{"id":"https://openalex.org/W4416602253","doi":"https://doi.org/10.1021/acs.jcim.5c01397","title":"OmniCLIC: A Unified Omics Contrastive Learning Framework for Effective Integration and Classification of Multiomics Data","display_name":"OmniCLIC: A Unified Omics Contrastive Learning Framework for Effective Integration and Classification of Multiomics Data","publication_year":2025,"publication_date":"2025-11-09","ids":{"openalex":"https://openalex.org/W4416602253","doi":"https://doi.org/10.1021/acs.jcim.5c01397","pmid":"https://pubmed.ncbi.nlm.nih.gov/41206807"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c01397","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c01397","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066992312","display_name":"Mingzhou Zhang","orcid":"https://orcid.org/0009-0006-5483-7166"},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingzhou Zhang","raw_affiliation_strings":["Hebei University of Technology","School of Artificial Intelligence","School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China"],"raw_orcid":"https://orcid.org/0009-0006-5483-7166","affiliations":[{"raw_affiliation_string":"Hebei University of Technology","institution_ids":["https://openalex.org/I184843921"]},{"raw_affiliation_string":"School of Artificial Intelligence","institution_ids":[]},{"raw_affiliation_string":"School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China","institution_ids":["https://openalex.org/I184843921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045575546","display_name":"X. Shirley Liu","orcid":"https://orcid.org/0000-0003-4736-7339"},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuzeng Liu","raw_affiliation_strings":["Hebei University of Technology","School of Artificial Intelligence","School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebei University of Technology","institution_ids":["https://openalex.org/I184843921"]},{"raw_affiliation_string":"School of Artificial Intelligence","institution_ids":[]},{"raw_affiliation_string":"School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China","institution_ids":["https://openalex.org/I184843921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010106814","display_name":"Wenyan Chu","orcid":"https://orcid.org/0000-0002-8898-5662"},"institutions":[{"id":"https://openalex.org/I34155123","display_name":"Hebei University of Science and Technology","ror":"https://ror.org/05h3pkk68","country_code":"CN","type":"education","lineage":["https://openalex.org/I34155123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyan Chu","raw_affiliation_strings":["Hebei Vocational University of Technology and Engineering","School of Electrical Engineering","School of Electrical Engineering, Hebei Vocational University of Technology and Engineering, Xing Tai 054000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebei Vocational University of Technology and Engineering","institution_ids":[]},{"raw_affiliation_string":"School of Electrical Engineering","institution_ids":[]},{"raw_affiliation_string":"School of Electrical Engineering, Hebei Vocational University of Technology and Engineering, Xing Tai 054000, China","institution_ids":["https://openalex.org/I34155123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438425","display_name":"Hang Zhang","orcid":"https://orcid.org/0000-0001-5570-8522"},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hang Zhang","raw_affiliation_strings":["Hebei University of Technology","School of Artificial Intelligence","School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebei University of Technology","institution_ids":["https://openalex.org/I184843921"]},{"raw_affiliation_string":"School of Artificial Intelligence","institution_ids":[]},{"raw_affiliation_string":"School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China","institution_ids":["https://openalex.org/I184843921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100727355","display_name":"Yunhe Wang","orcid":"https://orcid.org/0000-0002-0013-4530"},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]},{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210136497","display_name":"Jilin Medical University","ror":"https://ror.org/03mzw7781","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210136497"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yunhe Wang","raw_affiliation_strings":["Hebei University of Technology","Jilin University","Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education","School of Artificial Intelligence","Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun 130012, China","School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebei University of Technology","institution_ids":["https://openalex.org/I184843921"]},{"raw_affiliation_string":"Jilin University","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210136497"]},{"raw_affiliation_string":"Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education","institution_ids":[]},{"raw_affiliation_string":"School of Artificial Intelligence","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun 130012, China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China","institution_ids":["https://openalex.org/I184843921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100727355"],"corresponding_institution_ids":["https://openalex.org/I184843921","https://openalex.org/I194450716","https://openalex.org/I4210136497"],"apc_list":null,"apc_paid":null,"fwci":0.8477,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.74969764,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"65","issue":"22","first_page":"12592","last_page":"12607"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.6581000089645386,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.6581000089645386,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.2361000031232834,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.029500000178813934,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.6401000022888184},{"id":"https://openalex.org/keywords/data-integration","display_name":"Data integration","score":0.49950000643730164},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.38850000500679016},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.35920000076293945},{"id":"https://openalex.org/keywords/big-data","display_name":"Big data","score":0.3506999909877777},{"id":"https://openalex.org/keywords/external-data-representation","display_name":"External Data Representation","score":0.3228999972343445},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.320499986410141},{"id":"https://openalex.org/keywords/data-type","display_name":"Data type","score":0.3124000132083893}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7002999782562256},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.6401000022888184},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5825999975204468},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.49950000643730164},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.40310001373291016},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.38850000500679016},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.35920000076293945},{"id":"https://openalex.org/C75684735","wikidata":"https://www.wikidata.org/wiki/Q858810","display_name":"Big data","level":2,"score":0.3506999909877777},{"id":"https://openalex.org/C116409475","wikidata":"https://www.wikidata.org/wiki/Q1385056","display_name":"External Data Representation","level":2,"score":0.3228999972343445},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.320499986410141},{"id":"https://openalex.org/C138958017","wikidata":"https://www.wikidata.org/wiki/Q190087","display_name":"Data type","level":2,"score":0.3124000132083893},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.3107999861240387},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.31049999594688416},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.3082999885082245},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.28690001368522644},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2831999957561493},{"id":"https://openalex.org/C164614171","wikidata":"https://www.wikidata.org/wiki/Q5204775","display_name":"DECIPHER","level":2,"score":0.28029999136924744},{"id":"https://openalex.org/C2776135515","wikidata":"https://www.wikidata.org/wiki/Q17143721","display_name":"Regularization (linguistics)","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.26440000534057617},{"id":"https://openalex.org/C33954974","wikidata":"https://www.wikidata.org/wiki/Q486494","display_name":"Sensor fusion","level":2,"score":0.2612000107765198},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.25929999351501465},{"id":"https://openalex.org/C22019652","wikidata":"https://www.wikidata.org/wiki/Q331309","display_name":"Overfitting","level":3,"score":0.25609999895095825},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.2531000077724457}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5c01397","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c01397","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:41206807","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41206807","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G125660903","display_name":null,"funder_award_id":"62206086","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G46117027","display_name":null,"funder_award_id":"F2023202062","funder_id":"https://openalex.org/F4320322163","funder_display_name":"Natural Science Foundation of Hebei Province"},{"id":"https://openalex.org/G8669778295","display_name":null,"funder_award_id":"62376088","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322163","display_name":"Natural Science Foundation of Hebei Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1982645824","https://openalex.org/W1995341919","https://openalex.org/W2001619934","https://openalex.org/W2022774313","https://openalex.org/W2024273435","https://openalex.org/W2043895269","https://openalex.org/W2064675550","https://openalex.org/W2087347434","https://openalex.org/W2122111042","https://openalex.org/W2131994307","https://openalex.org/W2147800946","https://openalex.org/W2295598076","https://openalex.org/W2796153844","https://openalex.org/W2911964244","https://openalex.org/W2912322140","https://openalex.org/W3096353101","https://openalex.org/W3119371657","https://openalex.org/W3130969319","https://openalex.org/W3132191748","https://openalex.org/W3155110726","https://openalex.org/W3170986249","https://openalex.org/W3174086521","https://openalex.org/W3196650609","https://openalex.org/W3201807079","https://openalex.org/W3211269771","https://openalex.org/W4200307603","https://openalex.org/W4200581587","https://openalex.org/W4225278475","https://openalex.org/W4226194419","https://openalex.org/W4294805059","https://openalex.org/W4312946813","https://openalex.org/W4367051143","https://openalex.org/W4382318546","https://openalex.org/W4384207011","https://openalex.org/W4391294262","https://openalex.org/W4396888913","https://openalex.org/W4396895472","https://openalex.org/W4400434847","https://openalex.org/W4401093660","https://openalex.org/W4403351431"],"related_works":[],"abstract_inverted_index":{"Integrating":[0],"multiomics":[1,44,128,175,190],"data":[2,111,129,176,191],"for":[3,70],"cancer":[4,110,167],"subtype":[5],"classification":[6],"remains":[7],"a":[8,32,58,74,88,97],"critical":[9],"yet":[10],"challenging":[11],"task":[12],"due":[13],"to":[14,101,173],"the":[15,151,186],"high":[16],"dimensionality,":[17],"heterogeneity,":[18],"and":[19,37,48,67,83,86,121,126,161],"limited":[20],"interpretability":[21],"of":[22],"omics":[23],"features.":[24],"To":[25],"address":[26],"these":[27],"limitations,":[28],"we":[29],"propose":[30],"OmniCLIC,":[31],"unified":[33],"Omics":[34],"Contrastive":[35],"Learning":[36],"Integration":[38],"Classification":[39],"framework":[40],"that":[41,78,92],"enables":[42,133],"end-to-end":[43],"integration,":[45],"feature":[46],"learning,":[47],"prediction.":[49],"Three":[50],"key":[51,139],"components":[52],"are":[53],"proposed":[54],"in":[55,119],"OmniCLIC:":[56],"OmniNet,":[57],"customized":[59],"MLP":[60],"with":[61,165],"feature-wise":[62],"scaling,":[63],"neural":[64],"tangent":[65],"parametrization,":[66],"regularization":[68],"strategies":[69],"omics-specific":[71],"representation":[72],"learning;":[73],"contrastive":[75,82],"learning":[76],"module":[77,91],"jointly":[79],"optimizes":[80],"supervised":[81],"cross-entropy":[84],"losses;":[85],"OCDN,":[87],"decision-level":[89],"fusion":[90],"captures":[93],"interomics":[94],"correlations":[95],"via":[96],"cross-modal":[98],"correlation":[99],"tensor":[100],"enhance":[102],"generalization.":[103],"We":[104,169],"evaluate":[105],"OmniCLIC":[106,132,172],"on":[107,150],"four":[108],"benchmark":[109],"sets,":[112],"where":[113,179],"it":[114,180],"consistently":[115],"outperforms":[116,182],"state-of-the-art":[117],"methods":[118],"accuracy":[120],"robustness":[122],"across":[123,189],"both":[124],"binary":[125],"multiclass":[127],"sets.":[130],"Furthermore,":[131],"biologically":[134],"meaningful":[135],"interpretation":[136],"by":[137],"identifying":[138],"molecular":[140],"features":[141,153],"through":[142],"its":[143],"built-in":[144],"scaling":[145],"layers.":[146],"Functional":[147],"enrichment":[148],"analyses":[149],"selected":[152],"reveal":[154],"subtype-specific":[155],"pathways,":[156],"such":[157],"as":[158],"epithelial":[159],"morphogenesis":[160],"PI3K-Akt":[162],"signaling,":[163],"aligned":[164],"known":[166],"biology.":[168],"further":[170],"extend":[171],"single-cell":[174],"(RNA+ATAC,":[177],"RNA+ADT),":[178],"still":[181],"existing":[183],"methods,":[184],"verifying":[185],"framework's":[187],"generalizability":[188],"at":[192],"different":[193],"scales.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-11-09T00:00:00"}