{"id":"https://openalex.org/W2666052360","doi":"https://doi.org/10.1021/acs.jcim.7b00121","title":"Binding Space Concept: A New Approach To Enhance the Reliability of Docking Scores and Its Application to Predicting Butyrylcholinesterase Hydrolytic Activity","display_name":"Binding Space Concept: A New Approach To Enhance the Reliability of Docking Scores and Its Application to Predicting Butyrylcholinesterase Hydrolytic Activity","publication_year":2017,"publication_date":"2017-06-21","ids":{"openalex":"https://openalex.org/W2666052360","doi":"https://doi.org/10.1021/acs.jcim.7b00121","mag":"2666052360","pmid":"https://pubmed.ncbi.nlm.nih.gov/28633528"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.7b00121","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.7b00121","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028843194","display_name":"Giulio Vistoli","orcid":"https://orcid.org/0000-0002-3939-5172"},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giulio Vistoli","raw_affiliation_strings":["Dipartimento\rdi Scienze Farmaceutiche, Universit\u00e0 degli Studi di Milano, Via Mangiagalli, 25, I-20133 Milano, Italy"],"raw_orcid":"https://orcid.org/0000-0002-3939-5172","affiliations":[{"raw_affiliation_string":"Dipartimento\rdi Scienze Farmaceutiche, Universit\u00e0 degli Studi di Milano, Via Mangiagalli, 25, I-20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019195809","display_name":"Angelica Mazzolari","orcid":"https://orcid.org/0000-0003-1352-1094"},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angelica Mazzolari","raw_affiliation_strings":["Dipartimento\rdi Scienze Farmaceutiche, Universit\u00e0 degli Studi di Milano, Via Mangiagalli, 25, I-20133 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento\rdi Scienze Farmaceutiche, Universit\u00e0 degli Studi di Milano, Via Mangiagalli, 25, I-20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080796605","display_name":"Bernard Testa","orcid":"https://orcid.org/0000-0002-3218-4612"},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Bernard Testa","raw_affiliation_strings":["Department\rof Pharmacy, University Hospital Centre (CHUV), Rue du Bugnon, CH-1011 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Pharmacy, University Hospital Centre (CHUV), Rue du Bugnon, CH-1011 Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004734394","display_name":"Alessandro Pedretti","orcid":"https://orcid.org/0000-0001-5916-2029"},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Pedretti","raw_affiliation_strings":["Dipartimento\rdi Scienze Farmaceutiche, Universit\u00e0 degli Studi di Milano, Via Mangiagalli, 25, I-20133 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento\rdi Scienze Farmaceutiche, Universit\u00e0 degli Studi di Milano, Via Mangiagalli, 25, I-20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028843194"],"corresponding_institution_ids":["https://openalex.org/I189158943"],"apc_list":null,"apc_paid":null,"fwci":3.6131,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.93943261,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"57","issue":"7","first_page":"1691","last_page":"1702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9593999981880188,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.8563665151596069},{"id":"https://openalex.org/keywords/chemical-space","display_name":"Chemical space","score":0.5640180110931396},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5317068696022034},{"id":"https://openalex.org/keywords/protein\u2013ligand-docking","display_name":"Protein\u2013ligand docking","score":0.48398327827453613},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.4697815477848053},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3956334590911865},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3770636320114136},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.35015249252319336},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.30072712898254395},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.29267802834510803},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.16562777757644653},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15433552861213684},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1257055401802063},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09139814972877502}],"concepts":[{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.8563665151596069},{"id":"https://openalex.org/C99726746","wikidata":"https://www.wikidata.org/wiki/Q906396","display_name":"Chemical space","level":3,"score":0.5640180110931396},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5317068696022034},{"id":"https://openalex.org/C77319485","wikidata":"https://www.wikidata.org/wiki/Q7251520","display_name":"Protein\u2013ligand docking","level":4,"score":0.48398327827453613},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4697815477848053},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3956334590911865},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3770636320114136},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.35015249252319336},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.30072712898254395},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.29267802834510803},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.16562777757644653},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15433552861213684},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1257055401802063},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09139814972877502},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.jcim.7b00121","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.7b00121","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:28633528","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28633528","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:iris.unil.ch:iris/62654","is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/62654","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:serval.unil.ch:BIB_06CD6066A104","is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_06CD6066A104","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of chemical information and modeling, vol. 57, no. 7, pp. 1691-1702","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1653739410","https://openalex.org/W1759938974","https://openalex.org/W1825810262","https://openalex.org/W1881444267","https://openalex.org/W1966728055","https://openalex.org/W1972362308","https://openalex.org/W1977146112","https://openalex.org/W1988437166","https://openalex.org/W1994430543","https://openalex.org/W2001965999","https://openalex.org/W2002926326","https://openalex.org/W2003236700","https://openalex.org/W2020774484","https://openalex.org/W2024674972","https://openalex.org/W2035067870","https://openalex.org/W2037011249","https://openalex.org/W2041666513","https://openalex.org/W2047441116","https://openalex.org/W2075304800","https://openalex.org/W2075550795","https://openalex.org/W2075990166","https://openalex.org/W2081000338","https://openalex.org/W2087661061","https://openalex.org/W2100029387","https://openalex.org/W2104182950","https://openalex.org/W2107063279","https://openalex.org/W2112300060","https://openalex.org/W2127308401","https://openalex.org/W2147445502","https://openalex.org/W2150981663","https://openalex.org/W2155335820","https://openalex.org/W2235662413","https://openalex.org/W2416796969","https://openalex.org/W2461958429","https://openalex.org/W2465672040"],"related_works":["https://openalex.org/W1581147483","https://openalex.org/W2326230513","https://openalex.org/W4310018788","https://openalex.org/W2057846043","https://openalex.org/W2336040088","https://openalex.org/W2027065525","https://openalex.org/W2750247885","https://openalex.org/W2773493604","https://openalex.org/W2269591907","https://openalex.org/W2093426296"],"abstract_inverted_index":{"Docking":[0,20],"simulations":[1,21],"are":[2,22,255],"very":[3,143],"popular":[4],"approaches":[5],"able":[6],"to":[7,15,55,146,201,297],"assess":[8],"the":[9,56,67,75,79,97,109,115,120,149,152,159,164,174,182,195,202,205,225,229,240,244,256,259,265,278,290,302,305],"capacity":[10],"of":[11,51,74,108,151,166,204,208,228,239,243,292,304],"a":[12,18,26,38,42,142,169,186,190,236,281],"given":[13,170],"ligand":[14,58,76,86,171,187],"interact":[16],"with":[17,184],"target.":[19],"usually":[23],"focused":[24],"on":[25,224,289],"single":[27],"best":[28],"complex":[29],"even":[30],"though":[31],"many":[32],"studies":[33],"showed":[34],"that":[35],"ligands":[36],"retain":[37],"significant":[39,237],"mobility":[40,77,167,191],"within":[41,78,173],"binding":[43,48,68,80,121,156,175,196,230,306],"pocket":[44,81],"by":[45,82,90,105,126,210,249],"assuming":[46],"different":[47],"modes":[49],"all":[50,264],"which":[52,70,168,185,295],"may":[53],"contribute":[54],"monitored":[57],"affinity.":[59],"The":[60,93,138,219],"present":[61],"study":[62,279],"describes":[63,280],"an":[64,72],"innovative":[65],"concept,":[66,232],"space,":[69],"allows":[71],"exploration":[73],"simultaneously":[83],"considering":[84,212],"several":[85],"poses":[87,95,214],"as":[88,179,181,247],"generated":[89],"docking":[91,99,245],"simulations.":[92],"multiple":[94,213,216],"and":[96,133,215,263],"relative":[98],"scores":[100,254],"can":[101,123],"then":[102],"be":[103,124,298],"analyzed":[104],"taking":[106],"advantage":[107],"same":[110],"concepts":[111],"already":[112],"used":[113],"in":[114,273,301],"property":[116],"space":[117,122,197,231],"analysis;":[118],"hence":[119],"parametrized":[125],"(a)":[127],"mean":[128],"scores,":[129],"(b)":[130],"score":[131,135,283],"ranges,":[132],"(c)":[134],"sensitivity":[136],"values.":[137],"first":[139],"parameter":[140],"represents":[141],"simple":[144],"procedure":[145],"account":[147],"for":[148],"contribution":[150],"often":[153],"neglected":[154],"alternative":[155],"modes,":[157],"while":[158],"last":[160],"two":[161],"descriptors":[162,269],"encode":[163],"degree":[165],"retains":[172],"cavity":[176],"(score":[177,192],"range)":[178],"well":[180],"ease":[183],"explores":[188],"such":[189],"sensitivity).":[193],"Here,":[194],"concept":[198],"is":[199],"applied":[200],"prediction":[203],"hydrolytic":[206],"activity":[207],"BChE":[209],"synergistically":[211],"protein":[217],"structures.":[218],"obtained":[220],"results":[221,246],"shed":[222],"light":[223],"remarkable":[226],"potential":[227],"whose":[233],"parameters":[234,257],"allow":[235],"increase":[238],"predictive":[241,275],"power":[242],"revealed":[248],"extended":[250],"correlative":[251],"analyses.":[252],"Mean":[253],"affording":[258],"largest":[260],"statistical":[261],"improvement,":[262],"here":[266],"proposed":[267],"docking-based":[268],"show":[270],"enhancing":[271],"effects":[272],"developing":[274],"models.":[276],"Finally,":[277],"new":[282],"function":[284],"(Contacts":[285],"score)":[286],"simply":[287],"based":[288],"number":[291],"surrounding":[293],"residues":[294],"appears":[296],"particularly":[299],"productive":[300],"framework":[303],"space.":[307]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}