{"id":"https://openalex.org/W4408813386","doi":"https://doi.org/10.1021/acs.jcim.5c00174","title":"MFF-nDA: A Computational Model for ncRNA\u2013Disease Association Prediction Based on Multimodule Fusion","display_name":"MFF-nDA: A Computational Model for ncRNA\u2013Disease Association Prediction Based on Multimodule Fusion","publication_year":2025,"publication_date":"2025-03-25","ids":{"openalex":"https://openalex.org/W4408813386","doi":"https://doi.org/10.1021/acs.jcim.5c00174","pmid":"https://pubmed.ncbi.nlm.nih.gov/40129032"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c00174","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00174","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001344189","display_name":"Zhihao Guan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210164862","display_name":"Artificial Intelligence in Medicine (Canada)","ror":"https://ror.org/05p590m36","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210164862"]},{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]}],"countries":["CA","CN"],"is_corresponding":false,"raw_author_name":"Zhihao Guan","raw_affiliation_strings":["Anhui Agricultural University","Anhui Province Key Laboratory of Smart Agricultural Technology and Equipment","College of Information and Artificial Intelligence"],"affiliations":[{"raw_affiliation_string":"Anhui Agricultural University","institution_ids":["https://openalex.org/I140221134"]},{"raw_affiliation_string":"Anhui Province Key Laboratory of Smart Agricultural Technology and Equipment","institution_ids":[]},{"raw_affiliation_string":"College of Information and Artificial Intelligence","institution_ids":["https://openalex.org/I4210164862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071991982","display_name":"Xiu Jin","orcid":"https://orcid.org/0000-0003-3017-7328"},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]},{"id":"https://openalex.org/I4210164862","display_name":"Artificial Intelligence in Medicine (Canada)","ror":"https://ror.org/05p590m36","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210164862"]}],"countries":["CA","CN"],"is_corresponding":false,"raw_author_name":"Xiu Jin","raw_affiliation_strings":["Anhui Agricultural University","Anhui Province Key Laboratory of Smart Agricultural Technology and Equipment","College of Information and Artificial Intelligence"],"affiliations":[{"raw_affiliation_string":"Anhui Agricultural University","institution_ids":["https://openalex.org/I140221134"]},{"raw_affiliation_string":"Anhui Province Key Laboratory of Smart Agricultural Technology and Equipment","institution_ids":[]},{"raw_affiliation_string":"College of Information and Artificial Intelligence","institution_ids":["https://openalex.org/I4210164862"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109413565","display_name":"Xiaodan Zhang","orcid":"https://orcid.org/0000-0001-9196-1082"},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]},{"id":"https://openalex.org/I4210164862","display_name":"Artificial Intelligence in Medicine (Canada)","ror":"https://ror.org/05p590m36","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210164862"]}],"countries":["CA","CN"],"is_corresponding":true,"raw_author_name":"Xiaodan Zhang","raw_affiliation_strings":["Anhui Agricultural University","Anhui Province Key Laboratory of Smart Agricultural Technology and Equipment","College of Information and Artificial Intelligence"],"affiliations":[{"raw_affiliation_string":"Anhui Agricultural University","institution_ids":["https://openalex.org/I140221134"]},{"raw_affiliation_string":"Anhui Province Key Laboratory of Smart Agricultural Technology and Equipment","institution_ids":[]},{"raw_affiliation_string":"College of Information and Artificial Intelligence","institution_ids":["https://openalex.org/I4210164862"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109413565"],"corresponding_institution_ids":["https://openalex.org/I140221134","https://openalex.org/I4210164862"],"apc_list":null,"apc_paid":null,"fwci":2.8575,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.89749135,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"65","issue":"7","first_page":"3324","last_page":"3342"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fusion","display_name":"Fusion","score":0.5101778507232666},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.470990389585495},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44101816415786743},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35315996408462524},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19842174649238586},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.1236717700958252},{"id":"https://openalex.org/keywords/philosophy","display_name":"Philosophy","score":0.062397122383117676}],"concepts":[{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.5101778507232666},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.470990389585495},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44101816415786743},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35315996408462524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19842174649238586},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1236717700958252},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.062397122383117676},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5c00174","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00174","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:40129032","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40129032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2292039908","display_name":null,"funder_award_id":"KJ2020A0108","funder_id":"https://openalex.org/F4320329899","funder_display_name":"Scientific Research Foundation of Education Department of Anhui Province of China"}],"funders":[{"id":"https://openalex.org/F4320329899","display_name":"Scientific Research Foundation of Education Department of Anhui Province of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1982191152","https://openalex.org/W2006195332","https://openalex.org/W2011832929","https://openalex.org/W2014881329","https://openalex.org/W2036666348","https://openalex.org/W2046318418","https://openalex.org/W2055027431","https://openalex.org/W2087064593","https://openalex.org/W2088128227","https://openalex.org/W2103151642","https://openalex.org/W2106029302","https://openalex.org/W2113377893","https://openalex.org/W2116707781","https://openalex.org/W2120522615","https://openalex.org/W2120920586","https://openalex.org/W2124045889","https://openalex.org/W2124050695","https://openalex.org/W2125523389","https://openalex.org/W2128768066","https://openalex.org/W2130313087","https://openalex.org/W2134601791","https://openalex.org/W2140687871","https://openalex.org/W2141222510","https://openalex.org/W2153330772","https://openalex.org/W2579869402","https://openalex.org/W2586411032","https://openalex.org/W2617715606","https://openalex.org/W2782959626","https://openalex.org/W2807343509","https://openalex.org/W2810376110","https://openalex.org/W2888358121","https://openalex.org/W2897798868","https://openalex.org/W2900597665","https://openalex.org/W2952153265","https://openalex.org/W2955033696","https://openalex.org/W2980767508","https://openalex.org/W3016535584","https://openalex.org/W3085464158","https://openalex.org/W3099929518","https://openalex.org/W3108133122","https://openalex.org/W3120801559","https://openalex.org/W3137173150","https://openalex.org/W3146565636","https://openalex.org/W3185225911","https://openalex.org/W4200043717","https://openalex.org/W4206711189","https://openalex.org/W4214819937","https://openalex.org/W4225752318","https://openalex.org/W4283209287","https://openalex.org/W4285041302","https://openalex.org/W4285590326","https://openalex.org/W4294990936","https://openalex.org/W4297891375","https://openalex.org/W4300594341","https://openalex.org/W4307440230","https://openalex.org/W4307808166","https://openalex.org/W4321082506","https://openalex.org/W4377965465","https://openalex.org/W4381433853","https://openalex.org/W4383340895","https://openalex.org/W4386453506","https://openalex.org/W4386963628","https://openalex.org/W4387516871","https://openalex.org/W4388000718","https://openalex.org/W4390066222","https://openalex.org/W4392128268","https://openalex.org/W4392594134","https://openalex.org/W4393007257","https://openalex.org/W4394014417","https://openalex.org/W4394773567","https://openalex.org/W4396591803","https://openalex.org/W4399157485","https://openalex.org/W4400448110","https://openalex.org/W4400926737","https://openalex.org/W4402673179","https://openalex.org/W4403042146","https://openalex.org/W4403425884","https://openalex.org/W4404444331","https://openalex.org/W4405220491","https://openalex.org/W4406024492"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Noncoding":[0],"RNAs(ncRNAs),":[1],"including":[2,145],"piwi-interacting":[3],"RNA(piRNA),":[4],"long":[5],"noncoding":[6],"RNA(lncRNA),":[7],"microRNA(miRNA),":[8],"small":[9],"nucleolar":[10],"RNA(snoRNA),":[11],"and":[12,21,30,44,66,80,82,112,150,162,193,213],"circular":[13],"RNA(circRNA),":[14],"contribute":[15],"significantly":[16],"to":[17,94,117,121,159,234,243],"gene":[18],"expression":[19],"regulation":[20],"serve":[22],"as":[23],"key":[24],"factors":[25],"in":[26,91,157,210,218],"disease":[27,42,154],"association":[28,183,219],"studies":[29],"health-related":[31],"exploration.":[32],"Accurate":[33],"prediction":[34],"of":[35,110,141,148,153,208,224,249,288],"ncRNA-disease":[36],"associations":[37,62],"is":[38],"crucial":[39],"for":[40,60,265,279],"elucidating":[41],"mechanisms":[43],"advancing":[45],"therapeutic":[46],"development.":[47],"Recently,":[48],"computational":[49,70,128],"models":[50,71,86,102],"based":[51,131,180,187,198],"on":[52,78,84,132,168,181,188,199],"a":[53,107,127,276],"graph":[54,189,200],"neural":[55],"network":[56,143,177,184,191,202],"have":[57,72],"extensively":[58],"emerged":[59],"identifying":[61,280],"among":[63],"various":[64],"ncRNAs":[65],"diseases.":[67,285],"However,":[68],"existing":[69,101],"not":[73,114],"fully":[74,160],"utilized":[75],"integrative":[76],"information":[77,167,216],"ncRNs":[79],"diseases,":[81],"reliance":[83],"GNN-based":[85],"alone":[87],"may":[88,113],"be":[89,115,291],"limited":[90],"performance":[92],"due":[93],"oversmoothing":[95,232],"issues.":[96],"On":[97],"the":[98,164,225,231,239,246,255,270],"other":[99],"hand,":[100],"are":[103],"mainly":[104],"targeted":[105],"at":[106,293],"specific":[108],"type":[109],"ncRNA":[111,149,282],"applicable":[116],"most":[118],"ncRNAs.":[119],"Therefore,":[120],"overcome":[122],"these":[123,169,250],"limitations,":[124],"we":[125,136,172],"propound":[126],"model":[129,253],"MFF-nDA":[130,289],"multimodule":[133,240],"fusion.":[134],"Specifically,":[135],"first":[137],"introduce":[138],"five":[139],"types":[140,147,152],"similarity":[142,155],"information,":[144,156],"three":[146,174,226],"two":[151],"order":[158],"explore":[161],"optimize":[163],"multisource":[165],"feature":[166],"entities.":[170],"Subsequently,":[171],"establish":[173],"modules:":[175],"heterogeneous":[176,211],"representation":[178,185,196],"module":[179,186,197],"Transformer,":[182],"convolutional":[190],"(GCN),":[192],"topological":[194,214],"structure":[195,215],"attention":[201],"(GAT),":[203],"which":[204],"capture":[205,245],"diverse":[206,247],"features":[207,248],"nodes":[209],"networks":[212],"reflected":[217],"networks.":[220],"The":[221,286],"complementary":[222],"effects":[223],"modules":[227],"also":[228],"help":[229],"relieve":[230],"issue":[233],"some":[235],"extent.":[236],"By":[237],"leveraging":[238],"fusion":[241],"learning":[242],"comprehensively":[244],"entities,":[251],"our":[252],"outperforms":[254],"available":[256],"state-of-the-art":[257],"methods,":[258],"achieving":[259],"an":[260],"AUC":[261],"greater":[262],"than":[263],"0.9000":[264],"each":[266],"dataset.":[267],"This":[268],"demonstrates":[269],"highest":[271],"predictive":[272],"performance,":[273],"making":[274],"it":[275],"valuable":[277],"tool":[278],"potential":[281],"associated":[283],"with":[284],"code":[287],"can":[290],"accessed":[292],"https://github.com/Jack-Cxy/MFF-nDA.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-03-26T15:22:09.906841","created_date":"2025-10-10T00:00:00"}