{"id":"https://openalex.org/W2536177133","doi":"https://doi.org/10.1021/acs.jcim.6b00232","title":"A Multiscale Study on the Penetration Enhancement Mechanism of Menthol to Osthole","display_name":"A Multiscale Study on the Penetration Enhancement Mechanism of Menthol to Osthole","publication_year":2016,"publication_date":"2016-10-21","ids":{"openalex":"https://openalex.org/W2536177133","doi":"https://doi.org/10.1021/acs.jcim.6b00232","mag":"2536177133","pmid":"https://pubmed.ncbi.nlm.nih.gov/27768312"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.6b00232","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.6b00232","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108620567","display_name":"Shufang Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I2799435774","display_name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","ror":"https://ror.org/003cpqh10","country_code":"CN","type":"government","lineage":["https://openalex.org/I271893122","https://openalex.org/I2799435774","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shufang Yang","raw_affiliation_strings":["Beijing University of Chinese Medicine, Beijing 100102, China","Key Laboratory\rof TCM-information Engineer of State Administration of TCM, Beijing 100102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine, Beijing 100102, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"Key Laboratory\rof TCM-information Engineer of State Administration of TCM, Beijing 100102, China","institution_ids":["https://openalex.org/I2799435774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100447535","display_name":"Ran Wang","orcid":"https://orcid.org/0009-0007-4834-7248"},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ran Wang","raw_affiliation_strings":["School\rof Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School\rof Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110507573","display_name":"Guang Wan","orcid":null},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guang Wan","raw_affiliation_strings":["Beijing University of Chinese Medicine, Beijing 100102, China","School\rof Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine, Beijing 100102, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"School\rof Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086084034","display_name":"Zhimin Wu","orcid":"https://orcid.org/0000-0001-9965-7472"},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I2799435774","display_name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","ror":"https://ror.org/003cpqh10","country_code":"CN","type":"government","lineage":["https://openalex.org/I271893122","https://openalex.org/I2799435774","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhimin Wu","raw_affiliation_strings":["Beijing University of Chinese Medicine, Beijing 100102, China","Key Laboratory\rof TCM-information Engineer of State Administration of TCM, Beijing 100102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine, Beijing 100102, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"Key Laboratory\rof TCM-information Engineer of State Administration of TCM, Beijing 100102, China","institution_ids":["https://openalex.org/I2799435774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037122921","display_name":"Shujuan Guo","orcid":"https://orcid.org/0000-0002-8572-0933"},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shujuan Guo","raw_affiliation_strings":["Beijing University of Chinese Medicine, Beijing 100102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine, Beijing 100102, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081712002","display_name":"Xingxing Dai","orcid":"https://orcid.org/0000-0003-0342-3255"},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I2799435774","display_name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","ror":"https://ror.org/003cpqh10","country_code":"CN","type":"government","lineage":["https://openalex.org/I271893122","https://openalex.org/I2799435774","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingxing Dai","raw_affiliation_strings":["Beijing University of Chinese Medicine, Beijing 100102, China","Key Laboratory\rof TCM-information Engineer of State Administration of TCM, Beijing 100102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine, Beijing 100102, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"Key Laboratory\rof TCM-information Engineer of State Administration of TCM, Beijing 100102, China","institution_ids":["https://openalex.org/I2799435774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108053050","display_name":"Xinyuan Shi","orcid":"https://orcid.org/0000-0001-9048-3744"},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I2799435774","display_name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","ror":"https://ror.org/003cpqh10","country_code":"CN","type":"government","lineage":["https://openalex.org/I271893122","https://openalex.org/I2799435774","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinyuan Shi","raw_affiliation_strings":["Beijing University of Chinese Medicine, Beijing 100102, China","Key Laboratory\rof TCM-information Engineer of State Administration of TCM, Beijing 100102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine, Beijing 100102, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"Key Laboratory\rof TCM-information Engineer of State Administration of TCM, Beijing 100102, China","institution_ids":["https://openalex.org/I2799435774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111419769","display_name":"Yanjiang Qiao","orcid":"https://orcid.org/0009-0006-8319-2846"},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I2799435774","display_name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","ror":"https://ror.org/003cpqh10","country_code":"CN","type":"government","lineage":["https://openalex.org/I271893122","https://openalex.org/I2799435774","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanjiang Qiao","raw_affiliation_strings":["Beijing University of Chinese Medicine, Beijing 100102, China","Key Laboratory\rof TCM-information Engineer of State Administration of TCM, Beijing 100102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine, Beijing 100102, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"Key Laboratory\rof TCM-information Engineer of State Administration of TCM, Beijing 100102, China","institution_ids":["https://openalex.org/I2799435774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5108053050","https://openalex.org/A5111419769"],"corresponding_institution_ids":["https://openalex.org/I17747738","https://openalex.org/I2799435774"],"apc_list":null,"apc_paid":null,"fwci":0.6899,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.69694073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"56","issue":"11","first_page":"2234","last_page":"2242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/menthol","display_name":"Menthol","score":0.952445387840271},{"id":"https://openalex.org/keywords/penetration","display_name":"Penetration (warfare)","score":0.8936125040054321},{"id":"https://openalex.org/keywords/stratum-corneum","display_name":"Stratum corneum","score":0.7400861382484436},{"id":"https://openalex.org/keywords/bilayer","display_name":"Bilayer","score":0.5787927508354187},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5680444836616516},{"id":"https://openalex.org/keywords/micelle","display_name":"Micelle","score":0.4539186954498291},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4421415328979492},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3378618359565735},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.16197457909584045},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.13584718108177185},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.12555426359176636},{"id":"https://openalex.org/keywords/aqueous-solution","display_name":"Aqueous solution","score":0.09936237335205078}],"concepts":[{"id":"https://openalex.org/C2780194911","wikidata":"https://www.wikidata.org/wiki/Q407418","display_name":"Menthol","level":2,"score":0.952445387840271},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.8936125040054321},{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.7400861382484436},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.5787927508354187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5680444836616516},{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.4539186954498291},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4421415328979492},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3378618359565735},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.16197457909584045},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13584718108177185},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.12555426359176636},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.09936237335205078},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008610","descriptor_name":"Menthol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008610","descriptor_name":"Menthol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008610","descriptor_name":"Menthol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008610","descriptor_name":"Menthol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008610","descriptor_name":"Menthol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008610","descriptor_name":"Menthol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.6b00232","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.6b00232","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:27768312","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27768312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2084084214","display_name":null,"funder_award_id":"NCET-12-0803","funder_id":"https://openalex.org/F4320334924","funder_display_name":"Program for New Century Excellent Talents in University"},{"id":"https://openalex.org/G4107799260","display_name":null,"funder_award_id":"81473364","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334924","display_name":"Program for New Century Excellent Talents in University","ror":"https://ror.org/01mv9t934"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W605902771","https://openalex.org/W1643997545","https://openalex.org/W1806547840","https://openalex.org/W1972705654","https://openalex.org/W1974924012","https://openalex.org/W1980502113","https://openalex.org/W1993177346","https://openalex.org/W1999231173","https://openalex.org/W2003949305","https://openalex.org/W2005839003","https://openalex.org/W2009716048","https://openalex.org/W2019226992","https://openalex.org/W2026709799","https://openalex.org/W2028089650","https://openalex.org/W2029667189","https://openalex.org/W2033921570","https://openalex.org/W2051864856","https://openalex.org/W2053917544","https://openalex.org/W2057820363","https://openalex.org/W2060933570","https://openalex.org/W2068517215","https://openalex.org/W2072321032","https://openalex.org/W2079235499","https://openalex.org/W2081724315","https://openalex.org/W2082907536","https://openalex.org/W2093656664","https://openalex.org/W2105539783","https://openalex.org/W2108563621","https://openalex.org/W2112154906","https://openalex.org/W2119267663","https://openalex.org/W2119806687","https://openalex.org/W2124313980","https://openalex.org/W2131527384","https://openalex.org/W2141231437","https://openalex.org/W2141273392","https://openalex.org/W2149761516","https://openalex.org/W2152798374","https://openalex.org/W2153003531","https://openalex.org/W2171268876","https://openalex.org/W2172187417","https://openalex.org/W2312796845","https://openalex.org/W2314292783","https://openalex.org/W2329635064","https://openalex.org/W2410756938","https://openalex.org/W2494097376","https://openalex.org/W4239563848","https://openalex.org/W4240821889"],"related_works":["https://openalex.org/W2058912175","https://openalex.org/W2035411151","https://openalex.org/W4224107324","https://openalex.org/W2122601246","https://openalex.org/W2160352060","https://openalex.org/W2320494373","https://openalex.org/W4387074795","https://openalex.org/W2000450503","https://openalex.org/W2002191209","https://openalex.org/W2536177133"],"abstract_inverted_index":{"Menthol":[0],"is":[1,31,47,66,174],"a":[2,50,88,127,137,149,164,217],"widely":[3],"used":[4],"penetration":[5,22,41,59,119,169,218],"enhancer":[6],"in":[7,34,57,78,90,98,139,143,186,192,200],"clinical":[8],"medicine":[9],"due":[10,73],"to":[11,68,74,134,162],"its":[12,75],"high":[13,150,201],"efficiency":[14],"and":[15,61,81,111,117,141,159,189,212],"relative":[16],"safety.":[17],"However,":[18],"details":[19],"of":[20,25,45,107,157,172,180,195,214],"the":[21,28,35,40,70,91,104,118,132,144,154,178,181,193,198],"enhancement":[23,42,170],"mechanism":[24,44,171],"menthol":[26,46,86,97,130,152,173,215],"on":[27],"molecular":[29,54],"level":[30],"rarely":[32],"involved":[33],"discussion.":[36],"In":[37],"this":[38],"work,":[39],"(PE)":[43],"explored":[48],"by":[49,177],"multiscale":[51],"method":[52],"containing":[53],"dynamics":[55],"simulations,":[56],"vitro":[58],"experiments,":[60],"transmission":[62],"electron":[63],"microscopy.":[64],"Osthole":[65],"chosen":[67],"be":[69],"tested":[71],"drug":[72],"common":[76],"use":[77],"external":[79],"preparations":[80],"because":[82],"it":[83],"often":[84],"accompanies":[85],"as":[87,216],"PE":[89],"preparations.":[92],"The":[93,168,203],"results":[94,204],"show":[95],"that":[96],"each":[99],"testing":[100],"concentration":[101],"can":[102,205],"impair":[103],"lipid":[105,145,185],"packing":[106],"stratum":[108],"corneum":[109],"(SC)":[110],"promote":[112],"osthole":[113],"permeating":[114],"into":[115,197],"SC,":[116],"promoting":[120],"effect":[121],"has":[122],"an":[123,190],"optimal":[124],"concentration.":[125],"At":[126,148],"low":[128,187],"concentration,":[129,151],"causes":[131,160],"bilayer":[133,155],"relax":[135],"with":[136],"reduction":[138],"thickness":[140],"increment":[142],"headgroup":[146],"area.":[147],"destroys":[153],"structure":[156],"SC":[158,184,199],"lipids":[161],"form":[163],"reversed":[165],"micelle":[166],"structure.":[167],"characterized":[175],"mainly":[176],"disruption":[179],"highly":[182],"ordered":[183],"concentrations":[188],"improvement":[191],"partitioning":[194],"drugs":[196],"concentrations.":[202],"provide":[206],"some":[207],"assistance":[208],"for":[209],"additional":[210],"studies":[211],"applications":[213],"enhancer.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}
