{"id":"https://openalex.org/W2607067086","doi":"https://doi.org/10.1021/acs.jcim.7b00073","title":"Allosteric Autoinhibition Pathway in Transcription Factor ERG: Dynamics Network and Mutant Experimental Evaluations","display_name":"Allosteric Autoinhibition Pathway in Transcription Factor ERG: Dynamics Network and Mutant Experimental Evaluations","publication_year":2017,"publication_date":"2017-04-20","ids":{"openalex":"https://openalex.org/W2607067086","doi":"https://doi.org/10.1021/acs.jcim.7b00073","mag":"2607067086","pmid":"https://pubmed.ncbi.nlm.nih.gov/28425706"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.7b00073","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.7b00073","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5730271","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068798135","display_name":"Wei Ye","orcid":"https://orcid.org/0000-0001-6268-2703"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Ye","raw_affiliation_strings":["State Key Laboratory\rof Microbial Metabolism, Department of Bioinformatics and Biostatistics,\rSJTU-Yale Joint Center for Biostatistics, National Experimental Teaching\rCenter for Life Sciences and Biotechnology, School of Life Sciences\rand Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China","State Key Laboratory of Microbial Metabolism, Department of Bioinformatics and Biostatistics, SJTU-Yale Joint Center for Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory\rof Microbial Metabolism, Department of Bioinformatics and Biostatistics,\rSJTU-Yale Joint Center for Biostatistics, National Experimental Teaching\rCenter for Life Sciences and Biotechnology, School of Life Sciences\rand Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I183067930"]},{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, Department of Bioinformatics and Biostatistics, SJTU-Yale Joint Center for Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043028780","display_name":"Tianle Qian","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianle Qian","raw_affiliation_strings":["State Key Laboratory\rof Microbial Metabolism, Department of Bioinformatics and Biostatistics,\rSJTU-Yale Joint Center for Biostatistics, National Experimental Teaching\rCenter for Life Sciences and Biotechnology, School of Life Sciences\rand Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China","State Key Laboratory of Microbial Metabolism, Department of Bioinformatics and Biostatistics, SJTU-Yale Joint Center for Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory\rof Microbial Metabolism, Department of Bioinformatics and Biostatistics,\rSJTU-Yale Joint Center for Biostatistics, National Experimental Teaching\rCenter for Life Sciences and Biotechnology, School of Life Sciences\rand Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I183067930"]},{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, Department of Bioinformatics and Biostatistics, SJTU-Yale Joint Center for Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100458874","display_name":"Hao Liu","orcid":"https://orcid.org/0000-0003-0994-6284"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Liu","raw_affiliation_strings":["State Key Laboratory\rof Microbial Metabolism, Department of Bioinformatics and Biostatistics,\rSJTU-Yale Joint Center for Biostatistics, National Experimental Teaching\rCenter for Life Sciences and Biotechnology, School of Life Sciences\rand Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China","State Key Laboratory of Microbial Metabolism, Department of Bioinformatics and Biostatistics, SJTU-Yale Joint Center for Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory\rof Microbial Metabolism, Department of Bioinformatics and Biostatistics,\rSJTU-Yale Joint Center for Biostatistics, National Experimental Teaching\rCenter for Life Sciences and Biotechnology, School of Life Sciences\rand Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I183067930"]},{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, Department of Bioinformatics and Biostatistics, SJTU-Yale Joint Center for Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032088629","display_name":"Ray Luo","orcid":"https://orcid.org/0000-0002-6346-8271"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ray Luo","raw_affiliation_strings":["Departments of Molecular Biology and Biochemistry, Chemical\rEngineering and Materials Science, and Biomedical Engineering, University of California, Irvine, California 92697-3900, United States"],"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology and Biochemistry, Chemical\rEngineering and Materials Science, and Biomedical Engineering, University of California, Irvine, California 92697-3900, United States","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100456783","display_name":"Haifeng Chen","orcid":"https://orcid.org/0000-0002-7496-4182"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai-Feng Chen","raw_affiliation_strings":["Shanghai Center for Bioinformation Technology, 1278 Keyuan Road, Shanghai, 200235, China","State Key Laboratory\rof Microbial Metabolism, Department of Bioinformatics and Biostatistics,\rSJTU-Yale Joint Center for Biostatistics, National Experimental Teaching\rCenter for Life Sciences and Biotechnology, School of Life Sciences\rand Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China","State Key Laboratory of Microbial Metabolism, Department of Bioinformatics and Biostatistics, SJTU-Yale Joint Center for Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Center for Bioinformation Technology, 1278 Keyuan Road, Shanghai, 200235, China","institution_ids":["https://openalex.org/I4210162648"]},{"raw_affiliation_string":"State Key Laboratory\rof Microbial Metabolism, Department of Bioinformatics and Biostatistics,\rSJTU-Yale Joint Center for Biostatistics, National Experimental Teaching\rCenter for Life Sciences and Biotechnology, School of Life Sciences\rand Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I183067930"]},{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, Department of Bioinformatics and Biostatistics, SJTU-Yale Joint Center for Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5068798135"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210160507"],"apc_list":null,"apc_paid":null,"fwci":0.898,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.73147714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"57","issue":"5","first_page":"1153","last_page":"1165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9851999878883362,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"Allosteric regulation","score":0.8455451726913452},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.575104296207428},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.5590641498565674},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.45526862144470215},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4508044123649597},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4476718008518219},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3214128017425537},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29593223333358765},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1677866280078888},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.14203080534934998},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10500171780586243},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1015443503856659}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.8455451726913452},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.575104296207428},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5590641498565674},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.45526862144470215},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4508044123649597},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4476718008518219},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3214128017425537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29593223333358765},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1677866280078888},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14203080534934998},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10500171780586243},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1015443503856659},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071230","descriptor_name":"Transcriptional Regulator ERG","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071230","descriptor_name":"Transcriptional Regulator ERG","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071230","descriptor_name":"Transcriptional Regulator ERG","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071230","descriptor_name":"Transcriptional Regulator ERG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071230","descriptor_name":"Transcriptional Regulator ERG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071230","descriptor_name":"Transcriptional Regulator ERG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1021/acs.jcim.7b00073","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.7b00073","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:28425706","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28425706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:ark:/13030/qt9tv07692","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:escholarship.org:ark:/13030/qt9tv07692","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9tv07692","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Chemical Information and Modeling, vol 57, iss 5","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5730271","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5730271","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5730271","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5730271","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1329936481","display_name":null,"funder_award_id":"YG2013MS68","funder_id":"https://openalex.org/F4320322999","funder_display_name":"Shanghai Jiao Tong University"},{"id":"https://openalex.org/G1331740350","display_name":null,"funder_award_id":"YG2015MS56","funder_id":"https://openalex.org/F4320322999","funder_display_name":"Shanghai Jiao Tong University"},{"id":"https://openalex.org/G1337535711","display_name":null,"funder_award_id":"GM093040","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1962392006","display_name":null,"funder_award_id":"2012CB721003","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G227035267","display_name":null,"funder_award_id":"2014AA021502","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G5627191773","display_name":null,"funder_award_id":"YG2014MS47","funder_id":"https://openalex.org/F4320322999","funder_display_name":"Shanghai Jiao Tong University"},{"id":"https://openalex.org/G6757449341","display_name":null,"funder_award_id":"J1210047","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7349745844","display_name":null,"funder_award_id":"31620103901","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8759326567","display_name":null,"funder_award_id":"GM079383","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W67399661","https://openalex.org/W1606273823","https://openalex.org/W1835811038","https://openalex.org/W1868339174","https://openalex.org/W1935374737","https://openalex.org/W1964245683","https://openalex.org/W1969761972","https://openalex.org/W1972956845","https://openalex.org/W1991371921","https://openalex.org/W1995033729","https://openalex.org/W2003229373","https://openalex.org/W2004822259","https://openalex.org/W2007572995","https://openalex.org/W2009883127","https://openalex.org/W2016008760","https://openalex.org/W2017639069","https://openalex.org/W2019011769","https://openalex.org/W2020379597","https://openalex.org/W2023529914","https://openalex.org/W2031593809","https://openalex.org/W2037155998","https://openalex.org/W2038009467","https://openalex.org/W2038135364","https://openalex.org/W2049524895","https://openalex.org/W2054774767","https://openalex.org/W2055523288","https://openalex.org/W2056476746","https://openalex.org/W2057498577","https://openalex.org/W2063706707","https://openalex.org/W2065776015","https://openalex.org/W2067174909","https://openalex.org/W2069098917","https://openalex.org/W2072456220","https://openalex.org/W2086323657","https://openalex.org/W2090264443","https://openalex.org/W2092502874","https://openalex.org/W2100610993","https://openalex.org/W2103555733","https://openalex.org/W2106140689","https://openalex.org/W2114844053","https://openalex.org/W2121158863","https://openalex.org/W2129583552","https://openalex.org/W2132781864","https://openalex.org/W2138480068","https://openalex.org/W2153970368","https://openalex.org/W2159675211","https://openalex.org/W2160451368","https://openalex.org/W2161605421","https://openalex.org/W2167279962","https://openalex.org/W2289411371","https://openalex.org/W2313116527","https://openalex.org/W2330714421","https://openalex.org/W2336824349","https://openalex.org/W2468923062"],"related_works":["https://openalex.org/W2939998722","https://openalex.org/W2169750653","https://openalex.org/W2195592873","https://openalex.org/W1971782741","https://openalex.org/W3005062988","https://openalex.org/W2075777827","https://openalex.org/W4211217675","https://openalex.org/W2911329269","https://openalex.org/W2592466923","https://openalex.org/W1555254413"],"abstract_inverted_index":{"Allosteric":[0],"autoinhibition":[1,11,27,74,110],"exists":[2],"in":[3,71,102],"many":[4],"transcription":[5],"factors.":[6],"The":[7],"ERG":[8,33],"proteins":[9],"exhibit":[10],"on":[12,135],"DNA":[13,154],"binding":[14,80,142,155],"by":[15,97,123],"the":[16,26,43,72,124,136,151,161],"C-terminal":[17],"and":[18,23,29,47,55,89,99,105,114,120,126,144],"N-terminal":[19],"inhibitory":[20],"domains":[21],"(CID":[22],"NID).":[24],"However,":[25],"mechanism":[28,46],"allosteric":[30,45,73,109,137],"pathway":[31,48],"of":[32,53,78,112,173,180],"are":[34],"unknown.":[35],"In":[36],"this":[37],"study":[38],"we":[39,130],"intend":[40],"to":[41,66,85],"elucidate":[42],"residue-level":[44,60],"via":[49],"a":[50,170],"combined":[51],"approach":[52],"computational":[54,59,125],"experimental":[56,127],"analyses.":[57],"Specifically":[58,129],"fluctuation":[61],"correlation":[62],"data":[63],"was":[64],"analyzed":[65],"reveal":[67],"detailed":[68],"dynamics":[69],"signatures":[70],"process.":[75],"A":[76],"hypothesis":[77],"\"NID/CID":[79],"induced":[81],"allostery\"":[82],"is":[83,94],"proposed":[84],"link":[86],"similar":[87],"structures":[88],"different":[90],"protein":[91,163,174,181],"functions,":[92],"which":[93,148],"subsequently":[95],"validated":[96],"perturbation":[98],"mutation":[100,133],"analyses":[101,179],"both":[103],"computation":[104],"experiment.":[106],"Two":[107],"possible":[108],"pathways":[111],"L286-L382-A379-G377-I360-Y355-R353":[113],"L286-L382-A379-G377-I360-Y355-":[115],"A351-K347-R350":[116],"were":[117,121],"identified":[118,131],"computationally":[119],"confirmed":[122],"mutations.":[128],"two":[132],"sites":[134],"inhibition":[138],"pathways,":[139],"L286P/Q383P":[140],"(NID/CID":[141],"site)":[143],"I360G":[145],"(pathway":[146],"junction),":[147],"completely":[149],"restore":[150],"wild":[152],"type":[153],"affinity.":[156],"These":[157],"results":[158],"suggest":[159],"that":[160],"putative":[162],"structure-function":[164],"relationship":[165,172],"may":[166],"be":[167],"augmented":[168],"with":[169],"general":[171],"\"structure/fluctuation-correlation/function\"":[175],"for":[176],"more":[177],"thorough":[178],"functions.":[182]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}