{"id":"https://openalex.org/W4417457374","doi":"https://doi.org/10.1021/acs.jcim.5c01874","title":"Impact of Glycans Modulating Human Cytomegalovirus Glycoprotein B on Broad-Spectrum Neutralizing Human Antibody Recognition: Unveiled by Molecular Dynamics Simulation","display_name":"Impact of Glycans Modulating Human Cytomegalovirus Glycoprotein B on Broad-Spectrum Neutralizing Human Antibody Recognition: Unveiled by Molecular Dynamics Simulation","publication_year":2025,"publication_date":"2025-12-17","ids":{"openalex":"https://openalex.org/W4417457374","doi":"https://doi.org/10.1021/acs.jcim.5c01874","pmid":"https://pubmed.ncbi.nlm.nih.gov/41403066"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c01874","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c01874","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071724919","display_name":"Jiasheng Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162663","display_name":"Chemical Synthesis Lab","ror":"https://ror.org/04kbbt849","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210105704","https://openalex.org/I4210162663","https://openalex.org/I91275662"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN","SG"],"is_corresponding":false,"raw_author_name":"Jiasheng Zhao","raw_affiliation_strings":["MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics","Xi\u2019an Jiaotong University","MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics","institution_ids":["https://openalex.org/I4210162663"]},{"raw_affiliation_string":"Xi\u2019an Jiaotong University","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112479063","display_name":"Changwen Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210100303","display_name":"Biotech Park","ror":"https://ror.org/00mv0vt78","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210100303"]},{"id":"https://openalex.org/I4210159344","display_name":"Viva Biotech (China)","ror":"https://ror.org/05p50vw42","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210159344"]}],"countries":["CN","IN"],"is_corresponding":false,"raw_author_name":"Changwen Wu","raw_affiliation_strings":["Trinomab Biotech Co., Ltd","Trinomab Biotech Co., Ltd., Zhuhai 519040, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinomab Biotech Co., Ltd","institution_ids":["https://openalex.org/I4210100303"]},{"raw_affiliation_string":"Trinomab Biotech Co., Ltd., Zhuhai 519040, China","institution_ids":["https://openalex.org/I4210159344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101684844","display_name":"Yizhen Zhao","orcid":"https://orcid.org/0000-0002-1255-812X"},"institutions":[{"id":"https://openalex.org/I2802546215","display_name":"Shanghai Supercomputer Center (China)","ror":"https://ror.org/04dpx8b39","country_code":"CN","type":"company","lineage":["https://openalex.org/I2802546215"]},{"id":"https://openalex.org/I4210098117","display_name":"Coconut Research Institute","ror":"https://ror.org/00xjqd715","country_code":"CN","type":"facility","lineage":["https://openalex.org/I107851509","https://openalex.org/I4210098117","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210162663","display_name":"Chemical Synthesis Lab","ror":"https://ror.org/04kbbt849","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210105704","https://openalex.org/I4210162663","https://openalex.org/I91275662"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN","SG"],"is_corresponding":false,"raw_author_name":"Yizhen Zhao","raw_affiliation_strings":["MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics","Wecomput Technology Co., Ltd","Xi\u2019an Jiaotong University","MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China","Wecomput Technology Co., Ltd., Shanghai 200120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics","institution_ids":["https://openalex.org/I4210162663"]},{"raw_affiliation_string":"Wecomput Technology Co., Ltd","institution_ids":["https://openalex.org/I4210098117"]},{"raw_affiliation_string":"Xi\u2019an Jiaotong University","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"Wecomput Technology Co., Ltd., Shanghai 200120, China","institution_ids":["https://openalex.org/I2802546215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100733720","display_name":"Sijia Zhang","orcid":"https://orcid.org/0000-0002-7549-782X"},"institutions":[{"id":"https://openalex.org/I4210162663","display_name":"Chemical Synthesis Lab","ror":"https://ror.org/04kbbt849","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210105704","https://openalex.org/I4210162663","https://openalex.org/I91275662"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN","SG"],"is_corresponding":false,"raw_author_name":"Sijia Zhang","raw_affiliation_strings":["MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics","Xi\u2019an Jiaotong University","MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics","institution_ids":["https://openalex.org/I4210162663"]},{"raw_affiliation_string":"Xi\u2019an Jiaotong University","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qinjie Tang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162663","display_name":"Chemical Synthesis Lab","ror":"https://ror.org/04kbbt849","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210105704","https://openalex.org/I4210162663","https://openalex.org/I91275662"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN","SG"],"is_corresponding":false,"raw_author_name":"Qinjie Tang","raw_affiliation_strings":["MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics","Xi\u2019an Jiaotong University","MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics","institution_ids":["https://openalex.org/I4210162663"]},{"raw_affiliation_string":"Xi\u2019an Jiaotong University","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100433917","display_name":"Lei Zhang","orcid":"https://orcid.org/0000-0002-4880-824X"},"institutions":[{"id":"https://openalex.org/I4210162663","display_name":"Chemical Synthesis Lab","ror":"https://ror.org/04kbbt849","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210105704","https://openalex.org/I4210162663","https://openalex.org/I91275662"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN","SG"],"is_corresponding":false,"raw_author_name":"Lei Zhang","raw_affiliation_strings":["MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics","Xi\u2019an Jiaotong University","MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China"],"raw_orcid":"https://orcid.org/0000-0002-4880-824X","affiliations":[{"raw_affiliation_string":"MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics","institution_ids":["https://openalex.org/I4210162663"]},{"raw_affiliation_string":"Xi\u2019an Jiaotong University","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009570320","display_name":"Xiaohui Yuan","orcid":"https://orcid.org/0000-0002-2082-2146"},"institutions":[{"id":"https://openalex.org/I4210100303","display_name":"Biotech Park","ror":"https://ror.org/00mv0vt78","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210100303"]},{"id":"https://openalex.org/I4210159344","display_name":"Viva Biotech (China)","ror":"https://ror.org/05p50vw42","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210159344"]}],"countries":["CN","IN"],"is_corresponding":false,"raw_author_name":"Xiaohui Yuan","raw_affiliation_strings":["Trinomab Biotech Co., Ltd","Trinomab Biotech Co., Ltd., Zhuhai 519040, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinomab Biotech Co., Ltd","institution_ids":["https://openalex.org/I4210100303"]},{"raw_affiliation_string":"Trinomab Biotech Co., Ltd., Zhuhai 519040, China","institution_ids":["https://openalex.org/I4210159344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112246469","display_name":"Hua-Xin Liao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210100303","display_name":"Biotech Park","ror":"https://ror.org/00mv0vt78","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210100303"]},{"id":"https://openalex.org/I4210159344","display_name":"Viva Biotech (China)","ror":"https://ror.org/05p50vw42","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210159344"]}],"countries":["CN","IN"],"is_corresponding":true,"raw_author_name":"Hua-Xin Liao","raw_affiliation_strings":["Trinomab Biotech Co., Ltd","Trinomab Biotech Co., Ltd., Zhuhai 519040, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinomab Biotech Co., Ltd","institution_ids":["https://openalex.org/I4210100303"]},{"raw_affiliation_string":"Trinomab Biotech Co., Ltd., Zhuhai 519040, China","institution_ids":["https://openalex.org/I4210159344"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101703665","display_name":"Zhiwei Yang","orcid":"https://orcid.org/0000-0001-6158-8803"},"institutions":[{"id":"https://openalex.org/I4210162663","display_name":"Chemical Synthesis Lab","ror":"https://ror.org/04kbbt849","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210105704","https://openalex.org/I4210162663","https://openalex.org/I91275662"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN","SG"],"is_corresponding":true,"raw_author_name":"Zhiwei Yang","raw_affiliation_strings":["MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics","Xi\u2019an Jiaotong University","MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China"],"raw_orcid":"https://orcid.org/0000-0001-6158-8803","affiliations":[{"raw_affiliation_string":"MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics","institution_ids":["https://openalex.org/I4210162663"]},{"raw_affiliation_string":"Xi\u2019an Jiaotong University","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China","institution_ids":["https://openalex.org/I87445476"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5101703665","https://openalex.org/A5112246469"],"corresponding_institution_ids":["https://openalex.org/I4210100303","https://openalex.org/I4210159344","https://openalex.org/I4210162663","https://openalex.org/I87445476"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.50438295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":"1","first_page":"529","last_page":"540"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycoprotein","display_name":"Glycoprotein","score":0.8134999871253967},{"id":"https://openalex.org/keywords/glycan","display_name":"Glycan","score":0.7153000235557556},{"id":"https://openalex.org/keywords/glycosylation","display_name":"Glycosylation","score":0.6711999773979187},{"id":"https://openalex.org/keywords/epitope","display_name":"Epitope","score":0.5771999955177307},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.555899977684021},{"id":"https://openalex.org/keywords/neutralizing-antibody","display_name":"Neutralizing antibody","score":0.5519000291824341},{"id":"https://openalex.org/keywords/viral-membrane","display_name":"Viral membrane","score":0.5490000247955322},{"id":"https://openalex.org/keywords/lipid-bilayer-fusion","display_name":"Lipid bilayer fusion","score":0.5480999946594238},{"id":"https://openalex.org/keywords/herpesvirus-glycoprotein-b","display_name":"Herpesvirus glycoprotein B","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.8134999871253967},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.7153000235557556},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.6711999773979187},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5771999955177307},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.555899977684021},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.5519000291824341},{"id":"https://openalex.org/C2909404852","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral membrane","level":4,"score":0.5490000247955322},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.5480999946594238},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5461000204086304},{"id":"https://openalex.org/C132787861","wikidata":"https://www.wikidata.org/wiki/Q24720396","display_name":"Herpesvirus glycoprotein B","level":5,"score":0.5040000081062317},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.5011000037193298},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.428600013256073},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41929998993873596},{"id":"https://openalex.org/C97380033","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral envelope","level":3,"score":0.40470001101493835},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.38609999418258667},{"id":"https://openalex.org/C2777459641","wikidata":"https://www.wikidata.org/wiki/Q6815130","display_name":"Membrane glycoproteins","level":3,"score":0.37290000915527344},{"id":"https://openalex.org/C2776403692","wikidata":"https://www.wikidata.org/wiki/Q898416","display_name":"Trimer","level":3,"score":0.34389999508857727},{"id":"https://openalex.org/C30324644","wikidata":"https://www.wikidata.org/wiki/Q3334151","display_name":"N-linked glycosylation","level":4,"score":0.32679998874664307},{"id":"https://openalex.org/C92488253","wikidata":"https://www.wikidata.org/wiki/Q56592403","display_name":"Cell fusion","level":3,"score":0.32350000739097595},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.32179999351501465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3163999915122986},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.3012000024318695},{"id":"https://openalex.org/C2779026604","wikidata":"https://www.wikidata.org/wiki/Q4774742","display_name":"Antigenicity","level":3,"score":0.2727000117301941},{"id":"https://openalex.org/C196594336","wikidata":"https://www.wikidata.org/wiki/Q1662341","display_name":"Antibody-dependent enhancement","level":4,"score":0.27070000767707825},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.26260000467300415},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.260699987411499},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.25360000133514404},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.25040000677108765}],"mesh":[{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5c01874","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c01874","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:41403066","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41403066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W233479448","https://openalex.org/W1781411217","https://openalex.org/W1975734016","https://openalex.org/W1979729411","https://openalex.org/W1992899488","https://openalex.org/W2004822259","https://openalex.org/W2025116694","https://openalex.org/W2028062152","https://openalex.org/W2044624758","https://openalex.org/W2046635675","https://openalex.org/W2064288175","https://openalex.org/W2086769942","https://openalex.org/W2093381148","https://openalex.org/W2098943363","https://openalex.org/W2109680867","https://openalex.org/W2112194909","https://openalex.org/W2118233996","https://openalex.org/W2128163894","https://openalex.org/W2142868265","https://openalex.org/W2175485171","https://openalex.org/W2262975933","https://openalex.org/W2332712348","https://openalex.org/W2335200606","https://openalex.org/W2336507460","https://openalex.org/W2404280981","https://openalex.org/W2530696470","https://openalex.org/W2606049358","https://openalex.org/W2734356283","https://openalex.org/W2748874219","https://openalex.org/W2764338446","https://openalex.org/W2772606519","https://openalex.org/W2800728105","https://openalex.org/W2884071449","https://openalex.org/W2946482289","https://openalex.org/W2966719073","https://openalex.org/W3023376619","https://openalex.org/W3032445823","https://openalex.org/W3043431476","https://openalex.org/W3086603362","https://openalex.org/W3088579397","https://openalex.org/W3093517553","https://openalex.org/W3133749268","https://openalex.org/W3154000610","https://openalex.org/W3166713065","https://openalex.org/W3183822239","https://openalex.org/W3196014002","https://openalex.org/W3198820576","https://openalex.org/W3199472879","https://openalex.org/W4224291248","https://openalex.org/W4225566785","https://openalex.org/W4280510362","https://openalex.org/W4286454812","https://openalex.org/W4410459997"],"related_works":[],"abstract_inverted_index":{"Viral":[0],"fusion":[1,53,60,179],"glycoproteins":[2,180],"are":[3],"extensively":[4],"glycosylated,":[5],"a":[6,183],"feature":[7],"that":[8,109],"is":[9],"critical":[10],"for":[11,186],"viral":[12,51,59,67,178],"entry":[13,68],"and":[14,23,33,54,83,90,103,120,127,151,159,181],"antibody":[15,104,136,152],"responses.":[16,73],"However,":[17],"the":[18,34,79,112,131,134,147,165,171,187],"structural":[19],"complexity":[20],"of":[21,30,36,78,133,174,189],"N-glycans":[22,64,99,110,176],"experimental":[24],"limitations":[25],"have":[26],"hindered":[27],"mechanistic":[28,172],"studies":[29],"glycan-glycoprotein":[31],"interactions":[32,116],"impact":[35],"glycosylation":[37],"on":[38,45],"host":[39,71],"immunity.":[40],"Human":[41],"cytomegalovirus":[42],"(HCMV)":[43],"relies":[44],"glycoprotein":[46],"B":[47],"(gB)":[48],"to":[49,65,96,162,164],"mediate":[50],"membrane":[52],"cell":[55],"entry.":[56],"Like":[57],"other":[58],"proteins,":[61],"gB":[62,81,113,150],"employs":[63],"facilitate":[66],"while":[69,154],"evading":[70],"immune":[72,141],"Here,":[74],"we":[75],"constructed":[76],"models":[77],"glycosylated":[80],"trimer":[82],"its":[84,140],"complexes":[85],"with":[86,117],"different":[87],"neutralizing":[88,135,191],"antibodies":[89],"performed":[91],"large-scale":[92],"molecular":[93,184],"dynamics":[94,102],"simulations":[95],"investigate":[97],"how":[98,175],"influence":[100],"protein":[101],"recognition.":[105,142],"Our":[106],"results":[107],"show":[108],"stabilize":[111],"conformation":[114],"through":[115],"domains":[118],"DI":[119],"DII.":[121],"Moreover,":[122],"glycans":[123],"at":[124],"N281,":[125],"N286,":[126],"N302":[128],"unevenly":[129],"shield":[130],"epitope":[132],"1G2,":[137],"thereby":[138],"modulating":[139],"Glycosylation":[143],"also":[144],"moderately":[145],"reduces":[146],"interaction":[148],"between":[149],"1B03,":[153],"key":[155],"residues":[156],"His182,":[157],"Arg311,":[158],"Asn313":[160],"continue":[161],"contribute":[163],"binding":[166],"interface.":[167],"This":[168],"study":[169],"enhances":[170],"understanding":[173],"regulate":[177],"provides":[182],"foundation":[185],"development":[188],"broadly":[190],"antibodies.":[192]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-12-17T00:00:00"}
