{"id":"https://openalex.org/W4409109739","doi":"https://doi.org/10.1021/acs.jcim.5c00172","title":"TCnet: A Novel Strategy to Predict Target Combination of Alzheimer\u2019s Disease via Network-Based Methods","display_name":"TCnet: A Novel Strategy to Predict Target Combination of Alzheimer\u2019s Disease via Network-Based Methods","publication_year":2025,"publication_date":"2025-04-02","ids":{"openalex":"https://openalex.org/W4409109739","doi":"https://doi.org/10.1021/acs.jcim.5c00172","pmid":"https://pubmed.ncbi.nlm.nih.gov/40172120"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c00172","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00172","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Chengyuan Yue","orcid":null},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengyuan Yue","raw_affiliation_strings":["East China University of Science and Technology","Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China University of Science and Technology","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114549860","display_name":"Baiyu Chen","orcid":"https://orcid.org/0000-0002-0567-7729"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baiyu Chen","raw_affiliation_strings":["East China University of Science and Technology","Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China University of Science and Technology","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045631848","display_name":"Fei Pan","orcid":"https://orcid.org/0000-0001-9898-1238"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Pan","raw_affiliation_strings":["East China University of Science and Technology","Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China University of Science and Technology","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064443447","display_name":"Ze Wang","orcid":"https://orcid.org/0000-0003-3718-2605"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ze Wang","raw_affiliation_strings":["East China University of Science and Technology","Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China University of Science and Technology","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074194601","display_name":"Hongbo Yu","orcid":"https://orcid.org/0000-0002-7482-7292"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongbo Yu","raw_affiliation_strings":["East China University of Science and Technology","Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China University of Science and Technology","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101576373","display_name":"Guixia Liu","orcid":"https://orcid.org/0000-0001-9648-844X"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guixia Liu","raw_affiliation_strings":["East China University of Science and Technology","Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy"],"raw_orcid":"https://orcid.org/0000-0001-9648-844X","affiliations":[{"raw_affiliation_string":"East China University of Science and Technology","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400650","display_name":"Weihua Li","orcid":"https://orcid.org/0000-0001-7055-9836"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weihua Li","raw_affiliation_strings":["East China University of Science and Technology","Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy"],"raw_orcid":"https://orcid.org/0000-0001-7055-9836","affiliations":[{"raw_affiliation_string":"East China University of Science and Technology","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100431408","display_name":"Rui Wang","orcid":"https://orcid.org/0000-0003-3825-3620"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rui Wang","raw_affiliation_strings":["East China University of Science and Technology","Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China University of Science and Technology","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052049405","display_name":"Yun Tang","orcid":"https://orcid.org/0000-0003-2340-1109"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yun Tang","raw_affiliation_strings":["East China University of Science and Technology","Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy"],"raw_orcid":"https://orcid.org/0000-0003-2340-1109","affiliations":[{"raw_affiliation_string":"East China University of Science and Technology","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052049405","https://openalex.org/A5100431408"],"corresponding_institution_ids":["https://openalex.org/I143593769"],"apc_list":null,"apc_paid":null,"fwci":4.4269,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.94498166,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"65","issue":"7","first_page":"3866","last_page":"3878"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9898999929428101,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimers-disease","display_name":"Alzheimer's disease","score":0.4855153560638428},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47454962134361267},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.46083977818489075},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3966500163078308},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3574148416519165},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2858594059944153},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14416757225990295},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.08596089482307434}],"concepts":[{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4855153560638428},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47454962134361267},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46083977818489075},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3966500163078308},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3574148416519165},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2858594059944153},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14416757225990295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08596089482307434}],"mesh":[{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5c00172","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00172","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:40172120","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40172120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1104558580","display_name":null,"funder_award_id":"82173746","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G177194081","display_name":null,"funder_award_id":"U23A20530","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W74841586","https://openalex.org/W1987219048","https://openalex.org/W2004866439","https://openalex.org/W2124679671","https://openalex.org/W2295730657","https://openalex.org/W2321024968","https://openalex.org/W2341128841","https://openalex.org/W2522920646","https://openalex.org/W2537679995","https://openalex.org/W2777988535","https://openalex.org/W2808845633","https://openalex.org/W2900592617","https://openalex.org/W2904745014","https://openalex.org/W2922229918","https://openalex.org/W2944155053","https://openalex.org/W2950742983","https://openalex.org/W2951033368","https://openalex.org/W2951531839","https://openalex.org/W3004173255","https://openalex.org/W3006710361","https://openalex.org/W3093800747","https://openalex.org/W3104537585","https://openalex.org/W3108860514","https://openalex.org/W3111509171","https://openalex.org/W3119455494","https://openalex.org/W3200436391","https://openalex.org/W4200334558","https://openalex.org/W4205519906","https://openalex.org/W4206210788","https://openalex.org/W4206508717","https://openalex.org/W4210874196","https://openalex.org/W4212974057","https://openalex.org/W4223596392","https://openalex.org/W4229044956","https://openalex.org/W4280504434","https://openalex.org/W4281552597","https://openalex.org/W4283318905","https://openalex.org/W4307425304","https://openalex.org/W4309506674","https://openalex.org/W4312195021","https://openalex.org/W4317666349","https://openalex.org/W4321163664","https://openalex.org/W4324156239","https://openalex.org/W4360821293","https://openalex.org/W4365457471","https://openalex.org/W4367172711","https://openalex.org/W4382987966","https://openalex.org/W4389509833","https://openalex.org/W4391277692","https://openalex.org/W4391430575","https://openalex.org/W4391466334","https://openalex.org/W4392791500","https://openalex.org/W4395011414","https://openalex.org/W4395085030","https://openalex.org/W4395955053","https://openalex.org/W4396560090","https://openalex.org/W4396951419","https://openalex.org/W4397032861","https://openalex.org/W4399862569","https://openalex.org/W4401482467","https://openalex.org/W4401585050","https://openalex.org/W4401641654","https://openalex.org/W4401833590"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Alzheimer\u2019s":[0],"disease":[1,59,81],"(AD)":[2],"is":[3,19],"a":[4,27,51,71,104,125],"complex":[5],"neurodegenerative":[6],"disorder":[7],"with":[8],"an":[9],"unclear":[10],"pathogenesis;":[11],"the":[12,31,67,115],"traditional":[13],"\u2033single":[14],"gene-single":[15],"target-single":[16],"drug\u2033":[17],"strategy":[18,29],"insufficient":[20],"for":[21,30,128,138],"effective":[22],"treatment.":[23],"This":[24,89],"study":[25],"explores":[26],"novel":[28],"multitarget":[32],"therapy":[33],"of":[34,80,120],"AD":[35],"by":[36],"integrating":[37],"multiomics":[38,55],"data":[39,56],"and":[40,65,108,117,132,136],"employing":[41],"network":[42],"analysis.":[43],"Different":[44],"from":[45,98],"conventional":[46],"single-target":[47],"methods,":[48],"TCnet":[49,74,123],"adopts":[50],"mechanism-driven":[52],"strategy,":[53],"utilizing":[54],"to":[57,94],"decompose":[58],"mechanisms,":[60],"construct":[61],"potential":[62],"target":[63,130],"combinations,":[64],"prioritize":[66],"optimal":[68],"combinations":[69,131],"using":[70],"scoring":[72],"function.":[73],"not":[75],"only":[76],"advances":[77],"our":[78],"understanding":[79],"mechanisms":[82],"but":[83],"also":[84],"facilitates":[85],"large-scale":[86],"drug":[87,139],"screening.":[88],"approach":[90,127],"was":[91],"further":[92],"employed":[93],"screen":[95],"active":[96],"compounds":[97],"Huang-Lian-Jie-Du-Tang":[99],"(HLJDT),":[100],"identifying":[101],"quercetin":[102],"as":[103],"candidate":[105],"targeting":[106],"GSK3\u03b2":[107],"ADAM17.":[109],"Subsequent":[110],"in":[111,141],"vitro":[112],"experiments":[113],"confirmed":[114],"neuroprotective":[116],"anti-inflammatory":[118],"effects":[119],"quercetin.":[121],"Overall,":[122],"offers":[124],"promising":[126],"predicting":[129],"provides":[133],"new":[134],"insights":[135],"directions":[137],"discovery":[140],"AD.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
