{"id":"https://openalex.org/W4410875558","doi":"https://doi.org/10.1021/acs.jcim.5c00726","title":"Prediction of Ligand\u2013Receptor Interactions Based on CatBoost and Deep Forest and Their Application in Cell\u2013Cell Communication Analysis","display_name":"Prediction of Ligand\u2013Receptor Interactions Based on CatBoost and Deep Forest and Their Application in Cell\u2013Cell Communication Analysis","publication_year":2025,"publication_date":"2025-05-30","ids":{"openalex":"https://openalex.org/W4410875558","doi":"https://doi.org/10.1021/acs.jcim.5c00726","pmid":"https://pubmed.ncbi.nlm.nih.gov/40444832"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c00726","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00726","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090683194","display_name":"Wei Wu","orcid":"https://orcid.org/0000-0002-7672-7965"},"institutions":[{"id":"https://openalex.org/I49934816","display_name":"Hunan University of Technology","ror":"https://ror.org/04j3vr751","country_code":"CN","type":"education","lineage":["https://openalex.org/I49934816"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wu","raw_affiliation_strings":["College of Life Science and Chemistry","Hunan University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Chemistry","institution_ids":[]},{"raw_affiliation_string":"Hunan University of Technology","institution_ids":["https://openalex.org/I49934816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434574","display_name":"Zhao Wang","orcid":"https://orcid.org/0000-0003-4897-9986"},"institutions":[{"id":"https://openalex.org/I18452120","display_name":"Yantai University","ror":"https://ror.org/01rp41m56","country_code":"CN","type":"education","lineage":["https://openalex.org/I18452120"]},{"id":"https://openalex.org/I4210096047","display_name":"Yantai Automobile Engineering Professional College","ror":"https://ror.org/00sh5y950","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210096047"]},{"id":"https://openalex.org/I4210102741","display_name":"Jiangsu Vocational College of Medicine","ror":"https://ror.org/01jzst437","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210102741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhao Wang","raw_affiliation_strings":["Yantai Health Vocational College","Yantai Health Vocational College, Yantai 264670, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yantai Health Vocational College","institution_ids":["https://openalex.org/I4210102741"]},{"raw_affiliation_string":"Yantai Health Vocational College, Yantai 264670, China","institution_ids":["https://openalex.org/I18452120","https://openalex.org/I4210102741","https://openalex.org/I4210096047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032470574","display_name":"L. C. Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I49934816","display_name":"Hunan University of Technology","ror":"https://ror.org/04j3vr751","country_code":"CN","type":"education","lineage":["https://openalex.org/I49934816"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longlong Liu","raw_affiliation_strings":["College of Life Science and Chemistry","Hunan University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Chemistry","institution_ids":[]},{"raw_affiliation_string":"Hunan University of Technology","institution_ids":["https://openalex.org/I49934816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047143972","display_name":"Junfeng Huang","orcid":"https://orcid.org/0000-0002-1672-3751"},"institutions":[{"id":"https://openalex.org/I49934816","display_name":"Hunan University of Technology","ror":"https://ror.org/04j3vr751","country_code":"CN","type":"education","lineage":["https://openalex.org/I49934816"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junfeng Huang","raw_affiliation_strings":["College of Life Science and Chemistry","Hunan University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Chemistry","institution_ids":[]},{"raw_affiliation_string":"Hunan University of Technology","institution_ids":["https://openalex.org/I49934816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114116775","display_name":"Haifan Qiu","orcid":null},"institutions":[{"id":"https://openalex.org/I49934816","display_name":"Hunan University of Technology","ror":"https://ror.org/04j3vr751","country_code":"CN","type":"education","lineage":["https://openalex.org/I49934816"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haifan Qiu","raw_affiliation_strings":["College of Life Science and Chemistry","Hunan University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Chemistry","institution_ids":[]},{"raw_affiliation_string":"Hunan University of Technology","institution_ids":["https://openalex.org/I49934816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007339758","display_name":"Lihong Peng","orcid":"https://orcid.org/0000-0002-2321-3901"},"institutions":[{"id":"https://openalex.org/I49934816","display_name":"Hunan University of Technology","ror":"https://ror.org/04j3vr751","country_code":"CN","type":"education","lineage":["https://openalex.org/I49934816"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lihong Peng","raw_affiliation_strings":["College of Life Science and Chemistry","Hunan University of Technology"],"raw_orcid":"https://orcid.org/0000-0002-2321-3901","affiliations":[{"raw_affiliation_string":"College of Life Science and Chemistry","institution_ids":[]},{"raw_affiliation_string":"Hunan University of Technology","institution_ids":["https://openalex.org/I49934816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112113417","display_name":"Libo Nie","orcid":null},"institutions":[{"id":"https://openalex.org/I49934816","display_name":"Hunan University of Technology","ror":"https://ror.org/04j3vr751","country_code":"CN","type":"education","lineage":["https://openalex.org/I49934816"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Libo Nie","raw_affiliation_strings":["College of Life Science and Chemistry","Hunan University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Chemistry","institution_ids":[]},{"raw_affiliation_string":"Hunan University of Technology","institution_ids":["https://openalex.org/I49934816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5007339758","https://openalex.org/A5112113417"],"corresponding_institution_ids":["https://openalex.org/I49934816"],"apc_list":null,"apc_paid":null,"fwci":9.9612,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.98033508,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"65","issue":"12","first_page":"6341","last_page":"6366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5328866243362427},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5247811675071716},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.47157472372055054},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.45636624097824097},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.43538758158683777},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.4140756130218506},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.32837483286857605},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21505501866340637},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.17059364914894104}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5328866243362427},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5247811675071716},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.47157472372055054},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.45636624097824097},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.43538758158683777},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4140756130218506},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32837483286857605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21505501866340637},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17059364914894104}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000098404","descriptor_name":"Boosting Machine Learning Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098404","descriptor_name":"Boosting Machine Learning Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098404","descriptor_name":"Boosting Machine Learning Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5c00726","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00726","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:40444832","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40444832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G199574137","display_name":null,"funder_award_id":"2024JJ7133","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G4031356638","display_name":null,"funder_award_id":"61803151","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6068386712","display_name":null,"funder_award_id":"2023JJ50201","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W1016059894","https://openalex.org/W1963946540","https://openalex.org/W1983516942","https://openalex.org/W2035503835","https://openalex.org/W2041914114","https://openalex.org/W2047672715","https://openalex.org/W2067530106","https://openalex.org/W2070602352","https://openalex.org/W2116707508","https://openalex.org/W2117513900","https://openalex.org/W2118258530","https://openalex.org/W2145957695","https://openalex.org/W2152104067","https://openalex.org/W2154708791","https://openalex.org/W2170564629","https://openalex.org/W2295598076","https://openalex.org/W2332292689","https://openalex.org/W2600453489","https://openalex.org/W2610509384","https://openalex.org/W2769365148","https://openalex.org/W2771542157","https://openalex.org/W2783252067","https://openalex.org/W2896222795","https://openalex.org/W2900144939","https://openalex.org/W2908139053","https://openalex.org/W2912065541","https://openalex.org/W2921372942","https://openalex.org/W2957436444","https://openalex.org/W2975507539","https://openalex.org/W2981350712","https://openalex.org/W2992151131","https://openalex.org/W2995882574","https://openalex.org/W2999410311","https://openalex.org/W3007935255","https://openalex.org/W3009797991","https://openalex.org/W3012498554","https://openalex.org/W3013515554","https://openalex.org/W3092318937","https://openalex.org/W3093053585","https://openalex.org/W3094645479","https://openalex.org/W3095057922","https://openalex.org/W3099810371","https://openalex.org/W3110253137","https://openalex.org/W3114457750","https://openalex.org/W3120038913","https://openalex.org/W3123592252","https://openalex.org/W3132661792","https://openalex.org/W3132704218","https://openalex.org/W3133587532","https://openalex.org/W3136918052","https://openalex.org/W3138055079","https://openalex.org/W3155546248","https://openalex.org/W3161491075","https://openalex.org/W3166084369","https://openalex.org/W3184931457","https://openalex.org/W3193861087","https://openalex.org/W3202711716","https://openalex.org/W3214755680","https://openalex.org/W4221038504","https://openalex.org/W4232714830","https://openalex.org/W4280501504","https://openalex.org/W4281716326","https://openalex.org/W4283588821","https://openalex.org/W4283592141","https://openalex.org/W4284885575","https://openalex.org/W4312094047","https://openalex.org/W4313561039","https://openalex.org/W4313897518","https://openalex.org/W4327573938","https://openalex.org/W4360776424","https://openalex.org/W4377231491","https://openalex.org/W4380370418","https://openalex.org/W4381550243","https://openalex.org/W4386989792","https://openalex.org/W4387570050","https://openalex.org/W4388452734","https://openalex.org/W4388756595","https://openalex.org/W4388785133","https://openalex.org/W4389166577","https://openalex.org/W4389194065","https://openalex.org/W4390066222","https://openalex.org/W4390974497","https://openalex.org/W4391280974","https://openalex.org/W4391562790","https://openalex.org/W4392190144","https://openalex.org/W4392444915","https://openalex.org/W4392642426","https://openalex.org/W4392693790","https://openalex.org/W4394581635","https://openalex.org/W4401406616","https://openalex.org/W4401672420","https://openalex.org/W4401709175","https://openalex.org/W4401894636","https://openalex.org/W4402372433","https://openalex.org/W4402604581","https://openalex.org/W4403210286","https://openalex.org/W4403479110","https://openalex.org/W4403852249","https://openalex.org/W4404929164","https://openalex.org/W4405538235","https://openalex.org/W4406260650","https://openalex.org/W4406326174","https://openalex.org/W4406347961","https://openalex.org/W4406885099","https://openalex.org/W4407356329","https://openalex.org/W4407870211","https://openalex.org/W4407903277"],"related_works":["https://openalex.org/W2355466661","https://openalex.org/W1968459159","https://openalex.org/W2188270127","https://openalex.org/W2985048223","https://openalex.org/W2074785916","https://openalex.org/W2010808173","https://openalex.org/W1986249076","https://openalex.org/W4388309908","https://openalex.org/W1972166651","https://openalex.org/W4287836304"],"abstract_inverted_index":{"aximum":[0],"difference,":[1],"and":[2,13,33,47,55,66,78,99,105],"visualizes":[3],"crosstalk":[4],"through":[5],"the":[6],"heatmap":[7],"view,":[8,10,12],"network":[9],"circos":[11],"sigmoid":[14],"plot.":[15],"Using":[16],"8":[17,34],"evaluation":[18],"metrics,":[19],"CellCDmT":[20,42,52,88,113],"was":[21],"benchmarked":[22],"with":[23],"7":[24],"LRI":[25,30],"prediction":[26],"baselines,":[27],"5":[28],"state-of-the-art":[29],"validation":[31],"tools,":[32],"CCC":[35],"inference":[36],"competitors.":[37],"The":[38],"outcomes":[39],"demonstrated":[40],"that":[41],"accurately":[43],"classified":[44],"unlabeled":[45],"LRPs":[46,63],"decoded":[48],"cellular":[49],"crosstalk.":[50],"Moreover,":[51],"visualized":[53],"intercellular":[54],"intracellular":[56],"communication":[57],"networks":[58],"in":[59],"breast":[60,73,86],"cancer.":[61,74,87],"Interacting":[62],"MIF-CD74,":[64],"WNT7B-FZD1,":[65],"B2M-TFRC":[67],"may":[68,80],"be":[69,81,90,115],"vital":[70],"mediators":[71],"of":[72,85],"Ligands":[75],"FGF22,":[76],"B2M,":[77],"RSPO4":[79],"potential":[82],"drug":[83,106],"targets":[84],"will":[89],"conducive":[91],"to":[92],"facilitating":[93],"our":[94],"understanding":[95],"about":[96],"disease":[97],"mechanisms":[98],"further":[100],"promoting":[101],"tumor":[102],"targeted":[103],"therapy":[104],"design.":[107],"As":[108],"a":[109],"freely":[110],"available":[111],"tool,":[112],"can":[114],"accessed":[116],"at":[117],"https://github.com/plhhnu/CellCDmT.":[118]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5}],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2025-10-10T00:00:00"}