{"id":"https://openalex.org/W4410734917","doi":"https://doi.org/10.1021/acs.jcim.5c00376","title":"NA-DB: An Online Database of Nucleoside Analogues","display_name":"NA-DB: An Online Database of Nucleoside Analogues","publication_year":2025,"publication_date":"2025-05-26","ids":{"openalex":"https://openalex.org/W4410734917","doi":"https://doi.org/10.1021/acs.jcim.5c00376","pmid":"https://pubmed.ncbi.nlm.nih.gov/40419450"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c00376","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00376","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117698649","display_name":"Haolin Luo","orcid":null},"institutions":[{"id":"https://openalex.org/I4210090512","display_name":"Guangzhou Experimental Station","ror":"https://ror.org/00f2c2516","country_code":"CN","type":"facility","lineage":["https://openalex.org/I107851509","https://openalex.org/I4210090512","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210119150","display_name":"Institut de Recherche Vaccinale","ror":"https://ror.org/02f9r3321","country_code":"FR","type":"facility","lineage":["https://openalex.org/I197681013","https://openalex.org/I4210116296","https://openalex.org/I4210119150"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN","FR"],"is_corresponding":false,"raw_author_name":"Haolin Luo","raw_affiliation_strings":["Division of Drug and Vaccine Research","Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering, Joint International Research Laboratory of Synthetic Biology and Medicine, Ministry of Education, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering","Guangzhou National Laboratory","South China University of Technology","Division of Drug and Vaccine Research, Guangzhou National Laboratory, Guangzhou 510005, Guangdong, China","Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering, Joint International Research Laboratory of Synthetic Biology and Medicine, Ministry of Education, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China"],"affiliations":[{"raw_affiliation_string":"Division of Drug and Vaccine Research","institution_ids":["https://openalex.org/I4210119150"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering, Joint International Research Laboratory of Synthetic Biology and Medicine, Ministry of Education, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering","institution_ids":[]},{"raw_affiliation_string":"Guangzhou National Laboratory","institution_ids":["https://openalex.org/I4210090512"]},{"raw_affiliation_string":"South China University of Technology","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"Division of Drug and Vaccine Research, Guangzhou National Laboratory, Guangzhou 510005, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering, Joint International Research Laboratory of Synthetic Biology and Medicine, Ministry of Education, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028137045","display_name":"Ting Ran","orcid":"https://orcid.org/0000-0002-1387-4634"},"institutions":[{"id":"https://openalex.org/I4210090512","display_name":"Guangzhou Experimental Station","ror":"https://ror.org/00f2c2516","country_code":"CN","type":"facility","lineage":["https://openalex.org/I107851509","https://openalex.org/I4210090512","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210119150","display_name":"Institut de Recherche Vaccinale","ror":"https://ror.org/02f9r3321","country_code":"FR","type":"facility","lineage":["https://openalex.org/I197681013","https://openalex.org/I4210116296","https://openalex.org/I4210119150"]}],"countries":["CN","FR"],"is_corresponding":true,"raw_author_name":"Ting Ran","raw_affiliation_strings":["Division of Drug and Vaccine Research","Guangzhou National Laboratory","Division of Drug and Vaccine Research, Guangzhou National Laboratory, Guangzhou 510005, Guangdong, China"],"affiliations":[{"raw_affiliation_string":"Division of Drug and Vaccine Research","institution_ids":["https://openalex.org/I4210119150"]},{"raw_affiliation_string":"Guangzhou National Laboratory","institution_ids":["https://openalex.org/I4210090512"]},{"raw_affiliation_string":"Division of Drug and Vaccine Research, Guangzhou National Laboratory, Guangzhou 510005, Guangdong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100398640","display_name":"Ling Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ling Wang","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering, Joint International Research Laboratory of Synthetic Biology and Medicine, Ministry of Education, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering","South China University of Technology"],"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering, Joint International Research Laboratory of Synthetic Biology and Medicine, Ministry of Education, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering","institution_ids":[]},{"raw_affiliation_string":"South China University of Technology","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100729956","display_name":"Hongming Chen","orcid":"https://orcid.org/0000-0002-8065-8333"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4210090512","display_name":"Guangzhou Experimental Station","ror":"https://ror.org/00f2c2516","country_code":"CN","type":"facility","lineage":["https://openalex.org/I107851509","https://openalex.org/I4210090512","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210119150","display_name":"Institut de Recherche Vaccinale","ror":"https://ror.org/02f9r3321","country_code":"FR","type":"facility","lineage":["https://openalex.org/I197681013","https://openalex.org/I4210116296","https://openalex.org/I4210119150"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN","FR"],"is_corresponding":true,"raw_author_name":"Hongming Chen","raw_affiliation_strings":["Division of Drug and Vaccine Research","Guangzhou Medical University","Guangzhou National Laboratory","School of Basic Medical Sciences, Guangzhou Laboratory","State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China"],"affiliations":[{"raw_affiliation_string":"Division of Drug and Vaccine Research","institution_ids":["https://openalex.org/I4210119150"]},{"raw_affiliation_string":"Guangzhou Medical University","institution_ids":["https://openalex.org/I92039509"]},{"raw_affiliation_string":"Guangzhou National Laboratory","institution_ids":["https://openalex.org/I4210090512"]},{"raw_affiliation_string":"School of Basic Medical Sciences, Guangzhou Laboratory","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5028137045","https://openalex.org/A5100398640","https://openalex.org/A5100729956"],"corresponding_institution_ids":["https://openalex.org/I205237279","https://openalex.org/I4210090512","https://openalex.org/I4210119150","https://openalex.org/I90610280","https://openalex.org/I92039509"],"apc_list":null,"apc_paid":null,"fwci":1.3328,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.79059557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"65","issue":"11","first_page":"5255","last_page":"5272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleoside","display_name":"Nucleoside","score":0.5619131326675415},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.527971088886261},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44268590211868286},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3866555690765381},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.250529944896698}],"concepts":[{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.5619131326675415},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.527971088886261},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44268590211868286},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3866555690765381},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.250529944896698}],"mesh":[{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062126","descriptor_name":"Databases, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062126","descriptor_name":"Databases, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5c00376","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00376","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:40419450","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40419450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1164635587","display_name":null,"funder_award_id":"2023B1515020042","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G1674672033","display_name":null,"funder_award_id":"81973241","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8143382980","display_name":null,"funder_award_id":"2023YFF1204902","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W86427758","https://openalex.org/W1966937757","https://openalex.org/W1972185917","https://openalex.org/W1977169223","https://openalex.org/W1981737096","https://openalex.org/W1986799343","https://openalex.org/W1988669301","https://openalex.org/W1995173097","https://openalex.org/W2006821928","https://openalex.org/W2008849874","https://openalex.org/W2022917849","https://openalex.org/W2023958907","https://openalex.org/W2024074032","https://openalex.org/W2027461913","https://openalex.org/W2030323580","https://openalex.org/W2031124449","https://openalex.org/W2035780456","https://openalex.org/W2038921550","https://openalex.org/W2046307202","https://openalex.org/W2068392260","https://openalex.org/W2069032746","https://openalex.org/W2077108587","https://openalex.org/W2087957920","https://openalex.org/W2096541451","https://openalex.org/W2100966940","https://openalex.org/W2103868202","https://openalex.org/W2112592262","https://openalex.org/W2120869341","https://openalex.org/W2130245118","https://openalex.org/W2148903648","https://openalex.org/W2156914313","https://openalex.org/W2162024492","https://openalex.org/W2166410121","https://openalex.org/W2183163677","https://openalex.org/W2314805854","https://openalex.org/W2416267655","https://openalex.org/W2578575587","https://openalex.org/W2741083311","https://openalex.org/W2765176114","https://openalex.org/W2765304256","https://openalex.org/W2767891136","https://openalex.org/W2780053060","https://openalex.org/W2796947392","https://openalex.org/W2899070097","https://openalex.org/W2901801276","https://openalex.org/W2905424382","https://openalex.org/W2963647337","https://openalex.org/W2989341113","https://openalex.org/W3008251701","https://openalex.org/W3026599087","https://openalex.org/W3048090444","https://openalex.org/W3152728485","https://openalex.org/W3164139088","https://openalex.org/W4205426268","https://openalex.org/W4220840106","https://openalex.org/W4404997118"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487"],"abstract_inverted_index":{"Nucleoside":[0],"analogues":[1],"(NAs)":[2],"constitute":[3],"a":[4,42,77,113,148],"class":[5],"of":[6,12,37,49,61,65,72,104,151,155],"compounds":[7],"that":[8],"mirror":[9],"the":[10,35,47,58,69,135,152,158],"structure":[11],"natural":[13,32],"nucleosides":[14],"but":[15],"undergo":[16],"chemical":[17,54,121],"modifications,":[18],"rendering":[19],"them":[20],"an":[21],"important":[22],"compound":[23],"resource":[24],"for":[25,31],"drug":[26],"development":[27],"as":[28,127,129],"exogenous":[29],"substitutes":[30],"nucleosides.":[33],"Nevertheless,":[34],"design":[36,71],"novel":[38],"NA-based":[39],"drugs":[40],"remains":[41],"great":[43],"challenge":[44],"due":[45],"to":[46,57,82,119,134,145],"complexity":[48],"asymmetric":[50],"synthesis":[51],"and":[52,86,108,112,122,137],"restrained":[53],"space":[55],"owing":[56],"strict":[59],"requirement":[60],"hydrogen":[62],"boding":[63],"pattern":[64],"nucleotides.":[66],"To":[67],"facilitate":[68],"rational":[70],"NA":[73],"drugs,":[74],"we":[75],"build":[76],"specialized":[78],"database":[79,96],"named":[80],"NA-DB":[81,160],"integrate":[83],"both":[84],"structural":[85,131,153],"annotated":[87],"biological":[88,123],"information":[89,124],"about":[90],"NAs":[91,126,156],"reported":[92],"in":[93,147],"literatures.":[94],"The":[95],"contains":[97],"around":[98],"9074":[99],"NAs,":[100],"which":[101],"are":[102],"composed":[103],"4513":[105],"base-like":[106],"fragments":[107],"2602":[109],"ribose-like":[110],"fragments,":[111],"user-friendly":[114],"web":[115],"interface":[116],"is":[117,161],"provided":[118],"search":[120],"on":[125],"well":[128],"their":[130],"features":[132],"corresponding":[133],"base":[136],"ribose":[138],"moieties.":[139],"Simultaneously,":[140],"multiple":[141],"analyses":[142],"were":[143],"conducted":[144],"aid":[146],"comprehensive":[149],"understanding":[150],"characteristics":[154],"within":[157],"database.":[159],"freely":[162],"accessible":[163],"at":[164],"http://nadb.idruglab.cn/.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-10T00:00:00"}