{"id":"https://openalex.org/W2558349359","doi":"https://doi.org/10.1021/acs.jcim.6b00499","title":"Hydrophobic Ligand Entry and Exit Pathways of the CB1 Cannabinoid Receptor","display_name":"Hydrophobic Ligand Entry and Exit Pathways of the CB1 Cannabinoid Receptor","publication_year":2016,"publication_date":"2016-11-28","ids":{"openalex":"https://openalex.org/W2558349359","doi":"https://doi.org/10.1021/acs.jcim.6b00499","mag":"2558349359","pmid":"https://pubmed.ncbi.nlm.nih.gov/27966915"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.6b00499","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.6b00499","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080257017","display_name":"Jakub Jakowiecki","orcid":"https://orcid.org/0000-0001-5882-1029"},"institutions":[{"id":"https://openalex.org/I4654613","display_name":"University of Warsaw","ror":"https://ror.org/039bjqg32","country_code":"PL","type":"education","lineage":["https://openalex.org/I4654613"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jakub Jakowiecki","raw_affiliation_strings":["Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland","Faculty of Chemistry, Biological\rand Chemical Research Centre, University of Warsaw, ul. Pasteura\r1, 02-093 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland","institution_ids":["https://openalex.org/I4654613"]},{"raw_affiliation_string":"Faculty of Chemistry, Biological\rand Chemical Research Centre, University of Warsaw, ul. Pasteura\r1, 02-093 Warsaw, Poland","institution_ids":["https://openalex.org/I4654613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001609547","display_name":"S\u0142awomir Filipek","orcid":"https://orcid.org/0000-0003-3147-3858"},"institutions":[{"id":"https://openalex.org/I4654613","display_name":"University of Warsaw","ror":"https://ror.org/039bjqg32","country_code":"PL","type":"education","lineage":["https://openalex.org/I4654613"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Slawomir Filipek","raw_affiliation_strings":["Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland","Faculty of Chemistry, Biological\rand Chemical Research Centre, University of Warsaw, ul. Pasteura\r1, 02-093 Warsaw, Poland"],"raw_orcid":"https://orcid.org/0000-0003-3147-3858","affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland","institution_ids":["https://openalex.org/I4654613"]},{"raw_affiliation_string":"Faculty of Chemistry, Biological\rand Chemical Research Centre, University of Warsaw, ul. Pasteura\r1, 02-093 Warsaw, Poland","institution_ids":["https://openalex.org/I4654613"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001609547"],"corresponding_institution_ids":["https://openalex.org/I4654613"],"apc_list":null,"apc_paid":null,"fwci":2.775,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.89977844,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"56","issue":"12","first_page":"2457","last_page":"2466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9876000285148621,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cannabinoid-receptor","display_name":"Cannabinoid receptor","score":0.7876520156860352},{"id":"https://openalex.org/keywords/cannabinoid","display_name":"Cannabinoid","score":0.6510979533195496},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6166644096374512},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.5567643642425537},{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"Endocannabinoid system","score":0.44930368661880493},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.39948925375938416},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.25055748224258423},{"id":"https://openalex.org/keywords/antagonist","display_name":"Antagonist","score":0.07361415028572083}],"concepts":[{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.7876520156860352},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.6510979533195496},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6166644096374512},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5567643642425537},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.44930368661880493},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39948925375938416},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25055748224258423},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.07361415028572083}],"mesh":[{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D053284","descriptor_name":"Polyunsaturated Alkamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053284","descriptor_name":"Polyunsaturated Alkamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053284","descriptor_name":"Polyunsaturated Alkamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053284","descriptor_name":"Polyunsaturated Alkamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053284","descriptor_name":"Polyunsaturated Alkamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053284","descriptor_name":"Polyunsaturated Alkamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063386","descriptor_name":"Cannabinoid Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D063386","descriptor_name":"Cannabinoid Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D063386","descriptor_name":"Cannabinoid Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D063386","descriptor_name":"Cannabinoid Receptor Agonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D063386","descriptor_name":"Cannabinoid Receptor Agonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D063386","descriptor_name":"Cannabinoid Receptor Agonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D063388","descriptor_name":"Endocannabinoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D063388","descriptor_name":"Endocannabinoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D063388","descriptor_name":"Endocannabinoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D063388","descriptor_name":"Endocannabinoids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D063388","descriptor_name":"Endocannabinoids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D063388","descriptor_name":"Endocannabinoids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.6b00499","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.6b00499","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:27966915","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27966915","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","score":0.800000011920929,"display_name":"Clean water and sanitation"}],"awards":[{"id":"https://openalex.org/G871745490","display_name":null,"funder_award_id":"2011/03/B/NZ1/03204","funder_id":"https://openalex.org/F4320322511","funder_display_name":"Narodowe Centrum Nauki"}],"funders":[{"id":"https://openalex.org/F4320322511","display_name":"Narodowe Centrum Nauki","ror":"https://ror.org/03ha2q922"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1833104430","https://openalex.org/W1945751328","https://openalex.org/W1963514652","https://openalex.org/W1995965248","https://openalex.org/W1997772366","https://openalex.org/W2011223793","https://openalex.org/W2021520922","https://openalex.org/W2027736570","https://openalex.org/W2027991357","https://openalex.org/W2029173743","https://openalex.org/W2039866083","https://openalex.org/W2044309821","https://openalex.org/W2048209357","https://openalex.org/W2057827308","https://openalex.org/W2069505357","https://openalex.org/W2080649553","https://openalex.org/W2086836468","https://openalex.org/W2101810621","https://openalex.org/W2109254532","https://openalex.org/W2112924959","https://openalex.org/W2117003397","https://openalex.org/W2132262459","https://openalex.org/W2136160086","https://openalex.org/W2142409978","https://openalex.org/W2151029137","https://openalex.org/W2157965341","https://openalex.org/W2206954826","https://openalex.org/W2233758214","https://openalex.org/W2261451494","https://openalex.org/W2399856928","https://openalex.org/W2407957288","https://openalex.org/W4211156111"],"related_works":["https://openalex.org/W4380301998","https://openalex.org/W2201563430","https://openalex.org/W2083859343","https://openalex.org/W2417206429","https://openalex.org/W1996653993","https://openalex.org/W2044311961","https://openalex.org/W2204960186","https://openalex.org/W1990722385","https://openalex.org/W2060238106","https://openalex.org/W2061104962"],"abstract_inverted_index":{"It":[0],"has":[1],"been":[2],"reported":[3],"that":[4,180],"some":[5],"hydrophobic":[6],"ligands":[7],"of":[8,46,67,176],"G-protein-coupled":[9],"receptors":[10],"access":[11],"the":[12,17,28,35,56,87,115,122,127,139,145,157],"receptor\u2019s":[13,57,117],"binding":[14,58,118,170,192],"site":[15,59,119,171],"from":[16,21,55],"membrane":[18],"rather":[19],"than":[20],"bulk":[22,88],"water.":[23,89],"In":[24],"order":[25],"to":[26],"identify":[27],"most":[29],"probable":[30],"ligand":[31,68,154,158,191],"entrance":[32],"pathway":[33,124],"into":[34],"CB1":[36,48,116,190],"receptor,":[37],"we":[38,165],"performed":[39,103],"several":[40],"steered":[41],"molecular":[42,105],"dynamics":[43,106],"(SMD)":[44],"simulations":[45,108],"two":[47],"agonists,":[49],"THC":[50,113],"and":[51,75,79,83,85,99,112,120,134,184],"anandamide,":[52],"pulling":[53,69,96,128],"them":[54],"with":[60,153,196],"constant":[61],"velocity.":[62],"The":[63,90,130,174],"four":[64],"main":[65],"directions":[66],"were":[70,93],"probed:":[71],"between":[72,77,81,97],"helices":[73],"TM4":[74],"TM5,":[76],"TM5":[78],"TM6,":[80],"TM7":[82,98],"TM1/TM2,":[84],"toward":[86],"smallest":[91],"forces":[92],"measured":[94],"during":[95],"TM1/TM2.":[100],"We":[101],"also":[102,166],"supervised":[104],"(SuMD)":[107],"for":[109,161,172,189],"both":[110],"anandamide":[111],"entering":[114],"found":[121,167],"same":[123],"as":[125],"in":[126,144,194],"simulations.":[129],"residues":[131,181],"F174":[132,182],"2.61":[133,183],"F177":[135,185],"2.64":[136,186],"(both":[137],"on":[138],"TM2":[140],"helix)":[141],"are":[142,187,193],"involved":[143],"gating":[146],"mechanism":[147],"and,":[148],"by":[149],"forming":[150],"\u03c0\u2013\u03c0":[151],"interactions":[152],"molecules,":[155],"facilitated":[156],"orientation":[159],"required":[160],"passage.":[162],"Using":[163],"SuMD":[164],"an":[168],"alternative":[169],"THC.":[173],"results":[175],"mutagenesis":[177],"studies":[178],"evidencing":[179],"important":[188],"agreement":[195],"our":[197],"observations.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}
