{"id":"https://openalex.org/W4417122478","doi":"https://doi.org/10.1021/acs.jcim.5c02196","title":"AcidProNet: Acidophilic Protein Classification via DCGAN-GP-Based Data Augmentation and Parameter-Shared Mixture-of-Experts Transformer","display_name":"AcidProNet: Acidophilic Protein Classification via DCGAN-GP-Based Data Augmentation and Parameter-Shared Mixture-of-Experts Transformer","publication_year":2025,"publication_date":"2025-12-08","ids":{"openalex":"https://openalex.org/W4417122478","doi":"https://doi.org/10.1021/acs.jcim.5c02196","pmid":"https://pubmed.ncbi.nlm.nih.gov/41359016"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c02196","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c02196","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049356885","display_name":"Jiaxing Song","orcid":"https://orcid.org/0000-0002-1945-2360"},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxing Song","raw_affiliation_strings":["Hainan University","School of Cyberspace Security","School of Cyberspace Security, Hainan University, Haikou 570228, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan University","institution_ids":["https://openalex.org/I20942203"]},{"raw_affiliation_string":"School of Cyberspace Security","institution_ids":[]},{"raw_affiliation_string":"School of Cyberspace Security, Hainan University, Haikou 570228, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114270411","display_name":"Aoyun Geng","orcid":"https://orcid.org/0009-0004-9716-9415"},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]},{"id":"https://openalex.org/I4390039265","display_name":"PRG S&Tech (South Korea)","ror":"https://ror.org/02sr2ee22","country_code":null,"type":"company","lineage":["https://openalex.org/I4390039265"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aoyun Geng","raw_affiliation_strings":["Hainan University","School of Computer Science and Technology"],"raw_orcid":"https://orcid.org/0009-0004-9716-9415","affiliations":[{"raw_affiliation_string":"Hainan University","institution_ids":["https://openalex.org/I20942203"]},{"raw_affiliation_string":"School of Computer Science and Technology","institution_ids":["https://openalex.org/I4390039265"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qianmao Wen","orcid":null},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]},{"id":"https://openalex.org/I4390039265","display_name":"PRG S&Tech (South Korea)","ror":"https://ror.org/02sr2ee22","country_code":null,"type":"company","lineage":["https://openalex.org/I4390039265"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianmao Wen","raw_affiliation_strings":["Hainan University","School of Computer Science and Technology","School of Computer Science and Technology, Hainan University, Haikou 570228, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan University","institution_ids":["https://openalex.org/I20942203"]},{"raw_affiliation_string":"School of Computer Science and Technology","institution_ids":["https://openalex.org/I4390039265"]},{"raw_affiliation_string":"School of Computer Science and Technology, Hainan University, Haikou 570228, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Junlin Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I196699116","display_name":"Wuhan University of Technology","ror":"https://ror.org/03fe7t173","country_code":"CN","type":"education","lineage":["https://openalex.org/I196699116"]},{"id":"https://openalex.org/I4210136741","display_name":"Wuhan Applied Science and Technology School","ror":"https://ror.org/03pentr35","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210136741"]},{"id":"https://openalex.org/I4390039265","display_name":"PRG S&Tech (South Korea)","ror":"https://ror.org/02sr2ee22","country_code":null,"type":"company","lineage":["https://openalex.org/I4390039265"]},{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junlin Xu","raw_affiliation_strings":["School of Computer Science and Technology","Wuhan University of Science and Technology","School of Computer Science and Technology, Wuhan University of Science and Technology, Wuhan 430081 Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology","institution_ids":["https://openalex.org/I4390039265"]},{"raw_affiliation_string":"Wuhan University of Science and Technology","institution_ids":["https://openalex.org/I43922553"]},{"raw_affiliation_string":"School of Computer Science and Technology, Wuhan University of Science and Technology, Wuhan 430081 Hubei, China","institution_ids":["https://openalex.org/I196699116","https://openalex.org/I4210136741","https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006543131","display_name":"Yajie Meng","orcid":"https://orcid.org/0000-0002-2384-1158"},"institutions":[{"id":"https://openalex.org/I4210119942","display_name":"Wuhan Textile University","ror":"https://ror.org/02jgsf398","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210119942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yajie Meng","raw_affiliation_strings":["School of Computer Science and Artificial Intelligence","Wuhan Textile University","School of Computer Science and Artificial Intelligence, Wuhan Textile University, Wuhan 430200 Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Artificial Intelligence","institution_ids":[]},{"raw_affiliation_string":"Wuhan Textile University","institution_ids":["https://openalex.org/I4210119942"]},{"raw_affiliation_string":"School of Computer Science and Artificial Intelligence, Wuhan Textile University, Wuhan 430200 Hubei, China","institution_ids":["https://openalex.org/I4210119942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061028143","display_name":"Feifei Cui","orcid":"https://orcid.org/0000-0001-7055-3813"},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]},{"id":"https://openalex.org/I4390039265","display_name":"PRG S&Tech (South Korea)","ror":"https://ror.org/02sr2ee22","country_code":null,"type":"company","lineage":["https://openalex.org/I4390039265"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feifei Cui","raw_affiliation_strings":["Hainan University","School of Computer Science and Technology"],"raw_orcid":"https://orcid.org/0000-0001-7055-3813","affiliations":[{"raw_affiliation_string":"Hainan University","institution_ids":["https://openalex.org/I20942203"]},{"raw_affiliation_string":"School of Computer Science and Technology","institution_ids":["https://openalex.org/I4390039265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017426085","display_name":"Quan Zou","orcid":"https://orcid.org/0000-0001-6406-1142"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quan Zou","raw_affiliation_strings":["Institute of Fundamental and Frontier Sciences","University of Electronic Science and Technology of China","Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu 610054, China"],"raw_orcid":"https://orcid.org/0000-0001-6406-1142","affiliations":[{"raw_affiliation_string":"Institute of Fundamental and Frontier Sciences","institution_ids":[]},{"raw_affiliation_string":"University of Electronic Science and Technology of China","institution_ids":["https://openalex.org/I150229711"]},{"raw_affiliation_string":"Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu 610054, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086521244","display_name":"Leyi Wei","orcid":null},"institutions":[{"id":"https://openalex.org/I4210121405","display_name":"Centre for Artificial Intelligence and Robotics","ror":"https://ror.org/01xnbq218","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I4210121405","https://openalex.org/I4210150591"]},{"id":"https://openalex.org/I4210164862","display_name":"Artificial Intelligence in Medicine (Canada)","ror":"https://ror.org/05p590m36","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210164862"]},{"id":"https://openalex.org/I49835588","display_name":"Macao Polytechnic University","ror":"https://ror.org/02sf5td35","country_code":"MO","type":"education","lineage":["https://openalex.org/I49835588"]}],"countries":["CA","IN","MO"],"is_corresponding":false,"raw_author_name":"Leyi Wei","raw_affiliation_strings":["Centre for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Science","Macao Polytechnic University","Centre for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Science, Macao Polytechnic University, Macao SAR 999078, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Science","institution_ids":["https://openalex.org/I4210121405","https://openalex.org/I4210164862"]},{"raw_affiliation_string":"Macao Polytechnic University","institution_ids":["https://openalex.org/I49835588"]},{"raw_affiliation_string":"Centre for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Science, Macao Polytechnic University, Macao SAR 999078, China","institution_ids":["https://openalex.org/I49835588"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100353028","display_name":"Zilong Zhang","orcid":"https://orcid.org/0000-0002-4934-1258"},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]},{"id":"https://openalex.org/I4390039265","display_name":"PRG S&Tech (South Korea)","ror":"https://ror.org/02sr2ee22","country_code":null,"type":"company","lineage":["https://openalex.org/I4390039265"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zilong Zhang","raw_affiliation_strings":["Hainan University","School of Computer Science and Technology"],"raw_orcid":"https://orcid.org/0000-0002-4934-1258","affiliations":[{"raw_affiliation_string":"Hainan University","institution_ids":["https://openalex.org/I20942203"]},{"raw_affiliation_string":"School of Computer Science and Technology","institution_ids":["https://openalex.org/I4390039265"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5100353028"],"corresponding_institution_ids":["https://openalex.org/I20942203","https://openalex.org/I4390039265"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23951842,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":"24","first_page":"13145","last_page":"13162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9373999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9373999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.6069999933242798},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5081999897956848},{"id":"https://openalex.org/keywords/embedding","display_name":"Embedding","score":0.42640000581741333},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.4185999929904938},{"id":"https://openalex.org/keywords/transformer","display_name":"Transformer","score":0.41760000586509705},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.4092000126838684},{"id":"https://openalex.org/keywords/generative-grammar","display_name":"Generative grammar","score":0.37209999561309814},{"id":"https://openalex.org/keywords/exploit","display_name":"Exploit","score":0.37040001153945923}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.757099986076355},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.6069999933242798},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5163000226020813},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5081999897956848},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.47119998931884766},{"id":"https://openalex.org/C41608201","wikidata":"https://www.wikidata.org/wiki/Q980509","display_name":"Embedding","level":2,"score":0.42640000581741333},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.4185999929904938},{"id":"https://openalex.org/C66322947","wikidata":"https://www.wikidata.org/wiki/Q11658","display_name":"Transformer","level":3,"score":0.41760000586509705},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.4092000126838684},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.39989998936653137},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.37209999561309814},{"id":"https://openalex.org/C165696696","wikidata":"https://www.wikidata.org/wiki/Q11287","display_name":"Exploit","level":2,"score":0.37040001153945923},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.3495999872684479},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.34380000829696655},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.3084999918937683},{"id":"https://openalex.org/C51632099","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Training set","level":2,"score":0.3082999885082245},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.28519999980926514},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.2750000059604645},{"id":"https://openalex.org/C138958017","wikidata":"https://www.wikidata.org/wiki/Q190087","display_name":"Data type","level":2,"score":0.27459999918937683},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.26409998536109924},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.2630000114440918},{"id":"https://openalex.org/C69131567","wikidata":"https://www.wikidata.org/wiki/Q2068215","display_name":"Structural bioinformatics","level":3,"score":0.2531999945640564}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5c02196","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c02196","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:41359016","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41359016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1107098284","display_name":null,"funder_award_id":"ZDYF2024GXJS018","funder_id":"https://openalex.org/F4320324882","funder_display_name":"Hainan Provincial Department of Science and Technology"},{"id":"https://openalex.org/G1508426471","display_name":null,"funder_award_id":"0177/2023/RIA3","funder_id":"https://openalex.org/F4320323893","funder_display_name":"Fundo para o Desenvolvimento das Ci\u00eancias e da Tecnologia"},{"id":"https://openalex.org/G680931766","display_name":"\u57fa\u4e8e\u56fe\u795e\u7ecf\u7f51\u7edc\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u7b97\u6cd5\u7814\u53d1","funder_award_id":"324MS009","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"},{"id":"https://openalex.org/G771689064","display_name":null,"funder_award_id":"62450002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322866","display_name":"Natural Science Foundation of Hainan Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323893","display_name":"Fundo para o Desenvolvimento das Ci\u00eancias e da Tecnologia","ror":"https://ror.org/05vna4324"},{"id":"https://openalex.org/F4320324882","display_name":"Hainan Provincial Department of Science and Technology","ror":"https://ror.org/03rbw2w25"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W28412257","https://openalex.org/W1019830208","https://openalex.org/W1689711448","https://openalex.org/W1746104634","https://openalex.org/W1964168965","https://openalex.org/W1984907844","https://openalex.org/W1990727274","https://openalex.org/W1990932448","https://openalex.org/W2007765030","https://openalex.org/W2013971322","https://openalex.org/W2056108729","https://openalex.org/W2092216914","https://openalex.org/W2095172074","https://openalex.org/W2127132269","https://openalex.org/W2131281388","https://openalex.org/W2167917621","https://openalex.org/W2255466643","https://openalex.org/W2433743436","https://openalex.org/W2465248746","https://openalex.org/W2789758093","https://openalex.org/W2911964244","https://openalex.org/W2947612926","https://openalex.org/W2962793481","https://openalex.org/W2980298350","https://openalex.org/W3096831136","https://openalex.org/W3129230823","https://openalex.org/W3146944767","https://openalex.org/W3166142427","https://openalex.org/W4210452324","https://openalex.org/W4212965593","https://openalex.org/W4220793071","https://openalex.org/W4223655642","https://openalex.org/W4239510810","https://openalex.org/W4239678514","https://openalex.org/W4248018214","https://openalex.org/W4281921162","https://openalex.org/W4297001082","https://openalex.org/W4313544644","https://openalex.org/W4327550249","https://openalex.org/W4366089579","https://openalex.org/W4380079808","https://openalex.org/W4390582426","https://openalex.org/W4391102671","https://openalex.org/W4391483046","https://openalex.org/W4396773505","https://openalex.org/W4399153512","https://openalex.org/W4401046611","https://openalex.org/W4401335077","https://openalex.org/W4402671950","https://openalex.org/W4403409634","https://openalex.org/W4403782367","https://openalex.org/W4405355275","https://openalex.org/W4405917369","https://openalex.org/W4407493144","https://openalex.org/W4407740651","https://openalex.org/W4408079601","https://openalex.org/W4408145717","https://openalex.org/W4408977743","https://openalex.org/W4409369504","https://openalex.org/W4411865423","https://openalex.org/W4414163797"],"related_works":[],"abstract_inverted_index":{"With":[0],"the":[1,41,129,172],"continued":[2],"exploration":[3],"of":[4,44,131,218],"biological":[5,27],"resources":[6],"in":[7,85,163,204],"extreme":[8],"environments,":[9],"functional":[10,194],"proteins":[11,15,21,46],"such":[12],"as":[13],"acidophilic":[14,45,86,219],"have":[16,210],"attracted":[17],"increasing":[18],"attention.":[19],"These":[20],"can":[22,222],"maintain":[23],"structural":[24],"stability":[25,165],"and":[26,52,74,115,128,157,166,180,190,197],"functionality":[28],"under":[29],"highly":[30],"acidic":[31],"conditions":[32],"(pH":[33],"<":[34],"3),":[35],"demonstrating":[36],"significant":[37],"application":[38],"potential.":[39],"However,":[40],"current":[42],"identification":[43,217],"still":[47],"relies":[48],"on":[49],"labor-intensive,":[50],"time-consuming,":[51],"costly":[53],"wet-lab":[54],"experiments.":[55],"Existing":[56],"shallow":[57,75],"machine":[58],"learning":[59],"methods":[60],"(e.g.,":[61],"SVM,":[62],"RF)":[63],"are":[64],"limited":[65],"by":[66,71],"their":[67,78],"constrained":[68],"model":[69,164],"capacity\u2500characterized":[70],"fewer":[72],"parameters":[73],"architectures\u2500which":[76],"restricts":[77],"ability":[79],"to":[80,123,174],"capture":[81],"complex":[82],"sequence-function":[83],"relationships":[84],"proteins.":[87],"To":[88],"address":[89],"this":[90],"issue,":[91],"we":[92,209],"propose":[93],"an":[94,146,188],"integrated":[95],"computational":[96],"framework,":[97,186],"AcidProNet,":[98],"which":[99,221],"incorporates":[100],"three":[101],"key":[102],"components:":[103],"a":[104,113,132,184,199,212],"CNN-based":[105],"generative":[106],"adversarial":[107],"module,":[108],"DCGAN-GP,":[109],"for":[110,139,193,202,215],"data":[111,178],"augmentation;":[112],"sparsely":[114],"discretely":[116],"activated,":[117],"parameter-sharing":[118],"Mixture-of-Experts":[119],"Transformer,":[120],"PS-MoE,":[121],"designed":[122],"effectively":[124],"optimize":[125],"encoded":[126],"features;":[127],"utilization":[130],"pretrained":[133],"protein":[134,143,195,205],"language":[135],"model,":[136],"ESM":[137],"C,":[138],"extracting":[140],"biologically":[141],"meaningful":[142],"embeddings.":[144],"On":[145],"independent":[147],"test":[148],"set,":[149],"our":[150],"method":[151],"outperforms":[152],"existing":[153],"models.":[154],"Further":[155],"expert-grouped":[156],"ablation":[158],"experiments":[159],"confirm":[160],"its":[161],"advantages":[162],"representational":[167],"power.":[168],"This":[169],"study":[170],"is":[171],"first":[173],"integrate":[175],"embedding":[176],"generation,":[177],"augmentation,":[179],"expert":[181],"modeling":[182],"within":[183],"unified":[185],"providing":[187],"efficient":[189],"scalable":[191],"approach":[192],"prediction":[196],"laying":[198],"methodological":[200],"foundation":[201],"advances":[203],"engineering":[206],"applications.":[207],"Additionally,":[208],"developed":[211],"Web":[213],"site":[214],"direct":[216],"proteins,":[220],"be":[223],"accessed":[224],"at":[225],"http://www.bioai-lab.com/AcidNetPro.":[226]},"counts_by_year":[],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-12-08T00:00:00"}
