{"id":"https://openalex.org/W7117655609","doi":"https://doi.org/10.1021/acs.jcim.5c01945","title":"DRPMKB1.0: A Comprehensive Knowledge Base for an AI-Oriented Drug Repositioning Prediction Model","display_name":"DRPMKB1.0: A Comprehensive Knowledge Base for an AI-Oriented Drug Repositioning Prediction Model","publication_year":2025,"publication_date":"2025-12-31","ids":{"openalex":"https://openalex.org/W7117655609","doi":"https://doi.org/10.1021/acs.jcim.5c01945","pmid":"https://pubmed.ncbi.nlm.nih.gov/41474981"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c01945","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c01945","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xin Zheng","orcid":"https://orcid.org/0009-0000-9300-8949"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4210091339","display_name":"Laboratory of Molecular Genetics","ror":"https://ror.org/00fwhek95","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210091339"]}],"countries":["CN","PL"],"is_corresponding":false,"raw_author_name":"Xin Zheng","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network","West China Hospital, Sichuan University"],"raw_orcid":"https://orcid.org/0009-0000-9300-8949","affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network","institution_ids":["https://openalex.org/I4210091339"]},{"raw_affiliation_string":"West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037475370","display_name":"Cheng Bi","orcid":"https://orcid.org/0000-0002-8076-2704"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4210091339","display_name":"Laboratory of Molecular Genetics","ror":"https://ror.org/00fwhek95","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210091339"]}],"countries":["CN","PL"],"is_corresponding":false,"raw_author_name":"Cheng Bi","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network","West China Hospital, Sichuan University"],"raw_orcid":"https://orcid.org/0000-0002-8076-2704","affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network","institution_ids":["https://openalex.org/I4210091339"]},{"raw_affiliation_string":"West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057291050","display_name":"Weichen Bo","orcid":null},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weichen Bo","raw_affiliation_strings":["Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy","West China Hospital, Sichuan University"],"raw_orcid":"https://orcid.org/0009-0005-0919-693X","affiliations":[{"raw_affiliation_string":"Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy","institution_ids":[]},{"raw_affiliation_string":"West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100398030","display_name":"Yuxin Zhang","orcid":"https://orcid.org/0000-0002-5144-0693"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4210091339","display_name":"Laboratory of Molecular Genetics","ror":"https://ror.org/00fwhek95","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210091339"]}],"countries":["CN","PL"],"is_corresponding":false,"raw_author_name":"Yuxin Zhang","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network","West China Hospital, Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network","institution_ids":["https://openalex.org/I4210091339"]},{"raw_affiliation_string":"West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091150906","display_name":"Jie Song","orcid":"https://orcid.org/0000-0002-7357-2136"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4210091339","display_name":"Laboratory of Molecular Genetics","ror":"https://ror.org/00fwhek95","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210091339"]}],"countries":["CN","PL"],"is_corresponding":false,"raw_author_name":"Jie Song","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network","West China Hospital, Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network","institution_ids":["https://openalex.org/I4210091339"]},{"raw_affiliation_string":"West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065877893","display_name":"J Du","orcid":null},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4210091339","display_name":"Laboratory of Molecular Genetics","ror":"https://ror.org/00fwhek95","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210091339"]}],"countries":["CN","PL"],"is_corresponding":false,"raw_author_name":"Jiale Du","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network","West China Hospital, Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network","institution_ids":["https://openalex.org/I4210091339"]},{"raw_affiliation_string":"West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102229927","display_name":"Shanshan Hu","orcid":null},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4210091339","display_name":"Laboratory of Molecular Genetics","ror":"https://ror.org/00fwhek95","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210091339"]}],"countries":["CN","PL"],"is_corresponding":false,"raw_author_name":"Shanshan Hu","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network","West China Hospital, Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network","institution_ids":["https://openalex.org/I4210091339"]},{"raw_affiliation_string":"West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007190963","display_name":"Jinhua Feng","orcid":null},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinhua Feng","raw_affiliation_strings":["Sichuan University","West China School of Nursing, Sichuan University/Department of Biliary, West China Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan University","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"West China School of Nursing, Sichuan University/Department of Biliary, West China Hospital","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121606959","display_name":"Lu Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Yang","raw_affiliation_strings":["Department of Urology, West China Hospital","Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, West China Hospital","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Sichuan University","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112778451","display_name":"Bairong Shen","orcid":null},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4210091339","display_name":"Laboratory of Molecular Genetics","ror":"https://ror.org/00fwhek95","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210091339"]}],"countries":["CN","PL"],"is_corresponding":true,"raw_author_name":"Bairong Shen","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network","West China Hospital, Sichuan University"],"raw_orcid":"https://orcid.org/0000-0003-2899-1531","affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network","institution_ids":["https://openalex.org/I4210091339"]},{"raw_affiliation_string":"West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5112778451"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4210091339"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71653282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":"1","first_page":"122","last_page":"137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.6847000122070312,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.6847000122070312,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.04360000044107437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.042100001126527786,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/knowledge-base","display_name":"Knowledge base","score":0.8051999807357788},{"id":"https://openalex.org/keywords/base","display_name":"Base (topology)","score":0.5087000131607056},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.4706999957561493},{"id":"https://openalex.org/keywords/quality","display_name":"Quality (philosophy)","score":0.41929998993873596},{"id":"https://openalex.org/keywords/knowledge-based-systems","display_name":"Knowledge-based systems","score":0.34869998693466187},{"id":"https://openalex.org/keywords/knowledge-extraction","display_name":"Knowledge extraction","score":0.335999995470047},{"id":"https://openalex.org/keywords/predictive-modelling","display_name":"Predictive modelling","score":0.3215000033378601}],"concepts":[{"id":"https://openalex.org/C4554734","wikidata":"https://www.wikidata.org/wiki/Q593744","display_name":"Knowledge base","level":2,"score":0.8051999807357788},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7178000211715698},{"id":"https://openalex.org/C42058472","wikidata":"https://www.wikidata.org/wiki/Q810214","display_name":"Base (topology)","level":2,"score":0.5087000131607056},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.4706999957561493},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4560000002384186},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.41929998993873596},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4083999991416931},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3828999996185303},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3695000112056732},{"id":"https://openalex.org/C115925183","wikidata":"https://www.wikidata.org/wiki/Q1412694","display_name":"Knowledge-based systems","level":2,"score":0.34869998693466187},{"id":"https://openalex.org/C120567893","wikidata":"https://www.wikidata.org/wiki/Q1582085","display_name":"Knowledge extraction","level":2,"score":0.335999995470047},{"id":"https://openalex.org/C45804977","wikidata":"https://www.wikidata.org/wiki/Q7239673","display_name":"Predictive modelling","level":2,"score":0.3215000033378601},{"id":"https://openalex.org/C2776604539","wikidata":"https://www.wikidata.org/wiki/Q6423395","display_name":"Knowledge sharing","level":2,"score":0.32019999623298645},{"id":"https://openalex.org/C67186912","wikidata":"https://www.wikidata.org/wiki/Q367664","display_name":"Data modeling","level":2,"score":0.3158000111579895},{"id":"https://openalex.org/C2780966255","wikidata":"https://www.wikidata.org/wiki/Q5474306","display_name":"Foundation (evidence)","level":2,"score":0.2888999879360199},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.2870999872684479},{"id":"https://openalex.org/C2779965156","wikidata":"https://www.wikidata.org/wiki/Q5227350","display_name":"Data sharing","level":3,"score":0.2833000123500824},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.26899999380111694},{"id":"https://openalex.org/C75684735","wikidata":"https://www.wikidata.org/wiki/Q858810","display_name":"Big data","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.2581999897956848},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.2533999979496002},{"id":"https://openalex.org/C24756922","wikidata":"https://www.wikidata.org/wiki/Q1757694","display_name":"Data quality","level":3,"score":0.251800000667572}],"mesh":[{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051188","descriptor_name":"Knowledge Bases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051188","descriptor_name":"Knowledge Bases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5c01945","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c01945","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:41474981","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41474981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2927918106","display_name":null,"funder_award_id":"2024YFHZ0205","funder_id":"https://openalex.org/F4320322922","funder_display_name":"Department of Science and Technology of Sichuan Province"},{"id":"https://openalex.org/G4808893844","display_name":null,"funder_award_id":"32270690","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322922","display_name":"Department of Science and Technology of Sichuan Province","ror":"https://ror.org/04323m874"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1977070136","https://openalex.org/W1986935249","https://openalex.org/W1997362383","https://openalex.org/W2031954078","https://openalex.org/W2035585923","https://openalex.org/W2035761153","https://openalex.org/W2046511192","https://openalex.org/W2051997490","https://openalex.org/W2062941476","https://openalex.org/W2086286404","https://openalex.org/W2087007556","https://openalex.org/W2089499735","https://openalex.org/W2096541451","https://openalex.org/W2096864392","https://openalex.org/W2097596985","https://openalex.org/W2104244948","https://openalex.org/W2107252423","https://openalex.org/W2108069034","https://openalex.org/W2119412782","https://openalex.org/W2122863289","https://openalex.org/W2142233025","https://openalex.org/W2145578524","https://openalex.org/W2147487953","https://openalex.org/W2151697120","https://openalex.org/W2153838454","https://openalex.org/W2169678694","https://openalex.org/W2183717576","https://openalex.org/W2346950316","https://openalex.org/W2579434750","https://openalex.org/W2612436700","https://openalex.org/W2753953057","https://openalex.org/W2785947426","https://openalex.org/W2790385355","https://openalex.org/W2809156537","https://openalex.org/W2895370006","https://openalex.org/W2896741799","https://openalex.org/W2899349918","https://openalex.org/W2917925658","https://openalex.org/W2952522777","https://openalex.org/W2960557205","https://openalex.org/W3016077459","https://openalex.org/W3017154096","https://openalex.org/W3082081167","https://openalex.org/W3136918052","https://openalex.org/W3149821640","https://openalex.org/W3173351750","https://openalex.org/W3214137195","https://openalex.org/W4200333875","https://openalex.org/W4230927156","https://openalex.org/W4281488754","https://openalex.org/W4283387616","https://openalex.org/W4294216483","https://openalex.org/W4297458751","https://openalex.org/W4316507348","https://openalex.org/W4386142022","https://openalex.org/W4388451133","https://openalex.org/W4388467895","https://openalex.org/W4388615774","https://openalex.org/W4393180363","https://openalex.org/W4400000068","https://openalex.org/W4400111045","https://openalex.org/W4400118952","https://openalex.org/W4400475545","https://openalex.org/W4404534210","https://openalex.org/W4405234363","https://openalex.org/W4405582672","https://openalex.org/W4407414788","https://openalex.org/W4407454387","https://openalex.org/W4407709616","https://openalex.org/W4411090274","https://openalex.org/W4413472998"],"related_works":[],"abstract_inverted_index":{"Drug":[0],"repositioning":[1,71],"(DR)":[2],"reduces":[3],"the":[4,68,137],"risks":[5],"and":[6,40,93,95,101,109,136,148,175],"costs":[7],"of":[8,21],"drug":[9,70],"development":[10],"by":[11],"identifying":[12],"new":[13],"uses":[14],"for":[15,51,119,140,150,170,189],"approved":[16],"drugs.":[17],"The":[18,179],"rapid":[19],"growth":[20],"artificial":[22],"intelligence":[23],"(AI)":[24],"has":[25],"led":[26],"to":[27,86,127,172],"many":[28],"computational":[29],"models.":[30],"However,":[31],"without":[32],"effective":[33],"integration,":[34],"excess":[35],"models":[36,47,149,174],"can":[37],"waste":[38],"resources":[39],"obscure":[41],"valuable":[42],"ones.":[43],"While":[44],"large":[45],"language":[46],"(LLMs)":[48],"are":[49],"preferred":[50],"their":[52],"broad":[53],"applicability,":[54],"integrating":[55],"them":[56],"with":[57],"a":[58,114,124,168,186],"personalized":[59,151],"knowledge":[60,74,79,180,187],"base":[61,75,80,181,188],"improves":[62],"task-specific":[63],"accuracy.":[64,163],"Thus,":[65],"we":[66],"developed":[67],"AI-oriented":[69],"prediction":[72,162],"model":[73,129,134,155,191],"(DRPMKB":[76],"1.0).":[77],"This":[78],"compiles":[81],"data":[82,111,116,147,176],"from":[83],"PubMed":[84],"up":[85],"March":[87],"2024,":[88],"covering":[89],"two":[90],"interfaces":[91],"(display":[92],"interaction)":[94],"four":[96],"dimensions":[97],"(data,":[98],"model,":[99],"application,":[100],"reference).":[102],"It":[103],"includes":[104],"45":[105],"categories,":[106],"193":[107],"models,":[108],"693":[110],"entries,":[112],"offering":[113,153],"comprehensive":[115],"sharing":[117],"platform":[118],"DR.":[120],"DRPMKB":[121,143,164],"1.0":[122,144,165],"establishes":[123],"dual-evaluation":[125],"framework":[126],"standardize":[128],"selection,":[130],"appraising":[131],"both":[132],"inherent":[133],"quality":[135],"evidentiary":[138],"support":[139],"its":[141],"predictions.":[142],"integrates":[145],"diverse":[146],"DR,":[152],"tailored":[154],"recommendations":[156],"based":[157],"on":[158],"user":[159],"data,":[160],"improving":[161],"also":[166],"offers":[167],"foundation":[169],"developers":[171],"integrate":[173],"sets":[177],"seamlessly.":[178],"supports":[182],"AI":[183],"enhancement":[184],"through":[185],"continuous":[190],"refinement.":[192]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-12-31T00:00:00"}