{"id":"https://openalex.org/W4412076905","doi":"https://doi.org/10.1021/acs.jcim.5c00131","title":"Computational Elucidation of Sterol Recognition by SREBP Cleavage Activatory Protein","display_name":"Computational Elucidation of Sterol Recognition by SREBP Cleavage Activatory Protein","publication_year":2025,"publication_date":"2025-07-07","ids":{"openalex":"https://openalex.org/W4412076905","doi":"https://doi.org/10.1021/acs.jcim.5c00131","pmid":"https://pubmed.ncbi.nlm.nih.gov/40623681"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5c00131","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00131","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.jcim.5c00131","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114742356","display_name":"Charal Khiewdee","orcid":null},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Charal Khiewdee","raw_affiliation_strings":["Center of Excellence on Environmental Health and Toxicology (EHT), OPS","Department of Biology, Faculty of Science","MHESI","Mahidol University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence on Environmental Health and Toxicology (EHT), OPS","institution_ids":[]},{"raw_affiliation_string":"Department of Biology, Faculty of Science","institution_ids":[]},{"raw_affiliation_string":"MHESI","institution_ids":[]},{"raw_affiliation_string":"Mahidol University","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020770007","display_name":"Puey Ounjai","orcid":"https://orcid.org/0000-0002-3335-6199"},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Puey Ounjai","raw_affiliation_strings":["Center of Excellence on Environmental Health and Toxicology (EHT), OPS","Department of Biology, Faculty of Science","MHESI","Mahidol University"],"raw_orcid":"https://orcid.org/0000-0002-3335-6199","affiliations":[{"raw_affiliation_string":"Center of Excellence on Environmental Health and Toxicology (EHT), OPS","institution_ids":[]},{"raw_affiliation_string":"Department of Biology, Faculty of Science","institution_ids":[]},{"raw_affiliation_string":"MHESI","institution_ids":[]},{"raw_affiliation_string":"Mahidol University","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025167876","display_name":"Tanadet Pipatpolkai","orcid":"https://orcid.org/0000-0001-5396-4784"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Tanadet Pipatpolkai","raw_affiliation_strings":["Division of Physics and Applied Physics, School of Physical and Mathematical Sciences","Nanyang Technological University"],"raw_orcid":"https://orcid.org/0000-0001-5396-4784","affiliations":[{"raw_affiliation_string":"Division of Physics and Applied Physics, School of Physical and Mathematical Sciences","institution_ids":[]},{"raw_affiliation_string":"Nanyang Technological University","institution_ids":["https://openalex.org/I172675005"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020770007","https://openalex.org/A5025167876"],"corresponding_institution_ids":["https://openalex.org/I172675005","https://openalex.org/I25399158"],"apc_list":null,"apc_paid":null,"fwci":1.7547,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.84375665,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"65","issue":"14","first_page":"7668","last_page":"7677"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sterol","display_name":"Sterol","score":0.7124330401420593},{"id":"https://openalex.org/keywords/sterol-regulatory-element-binding-protein","display_name":"Sterol regulatory element-binding protein","score":0.711824893951416},{"id":"https://openalex.org/keywords/cleavage","display_name":"Cleavage (geology)","score":0.4997541904449463},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4371912479400635},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4200131297111511},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.3704375624656677},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3290385603904724},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2976330518722534},{"id":"https://openalex.org/keywords/cholesterol","display_name":"Cholesterol","score":0.2119288146495819}],"concepts":[{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.7124330401420593},{"id":"https://openalex.org/C85051948","wikidata":"https://www.wikidata.org/wiki/Q416064","display_name":"Sterol regulatory element-binding protein","level":4,"score":0.711824893951416},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.4997541904449463},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4371912479400635},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4200131297111511},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3704375624656677},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3290385603904724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2976330518722534},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2119288146495819},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.jcim.5c00131","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00131","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:40623681","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40623681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:dr.ntu.edu.sg:10356/207415","is_oa":false,"landing_page_url":"https://hdl.handle.net/10356/207415","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12308794","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12308794","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acs.jcim.5c00131","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5c00131","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.75,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320766","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302"},{"id":"https://openalex.org/F4320322401","display_name":"Mahidol University","ror":"https://ror.org/01znkr924"},{"id":"https://openalex.org/F4320329432","display_name":"Ministry of Higher Education, Science, Research and Innovation, Thailand","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1066547504","https://openalex.org/W1556918753","https://openalex.org/W1976514533","https://openalex.org/W1984662248","https://openalex.org/W1990771438","https://openalex.org/W2034767282","https://openalex.org/W2035266068","https://openalex.org/W2037132483","https://openalex.org/W2050412627","https://openalex.org/W2050777682","https://openalex.org/W2057477511","https://openalex.org/W2057680047","https://openalex.org/W2063206968","https://openalex.org/W2068689195","https://openalex.org/W2078800133","https://openalex.org/W2081693079","https://openalex.org/W2089086088","https://openalex.org/W2099102671","https://openalex.org/W2109154308","https://openalex.org/W2119267663","https://openalex.org/W2127162389","https://openalex.org/W2127322768","https://openalex.org/W2327174080","https://openalex.org/W2584139619","https://openalex.org/W2604760898","https://openalex.org/W2612598385","https://openalex.org/W2790705492","https://openalex.org/W2794383917","https://openalex.org/W2921443654","https://openalex.org/W2995904274","https://openalex.org/W2996185966","https://openalex.org/W2999269724","https://openalex.org/W3020639975","https://openalex.org/W3022682759","https://openalex.org/W3034390811","https://openalex.org/W3071443930","https://openalex.org/W3092402573","https://openalex.org/W3096713620","https://openalex.org/W3112376646","https://openalex.org/W3119674414","https://openalex.org/W3148042916","https://openalex.org/W3165958842","https://openalex.org/W3170321061","https://openalex.org/W3197665808","https://openalex.org/W4205616329","https://openalex.org/W4244071318","https://openalex.org/W4318984769","https://openalex.org/W4322732093","https://openalex.org/W4392501799","https://openalex.org/W4396721167","https://openalex.org/W4399631883","https://openalex.org/W4403324307","https://openalex.org/W4410015912"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2025659736","https://openalex.org/W2551093842","https://openalex.org/W2055732420","https://openalex.org/W2001969359","https://openalex.org/W2217969183","https://openalex.org/W2328236342","https://openalex.org/W2033437499","https://openalex.org/W4205303769","https://openalex.org/W2033119686"],"abstract_inverted_index":{"Intracellular":[0],"cholesterol":[1,32,46,58,116,137,158],"homeostasis":[2],"is":[3],"regulated":[4],"by":[5,156],"the":[6,14,20,34,51,55,85,90,100,143],"sterol":[7],"response":[8],"element-binding":[9],"protein":[10,17,23],"(SREBP)":[11],"pathway":[12],"through":[13],"SREBP":[15],"cleavage-activating":[16],"(SCAP)":[18],"and":[19,38,48,57,67,80,103,118,140],"insulin-induced":[21],"gene":[22],"(INSIG).":[24],"Previous":[25],"studies":[26],"highlighted":[27,84],"that":[28,109],"high":[29],"concentrations":[30],"of":[31,45,54,99,136,145],"mediated":[33],"dimerization":[35],"between":[36,77],"INSIG":[37],"SCAP,":[39,79],"which":[40,125],"led":[41],"to":[42,74,121,127],"an":[43],"inhibition":[44],"uptake":[47],"biogenesis.":[49],"However,":[50],"molecular":[52,70],"understanding":[53],"SCAP-INSIG":[56],"interactions":[59,76],"remains":[60],"elusive.":[61],"Here,":[62],"we":[63,107],"used":[64],"coarse-grained":[65],"(CG)":[66],"atomistic":[68,94],"(AT)":[69],"dynamics":[71,112],"(MD)":[72],"simulation":[73],"determine":[75],"INSIG,":[78],"cholesterol.":[81],"Our":[82],"work":[83,132],"novel":[86,134,146],"binding":[87,117],"pocket":[88],"in":[89],"luminal":[91],"domain":[92],"at":[93],"resolution.":[95],"Using":[96],"a":[97],"combination":[98],"AlphaFold3":[101],"model":[102],"Go\u0305-martini":[104],"force":[105],"field,":[106],"showed":[108],"loop":[110],"7":[111],"are":[113,119],"crucial":[114],"for":[115,149],"able":[120],"highlight":[122],"conserved":[123],"residues,":[124],"lead":[126],"INSIG-SCAP":[128],"dimerization.":[129],"Together,":[130],"our":[131],"highlights":[133],"mechanisms":[135],"sensor":[138],"pathways":[139],"will":[141],"benefit":[142],"development":[144],"therapeutic":[147],"strategies":[148],"diseases,":[150],"such":[151],"as":[152],"neuroinflammatory":[153],"disease,":[154],"caused":[155],"irregular":[157],"homeostasis.":[159]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
