434206008911},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2551591396331787},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.13287627696990967},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1254805624485016},{"id":"https://openalex.org/keywords/polymerase-chain-reaction","display_name":"Polymerase chain reaction","score":0.1016768217086792}],"concepts":[{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.8592729568481445},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7024224400520325},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6424469351768494},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6115623116493225},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5548676252365112},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5095527172088623},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4846092164516449},{"id":"https://openalex.org/C207201462","wikidata":"https://www.wikidata.org/wiki/Q182505","display_name":"Bayes' theorem","level":3,"score":0.4699699282646179},{"id":"https://openalex.org/C2778451633","wikidata":"https://www.wikidata.org/wiki/Q5629934","display_name":"HIV drug resistance","level":5,"score":0.4639456272125244},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4400627017021179},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39600658416748047},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.38168829679489136},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.34879958629608154},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3374333381652832},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.30015766620635986},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2552434206008911},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2551591396331787},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.13287627696990967},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1254805624485016},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.1016768217086792},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.7b00475","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.7b00475","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:29953819","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29953819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8100000023841858,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306193","display_name":"John Templeton Foundation","ror":"https://ror.org/035tnyy05"},{"id":"https://openalex.org/F4320309381","display_name":"Emory University","ror":"https://ror.org/03czfpz43"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W959778778","https://openalex.org/W1869829652","https://openalex.org/W1968937894","https://openalex.org/W1988037271","https://openalex.org/W2014619388","https://openalex.org/W2032529315","https://openalex.org/W2036807780","https://openalex.org/W2047066911","https://openalex.org/W2049863380","https://openalex.org/W2065600256","https://openalex.org/W2073327383","https://openalex.org/W2092408123","https://openalex.org/W2103866094","https://openalex.org/W2116844530","https://openalex.org/W2125900719","https://openalex.org/W2142602210","https://openalex.org/W2171830166","https://openalex.org/W2403369691","https://openalex.org/W4232932066"],"related_works":["https://openalex.org/W2034458000","https://openalex.org/W4303983510","https://openalex.org/W2115295975","https://openalex.org/W2322280852","https://openalex.org/W2001725728","https://openalex.org/W2030545030","https://openalex.org/W2004698251","https://openalex.org/W2017060041","https://openalex.org/W2040047403","https://openalex.org/W4213459675"],"abstract_inverted_index":{"HIV":[0],"resistance":[1,25],"emerging":[2],"against":[3,54],"antiretroviral":[4],"drugs":[5],"represents":[6],"a":[7,79,85,105,110,122],"great":[8,34],"threat":[9],"to":[10,62,84,90,103,140],"the":[11,15,28,38,49,58,115,142,148,157,162],"continued":[12],"prolongation":[13],"of":[14,17,23,30,52,87,131,144,150],"lifespans":[16],"HIV-infected":[18],"patients.":[19],"Therefore,":[20],"methods":[21],"capable":[22],"predicting":[24],"susceptibility":[26],"in":[27,33,161],"development":[29],"compounds":[31,53,99],"are":[32],"need.":[35],"By":[36],"targeting":[37],"major":[39],"reverse":[40,60],"transcription":[41],"residues":[42],"Y181,":[43],"K103,":[44],"and":[45,57,109,138],"L100,":[46],"we":[47,72,93],"used":[48],"biological":[50,154],"activities":[51],"these":[55],"enzymes":[56],"wild-type":[59],"transcriptase":[61],"create":[63],"Na\u00efve":[64],"Bayes":[65],"Networks.":[66],"Through":[67],"this":[68],"machine":[69,145],"learning":[70,146],"approach,":[71],"could":[73,94],"predict,":[74],"with":[75],"high":[76],"accuracy,":[77],"whether":[78,98],"compound":[80],"would":[81,100],"be":[82,101,130],"susceptible":[83,102],"loss":[86],"potency":[88],"due":[89],"resistance.":[91],"Also,":[92],"perfectly":[95],"predict":[96],"retrospectively":[97],"both":[104],"K103":[106],"mutant":[107,112],"RT":[108],"Y181":[111],"RT.":[113],"In":[114],"study":[116],"presented":[117],"here,":[118],"our":[119],"method":[120,128],"outperformed":[121],"traditional":[123],"molecular":[124],"mechanics":[125],"approach.":[126],"This":[127],"should":[129],"broad":[132],"interest":[133],"beyond":[134],"drug":[135],"discovery":[136],"efforts,":[137],"serves":[139],"expand":[141],"utility":[143],"for":[147],"prediction":[149],"physical,":[151],"chemical,":[152],"or":[153],"properties":[155],"using":[156],"vast":[158],"information":[159],"available":[160],"literature.":[163]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
