{"id":"https://openalex.org/W2555527096","doi":"https://doi.org/10.1021/acs.jcim.6b00615","title":"A Novel Scaffold for Developing Specific or Broad-Spectrum Chitinase Inhibitors","display_name":"A Novel Scaffold for Developing Specific or Broad-Spectrum Chitinase Inhibitors","publication_year":2016,"publication_date":"2016-11-09","ids":{"openalex":"https://openalex.org/W2555527096","doi":"https://doi.org/10.1021/acs.jcim.6b00615","mag":"2555527096","pmid":"https://pubmed.ncbi.nlm.nih.gov/28024404"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.6b00615","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.6b00615","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048680094","display_name":"Xi Zhuo Jiang","orcid":"https://orcid.org/0000-0002-1317-964X"},"institutions":[{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]},{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xi Jiang","raw_affiliation_strings":["State Key Laboratory of Fine Chemicals and School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, China","State\rKey Laboratory of Fine Chemicals and School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Fine Chemicals and School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, China","institution_ids":["https://openalex.org/I4210092944"]},{"raw_affiliation_string":"State\rKey Laboratory of Fine Chemicals and School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100757382","display_name":"Ashutosh Kumar","orcid":"https://orcid.org/0000-0003-3754-8996"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashutosh Kumar","raw_affiliation_strings":["Structural Bioinformatics Team, Center for Life Science Technologies, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan","Structural\rBioinformatics Team, Center for Life Science Technologies, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Bioinformatics Team, Center for Life Science Technologies, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan","institution_ids":[]},{"raw_affiliation_string":"Structural\rBioinformatics Team, Center for Life Science Technologies, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100365643","display_name":"Tian Liu","orcid":"https://orcid.org/0000-0001-9768-5496"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]},{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian Liu","raw_affiliation_strings":["State Key Laboratory of Fine Chemicals and School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, China","State\rKey Laboratory of Fine Chemicals and School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Fine Chemicals and School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, China","institution_ids":["https://openalex.org/I4210092944"]},{"raw_affiliation_string":"State\rKey Laboratory of Fine Chemicals and School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044307373","display_name":"Kam Y. J. Zhang","orcid":"https://orcid.org/0000-0002-9282-8045"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kam Y. J. Zhang","raw_affiliation_strings":["Structural Bioinformatics Team, Center for Life Science Technologies, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan","Structural\rBioinformatics Team, Center for Life Science Technologies, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Bioinformatics Team, Center for Life Science Technologies, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan","institution_ids":[]},{"raw_affiliation_string":"Structural\rBioinformatics Team, Center for Life Science Technologies, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100417913","display_name":"Qing Yang","orcid":"https://orcid.org/0000-0002-4789-430X"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]},{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]},{"id":"https://openalex.org/I4210097978","display_name":"Institute of Plant Protection","ror":"https://ror.org/0111f7045","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210097978","https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Yang","raw_affiliation_strings":["Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China","State Key Laboratory of Fine Chemicals and School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, China","State\rKey Laboratory of Fine Chemicals and School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, China","Institute\rof Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China","institution_ids":["https://openalex.org/I4210138501","https://openalex.org/I4210097978"]},{"raw_affiliation_string":"State Key Laboratory of Fine Chemicals and School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, China","institution_ids":["https://openalex.org/I4210092944"]},{"raw_affiliation_string":"State\rKey Laboratory of Fine Chemicals and School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I27357992"]},{"raw_affiliation_string":"Institute\rof Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China","institution_ids":["https://openalex.org/I4210138501","https://openalex.org/I4210097978"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5048680094"],"corresponding_institution_ids":["https://openalex.org/I27357992","https://openalex.org/I4210092944"],"apc_list":null,"apc_paid":null,"fwci":1.2203,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.81082933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"56","issue":"12","first_page":"2413","last_page":"2420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12683","display_name":"Studies on Chitinases and Chitosanases","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12683","display_name":"Studies on Chitinases and Chitosanases","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12134","display_name":"Insect symbiosis and bacterial influences","score":0.9843000173568726,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chitinase","display_name":"Chitinase","score":0.8931381702423096},{"id":"https://openalex.org/keywords/ostrinia-furnacalis","display_name":"Ostrinia furnacalis","score":0.6489298939704895},{"id":"https://openalex.org/keywords/broad-spectrum","display_name":"Broad spectrum","score":0.5937928557395935},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5136967897415161},{"id":"https://openalex.org/keywords/structure\u2013activity-relationship","display_name":"Structure\u2013activity relationship","score":0.4940388798713684},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.4930534064769745},{"id":"https://openalex.org/keywords/pathogen","display_name":"Pathogen","score":0.4694254994392395},{"id":"https://openalex.org/keywords/scaffold","display_name":"Scaffold","score":0.4520806670188904},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.45168644189834595},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.44895613193511963},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.43821507692337036},{"id":"https://openalex.org/keywords/human-pathogen","display_name":"Human pathogen","score":0.42633068561553955},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.40804779529571533},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.3622724711894989},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.29177582263946533},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.2201213538646698},{"id":"https://openalex.org/keywords/botany","display_name":"Botany","score":0.18376636505126953},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.17825549840927124},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.10877582430839539},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10498523712158203}],"concepts":[{"id":"https://openalex.org/C2780778831","wikidata":"https://www.wikidata.org/wiki/Q424099","display_name":"Chitinase","level":3,"score":0.8931381702423096},{"id":"https://openalex.org/C2775862463","wikidata":"https://www.wikidata.org/wiki/Q13972012","display_name":"Ostrinia furnacalis","level":3,"score":0.6489298939704895},{"id":"https://openalex.org/C3020442560","wikidata":"https://www.wikidata.org/wiki/Q4971815","display_name":"Broad spectrum","level":2,"score":0.5937928557395935},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5136967897415161},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.4940388798713684},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.4930534064769745},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.4694254994392395},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.4520806670188904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45168644189834595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44895613193511963},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.43821507692337036},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.42633068561553955},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40804779529571533},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3622724711894989},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.29177582263946533},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2201213538646698},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.18376636505126953},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17825549840927124},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10877582430839539},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10498523712158203},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002688","descriptor_name":"Chitinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002688","descriptor_name":"Chitinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002688","descriptor_name":"Chitinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002688","descriptor_name":"Chitinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002688","descriptor_name":"Chitinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002688","descriptor_name":"Chitinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007306","descriptor_name":"Insecticides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007306","descriptor_name":"Insecticides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007306","descriptor_name":"Insecticides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007306","descriptor_name":"Insecticides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007306","descriptor_name":"Insecticides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007306","descriptor_name":"Insecticides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007915","descriptor_name":"Lepidoptera","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007915","descriptor_name":"Lepidoptera","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007915","descriptor_name":"Lepidoptera","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007915","descriptor_name":"Lepidoptera","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007915","descriptor_name":"Lepidoptera","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007915","descriptor_name":"Lepidoptera","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010571","descriptor_name":"Pest Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010571","descriptor_name":"Pest Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010571","descriptor_name":"Pest Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.6b00615","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.6b00615","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:28024404","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28024404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6399999856948853}],"awards":[{"id":"https://openalex.org/G8154649535","display_name":null,"funder_award_id":"31425021","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1863451475","https://openalex.org/W1935712031","https://openalex.org/W1963741247","https://openalex.org/W1973505638","https://openalex.org/W1985588649","https://openalex.org/W1990724722","https://openalex.org/W1996453536","https://openalex.org/W2001865803","https://openalex.org/W2002195128","https://openalex.org/W2005361432","https://openalex.org/W2005764528","https://openalex.org/W2009423060","https://openalex.org/W2009485252","https://openalex.org/W2015814027","https://openalex.org/W2025613912","https://openalex.org/W2026265322","https://openalex.org/W2027065525","https://openalex.org/W2027223782","https://openalex.org/W2027423337","https://openalex.org/W2027482274","https://openalex.org/W2028999265","https://openalex.org/W2029623603","https://openalex.org/W2033403750","https://openalex.org/W2034419650","https://openalex.org/W2039557932","https://openalex.org/W2041189078","https://openalex.org/W2045437473","https://openalex.org/W2056979046","https://openalex.org/W2059230675","https://openalex.org/W2059464558","https://openalex.org/W2068348723","https://openalex.org/W2072705074","https://openalex.org/W2078374001","https://openalex.org/W2087112671","https://openalex.org/W2090431249","https://openalex.org/W2095730990","https://openalex.org/W2096541451","https://openalex.org/W2096814446","https://openalex.org/W2101328961","https://openalex.org/W2102089668","https://openalex.org/W2102377211","https://openalex.org/W2109293107","https://openalex.org/W2117475344","https://openalex.org/W2121853844","https://openalex.org/W2138331971","https://openalex.org/W2142666553","https://openalex.org/W2144456776","https://openalex.org/W2146875307","https://openalex.org/W2147421370","https://openalex.org/W2155241373","https://openalex.org/W2157571256","https://openalex.org/W2160806937","https://openalex.org/W2174055317","https://openalex.org/W2176516200","https://openalex.org/W2239290355","https://openalex.org/W2308911018","https://openalex.org/W2440823401","https://openalex.org/W4237042517","https://openalex.org/W4255776389"],"related_works":["https://openalex.org/W1979706958","https://openalex.org/W2617924233","https://openalex.org/W2977806836","https://openalex.org/W2793265838","https://openalex.org/W2977965831","https://openalex.org/W2483355791","https://openalex.org/W2369083097","https://openalex.org/W4394473110","https://openalex.org/W2363901770","https://openalex.org/W3000293054"],"abstract_inverted_index":{"values,":[0],"and":[1,22,30],"one":[2],"compound":[3],"from":[4],"another":[5],"chemical":[6],"class":[7],"exhibited":[8],"a":[9,31,41],"broad":[10],"inhibitory":[11],"activity":[12,33],"not":[13],"only":[14],"toward":[15,19],"OfChtI":[16],"but":[17],"also":[18],"bacterial,":[20],"fungal,":[21],"human":[23],"chitinases.":[24],"A":[25],"new":[26],"scaffold":[27],"was":[28,35],"discovered,":[29],"structure-inhibitory":[32],"relationship":[34],"proposed.":[36],"This":[37],"work":[38],"may":[39],"provide":[40],"novel":[42],"starting":[43],"point":[44],"for":[45],"the":[46],"development":[47],"of":[48],"specific":[49],"or":[50],"broad-spectrum":[51],"chitinase":[52],"inhibitors.":[53]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2025-10-10T00:00:00"}