{"id":"https://openalex.org/W4409706401","doi":"https://doi.org/10.1021/acs.jcim.5c00173","title":"Unraveling Disease-Associated PIWI-Interacting RNAs with a Contrastive Learning Methods","display_name":"Unraveling Disease-Associated PIWI-Interacting RNAs with a Contrastive Learning Methods","publication_year":2025,"publication_date":"2025-04-23","ids":{"openalex":"https://openalex.org/W4409706401","doi":"https://doi.org/10.1021/acs.jcim.5c00173","pmid":"https://pubmed.ncbi.nlm.nih.gov/40263714"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c00173","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00173","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xiaowen Hu","orcid":"https://orcid.org/0009-0001-1004-5099"},"institutions":[{"id":"https://openalex.org/I48168531","display_name":"South University","ror":"https://ror.org/01rjfjt94","country_code":"US","type":"education","lineage":["https://openalex.org/I48168531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaowen Hu","raw_affiliation_strings":["Center South University","School of Computer Science and Engineering"],"raw_orcid":"https://orcid.org/0009-0001-1004-5099","affiliations":[{"raw_affiliation_string":"Center South University","institution_ids":["https://openalex.org/I48168531"]},{"raw_affiliation_string":"School of Computer Science and Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001836351","display_name":"Hao Sun","orcid":"https://orcid.org/0000-0002-5547-9501"},"institutions":[{"id":"https://openalex.org/I48168531","display_name":"South University","ror":"https://ror.org/01rjfjt94","country_code":"US","type":"education","lineage":["https://openalex.org/I48168531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Sun","raw_affiliation_strings":["Center South University","School of Computer Science and Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center South University","institution_ids":["https://openalex.org/I48168531"]},{"raw_affiliation_string":"School of Computer Science and Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108379281","display_name":"L.Y. Shan","orcid":null},"institutions":[{"id":"https://openalex.org/I48168531","display_name":"South University","ror":"https://ror.org/01rjfjt94","country_code":"US","type":"education","lineage":["https://openalex.org/I48168531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linchao Shan","raw_affiliation_strings":["Center South University","School of Computer Science and Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center South University","institution_ids":["https://openalex.org/I48168531"]},{"raw_affiliation_string":"School of Computer Science and Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060187092","display_name":"Cong Ma","orcid":"https://orcid.org/0000-0002-9367-5685"},"institutions":[{"id":"https://openalex.org/I48168531","display_name":"South University","ror":"https://ror.org/01rjfjt94","country_code":"US","type":"education","lineage":["https://openalex.org/I48168531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenxi Ma","raw_affiliation_strings":["Center South University","School of Computer Science and Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center South University","institution_ids":["https://openalex.org/I48168531"]},{"raw_affiliation_string":"School of Computer Science and Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113346116","display_name":"H. Quan","orcid":null},"institutions":[{"id":"https://openalex.org/I48168531","display_name":"South University","ror":"https://ror.org/01rjfjt94","country_code":"US","type":"education","lineage":["https://openalex.org/I48168531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanming Quan","raw_affiliation_strings":["Center South University","School of Computer Science and Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center South University","institution_ids":["https://openalex.org/I48168531"]},{"raw_affiliation_string":"School of Computer Science and Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052229178","display_name":"Yuanpeng Zhang","orcid":"https://orcid.org/0000-0003-1736-3425"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanpeng Zhang","raw_affiliation_strings":["School of software","Xinjiang University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of software","institution_ids":[]},{"raw_affiliation_string":"Xinjiang University","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100628892","display_name":"Jiaxuan Zhang","orcid":"https://orcid.org/0009-0005-1931-2244"},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiaxuan Zhang","raw_affiliation_strings":["Department of Electrical and Computer Engineering","University of California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering","institution_ids":[]},{"raw_affiliation_string":"University of California","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056400750","display_name":"Ziyu Fan","orcid":"https://orcid.org/0009-0003-1962-8092"},"institutions":[{"id":"https://openalex.org/I48168531","display_name":"South University","ror":"https://ror.org/01rjfjt94","country_code":"US","type":"education","lineage":["https://openalex.org/I48168531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ziyu Fan","raw_affiliation_strings":["Center South University","School of Computer Science and Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center South University","institution_ids":["https://openalex.org/I48168531"]},{"raw_affiliation_string":"School of Computer Science and Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011917328","display_name":"Yongjun Tang","orcid":"https://orcid.org/0000-0002-7061-728X"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongjun Tang","raw_affiliation_strings":["Central South University","Department of Pediatrics, Xiangya Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central South University","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Department of Pediatrics, Xiangya Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085608332","display_name":"Lei Deng","orcid":"https://orcid.org/0000-0003-2869-1619"},"institutions":[{"id":"https://openalex.org/I48168531","display_name":"South University","ror":"https://ror.org/01rjfjt94","country_code":"US","type":"education","lineage":["https://openalex.org/I48168531"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lei Deng","raw_affiliation_strings":["Center South University","School of Computer Science and Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center South University","institution_ids":["https://openalex.org/I48168531"]},{"raw_affiliation_string":"School of Computer Science and Engineering","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5011917328","https://openalex.org/A5085608332"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I48168531"],"apc_list":null,"apc_paid":null,"fwci":2.1031,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.83951818,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"65","issue":"9","first_page":"4687","last_page":"4697"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piwi-interacting-rna","display_name":"Piwi-interacting RNA","score":0.7728614807128906},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5325901508331299},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5243445038795471},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3732560873031616},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.37062931060791016},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3494059145450592},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.32852715253829956},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2949351668357849},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22207477688789368},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.16663873195648193},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.13949799537658691},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09451249241828918}],"concepts":[{"id":"https://openalex.org/C147724379","wikidata":"https://www.wikidata.org/wiki/Q2367421","display_name":"Piwi-interacting RNA","level":5,"score":0.7728614807128906},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5325901508331299},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5243445038795471},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3732560873031616},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37062931060791016},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3494059145450592},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.32852715253829956},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2949351668357849},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22207477688789368},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.16663873195648193},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13949799537658691},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09451249241828918}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5c00173","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00173","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:40263714","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40263714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7606515264","display_name":null,"funder_award_id":"2025JJ20062","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8865982768","display_name":null,"funder_award_id":"2025JJ20062","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322866","display_name":"Natural Science Foundation of Hainan Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1583837637","https://openalex.org/W1970769181","https://openalex.org/W1977733607","https://openalex.org/W1985863431","https://openalex.org/W2014946489","https://openalex.org/W2047988520","https://openalex.org/W2078674740","https://openalex.org/W2150860105","https://openalex.org/W2151025094","https://openalex.org/W2157663132","https://openalex.org/W2414088510","https://openalex.org/W2579869402","https://openalex.org/W2766585573","https://openalex.org/W2771972353","https://openalex.org/W2776454016","https://openalex.org/W2788447865","https://openalex.org/W2903232440","https://openalex.org/W2910471371","https://openalex.org/W2913754224","https://openalex.org/W2955033696","https://openalex.org/W2966349991","https://openalex.org/W2970192475","https://openalex.org/W2999685656","https://openalex.org/W3000082418","https://openalex.org/W3013787003","https://openalex.org/W3014506286","https://openalex.org/W3024740577","https://openalex.org/W3025373576","https://openalex.org/W3045200674","https://openalex.org/W3046022368","https://openalex.org/W3080501980","https://openalex.org/W3082883165","https://openalex.org/W3097503632","https://openalex.org/W3116239416","https://openalex.org/W3156135334","https://openalex.org/W3156636935","https://openalex.org/W3158889654","https://openalex.org/W3188958746","https://openalex.org/W3201959323","https://openalex.org/W4205940173","https://openalex.org/W4206711189","https://openalex.org/W4220796987","https://openalex.org/W4281626231","https://openalex.org/W4291618428","https://openalex.org/W4307440230","https://openalex.org/W4311860121","https://openalex.org/W4320857183","https://openalex.org/W4323974793","https://openalex.org/W4378952262","https://openalex.org/W4381046896","https://openalex.org/W4381433853","https://openalex.org/W4383340895","https://openalex.org/W4385969617","https://openalex.org/W4392807214","https://openalex.org/W4394855882","https://openalex.org/W4396695828","https://openalex.org/W4400329083","https://openalex.org/W4400768688","https://openalex.org/W4401135966","https://openalex.org/W4402673179","https://openalex.org/W4404444331"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2158912913","https://openalex.org/W4221011377","https://openalex.org/W2027956742","https://openalex.org/W2924035798","https://openalex.org/W3192072282","https://openalex.org/W2965423738","https://openalex.org/W2796472296","https://openalex.org/W4366421230"],"abstract_inverted_index":{"PIWI-interacting":[0],"RNAs":[1,9],"(piRNAs)":[2],"are":[3,72,85,198],"a":[4,20,113,140,183,241],"class":[5],"of":[6,16,83,97,148,208,225],"small,":[7],"non-coding":[8],"predominantly":[10],"expressed":[11],"in":[12,23,37,44,77,99,177,217],"the":[13,145,163,178,228],"germ":[14],"cells":[15],"animals":[17],"and":[18,30,60,71,143,150,170,173,220,249],"play":[19,42],"crucial":[21],"role":[22],"maintaining":[24],"genomic":[25],"integrity,":[26],"mediating":[27],"transposon":[28],"suppression,":[29],"ensuring":[31],"gene":[32],"stability.":[33],"Beyond":[34],"their":[35,51],"functions":[36],"reproductive":[38],"cells,":[39],"piRNAs":[40,149],"also":[41],"roles":[43],"various":[45,236],"human":[46],"diseases,":[47],"including":[48],"cancer,":[49],"suggesting":[50],"potential":[52,92,120],"as":[53,139,246],"significant":[54],"biomarkers":[55],"critical":[56],"for":[57,252],"disease":[58],"diagnosis":[59],"treatment.":[61],"Wet-lab":[62],"methods":[63,88,197,216],"to":[64,89,118,181,200,227],"identify":[65],"piRNA-disease":[66,93,100,121,136,203,254],"associations":[67,122],"require":[68,130],"substantial":[69],"resources":[70],"often":[73],"hit-or-miss.":[74],"With":[75],"advancements":[76],"computational":[78,87,115,221],"technologies,":[79],"an":[80,247],"increasing":[81],"number":[82],"researchers":[84],"employing":[86],"efficiently":[90],"predict":[91,119],"associations.":[94,255],"The":[95,133,223],"sparsity":[96],"data":[98,175],"association":[101,137,204,230,238],"studies":[102],"significantly":[103],"limits":[104],"model":[105,134,189],"performance":[106,219],"improvement.":[107],"In":[108],"this":[109],"study,":[110],"we":[111],"propose":[112],"novel":[114],"model,":[116],"iPiDA_CL,":[117],"through":[123],"contrastive":[124,184],"learning":[125,185],"methods,":[126],"which":[127],"do":[128],"not":[129],"negative":[131,193],"samples.":[132,194],"represents":[135],"pairs":[138],"bipartite":[141],"graph":[142],"computes":[144],"initial":[146],"embeddings":[147],"diseases":[151],"using":[152],"Gaussian":[153],"kernel":[154],"similarity,":[155],"with":[156],"features":[157],"updated":[158],"via":[159],"LightGCN.":[160],"Based":[161],"on":[162],"siamese":[164],"network":[165,180],"framework,":[166],"iPiDA_CL":[167,213,226,245],"constructs":[168],"online":[169],"target":[171,179],"networks":[172],"employs":[174],"augmentation":[176],"build":[182],"objective":[186],"that":[187,212],"optimizes":[188],"parameters":[190],"without":[191],"introducing":[192],"Finally,":[195],"cross-prediction":[196],"used":[199],"calculate":[201],"specific":[202],"scores.":[205],"A":[206],"series":[207],"experimental":[209],"results":[210],"demonstrate":[211],"surpasses":[214],"state-of-the-art":[215],"both":[218],"efficiency.":[222],"application":[224],"miRNA-disease":[229],"dataset":[231],"underscores":[232],"its":[233],"versatility":[234],"across":[235],"ncRNA-disease":[237],"task.":[239],"Furthermore,":[240],"case":[242],"study":[243],"highlights":[244],"efficient":[248],"promising":[250],"tool":[251],"predicting":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}