{"id":"https://openalex.org/W4411548596","doi":"https://doi.org/10.1021/acs.jcim.5c00841","title":"CHARMM-GUI <i>Bicelle Builder</i>: An Extension of <i>Membrane Builder</i> for Modeling and Simulation of Bicelle Systems","display_name":"CHARMM-GUI <i>Bicelle Builder</i>: An Extension of <i>Membrane Builder</i> for Modeling and Simulation of Bicelle Systems","publication_year":2025,"publication_date":"2025-06-23","ids":{"openalex":"https://openalex.org/W4411548596","doi":"https://doi.org/10.1021/acs.jcim.5c00841","pmid":"https://pubmed.ncbi.nlm.nih.gov/40549978"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c00841","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00841","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.5c00841?ref=article_openPDF","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.5c00841?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091459701","display_name":"Seonghan Kim","orcid":"https://orcid.org/0000-0002-1890-0061"},"institutions":[{"id":"https://openalex.org/I186143895","display_name":"Lehigh University","ror":"https://ror.org/012afjb06","country_code":"US","type":"education","lineage":["https://openalex.org/I186143895"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seonghan Kim","raw_affiliation_strings":["Department of Bioengineering","Lehigh University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering","institution_ids":[]},{"raw_affiliation_string":"Lehigh University","institution_ids":["https://openalex.org/I186143895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013300573","display_name":"Nathan R. Kern","orcid":"https://orcid.org/0000-0003-0936-7274"},"institutions":[{"id":"https://openalex.org/I186143895","display_name":"Lehigh University","ror":"https://ror.org/012afjb06","country_code":"US","type":"education","lineage":["https://openalex.org/I186143895"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan R. Kern","raw_affiliation_strings":["Department of Computer Science & Engineering","Lehigh University"],"raw_orcid":"https://orcid.org/0000-0003-0936-7274","affiliations":[{"raw_affiliation_string":"Department of Computer Science & Engineering","institution_ids":[]},{"raw_affiliation_string":"Lehigh University","institution_ids":["https://openalex.org/I186143895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118595363","display_name":"Lauren Paolucci","orcid":null},"institutions":[{"id":"https://openalex.org/I186143895","display_name":"Lehigh University","ror":"https://ror.org/012afjb06","country_code":"US","type":"education","lineage":["https://openalex.org/I186143895"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Paolucci","raw_affiliation_strings":["Department of Bioengineering","Lehigh University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering","institution_ids":[]},{"raw_affiliation_string":"Lehigh University","institution_ids":["https://openalex.org/I186143895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118595364","display_name":"Alan Jaemin Jo","orcid":null},"institutions":[{"id":"https://openalex.org/I4210103791","display_name":"William Howard Taft University","ror":"https://ror.org/026s89d26","country_code":"US","type":"education","lineage":["https://openalex.org/I4210103791","https://openalex.org/I4210120201"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Jaemin Jo","raw_affiliation_strings":["William Howard Taft Charter High School","William Howard Taft Charter High School, Woodland Hills, California 91364, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Howard Taft Charter High School","institution_ids":["https://openalex.org/I4210103791"]},{"raw_affiliation_string":"William Howard Taft Charter High School, Woodland Hills, California 91364, United States","institution_ids":["https://openalex.org/I4210103791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019837519","display_name":"Christopher P. Baryiames","orcid":"https://orcid.org/0000-0001-5683-8126"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher P. Baryiames","raw_affiliation_strings":["Department of Chemistry","University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017696854","display_name":"D. Peter Tieleman","orcid":"https://orcid.org/0000-0001-5507-0688"},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D. Peter Tieleman","raw_affiliation_strings":["Department of Biological Sciences and Centre for Molecular Simulation","University of Calgary"],"raw_orcid":"https://orcid.org/0000-0001-5507-0688","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Centre for Molecular Simulation","institution_ids":[]},{"raw_affiliation_string":"University of Calgary","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006619315","display_name":"Linda Columbus","orcid":"https://orcid.org/0000-0002-2574-0561"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Columbus","raw_affiliation_strings":["Department of Chemistry","University of Virginia"],"raw_orcid":"https://orcid.org/0000-0002-2574-0561","affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030884127","display_name":"Wonpil Im","orcid":"https://orcid.org/0000-0001-5642-6041"},"institutions":[{"id":"https://openalex.org/I186143895","display_name":"Lehigh University","ror":"https://ror.org/012afjb06","country_code":"US","type":"education","lineage":["https://openalex.org/I186143895"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wonpil Im","raw_affiliation_strings":["Department of Bioengineering","Department of Biological Sciences","Department of Computer Science & Engineering","Lehigh University"],"raw_orcid":"https://orcid.org/0000-0001-5642-6041","affiliations":[{"raw_affiliation_string":"Department of Bioengineering","institution_ids":[]},{"raw_affiliation_string":"Department of Biological Sciences","institution_ids":[]},{"raw_affiliation_string":"Department of Computer Science & Engineering","institution_ids":[]},{"raw_affiliation_string":"Lehigh University","institution_ids":["https://openalex.org/I186143895"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5030884127"],"corresponding_institution_ids":["https://openalex.org/I186143895"],"apc_list":null,"apc_paid":null,"fwci":0.8126,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.70516885,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"65","issue":"13","first_page":"7081","last_page":"7088"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/model-lipid-bilayer","display_name":"Model lipid bilayer","score":0.9243245124816895},{"id":"https://openalex.org/keywords/micelle","display_name":"Micelle","score":0.7524930238723755},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5684642195701599},{"id":"https://openalex.org/keywords/lipid-bilayer","display_name":"Lipid bilayer","score":0.5323453545570374},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.5092214345932007},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1439824402332306},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.13713553547859192}],"concepts":[{"id":"https://openalex.org/C63491327","wikidata":"https://www.wikidata.org/wiki/Q6888332","display_name":"Model lipid bilayer","level":5,"score":0.9243245124816895},{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.7524930238723755},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5684642195701599},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.5323453545570374},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5092214345932007},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1439824402332306},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13713553547859192},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.0},{"id":"https://openalex.org/C76564549","wikidata":"https://www.wikidata.org/wiki/Q17154515","display_name":"Lipid bilayer phase behavior","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D003902","descriptor_name":"Detergents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003902","descriptor_name":"Detergents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003902","descriptor_name":"Detergents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004134","descriptor_name":"Dimyristoylphosphatidylcholine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004134","descriptor_name":"Dimyristoylphosphatidylcholine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004134","descriptor_name":"Dimyristoylphosphatidylcholine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jcim.5c00841","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00841","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.5c00841?ref=article_openPDF","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:40549978","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40549978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12264929","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12264929","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acs.jcim.5c00841","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00841","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.5c00841?ref=article_openPDF","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2585573574","display_name":null,"funder_award_id":"R35 GM153458","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3097597786","display_name":null,"funder_award_id":"MCB-1810695","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3457494668","display_name":null,"funder_award_id":"MCB\u20101810695","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3470625112","display_name":"Investigating the impact of lipid-protein interactions in membrane protein structure and conformational dynamics","funder_award_id":"1817735","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5119588400","display_name":null,"funder_award_id":"R35-GM153458","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5145629262","display_name":"Modeling and Simulation of Bacterial Outer Membranes and Interactions with Proteins","funder_award_id":"1810695","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5698576153","display_name":null,"funder_award_id":"GM153458","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5927531472","display_name":null,"funder_award_id":"MCB 1817735","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6529471742","display_name":null,"funder_award_id":"MCB-1810695","funder_id":"https://openalex.org/F4320337397","funder_display_name":"Division of Molecular and Cellular Biosciences"},{"id":"https://openalex.org/G8508186391","display_name":null,"funder_award_id":"MCB-1817735","funder_id":"https://openalex.org/F4320337397","funder_display_name":"Division of Molecular and Cellular Biosciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320994","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17"},{"id":"https://openalex.org/F4320331257","display_name":"Alliance de recherche num\u00e9rique du Canada","ror":"https://ror.org/010r6td27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337397","display_name":"Division of Molecular and Cellular Biosciences","ror":"https://ror.org/002jdaq33"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411548596.pdf","grobid_xml":"https://content.openalex.org/works/W4411548596.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1969189143","https://openalex.org/W1976203248","https://openalex.org/W1976499671","https://openalex.org/W1990771438","https://openalex.org/W1997394451","https://openalex.org/W1998247886","https://openalex.org/W2000277875","https://openalex.org/W2003193361","https://openalex.org/W2015214828","https://openalex.org/W2021520922","https://openalex.org/W2034358178","https://openalex.org/W2035687084","https://openalex.org/W2056090070","https://openalex.org/W2064697628","https://openalex.org/W2082547742","https://openalex.org/W2084284989","https://openalex.org/W2106140689","https://openalex.org/W2123323202","https://openalex.org/W2128824543","https://openalex.org/W2134762386","https://openalex.org/W2168269595","https://openalex.org/W2206954826","https://openalex.org/W2230915242","https://openalex.org/W2395696004","https://openalex.org/W2405075761","https://openalex.org/W2555870966","https://openalex.org/W2564298127","https://openalex.org/W2765153686","https://openalex.org/W2792171355","https://openalex.org/W2884654604","https://openalex.org/W2905232362","https://openalex.org/W2913254604","https://openalex.org/W3011371745","https://openalex.org/W3119574697","https://openalex.org/W3145808230","https://openalex.org/W3199102733","https://openalex.org/W3210500140","https://openalex.org/W4200064113","https://openalex.org/W4318979003","https://openalex.org/W4362548755","https://openalex.org/W4389429309","https://openalex.org/W4393237803","https://openalex.org/W4394629554","https://openalex.org/W4394724069","https://openalex.org/W4394982512","https://openalex.org/W4400082588","https://openalex.org/W4406852818"],"related_works":["https://openalex.org/W1985291272","https://openalex.org/W3113547055","https://openalex.org/W216598799","https://openalex.org/W12015570","https://openalex.org/W2033123532","https://openalex.org/W2072230736","https://openalex.org/W4206087209","https://openalex.org/W1968382956","https://openalex.org/W4238638345","https://openalex.org/W2370627827"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Membrane":[7,116],"mimetics,":[8],"such":[9],"as":[10],"detergent":[11],"micelles,":[12],"nanodiscs,":[13],"and":[14,25,41,68,80,113,121,131,148,158,172,177],"amphipol":[15],"complexes,":[16,150],"which":[17],"can":[18,55,98,169],"provide":[19],"membrane-like":[20],"environments":[21],"while":[22],"retaining":[23],"small":[24],"soluble":[26],"features,":[27],"have":[28,129],"been":[29],"utilized":[30],"to":[31,58,189,209],"study":[32],"membrane":[33,46],"proteins.":[34],"A":[35],"bicelle,":[36],"composed":[37,151],"of":[38,62,70,136,152,202],"varying":[39],"lipids":[40,112,141],"detergents,":[42],"is":[43,187],"a":[44,75,94,105],"useful":[45],"mimetic":[47],"because":[48],"the":[49,52,60,63,66,71],"lipid-to-detergent":[50],"ratio,":[51],"q":[53],"-value,":[54],"be":[56],"adjusted":[57],"alter":[59],"properties":[61],"aggregate,":[64],"including":[65],"thickness":[67],"size":[69],"bicelle.":[72],"However,":[73],"building":[74],"bicelle":[76,102,174],"model":[77],"for":[78,87],"modeling":[79],"simulation":[81,163],"studies":[82],"requires":[83],"nontrivial":[84],"efforts,":[85],"even":[86],"experts.":[88],"We":[89],"introduce":[90],"CHARMM-GUI":[91],"Bicelle":[92,123,167,185],"Builder,":[93],"web-based":[95],"platform":[96],"that":[97,166,180,205],"generate":[99,170],"various":[100],"all-atom":[101],"systems":[103],"via":[104],"graphical":[106],"user":[107],"interface":[108],"with":[109,125,142,154,176],"all":[110],"available":[111],"detergents":[114,147],"in":[115],"Builder":[117,124,168,186],".":[118],"To":[119],"illustrate":[120],"validate":[122],"practical":[126],"systems,":[127],"we":[128],"modeled":[130],"simulated":[132],"pure":[133],"bicelles":[134,196],"consisting":[135],"1,2-dimyristoyl-":[137],"sn":[138,144],"-glycero-3-phosphocholine":[139,145],"(DMPC)":[140],"1,2-dihexanoyl-":[143],"(C6DHPC)":[146],"protein\u2013bicelle":[149,203],"DMPC":[153,182],"C6DHPC,":[155],"foscholine-10":[156],"(FOS10),":[157],"lysophosphatidylcholine-12":[159],"(LPC12)":[160],"detergents.":[161],"Our":[162],"results":[164],"indicate":[165],"reliable":[171],"robust":[173],"models":[175],"without":[178],"proteins":[179],"retain":[181],"bilayer":[183],"characteristics.":[184],"expected":[188],"help":[190],"researchers":[191],"better":[192],"understand":[193],"not":[194],"only":[195],"themselves":[197],"but":[198],"also":[199],"atomistic-level":[200],"structures":[201],"complexes":[204],"are":[206],"often":[207],"difficult":[208],"access":[210],"through":[211],"experimental":[212],"approaches.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-06-24T00:00:00"}
