{"id":"https://openalex.org/W4414323178","doi":"https://doi.org/10.1021/acs.jcim.5c01693","title":"MCMFPP: A Multifunctional Peptides Prediction Method Based on Class Feature Enhancement and Classifier Fusion","display_name":"MCMFPP: A Multifunctional Peptides Prediction Method Based on Class Feature Enhancement and Classifier Fusion","publication_year":2025,"publication_date":"2025-09-18","ids":{"openalex":"https://openalex.org/W4414323178","doi":"https://doi.org/10.1021/acs.jcim.5c01693","pmid":"https://pubmed.ncbi.nlm.nih.gov/40968106"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c01693","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c01693","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102443929","display_name":"Jintao Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I3132770690","display_name":"Florida College System","ror":"https://ror.org/04qy3pa58","country_code":"US","type":"education","lineage":["https://openalex.org/I3132770690"]},{"id":"https://openalex.org/I4210123509","display_name":"Institute of Mathematics and Physics","ror":"https://ror.org/035seyp42","country_code":"BJ","type":"facility","lineage":["https://openalex.org/I4210123509"]},{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["BJ","CN","US"],"is_corresponding":false,"raw_author_name":"Jintao Zhao","raw_affiliation_strings":["College of Mathematics and System Sciences","Institute of Mathematics and Physics","Xinjiang University"],"raw_orcid":"https://orcid.org/0009-0000-2314-534X","affiliations":[{"raw_affiliation_string":"College of Mathematics and System Sciences","institution_ids":["https://openalex.org/I3132770690"]},{"raw_affiliation_string":"Institute of Mathematics and Physics","institution_ids":["https://openalex.org/I4210123509"]},{"raw_affiliation_string":"Xinjiang University","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102443929","display_name":"Jintao Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]},{"id":"https://openalex.org/I3132770690","display_name":"Florida College System","ror":"https://ror.org/04qy3pa58","country_code":"US","type":"education","lineage":["https://openalex.org/I3132770690"]},{"id":"https://openalex.org/I4210123509","display_name":"Institute of Mathematics and Physics","ror":"https://ror.org/035seyp42","country_code":"BJ","type":"facility","lineage":["https://openalex.org/I4210123509"]},{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["BJ","CN","US"],"is_corresponding":true,"raw_author_name":"Jintao Zhao","raw_affiliation_strings":["College of Mathematics and System Sciences","Institute of Mathematics and Physics","Xinjiang University","Anhui University","Institutes of Physical Science and Information Technology"],"raw_orcid":"https://orcid.org/0009-0000-2314-534X","affiliations":[{"raw_affiliation_string":"College of Mathematics and System Sciences","institution_ids":["https://openalex.org/I3132770690"]},{"raw_affiliation_string":"Institute of Mathematics and Physics","institution_ids":["https://openalex.org/I4210123509"]},{"raw_affiliation_string":"Xinjiang University","institution_ids":["https://openalex.org/I96908189"]},{"raw_affiliation_string":"Anhui University","institution_ids":["https://openalex.org/I143868143"]},{"raw_affiliation_string":"Institutes of Physical Science and Information Technology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102537220","display_name":"Haibo Fan","orcid":null},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]},{"id":"https://openalex.org/I3132770690","display_name":"Florida College System","ror":"https://ror.org/04qy3pa58","country_code":"US","type":"education","lineage":["https://openalex.org/I3132770690"]},{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Henghui Fan","raw_affiliation_strings":["Anhui University","Institutes of Physical Science and Information Technology","Xinjiang University","College of Mathematics and System Sciences"],"raw_orcid":"https://orcid.org/0009-0005-3949-0064","affiliations":[{"raw_affiliation_string":"Anhui University","institution_ids":["https://openalex.org/I143868143"]},{"raw_affiliation_string":"Institutes of Physical Science and Information Technology","institution_ids":[]},{"raw_affiliation_string":"Xinjiang University","institution_ids":["https://openalex.org/I96908189"]},{"raw_affiliation_string":"College of Mathematics and System Sciences","institution_ids":["https://openalex.org/I3132770690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043441938","display_name":"Jiwei Fang","orcid":null},"institutions":[{"id":"https://openalex.org/I3132770690","display_name":"Florida College System","ror":"https://ror.org/04qy3pa58","country_code":"US","type":"education","lineage":["https://openalex.org/I3132770690"]},{"id":"https://openalex.org/I4210123509","display_name":"Institute of Mathematics and Physics","ror":"https://ror.org/035seyp42","country_code":"BJ","type":"facility","lineage":["https://openalex.org/I4210123509"]},{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["BJ","CN","US"],"is_corresponding":false,"raw_author_name":"Jiwei Fang","raw_affiliation_strings":["College of Mathematics and System Sciences","Xinjiang University","Institute of Mathematics and Physics"],"raw_orcid":"https://orcid.org/0009-0003-1693-9928","affiliations":[{"raw_affiliation_string":"College of Mathematics and System Sciences","institution_ids":["https://openalex.org/I3132770690"]},{"raw_affiliation_string":"Xinjiang University","institution_ids":["https://openalex.org/I96908189"]},{"raw_affiliation_string":"Institute of Mathematics and Physics","institution_ids":["https://openalex.org/I4210123509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078955823","display_name":"Jianping Zhao","orcid":"https://orcid.org/0000-0002-8486-744X"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]},{"id":"https://openalex.org/I3132770690","display_name":"Florida College System","ror":"https://ror.org/04qy3pa58","country_code":"US","type":"education","lineage":["https://openalex.org/I3132770690"]},{"id":"https://openalex.org/I4210111575","display_name":"Xinjiang Institute of Engineering","ror":"https://ror.org/01s5hh873","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210111575","https://openalex.org/I4210157944"]},{"id":"https://openalex.org/I4210123509","display_name":"Institute of Mathematics and Physics","ror":"https://ror.org/035seyp42","country_code":"BJ","type":"facility","lineage":["https://openalex.org/I4210123509"]},{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["BJ","CN","US"],"is_corresponding":false,"raw_author_name":"Jianping Zhao","raw_affiliation_strings":["College of Mathematics and System Sciences","Institute of Mathematics and Physics","Xinjiang University","College of Mathematics and System Sciences, Xinjiang University, Xinjiang, 830017, China","Institutes of Physical Science and Information Technology","Anhui University"],"raw_orcid":"https://orcid.org/0000-0002-8486-744X","affiliations":[{"raw_affiliation_string":"College of Mathematics and System Sciences","institution_ids":["https://openalex.org/I3132770690"]},{"raw_affiliation_string":"Institute of Mathematics and Physics","institution_ids":["https://openalex.org/I4210123509"]},{"raw_affiliation_string":"Xinjiang University","institution_ids":["https://openalex.org/I96908189"]},{"raw_affiliation_string":"College of Mathematics and System Sciences, Xinjiang University, Xinjiang, 830017, China","institution_ids":["https://openalex.org/I4210111575","https://openalex.org/I96908189"]},{"raw_affiliation_string":"Institutes of Physical Science and Information Technology","institution_ids":[]},{"raw_affiliation_string":"Anhui University","institution_ids":["https://openalex.org/I143868143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078955823","display_name":"Jianping Zhao","orcid":"https://orcid.org/0000-0002-8486-744X"},"institutions":[{"id":"https://openalex.org/I3132770690","display_name":"Florida College System","ror":"https://ror.org/04qy3pa58","country_code":"US","type":"education","lineage":["https://openalex.org/I3132770690"]},{"id":"https://openalex.org/I4210123509","display_name":"Institute of Mathematics and Physics","ror":"https://ror.org/035seyp42","country_code":"BJ","type":"facility","lineage":["https://openalex.org/I4210123509"]},{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["BJ","CN","US"],"is_corresponding":true,"raw_author_name":"Jianping Zhao","raw_affiliation_strings":["College of Mathematics and System Sciences","Institute of Mathematics and Physics","Xinjiang University"],"raw_orcid":"https://orcid.org/0000-0002-8486-744X","affiliations":[{"raw_affiliation_string":"College of Mathematics and System Sciences","institution_ids":["https://openalex.org/I3132770690"]},{"raw_affiliation_string":"Institute of Mathematics and Physics","institution_ids":["https://openalex.org/I4210123509"]},{"raw_affiliation_string":"Xinjiang University","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065943710","display_name":"Junfeng Xia","orcid":"https://orcid.org/0000-0003-3024-1705"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]},{"id":"https://openalex.org/I3132770690","display_name":"Florida College System","ror":"https://ror.org/04qy3pa58","country_code":"US","type":"education","lineage":["https://openalex.org/I3132770690"]},{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Junfeng Xia","raw_affiliation_strings":["Anhui University","College of Mathematics and System Sciences","Institutes of Physical Science and Information Technology","Xinjiang University"],"raw_orcid":"https://orcid.org/0000-0003-3024-1705","affiliations":[{"raw_affiliation_string":"Anhui University","institution_ids":["https://openalex.org/I143868143"]},{"raw_affiliation_string":"College of Mathematics and System Sciences","institution_ids":["https://openalex.org/I3132770690"]},{"raw_affiliation_string":"Institutes of Physical Science and Information Technology","institution_ids":[]},{"raw_affiliation_string":"Xinjiang University","institution_ids":["https://openalex.org/I96908189"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5065943710","https://openalex.org/A5078955823","https://openalex.org/A5102443929"],"corresponding_institution_ids":["https://openalex.org/I143868143","https://openalex.org/I3132770690","https://openalex.org/I4210123509","https://openalex.org/I96908189"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15139142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":"19","first_page":"10124","last_page":"10140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.6276999711990356},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.5414999723434448},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.5389000177383423},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4876999855041504},{"id":"https://openalex.org/keywords/complement","display_name":"Complement (music)","score":0.46549999713897705},{"id":"https://openalex.org/keywords/class","display_name":"Class (philosophy)","score":0.44290000200271606},{"id":"https://openalex.org/keywords/dependency","display_name":"Dependency (UML)","score":0.435699999332428},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4068000018596649}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7116000056266785},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6948999762535095},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.6276999711990356},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.5414999723434448},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.5389000177383423},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4876999855041504},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.47130000591278076},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.46549999713897705},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.44290000200271606},{"id":"https://openalex.org/C19768560","wikidata":"https://www.wikidata.org/wiki/Q320727","display_name":"Dependency (UML)","level":2,"score":0.435699999332428},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4068000018596649},{"id":"https://openalex.org/C59404180","wikidata":"https://www.wikidata.org/wiki/Q17013334","display_name":"Feature learning","level":2,"score":0.37689998745918274},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.34940001368522644},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.34310001134872437},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.34209999442100525},{"id":"https://openalex.org/C116409475","wikidata":"https://www.wikidata.org/wiki/Q1385056","display_name":"External Data Representation","level":2,"score":0.2879999876022339},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.27950000762939453},{"id":"https://openalex.org/C2778827112","wikidata":"https://www.wikidata.org/wiki/Q22245680","display_name":"Feature engineering","level":3,"score":0.2727999985218048},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.26980000734329224},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.2533999979496002},{"id":"https://openalex.org/C35639132","wikidata":"https://www.wikidata.org/wiki/Q7452468","display_name":"Sequence labeling","level":3,"score":0.2524000108242035}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5c01693","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c01693","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:40968106","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40968106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2245046682","display_name":null,"funder_award_id":"U22A2038","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7779363393","display_name":null,"funder_award_id":"62362062","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7875118602","display_name":null,"funder_award_id":"2023TSYCCX0104","funder_id":"https://openalex.org/F4320328897","funder_display_name":"Science and Technology Department of Xinjiang Uyghur Autonomous Region"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320328897","display_name":"Science and Technology Department of Xinjiang Uyghur Autonomous Region","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1985718949","https://openalex.org/W2023313300","https://openalex.org/W2097099115","https://openalex.org/W2158266834","https://openalex.org/W2161621183","https://openalex.org/W2291955298","https://openalex.org/W2616247523","https://openalex.org/W2884561390","https://openalex.org/W2936599975","https://openalex.org/W2962946486","https://openalex.org/W2963691377","https://openalex.org/W2982010568","https://openalex.org/W2987660980","https://openalex.org/W2988152053","https://openalex.org/W3017630416","https://openalex.org/W3095707208","https://openalex.org/W3102564565","https://openalex.org/W3177500196","https://openalex.org/W3191622657","https://openalex.org/W3196522895","https://openalex.org/W3205925781","https://openalex.org/W3212589311","https://openalex.org/W4212959738","https://openalex.org/W4225983992","https://openalex.org/W4280580514","https://openalex.org/W4286500588","https://openalex.org/W4295879738","https://openalex.org/W4297733535","https://openalex.org/W4307645443","https://openalex.org/W4317388119","https://openalex.org/W4363671627","https://openalex.org/W4377223989","https://openalex.org/W4384789364","https://openalex.org/W4386736447","https://openalex.org/W4387670171","https://openalex.org/W4387776183","https://openalex.org/W4388035706","https://openalex.org/W4389060417","https://openalex.org/W4390190773","https://openalex.org/W4391216324","https://openalex.org/W4391420880","https://openalex.org/W4392162030","https://openalex.org/W4393160187","https://openalex.org/W4399768828","https://openalex.org/W4400189017","https://openalex.org/W4400878675","https://openalex.org/W4401732620","https://openalex.org/W4403782504","https://openalex.org/W4404447386","https://openalex.org/W4404677102","https://openalex.org/W4405703001","https://openalex.org/W4406440058","https://openalex.org/W4408416453","https://openalex.org/W4409347189"],"related_works":[],"abstract_inverted_index":{"With":[0],"the":[1,8,39,45,101,125,148,160,199],"increasing":[2],"discovery":[3],"of":[4,41,48,150,162,169,182,225],"peptide":[5,22,49,129,178,217],"sequences":[6],"and":[7,30,71,97,110,152,192,222],"growing":[9],"demand":[10],"for":[11,21,44,215],"peptide-targeted":[12],"drugs,":[13],"traditional":[14],"wet-lab":[15],"experiment":[16],"methods":[17,56,175],"have":[18],"become":[19],"inadequate":[20,72],"function":[23],"prediction":[24,81,168],"due":[25],"to":[26,106],"their":[27],"high":[28],"cost":[29],"that":[31,146,207],"they":[32],"are":[33,57],"time":[34],"consuming.":[35],"This":[36,157],"has":[37],"made":[38],"development":[40],"computational":[42,55],"tools":[43],"accurate":[46,167,223],"identification":[47,224],"functions":[50],"particularly":[51],"urgent.":[52],"However,":[53],"existing":[54],"limited":[58],"by":[59,123,203],"challenges":[60],"such":[61],"as":[62,211],"data":[63],"sparsity,":[64],"long-tailed":[65],"distribution":[66],"imbalance,":[67],"label":[68],"dependency":[69],"modeling":[70],"class":[73,120],"feature":[74,112,121],"representation":[75,109,122],"in":[76,84,114,176,184,187,190,194],"multifunctional":[77,177,216],"therapeutic":[78],"peptides":[79],"(MFTP)":[80],"tasks,":[82],"resulting":[83],"suboptimal":[85],"performance.":[86],"To":[87],"address":[88],"these":[89,137],"limitations,":[90],"we":[91,139],"first":[92],"introduce":[93],"two":[94],"subclassifiers:":[95],"SLFE":[96,99,151],"CFEC.":[98],"leverages":[100],"large":[102],"language":[103],"model":[104],"ESMC":[105],"complement":[107],"sequence":[108],"alleviate":[111],"insufficiency":[113],"tail-class":[115],"data,":[116],"while":[117,197],"CFEC":[118,153],"improves":[119],"enhancing":[124],"learning":[126,144],"on":[127,136],"single-function":[128],"samples":[130],"combined":[131],"with":[132],"contrastive":[133],"learning.":[134],"Based":[135],"subclassifiers,":[138],"propose":[140],"MCMFPP,":[141],"a":[142,212],"deep":[143],"method":[145,158],"integrates":[147],"predictions":[149],"through":[154],"weighted":[155],"fusion.":[156],"overcomes":[159],"constraints":[161],"single-classifier":[163],"approaches,":[164],"enabling":[165,219],"more":[166,220],"challenging":[170],"samples.":[171],"MCMFPP":[172,208],"outperforms":[173],"state-of-the-art":[174],"prediction,":[179,218],"achieving":[180],"improvements":[181],"3.1%":[183],"precision,":[185],"2.7%":[186,193],"coverage,":[188],"2.8%":[189],"accuracy,":[191],"absolute":[195,200],"true":[196],"reducing":[198],"false":[201],"rate":[202],"0.3%.":[204],"We":[205],"anticipate":[206],"will":[209],"serve":[210],"valuable":[213],"tool":[214],"efficient":[221],"candidate":[226],"peptides.":[227]},"counts_by_year":[],"updated_date":"2026-07-25T09:21:30.201066","created_date":"2025-10-10T00:00:00"}
