{"id":"https://openalex.org/W4411146967","doi":"https://doi.org/10.1021/acs.jcim.5c00557","title":"Identification of DSC2 as a Key Biomarker for Induction Chemotherapy Sensitivity in Locally Advanced Laryngeal and Hypopharyngeal Squamous Cell Carcinoma","display_name":"Identification of DSC2 as a Key Biomarker for Induction Chemotherapy Sensitivity in Locally Advanced Laryngeal and Hypopharyngeal Squamous Cell Carcinoma","publication_year":2025,"publication_date":"2025-06-09","ids":{"openalex":"https://openalex.org/W4411146967","doi":"https://doi.org/10.1021/acs.jcim.5c00557","pmid":"https://pubmed.ncbi.nlm.nih.gov/40489222"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c00557","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00557","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Qianyue Yang","orcid":"https://orcid.org/0009-0000-5819-853X"},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210126592","display_name":"National Clinical Research","ror":"https://ror.org/03ddkvp86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210126592"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Qianyue Yang","raw_affiliation_strings":["Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health","The First Affiliated Hospital of Guangzhou Medical University"],"raw_orcid":"https://orcid.org/0009-0000-5819-853X","affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health","institution_ids":["https://openalex.org/I4210154954","https://openalex.org/I4210126592"]},{"raw_affiliation_string":"The First Affiliated Hospital of Guangzhou Medical University","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100370770","display_name":"Jiayi Liu","orcid":"https://orcid.org/0000-0003-1819-2998"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiayi Liu","raw_affiliation_strings":["Innovation and Transformation Platform of Upper Airway Disease in Guangdong Province"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation and Transformation Platform of Upper Airway Disease in Guangdong Province","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101323344","display_name":"Zhiwei Lin","orcid":"https://orcid.org/0009-0007-0625-5388"},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210126592","display_name":"National Clinical Research","ror":"https://ror.org/03ddkvp86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210126592"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zhiwei Lin","raw_affiliation_strings":["Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health","The First Affiliated Hospital of Guangzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health","institution_ids":["https://openalex.org/I4210154954","https://openalex.org/I4210126592"]},{"raw_affiliation_string":"The First Affiliated Hospital of Guangzhou Medical University","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100731286","display_name":"Shuang Liu","orcid":"https://orcid.org/0000-0003-2347-413X"},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210126592","display_name":"National Clinical Research","ror":"https://ror.org/03ddkvp86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210126592"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Shuang Liu","raw_affiliation_strings":["Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health","The First Affiliated Hospital of Guangzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health","institution_ids":["https://openalex.org/I4210154954","https://openalex.org/I4210126592"]},{"raw_affiliation_string":"The First Affiliated Hospital of Guangzhou Medical University","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068361165","display_name":"Zhaoming Hu","orcid":"https://orcid.org/0000-0002-1870-4167"},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210126592","display_name":"National Clinical Research","ror":"https://ror.org/03ddkvp86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210126592"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zhaoming Hu","raw_affiliation_strings":["Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health","The First Affiliated Hospital of Guangzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health","institution_ids":["https://openalex.org/I4210154954","https://openalex.org/I4210126592"]},{"raw_affiliation_string":"The First Affiliated Hospital of Guangzhou Medical University","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085695020","display_name":"Xiaowen Zhang","orcid":"https://orcid.org/0000-0001-5255-8610"},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaowen Zhang","raw_affiliation_strings":["Department of Allergy and Clinical Immunology, The First Affiliated Hospital","Department of Oncology, The First Affiliated Hospital","First Affiliated Hospital of Guangzhou Medical University","Guangzhou Medical University","Innovation and Transformation Platform of Upper Airway Disease in Guangdong Province","State Key Laboratory of Respiratory Disease"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Clinical Immunology, The First Affiliated Hospital","institution_ids":[]},{"raw_affiliation_string":"Department of Oncology, The First Affiliated Hospital","institution_ids":[]},{"raw_affiliation_string":"First Affiliated Hospital of Guangzhou Medical University","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I92039509"]},{"raw_affiliation_string":"Guangzhou Medical University","institution_ids":["https://openalex.org/I92039509"]},{"raw_affiliation_string":"Innovation and Transformation Platform of Upper Airway Disease in Guangdong Province","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Respiratory Disease","institution_ids":["https://openalex.org/I4210154954"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109722109","display_name":"Baoqing Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210126592","display_name":"National Clinical Research","ror":"https://ror.org/03ddkvp86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210126592"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Baoqing Sun","raw_affiliation_strings":["Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health","The First Affiliated Hospital of Guangzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health","institution_ids":["https://openalex.org/I4210154954","https://openalex.org/I4210126592"]},{"raw_affiliation_string":"The First Affiliated Hospital of Guangzhou Medical University","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I92039509"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5085695020","https://openalex.org/A5109722109"],"corresponding_institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210126592","https://openalex.org/I4210154954","https://openalex.org/I92039509"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16289622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":"12","first_page":"5899","last_page":"5911"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.6957074403762817},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.5181583166122437},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"Chemoradiotherapy","score":0.476227343082428},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.44100287556648254},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4151732325553894},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.40631091594696045},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"Chemotherapy","score":0.3672669529914856},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3013281226158142},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2895810008049011}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6957074403762817},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5181583166122437},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.476227343082428},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44100287556648254},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4151732325553894},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40631091594696045},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3672669529914856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3013281226158142},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2895810008049011},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007012","descriptor_name":"Hypopharyngeal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007012","descriptor_name":"Hypopharyngeal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007012","descriptor_name":"Hypopharyngeal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007012","descriptor_name":"Hypopharyngeal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007012","descriptor_name":"Hypopharyngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007012","descriptor_name":"Hypopharyngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D060828","descriptor_name":"Induction Chemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060828","descriptor_name":"Induction Chemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5c00557","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00557","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:40489222","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40489222","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5099999904632568,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1487853058","https://openalex.org/W1966327575","https://openalex.org/W1976521356","https://openalex.org/W1980514342","https://openalex.org/W1997829811","https://openalex.org/W2000219306","https://openalex.org/W2006099476","https://openalex.org/W2024156824","https://openalex.org/W2061361553","https://openalex.org/W2089296522","https://openalex.org/W2103912979","https://openalex.org/W2140706655","https://openalex.org/W2148618853","https://openalex.org/W2156689307","https://openalex.org/W2258612587","https://openalex.org/W2557888310","https://openalex.org/W2562414697","https://openalex.org/W2620936400","https://openalex.org/W2778455075","https://openalex.org/W2785390423","https://openalex.org/W2941565518","https://openalex.org/W2946851139","https://openalex.org/W3082299892","https://openalex.org/W3092915924","https://openalex.org/W3114486788","https://openalex.org/W3138477213","https://openalex.org/W3156806965","https://openalex.org/W4212857529","https://openalex.org/W4308572408","https://openalex.org/W4317388187","https://openalex.org/W4319440729","https://openalex.org/W4383618578","https://openalex.org/W4386265361","https://openalex.org/W4387426816","https://openalex.org/W4390402650","https://openalex.org/W4391844490","https://openalex.org/W4392231981","https://openalex.org/W4399522781","https://openalex.org/W4403037519","https://openalex.org/W4403074818"],"related_works":["https://openalex.org/W4385649027","https://openalex.org/W4400094315","https://openalex.org/W2970784617","https://openalex.org/W2126639667","https://openalex.org/W2217963778","https://openalex.org/W2474554762","https://openalex.org/W2129882004","https://openalex.org/W4303685026","https://openalex.org/W2058137177","https://openalex.org/W2074657476"],"abstract_inverted_index":{"Patients":[0],"with":[1,97],"locally":[2],"advanced":[3],"laryngeal":[4,23],"and":[5,29,46,64,73,129,150,165,198,201],"hypopharyngeal":[6],"squamous":[7],"cell":[8],"carcinoma":[9],"(LA-LHSCC)":[10],"urgently":[11],"need":[12],"precise":[13],"treatment":[14],"strategies":[15,197],"to":[16,21,39,50,143,174],"improve":[17],"the":[18,35,44,77,94,106,130,151,155,160,172,192],"prognosis":[19],"due":[20],"severe":[22],"functional":[24],"impairment":[25],"following":[26],"traditional":[27],"surgery":[28],"chemoradiotherapy.":[30],"This":[31],"study":[32,170],"focuses":[33],"on":[34],"mechanism":[36],"of":[37,109,133,194],"sensitivity":[38,146,183],"induction":[40],"chemotherapy":[41],"(IC),":[42],"integrating":[43],"GSE184072":[45],"TCGA-HNSC":[47],"data":[48,158],"sets":[49],"screen":[51],"for":[52,181,191],"differentially":[53],"expressed":[54,92],"genes":[55],"(DEGs).":[56],"Combining":[57],"weighted":[58],"gene":[59,79],"coexpression":[60],"network":[61],"analysis":[62,121],"(WGCNA)":[63],"machine":[65],"learning":[66],"methods,":[67],"including":[68],"MCC,":[69],"MCODE,":[70],"LASSO,":[71],"SVM-RFE,":[72],"Random":[74],"Forest":[75],"(RF),":[76],"core":[78],"DSC2":[80,88,128,163,176],"(Desmocollin-2)":[81],"was":[82],"identified.":[83],"The":[84],"results":[85],"show":[86],"that":[87],"is":[89,171],"significantly":[90],"highly":[91],"in":[93,184],"IC-sensitive":[95],"group":[96],"a":[98,117,124,178,188],"receiver":[99],"operating":[100],"characteristic":[101],"(ROC)":[102],"curve":[103,107],"area":[104],"under":[105],"(AUC)":[108],"0.9111,":[110],"indicating":[111],"its":[112,141],"high":[113],"predictive":[114],"efficacy":[115],"as":[116,137,177],"biomarker.":[118],"Immune":[119],"infiltration":[120,131],"further":[122],"revealed":[123],"significant":[125],"correlation":[126,161],"between":[127,162],"levels":[132],"immune":[134,152],"cells":[135],"such":[136],"M1":[138],"macrophages,":[139],"suggesting":[140],"potential":[142],"influence":[144],"IC":[145,182],"by":[147],"regulating":[148],"apoptosis":[149],"microenvironment.":[153],"Furthermore,":[154],"TCGA":[156],"clinical":[157],"validated":[159],"expression":[164],"patient":[166],"survival":[167],"rates.":[168],"Our":[169],"first":[173],"establish":[175],"pivotal":[179],"biomarker":[180],"LA-LHSCC":[185],"patients,":[186],"offering":[187],"novel":[189],"avenue":[190],"development":[193],"targeted":[195],"therapeutic":[196],"personalized":[199],"diagnosis":[200],"treatment.":[202]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
