{"id":"https://openalex.org/W4410874758","doi":"https://doi.org/10.1021/acs.jcim.5c00831","title":"In Silico Screening of Small Molecule Inhibitors for Amyloid-\u03b2 Aggregation","display_name":"In Silico Screening of Small Molecule Inhibitors for Amyloid-\u03b2 Aggregation","publication_year":2025,"publication_date":"2025-05-29","ids":{"openalex":"https://openalex.org/W4410874758","doi":"https://doi.org/10.1021/acs.jcim.5c00831","pmid":"https://pubmed.ncbi.nlm.nih.gov/40442621"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c00831","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00831","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013175065","display_name":"Yin-Lei Han","orcid":null},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yin-Lei Han","raw_affiliation_strings":["College of Chemical and Biological Engineering","Zhejiang University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemical and Biological Engineering","institution_ids":[]},{"raw_affiliation_string":"Zhejiang University","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021167945","display_name":"Chen Li","orcid":"https://orcid.org/0000-0002-6302-3491"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Li","raw_affiliation_strings":["College of Chemical and Biological Engineering","Zhejiang University"],"raw_orcid":"https://orcid.org/0000-0002-6302-3491","affiliations":[{"raw_affiliation_string":"College of Chemical and Biological Engineering","institution_ids":[]},{"raw_affiliation_string":"Zhejiang University","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102874774","display_name":"Huanhuan Yin","orcid":"https://orcid.org/0000-0001-6755-0697"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan-Huan Yin","raw_affiliation_strings":["College of Chemical and Biological Engineering","Zhejiang University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemical and Biological Engineering","institution_ids":[]},{"raw_affiliation_string":"Zhejiang University","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080069508","display_name":"Yi He","orcid":"https://orcid.org/0000-0002-8807-0892"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Yi He","raw_affiliation_strings":["College of Chemical and Biological Engineering","Department of Chemical Engineering","University of Washington","Zhejiang University","College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China"],"raw_orcid":"https://orcid.org/0000-0002-8807-0892","affiliations":[{"raw_affiliation_string":"College of Chemical and Biological Engineering","institution_ids":[]},{"raw_affiliation_string":"Department of Chemical Engineering","institution_ids":[]},{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Zhejiang University","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101971354","display_name":"Yi\u2010Xin Guan","orcid":"https://orcid.org/0000-0001-6983-7843"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi-Xin Guan","raw_affiliation_strings":["College of Chemical and Biological Engineering","Zhejiang University"],"raw_orcid":"https://orcid.org/0000-0001-6983-7843","affiliations":[{"raw_affiliation_string":"College of Chemical and Biological Engineering","institution_ids":[]},{"raw_affiliation_string":"Zhejiang University","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080069508","https://openalex.org/A5101971354"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I76130692"],"apc_list":null,"apc_paid":null,"fwci":2.2102,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.87383675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"65","issue":"12","first_page":"6238","last_page":"6248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.8832412958145142},{"id":"https://openalex.org/keywords/amyloid","display_name":"Amyloid (mycology)","score":0.5763940811157227},{"id":"https://openalex.org/keywords/small-molecule","display_name":"Small molecule","score":0.5604302883148193},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5140773057937622},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4932369589805603},{"id":"https://openalex.org/keywords/amyloid-fibril","display_name":"Amyloid fibril","score":0.44601231813430786},{"id":"https://openalex.org/keywords/amyloid-\u03b2","display_name":"Amyloid \u03b2","score":0.3965776562690735},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2861657738685608},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2554766535758972},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.21024850010871887},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.11410704255104065},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.08409479260444641}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8832412958145142},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5763940811157227},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.5604302883148193},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5140773057937622},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4932369589805603},{"id":"https://openalex.org/C2994168385","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid fibril","level":4,"score":0.44601231813430786},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.3965776562690735},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2861657738685608},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2554766535758972},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21024850010871887},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11410704255104065},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08409479260444641},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066329","descriptor_name":"Protein Aggregates","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D066329","descriptor_name":"Protein Aggregates","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5c00831","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00831","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:40442621","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40442621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4786766655","display_name":null,"funder_award_id":"2022YFB3807301","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5092881111","display_name":null,"funder_award_id":"21878262","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6465505757","display_name":null,"funder_award_id":"2022YFE0106100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8017081833","display_name":null,"funder_award_id":"51933009","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8818909226","display_name":null,"funder_award_id":"22178299","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W883434158","https://openalex.org/W1031578623","https://openalex.org/W1757990252","https://openalex.org/W1966172022","https://openalex.org/W1970577444","https://openalex.org/W1988745994","https://openalex.org/W1995272223","https://openalex.org/W2025625972","https://openalex.org/W2025816743","https://openalex.org/W2028046413","https://openalex.org/W2030325989","https://openalex.org/W2039864411","https://openalex.org/W2043812489","https://openalex.org/W2053267653","https://openalex.org/W2057477511","https://openalex.org/W2067174909","https://openalex.org/W2067718414","https://openalex.org/W2081855136","https://openalex.org/W2091260212","https://openalex.org/W2122294662","https://openalex.org/W2126607520","https://openalex.org/W2128572087","https://openalex.org/W2132525235","https://openalex.org/W2147993766","https://openalex.org/W2161605421","https://openalex.org/W2329336071","https://openalex.org/W2538837691","https://openalex.org/W2587428731","https://openalex.org/W2594659374","https://openalex.org/W2614053601","https://openalex.org/W2753422767","https://openalex.org/W2753860285","https://openalex.org/W2772202429","https://openalex.org/W2791355014","https://openalex.org/W2808430401","https://openalex.org/W2901539124","https://openalex.org/W2909386993","https://openalex.org/W2920210846","https://openalex.org/W2927667967","https://openalex.org/W2998415747","https://openalex.org/W3014614371","https://openalex.org/W3020610908","https://openalex.org/W3021503072","https://openalex.org/W3027841912","https://openalex.org/W3033048806","https://openalex.org/W3034762187","https://openalex.org/W3038724466","https://openalex.org/W3047101549","https://openalex.org/W3047452102","https://openalex.org/W3087576075","https://openalex.org/W3106725626","https://openalex.org/W3127602688","https://openalex.org/W3151482983","https://openalex.org/W3154258817","https://openalex.org/W3188402951","https://openalex.org/W3203735717","https://openalex.org/W3207579036","https://openalex.org/W3208801682","https://openalex.org/W3215773398","https://openalex.org/W4214868967","https://openalex.org/W4280643537","https://openalex.org/W4285132881","https://openalex.org/W4307724679","https://openalex.org/W4309712906","https://openalex.org/W4311574921","https://openalex.org/W4323304388","https://openalex.org/W4384067609","https://openalex.org/W4384119991","https://openalex.org/W4387969253","https://openalex.org/W4391262776"],"related_works":["https://openalex.org/W4404961439","https://openalex.org/W2900838411","https://openalex.org/W2313742489","https://openalex.org/W4323848845","https://openalex.org/W2418228579","https://openalex.org/W2341969299","https://openalex.org/W2006116784","https://openalex.org/W2559356300","https://openalex.org/W3200937902","https://openalex.org/W2023973572"],"abstract_inverted_index":{"The":[0,114,174],"self-aggregation":[1],"of":[2,10,15,39,66,106,133,144,156],"amyloid-\u03b2":[3],"(A\u03b2)":[4],"into":[5],"fibrils":[6],"is":[7,33],"a":[8,23,134],"hallmark":[9],"Alzheimer's":[11],"disease":[12],"(AD).":[13],"Inhibition":[14],"A\u03b2":[16,53,121,165],"aggregation":[17,54,166],"with":[18,168],"small":[19,91,135],"molecule":[20,136],"compounds":[21],"represents":[22],"promising":[24],"therapeutic":[25],"strategy":[26],"for":[27,52,87,163],"AD.":[28],"However,":[29],"designing":[30],"effective":[31],"ligands":[32],"challenging":[34],"due":[35],"to":[36,140],"the":[37,43,64,80,82,97,117,131,141,145,154],"lack":[38],"structural":[40],"information":[41],"about":[42],"binding":[44,132],"target.":[45],"In":[46],"this":[47,179],"work,":[48],"ligand-based":[49],"virtual":[50,160,180],"screening":[51,161,181],"inhibitors":[55,167],"was":[56,85,183],"conducted":[57],"using":[58,76,178],"molecular":[59,73,126,157],"representation":[60,74,158],"models.":[61],"After":[62],"comparing":[63],"performance":[65],"four":[67,105,118],"machine":[68],"learning":[69],"models":[70,75],"and":[71,89,104,120,147,171],"two":[72],"inhibitor":[77],"data":[78],"from":[79],"literature,":[81],"optimal":[83],"model":[84],"applied":[86],"prediction,":[88],"novel":[90,169],"molecules":[92],"were":[93,101,123],"screened":[94],"out.":[95],"Among":[96],"top-ranked":[98],"compounds,":[99],"11":[100],"experimentally":[102],"investigated":[103],"them":[107],"demonstrated":[108],"better":[109],"inhibition":[110],"effects":[111],"than":[112],"EGCG.":[113],"interactions":[115],"between":[116],"candidates":[119],"aggregates":[122],"analyzed":[124],"via":[125],"dynamics":[127],"simulation,":[128],"revealing":[129],"that":[130],"compound":[137],"brought":[138],"interference":[139],"fluctuation":[142],"mode":[143],"pentamer":[146],"weakened":[148],"its":[149],"stability.":[150],"This":[151],"work":[152],"highlights":[153],"efficacy":[155],"based":[159],"approach":[162,182],"discovering":[164],"structure":[170],"high":[172],"affinity.":[173],"experimental":[175],"hit":[176],"rate":[177],"36.4%.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
