{"id":"https://openalex.org/W2737924751","doi":"https://doi.org/10.1021/acs.jcim.7b00026","title":"Proteochemometrics-Based Prediction of Peptide Binding to HLA-DP Proteins","display_name":"Proteochemometrics-Based Prediction of Peptide Binding to HLA-DP Proteins","publication_year":2017,"publication_date":"2017-07-18","ids":{"openalex":"https://openalex.org/W2737924751","doi":"https://doi.org/10.1021/acs.jcim.7b00026","mag":"2737924751","pmid":"https://pubmed.ncbi.nlm.nih.gov/28719212"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.7b00026","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.7b00026","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040003270","display_name":"Ventsislav Yordanov","orcid":null},"institutions":[{"id":"https://openalex.org/I30147112","display_name":"Medical University of Sofia","ror":"https://ror.org/01n9zy652","country_code":"BG","type":"education","lineage":["https://openalex.org/I30147112"]}],"countries":["BG"],"is_corresponding":true,"raw_author_name":"Ventsislav Yordanov","raw_affiliation_strings":["Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, Sofia 1000, Bulgaria"],"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, Sofia 1000, Bulgaria","institution_ids":["https://openalex.org/I30147112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051812430","display_name":"Ivan Dimitrov","orcid":"https://orcid.org/0000-0003-4838-312X"},"institutions":[{"id":"https://openalex.org/I30147112","display_name":"Medical University of Sofia","ror":"https://ror.org/01n9zy652","country_code":"BG","type":"education","lineage":["https://openalex.org/I30147112"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Ivan Dimitrov","raw_affiliation_strings":["Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, Sofia 1000, Bulgaria"],"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, Sofia 1000, Bulgaria","institution_ids":["https://openalex.org/I30147112"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052238096","display_name":"Irini Doytchinova","orcid":"https://orcid.org/0000-0002-1469-1768"},"institutions":[{"id":"https://openalex.org/I30147112","display_name":"Medical University of Sofia","ror":"https://ror.org/01n9zy652","country_code":"BG","type":"education","lineage":["https://openalex.org/I30147112"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Irini Doytchinova","raw_affiliation_strings":["Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, Sofia 1000, Bulgaria"],"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, Sofia 1000, Bulgaria","institution_ids":["https://openalex.org/I30147112"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040003270"],"corresponding_institution_ids":["https://openalex.org/I30147112"],"apc_list":null,"apc_paid":null,"fwci":0.638,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.6729119,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"58","issue":"2","first_page":"297","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.6003885865211487},{"id":"https://openalex.org/keywords/human-leukocyte-antigen","display_name":"Human leukocyte antigen","score":0.5994924306869507},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5068743824958801},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.38266104459762573},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32061561942100525},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25045937299728394},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.24546244740486145},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.22595557570457458},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.19241246581077576}],"concepts":[{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6003885865211487},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.5994924306869507},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5068743824958801},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38266104459762573},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32061561942100525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25045937299728394},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24546244740486145},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22595557570457458},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.19241246581077576}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006682","descriptor_name":"HLA-DP Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006682","descriptor_name":"HLA-DP Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006682","descriptor_name":"HLA-DP Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006682","descriptor_name":"HLA-DP Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006682","descriptor_name":"HLA-DP Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006682","descriptor_name":"HLA-DP Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.7b00026","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.7b00026","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:28719212","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28719212","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7099999785423279}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1587597128","https://openalex.org/W1651886044","https://openalex.org/W1740864292","https://openalex.org/W1970557199","https://openalex.org/W1972403630","https://openalex.org/W1977665693","https://openalex.org/W1982131304","https://openalex.org/W1983768633","https://openalex.org/W1993904189","https://openalex.org/W1994820490","https://openalex.org/W2023306209","https://openalex.org/W2024378867","https://openalex.org/W2025974789","https://openalex.org/W2032265689","https://openalex.org/W2053707749","https://openalex.org/W2066494078","https://openalex.org/W2089469712","https://openalex.org/W2100076566","https://openalex.org/W2106440817","https://openalex.org/W2111091779","https://openalex.org/W2112752664","https://openalex.org/W2126624551","https://openalex.org/W2129434099","https://openalex.org/W2135455279","https://openalex.org/W2146729150","https://openalex.org/W2164510411","https://openalex.org/W3199180046"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487","https://openalex.org/W1986764834"],"abstract_inverted_index":{"Human":[0],"leukocyte":[1],"antigens":[2],"(HLA)":[3],"class":[4,52],"II":[5,53],"proteins":[6,57],"are":[7,29,37,58],"involved":[8],"in":[9,13,127],"the":[10,14,32,49,82,111,125,128,132],"antigen":[11,15,22],"processing":[12],"presenting":[16],"cells.":[17],"They":[18],"form":[19],"complexes":[20,28],"with":[21,60,70],"peptide":[23,107],"fragments.":[24],"The":[25,55,117],"peptide-HLA":[26],"protein":[27],"presented":[30],"on":[31],"cell":[33],"surface":[34],"where":[35],"they":[36],"recognized":[38],"by":[39],"helper":[40],"T":[41],"cells":[42],"(Th":[43],"cells).":[44],"HLA-DP":[45,56,115],"is":[46,119],"one":[47,138],"of":[48,64,78,92,124,131],"three":[50],"HLA":[51],"loci.":[54],"associated":[59],"a":[61,71,76,103],"significant":[62],"number":[63,77],"autoimmune":[65],"diseases,":[66],"as":[67,69],"well":[68],"susceptibility":[72],"or":[73],"resistance":[74],"to":[75,96,110,121],"infectious":[79],"agents.":[80],"In":[81],"present":[83],"study,":[84],"we":[85],"apply":[86],"proteochemometrics-a":[87],"method":[88],"for":[89,106],"bioactivity":[90],"modeling":[91],"multiple":[93,97],"ligands":[94],"binding":[95,108],"target":[98],"proteins-to":[99],"derive":[100],"and":[101],"validate":[102],"robust":[104],"model":[105,118],"prediction":[109],"7":[112],"most":[113],"frequent":[114],"proteins.":[116],"able":[120],"identify":[122],"86%":[123],"binders":[126],"top":[129],"10%":[130],"best":[133],"predicted":[134],"nonamers":[135],"generated":[136],"from":[137],"protein.":[139]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}