{"id":"https://openalex.org/W4410431103","doi":"https://doi.org/10.1021/acs.jcim.5c00663","title":"ABP-Xplorer: A Machine Learning Approach for Prediction of Antibacterial Peptides Targeting <i>Mycobacterium abscessus</i>-tRNA-Methyltransferase (TrmD)","display_name":"ABP-Xplorer: A Machine Learning Approach for Prediction of Antibacterial Peptides Targeting <i>Mycobacterium abscessus</i>-tRNA-Methyltransferase (TrmD)","publication_year":2025,"publication_date":"2025-05-16","ids":{"openalex":"https://openalex.org/W4410431103","doi":"https://doi.org/10.1021/acs.jcim.5c00663","pmid":"https://pubmed.ncbi.nlm.nih.gov/40377983"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c00663","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00663","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075643370","display_name":"Munawar Abbas","orcid":"https://orcid.org/0009-0001-9847-7936"},"institutions":[{"id":"https://openalex.org/I36152291","display_name":"Henan University of Technology","ror":"https://ror.org/05sbgwt55","country_code":"CN","type":"education","lineage":["https://openalex.org/I36152291"]},{"id":"https://openalex.org/I4210125155","display_name":"Institute of Food Science & Technology","ror":"https://ror.org/036d5sh68","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210125155"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Munawar Abbas","raw_affiliation_strings":["College of Food Science and Technology","Henan University of Technology"],"affiliations":[{"raw_affiliation_string":"College of Food Science and Technology","institution_ids":["https://openalex.org/I4210125155"]},{"raw_affiliation_string":"Henan University of Technology","institution_ids":["https://openalex.org/I36152291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115868837","display_name":"Kashif Iqbal Sahibzada","orcid":"https://orcid.org/0009-0005-9323-0255"},"institutions":[{"id":"https://openalex.org/I36152291","display_name":"Henan University of Technology","ror":"https://ror.org/05sbgwt55","country_code":"CN","type":"education","lineage":["https://openalex.org/I36152291"]},{"id":"https://openalex.org/I142204992","display_name":"University of Lahore","ror":"https://ror.org/051jrjw38","country_code":"PK","type":"education","lineage":["https://openalex.org/I142204992"]},{"id":"https://openalex.org/I4210097193","display_name":"Technologies pour la Sant\u00e9","ror":"https://ror.org/012hpz460","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210097193"]}],"countries":["CN","FR","PK"],"is_corresponding":true,"raw_author_name":"Kashif Iqbal Sahibzada","raw_affiliation_strings":["College of Biological Engineering","Department of Health Professional Technologies, Faculty of Allied Health Sciences","Henan University of Technology","The University of Lahore"],"affiliations":[{"raw_affiliation_string":"College of Biological Engineering","institution_ids":[]},{"raw_affiliation_string":"Department of Health Professional Technologies, Faculty of Allied Health Sciences","institution_ids":["https://openalex.org/I4210097193"]},{"raw_affiliation_string":"Henan University of Technology","institution_ids":["https://openalex.org/I36152291"]},{"raw_affiliation_string":"The University of Lahore","institution_ids":["https://openalex.org/I142204992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043866204","display_name":"Syed M. Shahid","orcid":"https://orcid.org/0000-0003-0185-9362"},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Shumaila Shahid","raw_affiliation_strings":["School of Biochemistry and Biotechnology","University of the Punjab"],"affiliations":[{"raw_affiliation_string":"School of Biochemistry and Biotechnology","institution_ids":[]},{"raw_affiliation_string":"University of the Punjab","institution_ids":["https://openalex.org/I172780181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091353538","display_name":"Numan Yousaf","orcid":"https://orcid.org/0000-0003-2783-7823"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Numan Yousaf","raw_affiliation_strings":["Shanghai Jiao Tong University","State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences and School of Life Sciences and Biotechnology"],"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences and School of Life Sciences and Biotechnology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075313324","display_name":"Yuansen Hu","orcid":"https://orcid.org/0000-0002-5611-8783"},"institutions":[{"id":"https://openalex.org/I36152291","display_name":"Henan University of Technology","ror":"https://ror.org/05sbgwt55","country_code":"CN","type":"education","lineage":["https://openalex.org/I36152291"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuansen Hu","raw_affiliation_strings":["College of Biological Engineering","Henan University of Technology"],"affiliations":[{"raw_affiliation_string":"College of Biological Engineering","institution_ids":[]},{"raw_affiliation_string":"Henan University of Technology","institution_ids":["https://openalex.org/I36152291"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041491902","display_name":"Dong\u2010Qing Wei","orcid":"https://orcid.org/0000-0003-4200-7502"},"institutions":[{"id":"https://openalex.org/I4210125155","display_name":"Institute of Food Science & Technology","ror":"https://ror.org/036d5sh68","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210125155"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I36152291","display_name":"Henan University of Technology","ror":"https://ror.org/05sbgwt55","country_code":"CN","type":"education","lineage":["https://openalex.org/I36152291"]}],"countries":["CN","GB"],"is_corresponding":true,"raw_author_name":"Dong-Qing Wei","raw_affiliation_strings":["College of Food Science and Technology","Henan University of Technology","Shanghai Jiao Tong University","State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences and School of Life Sciences and Biotechnology","Zhongjing Research and Industrialization Institute of Chinese Medicine, Zhongguancun Scientific Park, Meixi, Nanyang, Henan 473006, P. R. China"],"affiliations":[{"raw_affiliation_string":"College of Food Science and Technology","institution_ids":["https://openalex.org/I4210125155"]},{"raw_affiliation_string":"Henan University of Technology","institution_ids":["https://openalex.org/I36152291"]},{"raw_affiliation_string":"Shanghai Jiao Tong University","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences and School of Life Sciences and Biotechnology","institution_ids":[]},{"raw_affiliation_string":"Zhongjing Research and Industrialization Institute of Chinese Medicine, Zhongguancun Scientific Park, Meixi, Nanyang, Henan 473006, P. R. China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5041491902","https://openalex.org/A5115868837"],"corresponding_institution_ids":["https://openalex.org/I142204992","https://openalex.org/I183067930","https://openalex.org/I36152291","https://openalex.org/I4210097193","https://openalex.org/I4210125155"],"apc_list":null,"apc_paid":null,"fwci":2.7605,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.89770693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"65","issue":"11","first_page":"5456","last_page":"5468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9445000290870667,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transfer-rna","display_name":"Transfer RNA","score":0.6336989402770996},{"id":"https://openalex.org/keywords/methyltransferase","display_name":"Methyltransferase","score":0.5526655912399292},{"id":"https://openalex.org/keywords/antibacterial-peptide","display_name":"Antibacterial peptide","score":0.4700925350189209},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.42835134267807007},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4023682773113251},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3536154329776764},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"Antibacterial activity","score":0.334034264087677},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.3209472894668579},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.28769415616989136},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.2703344225883484},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.24923822283744812},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.14002832770347595},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.1273117959499359},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.0928356945514679},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08235234022140503}],"concepts":[{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.6336989402770996},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.5526655912399292},{"id":"https://openalex.org/C2993778972","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antibacterial peptide","level":4,"score":0.4700925350189209},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42835134267807007},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4023682773113251},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3536154329776764},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.334034264087677},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3209472894668579},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28769415616989136},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2703344225883484},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24923822283744812},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.14002832770347595},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1273117959499359},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.0928356945514679},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08235234022140503}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073358","descriptor_name":"Mycobacterium abscessus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000073358","descriptor_name":"Mycobacterium abscessus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000073358","descriptor_name":"Mycobacterium abscessus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000073358","descriptor_name":"Mycobacterium abscessus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012359","descriptor_name":"tRNA Methyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D012359","descriptor_name":"tRNA Methyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D012359","descriptor_name":"tRNA Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012359","descriptor_name":"tRNA Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012359","descriptor_name":"tRNA Methyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012359","descriptor_name":"tRNA Methyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5c00663","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00663","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:40377983","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40377983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2191216477","display_name":null,"funder_award_id":"32030063","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3039896822","display_name":null,"funder_award_id":"2023YFE0199200","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6158189567","display_name":null,"funder_award_id":"2024YFA1306402","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W2059390726","https://openalex.org/W2061939373","https://openalex.org/W2085630244","https://openalex.org/W2104145304","https://openalex.org/W2114850508","https://openalex.org/W2128482141","https://openalex.org/W2142447693","https://openalex.org/W2152238416","https://openalex.org/W2272725999","https://openalex.org/W2340254326","https://openalex.org/W2568556896","https://openalex.org/W2568617656","https://openalex.org/W2579441661","https://openalex.org/W2601992375","https://openalex.org/W2607561273","https://openalex.org/W2751476102","https://openalex.org/W2796455598","https://openalex.org/W2889161855","https://openalex.org/W2893348872","https://openalex.org/W2912861589","https://openalex.org/W3004647566","https://openalex.org/W3007838744","https://openalex.org/W3013916086","https://openalex.org/W3035965352","https://openalex.org/W3036319615","https://openalex.org/W3037494304","https://openalex.org/W3038160084","https://openalex.org/W3039814204","https://openalex.org/W3049002444","https://openalex.org/W3099878876","https://openalex.org/W3113150977","https://openalex.org/W3198122771","https://openalex.org/W3206629920","https://openalex.org/W4220874730","https://openalex.org/W4225760699","https://openalex.org/W4226166856","https://openalex.org/W4283220848","https://openalex.org/W4296826847","https://openalex.org/W4305082653","https://openalex.org/W4306697720","https://openalex.org/W4320495200","https://openalex.org/W4324143928","https://openalex.org/W4378348175","https://openalex.org/W4378901723","https://openalex.org/W4387191224","https://openalex.org/W4387237746","https://openalex.org/W4387357646","https://openalex.org/W4388998454","https://openalex.org/W4390954520","https://openalex.org/W4391573562","https://openalex.org/W4392361807","https://openalex.org/W4396594465","https://openalex.org/W4399731408","https://openalex.org/W4401251375","https://openalex.org/W4401438833","https://openalex.org/W4402264558","https://openalex.org/W4402727756","https://openalex.org/W4405045665","https://openalex.org/W4405742885","https://openalex.org/W4406240384"],"related_works":["https://openalex.org/W1243787592","https://openalex.org/W2033872236","https://openalex.org/W2053492137","https://openalex.org/W2387731647","https://openalex.org/W2354214183","https://openalex.org/W2385803481","https://openalex.org/W2364756590","https://openalex.org/W2150087752","https://openalex.org/W1909802592","https://openalex.org/W2390509371"],"abstract_inverted_index":{"<i>Mycobacterium":[0],"abscessus</i>":[1],"(MAB)":[2],"infections":[3],"pose":[4],"a":[5,47,59,187],"significant":[6],"treatment":[7],"challenge":[8],"due":[9],"to":[10,14,65,127,169],"their":[11,200,228],"intrinsic":[12],"resistance":[13],"antibiotics,":[15],"requiring":[16],"prolonged":[17],"multidrug":[18],"regimens":[19],"with":[20,150,171,186],"limited":[21],"success":[22],"and":[23,43,102,117,130,139,175,196,226,230],"frequent":[24],"relapses.":[25],"tRNA":[26],"(m1G37)":[27],"methyltransferase":[28],"(TrmD),":[29],"an":[30,122],"enzyme":[31],"essential":[32],"for":[33,51,156,202,232],"maintaining":[34],"the":[35,67,85,91,106,183,212,220],"reading":[36],"frame":[37],"during":[38],"protein":[39],"synthesis":[40],"in":[41],"MAB":[42],"other":[44],"mycobacteria,":[45],"is":[46],"potential":[48,69,201],"therapeutic":[49,233],"target":[50],"identifying":[52],"new":[53],"inhibitors.":[54],"This":[55],"study":[56],"introduces":[57],"ABP-Xplorer,":[58],"machine":[60,81],"learning-based":[61],"(ML)":[62],"model":[63,115],"designed":[64],"predict":[66,128],"antibacterial":[68,132],"of":[70,79,163,190,223],"peptides":[71,133,149,165,225],"targeting":[72],"MAB-TrmD":[73],"ribosomal":[74],"sites.":[75],"A":[76],"systematic":[77],"evaluation":[78],"26":[80],"learning":[82],"models":[83],"identified":[84],"Random":[86],"Forest":[87],"(RF)":[88],"classifier":[89],"as":[90,177,205],"most":[92],"effective,":[93],"achieving":[94],"96%":[95],"accuracy.":[96],"To":[97],"address":[98],"data":[99],"set":[100],"imbalance":[101],"enhance":[103],"predictive":[104,143,152],"reliability,":[105],"Synthetic":[107],"Minority":[108],"Oversampling":[109],"Technique":[110],"(SMOTE)":[111],"was":[112,125],"applied,":[113],"improving":[114],"generalization":[116],"reducing":[118],"bias.":[119],"After":[120],"that,":[121],"ABP-Xplorer":[123],"streamlit":[124],"developed":[126],"positive":[129,148],"negative":[131],"(ABP),":[134],"enabling":[135],"easy":[136],"sequence":[137],"input":[138],"classification":[140],"based":[141],"on":[142,219],"scoring.":[144],"For":[145],"validation,":[146],"12":[147],"high":[151],"scores":[153],"were":[154],"selected":[155,164],"molecular":[157],"docking":[158],"by":[159,193],"HADDOCK.":[160],"Docking":[161],"analysis":[162,210],"confirmed":[166],"strong":[167],"binding":[168],"TrmD,":[170],"P1,":[172],"P7,":[173],"P8,":[174],"P9":[176],"top":[178],"candidates.":[179],"Notably,":[180],"P1":[181],"exhibited":[182],"best":[184],"interaction":[185],"HADDOCK":[188],"score":[189],"-102.2,":[191],"followed":[192],"P7":[194],"(-93.6)":[195],"P8":[197],"(-91.4),":[198],"indicating":[199],"further":[203],"development":[204],"TrmD":[206],"inhibitors.Moreover,":[207],"Ramachandran":[208],"plot":[209],"validated":[211],"structural":[213],"reliability.":[214],"Future":[215],"research":[216],"should":[217],"focus":[218],"experimental":[221],"validation":[222],"these":[224],"optimizing":[227],"stability":[229],"bioavailability":[231],"applications.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-03-26T15:22:09.906841","created_date":"2025-10-10T00:00:00"}