{"id":"https://openalex.org/W4408681177","doi":"https://doi.org/10.1021/acs.jcim.5c00275","title":"Application of Large Language Models in Drug-Induced Osteotoxicity Prediction","display_name":"Application of Large Language Models in Drug-Induced Osteotoxicity Prediction","publication_year":2025,"publication_date":"2025-03-21","ids":{"openalex":"https://openalex.org/W4408681177","doi":"https://doi.org/10.1021/acs.jcim.5c00275","pmid":"https://pubmed.ncbi.nlm.nih.gov/40114317"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c00275","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00275","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yi-Qi Chen","orcid":"https://orcid.org/0009-0007-9370-4005"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Qi Chen","raw_affiliation_strings":["Department of Orthopaedics","The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 32500, China"],"raw_orcid":"https://orcid.org/0009-0007-9370-4005","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics","institution_ids":[]},{"raw_affiliation_string":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I4210099512","https://openalex.org/I27781120"]},{"raw_affiliation_string":"Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 32500, China","institution_ids":["https://openalex.org/I4210099512","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402028","display_name":"Changyuan Yu","orcid":"https://orcid.org/0000-0002-3185-0441"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Yu","raw_affiliation_strings":["Department of Orthopaedics","The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 32500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics","institution_ids":[]},{"raw_affiliation_string":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I4210099512","https://openalex.org/I27781120"]},{"raw_affiliation_string":"Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 32500, China","institution_ids":["https://openalex.org/I4210099512","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110985998","display_name":"Zheng-Qi Song","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng-Qi Song","raw_affiliation_strings":["Department of Orthopaedics","The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 32500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics","institution_ids":[]},{"raw_affiliation_string":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I4210099512","https://openalex.org/I27781120"]},{"raw_affiliation_string":"Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 32500, China","institution_ids":["https://openalex.org/I4210099512","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100385880","display_name":"Chenyu Wang","orcid":"https://orcid.org/0000-0002-9199-3735"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen-Yu Wang","raw_affiliation_strings":["Department of Orthopaedics","The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 32500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics","institution_ids":[]},{"raw_affiliation_string":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I4210099512","https://openalex.org/I27781120"]},{"raw_affiliation_string":"Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 32500, China","institution_ids":["https://openalex.org/I4210099512","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101758724","display_name":"Jiangtao Luo","orcid":"https://orcid.org/0009-0008-9205-0254"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiang-Tao Luo","raw_affiliation_strings":["Department of Orthopaedics","The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 32500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics","institution_ids":[]},{"raw_affiliation_string":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I4210099512","https://openalex.org/I27781120"]},{"raw_affiliation_string":"Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 32500, China","institution_ids":["https://openalex.org/I4210099512","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003491752","display_name":"Yong Xiao","orcid":"https://orcid.org/0000-0003-3230-8758"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Xiao","raw_affiliation_strings":["Department of Orthopaedics","The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 32500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics","institution_ids":[]},{"raw_affiliation_string":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I4210099512","https://openalex.org/I27781120"]},{"raw_affiliation_string":"Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 32500, China","institution_ids":["https://openalex.org/I4210099512","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056044419","display_name":"Heng Qiu","orcid":"https://orcid.org/0000-0002-0864-317X"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Heng Qiu","raw_affiliation_strings":["Department of Chemistry","The University of Hong Kong","Department of Chemistry, The University of Hong Kong, Hong Kong, SAR 999077, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"The University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Department of Chemistry, The University of Hong Kong, Hong Kong, SAR 999077, China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100638423","display_name":"Qingqing Wang","orcid":"https://orcid.org/0000-0002-5846-2801"},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qing-Qing Wang","raw_affiliation_strings":["Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital","Zhejiang University School of Medicine","Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital","institution_ids":["https://openalex.org/I2802390878"]},{"raw_affiliation_string":"Zhejiang University School of Medicine","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006962649","display_name":"Haiming Jin","orcid":"https://orcid.org/0000-0003-2666-8415"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hai-Ming Jin","raw_affiliation_strings":["Department of Orthopaedics","The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 32500, China"],"raw_orcid":"https://orcid.org/0000-0003-2666-8415","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics","institution_ids":[]},{"raw_affiliation_string":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I4210099512","https://openalex.org/I27781120"]},{"raw_affiliation_string":"Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 32500, China","institution_ids":["https://openalex.org/I4210099512","https://openalex.org/I27781120"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5006962649","https://openalex.org/A5100638423"],"corresponding_institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2802390878","https://openalex.org/I4210099512","https://openalex.org/I76130692"],"apc_list":null,"apc_paid":null,"fwci":15.3362,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.99039272,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"65","issue":"7","first_page":"3370","last_page":"3379"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9196000099182129,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9072999954223633,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5269642472267151},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.49202486872673035},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.4491443932056427},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.39984047412872314},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.20468324422836304},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1546861231327057}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5269642472267151},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.49202486872673035},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.4491443932056427},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.39984047412872314},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.20468324422836304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1546861231327057}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098342","descriptor_name":"Large Language Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098342","descriptor_name":"Large Language Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5c00275","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00275","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:40114317","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40114317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3720904879","display_name":null,"funder_award_id":"2022RC192","funder_id":"https://openalex.org/F4320328762","funder_display_name":"Health Commission of Zhejiang Province"},{"id":"https://openalex.org/G6504963701","display_name":null,"funder_award_id":"82202757","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320328762","display_name":"Health Commission of Zhejiang Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1771028704","https://openalex.org/W1975147762","https://openalex.org/W1975344303","https://openalex.org/W2000189060","https://openalex.org/W2005326563","https://openalex.org/W2123159115","https://openalex.org/W2166447472","https://openalex.org/W2170973067","https://openalex.org/W2289713660","https://openalex.org/W2295598076","https://openalex.org/W2767891136","https://openalex.org/W2769487897","https://openalex.org/W2773405722","https://openalex.org/W2810664820","https://openalex.org/W2973114758","https://openalex.org/W2995988606","https://openalex.org/W3083410900","https://openalex.org/W3124015954","https://openalex.org/W3126259453","https://openalex.org/W3157775920","https://openalex.org/W3202336137","https://openalex.org/W4241632268","https://openalex.org/W4245194588","https://openalex.org/W4327564965","https://openalex.org/W4385849028","https://openalex.org/W4386046317","https://openalex.org/W4387865897","https://openalex.org/W4389451366","https://openalex.org/W4389485341","https://openalex.org/W4396706972","https://openalex.org/W4399304224","https://openalex.org/W4403990572","https://openalex.org/W4404123553","https://openalex.org/W4405443649","https://openalex.org/W4405443777","https://openalex.org/W4407802602"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W3204019825"],"abstract_inverted_index":{"Drug-induced":[0],"osteotoxicity":[1],"refers":[2],"to":[3,69],"the":[4,11,75,101,129,143],"harmful":[5,104],"effects":[6,20],"certain":[7],"drugs":[8],"have":[9],"on":[10,106],"skeletal":[12,116],"system,":[13],"posing":[14],"significant":[15],"safety":[16,113],"risks.":[17],"These":[18],"toxic":[19],"are":[21],"a":[22],"key":[23],"concern":[24],"in":[25,99,135,142],"clinical":[26],"practice,":[27],"drug":[28,110],"development,":[29,111],"and":[30,42,54,62,78,87,119,123,139,147],"environmental":[31],"management.":[32],"However,":[33],"existing":[34],"toxicity":[35,138],"assessment":[36],"models":[37,81,134],"lack":[38],"specialized":[39],"data":[40],"sets":[41],"algorithms":[43],"for":[44],"predicting":[45,136],"osteotoxicity.":[46],"In":[47],"our":[48],"study,":[49],"we":[50],"collected":[51],"osteotoxic":[52],"molecules":[53],"employed":[55],"various":[56],"large":[57,132],"language":[58,133],"models,":[59],"including":[60],"DeepSeek":[61,76],"ChatGPT,":[63],"alongside":[64],"traditional":[65],"machine":[66,94],"learning":[67,95],"methods":[68,96],"predict":[70],"their":[71,140],"properties.":[72],"Among":[73],"these,":[74],"R1":[77],"ChatGPT":[79],"o3":[80],"achieved":[82],"ACC":[83],"values":[84],"of":[85,103,131,145],"0.87":[86],"0.88,":[88],"respectively.":[89],"Our":[90],"results":[91],"indicate":[92],"that":[93],"can":[97],"assist":[98],"evaluating":[100],"impact":[102],"substances":[105],"bone":[107],"health":[108,146],"during":[109],"improving":[112],"protocols,":[114],"mitigating":[115],"side":[117],"effects,":[118],"enhancing":[120],"treatment":[121],"outcomes":[122],"public":[124],"safety.":[125],"Furthermore,":[126],"it":[127],"highlights":[128],"potential":[130],"molecular":[137],"significance":[141],"fields":[144],"chemical":[148],"sciences.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
