{"id":"https://openalex.org/W7154904523","doi":"https://doi.org/10.1021/acs.jcim.6c00311","title":"DRHIN: An Integrated and Interactive Web Server for Drug Repositioning","display_name":"DRHIN: An Integrated and Interactive Web Server for Drug Repositioning","publication_year":2026,"publication_date":"2026-04-19","ids":{"openalex":"https://openalex.org/W7154904523","doi":"https://doi.org/10.1021/acs.jcim.6c00311","pmid":"https://pubmed.ncbi.nlm.nih.gov/42001407"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.6c00311","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.6c00311","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105097901","display_name":"Bowei Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210160211","display_name":"Pharmaceutical Biotechnology (Czechia)","ror":"https://ror.org/051tvr365","country_code":"CZ","type":"company","lineage":["https://openalex.org/I4210160211"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN","CZ"],"is_corresponding":false,"raw_author_name":"Bowei Zhao","raw_affiliation_strings":["College of Pharmaceutical Sciences","Zhejiang University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences","institution_ids":["https://openalex.org/I4210160211"]},{"raw_affiliation_string":"Zhejiang University","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134002626","display_name":"Dongxu Li","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongxu Li","raw_affiliation_strings":["Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210106108","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044370467","display_name":"Yanrong Yang","orcid":"https://orcid.org/0000-0002-2642-2207"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Yang","raw_affiliation_strings":["Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210106108","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134000905","display_name":"Tingjun Hou","orcid":"https://orcid.org/0000-0001-7227-2580"},"institutions":[{"id":"https://openalex.org/I4210119757","display_name":"Jinhua Academy of Agricultural Sciences","ror":"https://ror.org/02n6fv369","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210119757"]},{"id":"https://openalex.org/I4210123185","display_name":"Zhejiang Lab","ror":"https://ror.org/02m2h7991","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210123185"]},{"id":"https://openalex.org/I4210137452","display_name":"Drug Discovery Laboratory (Norway)","ror":"https://ror.org/04nybae35","country_code":"NO","type":"company","lineage":["https://openalex.org/I4210137452"]},{"id":"https://openalex.org/I4210160211","display_name":"Pharmaceutical Biotechnology (Czechia)","ror":"https://ror.org/051tvr365","country_code":"CZ","type":"company","lineage":["https://openalex.org/I4210160211"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN","CZ","NO"],"is_corresponding":true,"raw_author_name":"Tingjun Hou","raw_affiliation_strings":["College of Pharmaceutical Sciences","Jinhua Institute of Zhejiang University","Zhejiang Key Laboratory of Intelligent Drug Discovery and Development","Zhejiang University"],"raw_orcid":"https://orcid.org/0000-0001-7227-2580","affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences","institution_ids":["https://openalex.org/I4210160211"]},{"raw_affiliation_string":"Jinhua Institute of Zhejiang University","institution_ids":["https://openalex.org/I4210119757","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Intelligent Drug Discovery and Development","institution_ids":["https://openalex.org/I4210123185","https://openalex.org/I4210137452"]},{"raw_affiliation_string":"Zhejiang University","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008221100","display_name":"Lun Hu","orcid":"https://orcid.org/0000-0002-1591-8549"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lun Hu","raw_affiliation_strings":["Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences"],"raw_orcid":"https://orcid.org/0000-0002-1591-8549","affiliations":[{"raw_affiliation_string":"Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210106108","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5008221100","https://openalex.org/A5134000905"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108","https://openalex.org/I4210119757","https://openalex.org/I4210123185","https://openalex.org/I4210137452","https://openalex.org/I4210160211","https://openalex.org/I76130692"],"apc_list":null,"apc_paid":null,"fwci":10.2382,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.982222,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"66","issue":"9","first_page":"5008","last_page":"5017"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.5101000070571899,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.5101000070571899,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.38350000977516174,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.855400025844574},{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.7754999995231628},{"id":"https://openalex.org/keywords/safer","display_name":"SAFER","score":0.5687000155448914},{"id":"https://openalex.org/keywords/web-server","display_name":"Web server","score":0.5069000124931335},{"id":"https://openalex.org/keywords/web-application","display_name":"Web application","score":0.4810999929904938},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.4645000100135803},{"id":"https://openalex.org/keywords/server","display_name":"Server","score":0.41659998893737793}],"concepts":[{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.855400025844574},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.7754999995231628},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7502999901771545},{"id":"https://openalex.org/C2776654903","wikidata":"https://www.wikidata.org/wiki/Q2601463","display_name":"SAFER","level":2,"score":0.5687000155448914},{"id":"https://openalex.org/C11392498","wikidata":"https://www.wikidata.org/wiki/Q11288","display_name":"Web server","level":3,"score":0.5069000124931335},{"id":"https://openalex.org/C118643609","wikidata":"https://www.wikidata.org/wiki/Q189210","display_name":"Web application","level":2,"score":0.4810999929904938},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.4645000100135803},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.44690001010894775},{"id":"https://openalex.org/C93996380","wikidata":"https://www.wikidata.org/wiki/Q44127","display_name":"Server","level":2,"score":0.41659998893737793},{"id":"https://openalex.org/C110875604","wikidata":"https://www.wikidata.org/wiki/Q75","display_name":"The Internet","level":2,"score":0.40869998931884766},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.29010000824928284},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.2865999937057495},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.28189998865127563},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.28040000796318054},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.26460000872612},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.25220000743865967},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.25029999017715454}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.6c00311","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.6c00311","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:42001407","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42001407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1378212379","display_name":null,"funder_award_id":"xbzgzdsys-202114","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G6148233943","display_name":null,"funder_award_id":"2025M781524","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G6667929024","display_name":null,"funder_award_id":"2025C01117","funder_id":"https://openalex.org/F4320338110","funder_display_name":"Science and Technology Department of Zhejiang Province"},{"id":"https://openalex.org/G826153484","display_name":null,"funder_award_id":"62373348","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320338110","display_name":"Science and Technology Department of Zhejiang Province","ror":"https://ror.org/05yj3y977"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1537029917","https://openalex.org/W1737223868","https://openalex.org/W1888005072","https://openalex.org/W1982267716","https://openalex.org/W1991820743","https://openalex.org/W2052938279","https://openalex.org/W2066205394","https://openalex.org/W2090891622","https://openalex.org/W2106210472","https://openalex.org/W2127069089","https://openalex.org/W2142535891","https://openalex.org/W2154851992","https://openalex.org/W2224886296","https://openalex.org/W2322763599","https://openalex.org/W2336850185","https://openalex.org/W2393319904","https://openalex.org/W2537679995","https://openalex.org/W2743104969","https://openalex.org/W2747157901","https://openalex.org/W2767061187","https://openalex.org/W2767546566","https://openalex.org/W2767891136","https://openalex.org/W2768412315","https://openalex.org/W2800766678","https://openalex.org/W2884943532","https://openalex.org/W2895679848","https://openalex.org/W2898440040","https://openalex.org/W2899288360","https://openalex.org/W2899510892","https://openalex.org/W2900569176","https://openalex.org/W2950954328","https://openalex.org/W2962756421","https://openalex.org/W3000082418","https://openalex.org/W3012012790","https://openalex.org/W3045200674","https://openalex.org/W3048090444","https://openalex.org/W3093030756","https://openalex.org/W3093194543","https://openalex.org/W3136918052","https://openalex.org/W3167140978","https://openalex.org/W3192134500","https://openalex.org/W3195317458","https://openalex.org/W4200140951","https://openalex.org/W4211219865","https://openalex.org/W4246271082","https://openalex.org/W4285138922","https://openalex.org/W4286615456","https://openalex.org/W4327716444","https://openalex.org/W4368373587","https://openalex.org/W4388454971","https://openalex.org/W4390331481","https://openalex.org/W4391476441","https://openalex.org/W4393380917","https://openalex.org/W4399139514","https://openalex.org/W4400042185","https://openalex.org/W4406234938","https://openalex.org/W4410288329","https://openalex.org/W4411054984","https://openalex.org/W4411086054","https://openalex.org/W4411949398","https://openalex.org/W4412421508","https://openalex.org/W4412947635"],"related_works":[],"abstract_inverted_index":{"Drug":[0],"repositioning":[1],"(DR)":[2],"identifies":[3],"new":[4,123],"therapeutic":[5],"uses":[6],"for":[7,18,51,122,129],"approved":[8],"drugs,":[9],"reducing":[10],"development":[11],"burdens":[12],"and":[13,67,74,82,99,125,135],"offering":[14],"safer":[15],"treatment":[16],"options":[17],"patients.":[19],"While":[20],"high-throughput":[21],"technologies":[22],"generate":[23],"complex,":[24],"large-scale":[25],"multiomics":[26],"data,":[27,69],"existing":[28,120],"DR":[29,52],"tools":[30],"struggle":[31],"to":[32,78],"comprehensively":[33],"analyze":[34],"the":[35,84],"resulting":[36],"biological":[37,72],"networks.":[38],"To":[39],"address":[40],"this":[41],"challenge,":[42],"we":[43],"present":[44],"DRHIN,":[45],"an":[46],"integrated,":[47],"interactive":[48],"web":[49,152],"server":[50,153],"over":[53],"heterogeneous":[54,102],"information":[55],"networks":[56],"(HINs)":[57],"using":[58],"advanced":[59],"deep":[60],"learning":[61],"techniques.":[62],"DRHIN":[63,140],"integrates":[64],"transcriptomics,":[65],"proteomics,":[66],"microbiome":[68],"incorporating":[70],"eight":[71],"entities":[73],"19":[75,90],"association":[76],"types":[77],"build":[79],"diverse":[80],"HINs":[81],"elucidate":[83],"underlying":[85],"molecular":[86],"mechanisms.":[87],"It":[88],"includes":[89],"state-of-the-art":[91],"graph":[92],"representation":[93],"algorithms,":[94],"enabling":[95],"flexible":[96],"training,":[97],"comparison,":[98],"evaluation":[100],"of":[101],"network":[103],"data.":[104],"The":[105,151],"platform":[106],"provides":[107],"a":[108],"code-free":[109],"portal":[110],"supporting":[111],"three":[112],"key":[113],"predictive":[114],"tasks:":[115],"discovering":[116],"drug-disease":[117],"associations,":[118],"repurposing":[119],"drugs":[121],"indications,":[124],"identifying":[126],"potential":[127],"therapies":[128],"specific":[130],"diseases,":[131],"making":[132],"analyses":[133],"accessible":[134,156],"reproducible.":[136],"Leveraging":[137],"high-performance":[138],"computing,":[139],"efficiently":[141],"processes":[142],"million-scale":[143],"networks,":[144],"ensuring":[145],"practical":[146],"applicability":[147],"in":[148],"real-world":[149],"scenarios.":[150],"is":[154],"freely":[155],"at":[157],"http://drhin.tianshanzw.cn.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-05-12T06:07:45.972803","created_date":"2026-04-20T00:00:00"}
