{"id":"https://openalex.org/W7154181755","doi":"https://doi.org/10.1021/acs.jcim.6c00357","title":"ToxCML: A Hybrid mfCoQ-RASAR-Based Platform Integrating Consensus QSAR and Read-Across for Comprehensive Multi-End Point Toxicity Assessment","display_name":"ToxCML: A Hybrid mfCoQ-RASAR-Based Platform Integrating Consensus QSAR and Read-Across for Comprehensive Multi-End Point Toxicity Assessment","publication_year":2026,"publication_date":"2026-04-13","ids":{"openalex":"https://openalex.org/W7154181755","doi":"https://doi.org/10.1021/acs.jcim.6c00357","pmid":"https://pubmed.ncbi.nlm.nih.gov/41973763"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.6c00357","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.6c00357","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122732584","display_name":"Fauzan Syarif Nursyafi","orcid":"https://orcid.org/0009-0001-5330-2008"},"institutions":[{"id":"https://openalex.org/I113409471","display_name":"Kumoh National Institute of Technology","ror":"https://ror.org/05dkjfz60","country_code":"KR","type":"education","lineage":["https://openalex.org/I113409471"]},{"id":"https://openalex.org/I4210138427","display_name":"Computational Physics (United States)","ror":"https://ror.org/03grsxg62","country_code":"US","type":"company","lineage":["https://openalex.org/I4210138427"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Fauzan Syarif Nursyafi","raw_affiliation_strings":["Computational Medicine Lab, Department of Biomedical Engineering","Kumoh National Institute of Technology"],"raw_orcid":"https://orcid.org/0009-0001-5330-2008","affiliations":[{"raw_affiliation_string":"Computational Medicine Lab, Department of Biomedical Engineering","institution_ids":["https://openalex.org/I4210138427"]},{"raw_affiliation_string":"Kumoh National Institute of Technology","institution_ids":["https://openalex.org/I113409471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030911848","display_name":"Muhammad Adnan Pramudito","orcid":"https://orcid.org/0000-0001-5944-2784"},"institutions":[{"id":"https://openalex.org/I113409471","display_name":"Kumoh National Institute of Technology","ror":"https://ror.org/05dkjfz60","country_code":"KR","type":"education","lineage":["https://openalex.org/I113409471"]},{"id":"https://openalex.org/I4210147194","display_name":"Convergence","ror":"https://ror.org/03kcznq08","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210147194"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Muhammad Adnan Pramudito","raw_affiliation_strings":["Computational Medicine Lab, Department of IT Convergence Engineering","Kumoh National Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Medicine Lab, Department of IT Convergence Engineering","institution_ids":["https://openalex.org/I4210147194"]},{"raw_affiliation_string":"Kumoh National Institute of Technology","institution_ids":["https://openalex.org/I113409471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081424669","display_name":"Yunendah Nur Fuadah","orcid":"https://orcid.org/0000-0003-4285-4824"},"institutions":[{"id":"https://openalex.org/I862893732","display_name":"Telkom University","ror":"https://ror.org/0004wsx81","country_code":"ID","type":"education","lineage":["https://openalex.org/I862893732"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Yunendah Nur Fuadah","raw_affiliation_strings":["Telecommunication Engineering Study Program, School of Electrical Engineering, Telkom University, Jl. Telekomunikasi No. 1, Bandung 40257, West Java, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Telecommunication Engineering Study Program, School of Electrical Engineering, Telkom University, Jl. Telekomunikasi No. 1, Bandung 40257, West Java, Indonesia","institution_ids":["https://openalex.org/I862893732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117635120","display_name":"Rahmafatin Nurul Izza","orcid":"https://orcid.org/0009-0003-0842-027X"},"institutions":[{"id":"https://openalex.org/I113409471","display_name":"Kumoh National Institute of Technology","ror":"https://ror.org/05dkjfz60","country_code":"KR","type":"education","lineage":["https://openalex.org/I113409471"]},{"id":"https://openalex.org/I4210147194","display_name":"Convergence","ror":"https://ror.org/03kcznq08","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210147194"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Rahmafatin Nurul Izza","raw_affiliation_strings":["Computational Medicine Lab, Department of IT Convergence Engineering","Kumoh National Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Medicine Lab, Department of IT Convergence Engineering","institution_ids":["https://openalex.org/I4210147194"]},{"raw_affiliation_string":"Kumoh National Institute of Technology","institution_ids":["https://openalex.org/I113409471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052594069","display_name":"Abdul Latif Fauzan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210092022","display_name":"Heart Foundation","ror":"https://ror.org/00h4cdy24","country_code":"US","type":"other","lineage":["https://openalex.org/I4210092022"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdul Latif Fauzan","raw_affiliation_strings":["Meta Heart Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meta Heart Co., Ltd","institution_ids":["https://openalex.org/I4210092022"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090859517","display_name":"Ki Moo Lim","orcid":"https://orcid.org/0000-0001-6729-8129"},"institutions":[{"id":"https://openalex.org/I113409471","display_name":"Kumoh National Institute of Technology","ror":"https://ror.org/05dkjfz60","country_code":"KR","type":"education","lineage":["https://openalex.org/I113409471"]},{"id":"https://openalex.org/I4210092022","display_name":"Heart Foundation","ror":"https://ror.org/00h4cdy24","country_code":"US","type":"other","lineage":["https://openalex.org/I4210092022"]},{"id":"https://openalex.org/I4210138427","display_name":"Computational Physics (United States)","ror":"https://ror.org/03grsxg62","country_code":"US","type":"company","lineage":["https://openalex.org/I4210138427"]}],"countries":["KR","US"],"is_corresponding":true,"raw_author_name":"Ki Moo Lim","raw_affiliation_strings":["Computational Medicine Lab, Department of Biomedical Engineering","Kumoh National Institute of Technology","Meta Heart Co., Ltd"],"raw_orcid":"https://orcid.org/0000-0001-6729-8129","affiliations":[{"raw_affiliation_string":"Computational Medicine Lab, Department of Biomedical Engineering","institution_ids":["https://openalex.org/I4210138427"]},{"raw_affiliation_string":"Kumoh National Institute of Technology","institution_ids":["https://openalex.org/I113409471"]},{"raw_affiliation_string":"Meta Heart Co., Ltd","institution_ids":["https://openalex.org/I4210092022"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5090859517"],"corresponding_institution_ids":["https://openalex.org/I113409471","https://openalex.org/I4210092022","https://openalex.org/I4210138427"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.56506305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":"8","first_page":"4538","last_page":"4575"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8370000123977661,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8370000123977661,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantitative-structure\u2013activity-relationship","display_name":"Quantitative structure\u2013activity relationship","score":0.8353999853134155},{"id":"https://openalex.org/keywords/point","display_name":"Point (geometry)","score":0.4440000057220459},{"id":"https://openalex.org/keywords/toxicity","display_name":"Toxicity","score":0.26269999146461487}],"concepts":[{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.8353999853134155},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5443999767303467},{"id":"https://openalex.org/C28719098","wikidata":"https://www.wikidata.org/wiki/Q44946","display_name":"Point (geometry)","level":2,"score":0.4440000057220459},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.414000004529953},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.39719998836517334},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.32249999046325684},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.31790000200271606},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.26420000195503235},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.2393999993801117}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023381","descriptor_name":"Endpoint Determination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.6c00357","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.6c00357","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:41973763","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41973763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.53184974193573}],"awards":[{"id":"https://openalex.org/G1805933165","display_name":null,"funder_award_id":"RS-2025-04003017","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G5341561098","display_name":null,"funder_award_id":"IITP-2025-RS-2020-II201612","funder_id":"https://openalex.org/F4320335489","funder_display_name":"Institute for Information and Communications Technology Promotion"},{"id":"https://openalex.org/G7363998548","display_name":null,"funder_award_id":"2022R1A2C2006326","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320321408","display_name":"Ministry of Education","ror":"https://ror.org/01p262204"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"},{"id":"https://openalex.org/F4320335489","display_name":"Institute for Information and Communications Technology Promotion","ror":"https://ror.org/01g0hqq23"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":122,"referenced_works":["https://openalex.org/W859136062","https://openalex.org/W1605711358","https://openalex.org/W1966441763","https://openalex.org/W1972234779","https://openalex.org/W1983394040","https://openalex.org/W1987833374","https://openalex.org/W1992882958","https://openalex.org/W2024303294","https://openalex.org/W2033757486","https://openalex.org/W2043889582","https://openalex.org/W2052396986","https://openalex.org/W2054203041","https://openalex.org/W2066532920","https://openalex.org/W2072441101","https://openalex.org/W2081803746","https://openalex.org/W2092493635","https://openalex.org/W2098889731","https://openalex.org/W2103520945","https://openalex.org/W2116133514","https://openalex.org/W2123366876","https://openalex.org/W2130462726","https://openalex.org/W2137454940","https://openalex.org/W2166556144","https://openalex.org/W2171014100","https://openalex.org/W2174991771","https://openalex.org/W2193346814","https://openalex.org/W2234529989","https://openalex.org/W2266978829","https://openalex.org/W2292175535","https://openalex.org/W2309296013","https://openalex.org/W2322996205","https://openalex.org/W2328176404","https://openalex.org/W2350768440","https://openalex.org/W2512989884","https://openalex.org/W2580289839","https://openalex.org/W2586210924","https://openalex.org/W2622236128","https://openalex.org/W2787568625","https://openalex.org/W2806715130","https://openalex.org/W2884815923","https://openalex.org/W2894943857","https://openalex.org/W2900484719","https://openalex.org/W2913617401","https://openalex.org/W2920795827","https://openalex.org/W2941458018","https://openalex.org/W2976546053","https://openalex.org/W2984957779","https://openalex.org/W2999397809","https://openalex.org/W3015905681","https://openalex.org/W3023042104","https://openalex.org/W3024033076","https://openalex.org/W3027911235","https://openalex.org/W3029442503","https://openalex.org/W3035302862","https://openalex.org/W3037799391","https://openalex.org/W3082081167","https://openalex.org/W3112376181","https://openalex.org/W3112905768","https://openalex.org/W3120518060","https://openalex.org/W3124745894","https://openalex.org/W3128321809","https://openalex.org/W3136198265","https://openalex.org/W3146191650","https://openalex.org/W3156137178","https://openalex.org/W3158507782","https://openalex.org/W3162487006","https://openalex.org/W3174585465","https://openalex.org/W3184301790","https://openalex.org/W3193786816","https://openalex.org/W3195831412","https://openalex.org/W3210899060","https://openalex.org/W4210373151","https://openalex.org/W4223929971","https://openalex.org/W4224260803","https://openalex.org/W4226086528","https://openalex.org/W4281388588","https://openalex.org/W4283704882","https://openalex.org/W4310388409","https://openalex.org/W4310592636","https://openalex.org/W4310774636","https://openalex.org/W4312084649","https://openalex.org/W4312221564","https://openalex.org/W4317932333","https://openalex.org/W4319826836","https://openalex.org/W4321501969","https://openalex.org/W4365505282","https://openalex.org/W4380357668","https://openalex.org/W4382792820","https://openalex.org/W4383216745","https://openalex.org/W4385442674","https://openalex.org/W4386454031","https://openalex.org/W4387296925","https://openalex.org/W4389305457","https://openalex.org/W4390824746","https://openalex.org/W4393152099","https://openalex.org/W4396639527","https://openalex.org/W4398781103","https://openalex.org/W4399069537","https://openalex.org/W4399625937","https://openalex.org/W4400095271","https://openalex.org/W4402138994","https://openalex.org/W4402207134","https://openalex.org/W4402555999","https://openalex.org/W4402659192","https://openalex.org/W4402824108","https://openalex.org/W4404729752","https://openalex.org/W4405081424","https://openalex.org/W4405333811","https://openalex.org/W4406225564","https://openalex.org/W4406230016","https://openalex.org/W4407096622","https://openalex.org/W4408258572","https://openalex.org/W4409222028","https://openalex.org/W4409834100","https://openalex.org/W4410038804","https://openalex.org/W4411919377","https://openalex.org/W4412691851","https://openalex.org/W4413054652","https://openalex.org/W4413969675","https://openalex.org/W4415229870","https://openalex.org/W7118989054","https://openalex.org/W7138190426"],"related_works":[],"abstract_inverted_index":{"Computational":[0],"in":[1,54,179,240],"silico":[2],"methods":[3],"offer":[4],"a":[5,66,86,175,251],"powerful":[6],"alternative":[7],"to":[8,52,236],"animal-based":[9],"toxicity":[10,92,221,230],"testing,":[11],"which":[12,180],"remains":[13,190],"time-consuming,":[14],"expensive,":[15],"and":[16,22,50,81,112,118,122,127,136,149,167,193,202,216,226,234,242],"ethically":[17],"challenging.":[18],"In":[19],"practice,":[20],"QSAR":[21,80,117,189],"read-across":[23],"(RA)":[24],"are":[25],"among":[26],"the":[27,160,183],"most":[28],"widely":[29],"explored":[30],"approaches,":[31],"yet":[32],"both":[33],"suffer":[34],"from":[35],"important":[36],"limitations,":[37,61],"including":[38],"end":[39,93,143,147],"point-specific":[40],"modeling,":[41],"restricted":[42],"applicability":[43],"domains,":[44],"nonquantitative":[45],"or":[46,156,185],"subjective":[47],"analogue":[48],"selection,":[49],"sensitivity":[51],"biases":[53],"chemical":[55],"space":[56],"coverage.":[57],"To":[58],"address":[59],"these":[60],"this":[62],"study":[63],"introduces":[64],"ToxCML,":[65],"large-scale":[67,229],"hybrid":[68,161],"multifeature":[69],"consensus":[70,79,83,188,194],"quantitative":[71],"RA":[72,84,120],"Structure-Activity":[73],"Relationship":[74],"(mfCoQ-RASAR)":[75],"platform":[76,247],"that":[77,130,209],"unifies":[78],"similarity-based":[82],"into":[85],"weight-optimized":[87],"workflow":[88],"for":[89,223],"predicting":[90],"18":[91],"points":[94,148],"across":[95,142],"54,601":[96],"unique":[97],"chemicals.":[98],"The":[99,245],"framework":[100,211],"combines":[101],"multiple":[102],"molecular":[103],"representations":[104],"(MACCS,":[105],"Morgan,":[106],"atom":[107],"pair":[108],"fingerprints,":[109,111],"RDKit":[110],"physicochemical":[113],"descriptors)":[114],"with":[115,174],"machine-learning-based":[116],"k-NN":[119],"models":[121,163],"incorporates":[123],"tiered":[124],"applicability-domain":[125],"analysis":[126],"chemical-space":[128],"mapping":[129],"indicate":[131,208],"broadly":[132,217],"overlapping":[133],"training-test":[134],"distributions":[135],"in-domain":[137],"coverage":[138],"generally":[139],"exceeding":[140],"95%":[141],"points.":[144],"Across":[145],"all":[146],"evaluation":[150],"settings":[151],"involving":[152],"unseen":[153,224],"test":[154],"sets":[155],"external":[157],"validation":[158],"sets,":[159],"mfCoQ-RASAR":[162,181],"achieve":[164],"strong":[165],"discrimination":[166],"accuracy":[168],"(AUC":[169],"approximately":[170],"0.86-0.99;":[171],"BACC":[172],"0.73-0.98),":[173],"consistent":[176],"performance":[177],"hierarchy":[178],"provides":[182],"highest":[184],"near-highest":[186],"performance,":[187],"highly":[191],"competitive,":[192],"RA,":[195],"while":[196],"weaker,":[197],"still":[198],"offers":[199],"informative":[200],"predictive":[201],"analogue-based":[203],"discriminatory":[204],"capability.":[205],"These":[206],"results":[207],"our":[210],"delivers":[212],"reliable,":[213],"chemically":[214],"well-contextualized,":[215],"applicable":[218],"multiend":[219],"point":[220],"predictions":[222],"compounds":[225],"may":[227],"support":[228],"screening,":[231],"hazard":[232],"prioritization,":[233],"efforts":[235],"reduce":[237],"animal":[238],"testing":[239],"regulatory":[241],"industrial":[243],"settings.":[244],"ToxCML":[246],"is":[248],"accessible":[249],"through":[250],"public":[252],"web":[253],"server":[254],"available":[255],"at":[256],"http://cardiosim.metaheart.kr:8080/.":[257]},"counts_by_year":[],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2026-04-14T00:00:00"}
