{"id":"https://openalex.org/W4411365234","doi":"https://doi.org/10.1021/acs.jcim.5c00946","title":"Higher-Order Weighted Perturbation-Based Multilevel Information Fusion Model for Predicting CircRNA\u2013Disease Associations","display_name":"Higher-Order Weighted Perturbation-Based Multilevel Information Fusion Model for Predicting CircRNA\u2013Disease Associations","publication_year":2025,"publication_date":"2025-06-17","ids":{"openalex":"https://openalex.org/W4411365234","doi":"https://doi.org/10.1021/acs.jcim.5c00946","pmid":"https://pubmed.ncbi.nlm.nih.gov/40526477"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c00946","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00946","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054060458","display_name":"Shanchen Pang","orcid":"https://orcid.org/0000-0002-5705-1218"},"institutions":[{"id":"https://openalex.org/I4210128818","display_name":"Institute of Software","ror":"https://ror.org/033dfsn42","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210128818"]},{"id":"https://openalex.org/I4210156066","display_name":"State Key Laboratory of Chemical Engineering","ror":"https://ror.org/05803vc71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210156066"]},{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanchen Pang","raw_affiliation_strings":["China University of Petroleum (East China)","College of Computer Science and Technology, Qingdao Institute of Software","Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software","State Key Laboratory of Chemical Safety","College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum (East China), Qingdao 266580, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China University of Petroleum (East China)","institution_ids":["https://openalex.org/I4210162190"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software","institution_ids":["https://openalex.org/I4210128818"]},{"raw_affiliation_string":"Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Chemical Safety","institution_ids":["https://openalex.org/I4210156066"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum (East China), Qingdao 266580, China","institution_ids":["https://openalex.org/I4210162190"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zheqi Song","orcid":"https://orcid.org/0009-0003-3932-8943"},"institutions":[{"id":"https://openalex.org/I4210128818","display_name":"Institute of Software","ror":"https://ror.org/033dfsn42","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210128818"]},{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheqi Song","raw_affiliation_strings":["China University of Petroleum (East China)","College of Computer Science and Technology, Qingdao Institute of Software","College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum (East China), Qingdao 266580, China"],"raw_orcid":"https://orcid.org/0009-0003-3932-8943","affiliations":[{"raw_affiliation_string":"China University of Petroleum (East China)","institution_ids":["https://openalex.org/I4210162190"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software","institution_ids":["https://openalex.org/I4210128818"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum (East China), Qingdao 266580, China","institution_ids":["https://openalex.org/I4210162190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025726387","display_name":"Yunyin Li","orcid":"https://orcid.org/0009-0001-5042-5504"},"institutions":[{"id":"https://openalex.org/I4210128818","display_name":"Institute of Software","ror":"https://ror.org/033dfsn42","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210128818"]},{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunyin Li","raw_affiliation_strings":["China University of Petroleum (East China)","College of Computer Science and Technology, Qingdao Institute of Software","College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum (East China), Qingdao 266580, China"],"raw_orcid":"https://orcid.org/0009-0001-5042-5504","affiliations":[{"raw_affiliation_string":"China University of Petroleum (East China)","institution_ids":["https://openalex.org/I4210162190"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software","institution_ids":["https://openalex.org/I4210128818"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum (East China), Qingdao 266580, China","institution_ids":["https://openalex.org/I4210162190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055241786","display_name":"Wenhao Wu","orcid":"https://orcid.org/0000-0002-2244-6543"},"institutions":[{"id":"https://openalex.org/I4210128818","display_name":"Institute of Software","ror":"https://ror.org/033dfsn42","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210128818"]},{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhao Wu","raw_affiliation_strings":["China University of Petroleum (East China)","College of Computer Science and Technology, Qingdao Institute of Software","College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum (East China), Qingdao 266580, China"],"raw_orcid":"https://orcid.org/0000-0002-2244-6543","affiliations":[{"raw_affiliation_string":"China University of Petroleum (East China)","institution_ids":["https://openalex.org/I4210162190"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software","institution_ids":["https://openalex.org/I4210128818"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum (East China), Qingdao 266580, China","institution_ids":["https://openalex.org/I4210162190"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu Zhang","orcid":"https://orcid.org/0009-0009-8363-4132"},"institutions":[{"id":"https://openalex.org/I4210128818","display_name":"Institute of Software","ror":"https://ror.org/033dfsn42","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210128818"]},{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]},{"id":"https://openalex.org/I44468530","display_name":"Qingdao University of Technology","ror":"https://ror.org/01qzc0f54","country_code":"CN","type":"education","lineage":["https://openalex.org/I44468530"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Zhang","raw_affiliation_strings":["China University of Petroleum (East China)","College of Computer Science and Technology, Qingdao Institute of Software","Qingdao University of Technology","School of Information and Control Engineering","College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum (East China), Qingdao 266580, China"],"raw_orcid":"https://orcid.org/0009-0009-8363-4132","affiliations":[{"raw_affiliation_string":"China University of Petroleum (East China)","institution_ids":["https://openalex.org/I4210162190"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software","institution_ids":["https://openalex.org/I4210128818"]},{"raw_affiliation_string":"Qingdao University of Technology","institution_ids":["https://openalex.org/I44468530"]},{"raw_affiliation_string":"School of Information and Control Engineering","institution_ids":[]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum (East China), Qingdao 266580, China","institution_ids":["https://openalex.org/I4210162190"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu Zhang","orcid":"https://orcid.org/0009-0009-8363-4132"},"institutions":[{"id":"https://openalex.org/I4210128818","display_name":"Institute of Software","ror":"https://ror.org/033dfsn42","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210128818"]},{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]},{"id":"https://openalex.org/I44468530","display_name":"Qingdao University of Technology","ror":"https://ror.org/01qzc0f54","country_code":"CN","type":"education","lineage":["https://openalex.org/I44468530"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yu Zhang","raw_affiliation_strings":["China University of Petroleum (East China)","College of Computer Science and Technology, Qingdao Institute of Software","Qingdao University of Technology","School of Information and Control Engineering"],"raw_orcid":"https://orcid.org/0009-0009-8363-4132","affiliations":[{"raw_affiliation_string":"China University of Petroleum (East China)","institution_ids":["https://openalex.org/I4210162190"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software","institution_ids":["https://openalex.org/I4210128818"]},{"raw_affiliation_string":"Qingdao University of Technology","institution_ids":["https://openalex.org/I44468530"]},{"raw_affiliation_string":"School of Information and Control Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320647","display_name":"Yuanyuan Zhang","orcid":"https://orcid.org/0009-0005-6934-8245"},"institutions":[{"id":"https://openalex.org/I4210128818","display_name":"Institute of Software","ror":"https://ror.org/033dfsn42","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210128818"]},{"id":"https://openalex.org/I4210156066","display_name":"State Key Laboratory of Chemical Engineering","ror":"https://ror.org/05803vc71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210156066"]},{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]},{"id":"https://openalex.org/I44468530","display_name":"Qingdao University of Technology","ror":"https://ror.org/01qzc0f54","country_code":"CN","type":"education","lineage":["https://openalex.org/I44468530"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Zhang","raw_affiliation_strings":["China University of Petroleum (East China)","College of Computer Science and Technology, Qingdao Institute of Software","Qingdao University of Technology","School of Information and Control Engineering","College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum (East China), Qingdao 266580, China","Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software","State Key Laboratory of Chemical Safety"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China University of Petroleum (East China)","institution_ids":["https://openalex.org/I4210162190"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software","institution_ids":["https://openalex.org/I4210128818"]},{"raw_affiliation_string":"Qingdao University of Technology","institution_ids":["https://openalex.org/I44468530"]},{"raw_affiliation_string":"School of Information and Control Engineering","institution_ids":[]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum (East China), Qingdao 266580, China","institution_ids":["https://openalex.org/I4210162190"]},{"raw_affiliation_string":"Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Chemical Safety","institution_ids":["https://openalex.org/I4210156066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320647","display_name":"Yuanyuan Zhang","orcid":"https://orcid.org/0009-0005-6934-8245"},"institutions":[{"id":"https://openalex.org/I4210128818","display_name":"Institute of Software","ror":"https://ror.org/033dfsn42","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210128818"]},{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]},{"id":"https://openalex.org/I44468530","display_name":"Qingdao University of Technology","ror":"https://ror.org/01qzc0f54","country_code":"CN","type":"education","lineage":["https://openalex.org/I44468530"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuanyuan Zhang","raw_affiliation_strings":["China University of Petroleum (East China)","College of Computer Science and Technology, Qingdao Institute of Software","Qingdao University of Technology","School of Information and Control Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China University of Petroleum (East China)","institution_ids":["https://openalex.org/I4210162190"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software","institution_ids":["https://openalex.org/I4210128818"]},{"raw_affiliation_string":"Qingdao University of Technology","institution_ids":["https://openalex.org/I44468530"]},{"raw_affiliation_string":"School of Information and Control Engineering","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076511286","display_name":"Shudong Wang","orcid":"https://orcid.org/0000-0001-6225-5525"},"institutions":[{"id":"https://openalex.org/I4210128818","display_name":"Institute of Software","ror":"https://ror.org/033dfsn42","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210128818"]},{"id":"https://openalex.org/I4210156066","display_name":"State Key Laboratory of Chemical Engineering","ror":"https://ror.org/05803vc71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210156066"]},{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shudong Wang","raw_affiliation_strings":["China University of Petroleum (East China)","College of Computer Science and Technology, Qingdao Institute of Software","Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software","State Key Laboratory of Chemical Safety"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China University of Petroleum (East China)","institution_ids":["https://openalex.org/I4210162190"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software","institution_ids":["https://openalex.org/I4210128818"]},{"raw_affiliation_string":"Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Chemical Safety","institution_ids":["https://openalex.org/I4210156066"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5076511286","https://openalex.org/A5100320647"],"corresponding_institution_ids":["https://openalex.org/I4210128818","https://openalex.org/I4210156066","https://openalex.org/I4210162190","https://openalex.org/I44468530"],"apc_list":null,"apc_paid":null,"fwci":0.5942,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.6760295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"65","issue":"13","first_page":"7302","last_page":"7314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9686999917030334,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11222","display_name":"Magnetic Properties and Applications","score":0.9333999752998352,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fusion","display_name":"Fusion","score":0.49647241830825806},{"id":"https://openalex.org/keywords/perturbation","display_name":"Perturbation (astronomy)","score":0.47407951951026917},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45155584812164307},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4416019916534424},{"id":"https://openalex.org/keywords/order","display_name":"Order (exchange)","score":0.44001591205596924},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.36799728870391846},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.33503419160842896},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2682918310165405},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.15337088704109192},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13087159395217896}],"concepts":[{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.49647241830825806},{"id":"https://openalex.org/C177918212","wikidata":"https://www.wikidata.org/wiki/Q803623","display_name":"Perturbation (astronomy)","level":2,"score":0.47407951951026917},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45155584812164307},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4416019916534424},{"id":"https://openalex.org/C182306322","wikidata":"https://www.wikidata.org/wiki/Q1779371","display_name":"Order (exchange)","level":2,"score":0.44001591205596924},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.36799728870391846},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.33503419160842896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2682918310165405},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15337088704109192},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13087159395217896},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5c00946","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00946","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:40526477","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40526477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/13","score":0.5400000214576721,"display_name":"Climate action"}],"awards":[{"id":"https://openalex.org/G1766936458","display_name":null,"funder_award_id":"25CX04026A","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G3390906453","display_name":null,"funder_award_id":"2021YFA10000102","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W2106029302","https://openalex.org/W2141222510","https://openalex.org/W2148489082","https://openalex.org/W2741786914","https://openalex.org/W2789309338","https://openalex.org/W2800766678","https://openalex.org/W2807602500","https://openalex.org/W2884943532","https://openalex.org/W2927302367","https://openalex.org/W2999565738","https://openalex.org/W3034046925","https://openalex.org/W3088932934","https://openalex.org/W3187741653","https://openalex.org/W3206737896","https://openalex.org/W4213326951","https://openalex.org/W4226097900","https://openalex.org/W4283772644","https://openalex.org/W4294908570","https://openalex.org/W4308425600","https://openalex.org/W4313706461","https://openalex.org/W4367049415","https://openalex.org/W4382631659","https://openalex.org/W4384664737","https://openalex.org/W4388698606","https://openalex.org/W4388820050","https://openalex.org/W4389751883","https://openalex.org/W4391618879","https://openalex.org/W4392558716","https://openalex.org/W4401009333","https://openalex.org/W4401019921","https://openalex.org/W4402036549","https://openalex.org/W4405474866","https://openalex.org/W4406081014","https://openalex.org/W4406238070","https://openalex.org/W4407892787","https://openalex.org/W4408082228","https://openalex.org/W4408209802"],"related_works":["https://openalex.org/W2099421762","https://openalex.org/W2530546662","https://openalex.org/W2967030268","https://openalex.org/W2185253430","https://openalex.org/W4210345652","https://openalex.org/W1984333081","https://openalex.org/W2945063165","https://openalex.org/W3188962172","https://openalex.org/W2205042400","https://openalex.org/W2090790166"],"abstract_inverted_index":{"CircRNAs":[0],"are":[1],"closely":[2],"associated":[3],"with":[4],"the":[5,34,84,133,168,174],"initiation":[6],"and":[7,12,43,112,163,170],"progression":[8],"of":[9,86,136,158,173],"various":[10],"diseases,":[11],"investigating":[13],"their":[14],"potential":[15],"associations":[16,40],"is":[17,78,105,122],"crucial":[18],"for":[19],"understanding":[20],"disease":[21],"mechanisms.":[22],"Although":[23],"existing":[24],"computational":[25],"methods":[26,47,155],"have":[27],"made":[28],"notable":[29],"progress,":[30],"they":[31],"often":[32,48],"overlook":[33],"latent":[35],"information":[36,74],"contained":[37],"in":[38,143,156],"higher-order":[39,91,97],"between":[41],"circRNAs":[42],"diseases.":[44],"Moreover,":[45],"these":[46],"rely":[49],"on":[50,146],"a":[51,69,90,109,117],"single":[52],"linear":[53,114],"or":[54],"nonlinear":[55,127],"feature":[56,119],"learning":[57,120],"approach,":[58],"which":[59],"fails":[60],"to":[61,95,107,124],"comprehensively":[62],"capture":[63,135],"multilevel":[64,73,137],"features.":[65,115,138],"To":[66],"address":[67],"this,":[68],"high-order":[70],"weighted":[71,92],"perturbation-based":[72],"fusion":[75],"model":[76,81],"(HWP-MIFM)":[77],"proposed.":[79],"The":[80],"dynamically":[82],"adjusts":[83],"weights":[85],"different":[87],"orders":[88],"using":[89],"perturbation":[93],"method":[94],"extract":[96,113],"association":[98],"information.":[99],"A":[100],"dual-stage":[101],"matrix":[102],"factorization":[103],"module":[104,121],"applied":[106],"construct":[108],"multilayer":[110],"structure":[111],"Additionally,":[116],"dual-path":[118],"utilized":[123],"dig":[125],"complex":[126],"relationships":[128],"within":[129],"similarity":[130],"networks,":[131],"ensuring":[132],"comprehensive":[134],"Experimental":[139],"results":[140],"demonstrate":[141],"that,":[142],"5-fold":[144],"cross-validation":[145],"four":[147],"data":[148],"sets,":[149],"HWP-MIFM":[150],"outperforms":[151],"seven":[152],"state-of-the-art":[153],"prediction":[154],"terms":[157],"overall":[159],"performance.":[160],"Ablation":[161],"studies":[162],"case":[164],"analyses":[165],"further":[166],"confirm":[167],"accuracy":[169],"practical":[171],"value":[172],"model.":[175]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-06-04T09:04:59.091469","created_date":"2025-10-10T00:00:00"}