{"id":"https://openalex.org/W2286315529","doi":"https://doi.org/10.1021/acs.jcim.5b00592","title":"Discovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual Screening","display_name":"Discovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual Screening","publication_year":2016,"publication_date":"2016-02-16","ids":{"openalex":"https://openalex.org/W2286315529","doi":"https://doi.org/10.1021/acs.jcim.5b00592","mag":"2286315529","pmid":"https://pubmed.ncbi.nlm.nih.gov/26882208"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5b00592","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5b00592","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051211878","display_name":"Birgit Waltenberger","orcid":"https://orcid.org/0000-0002-2718-4677"},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Birgit Waltenberger","raw_affiliation_strings":["Institute\rof Pharmacy/Pharmacognosy and Center for\rMolecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute\rof Pharmacy/Pharmacognosy and Center for\rMolecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068736070","display_name":"Ulrike Garscha","orcid":"https://orcid.org/0000-0002-3645-7833"},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrike Garscha","raw_affiliation_strings":["Chair\rof Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University of Jena, Philosophenweg 14, D-07743 Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair\rof Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University of Jena, Philosophenweg 14, D-07743 Jena, Germany","institution_ids":["https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070095076","display_name":"Veronika Temml","orcid":"https://orcid.org/0000-0001-7662-9882"},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Veronika Temml","raw_affiliation_strings":["Institute\rof Pharmacy/Pharmacognosy and Center for\rMolecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute\rof Pharmacy/Pharmacognosy and Center for\rMolecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019461747","display_name":"Josephine Liers","orcid":null},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Josephine Liers","raw_affiliation_strings":["Chair\rof Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University of Jena, Philosophenweg 14, D-07743 Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair\rof Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University of Jena, Philosophenweg 14, D-07743 Jena, Germany","institution_ids":["https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045395183","display_name":"Oliver Werz","orcid":"https://orcid.org/0000-0002-5064-4379"},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Werz","raw_affiliation_strings":["Chair\rof Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University of Jena, Philosophenweg 14, D-07743 Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair\rof Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University of Jena, Philosophenweg 14, D-07743 Jena, Germany","institution_ids":["https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005983172","display_name":"Daniela Schuster","orcid":"https://orcid.org/0000-0002-9933-8938"},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["AT","DE"],"is_corresponding":true,"raw_author_name":"Daniela Schuster","raw_affiliation_strings":["Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University of Jena, Philosophenweg 14, D-07743 Jena, Germany","Institute of Pharmacy/Pharmaceutical Chemistry and CMBI, University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria","Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University of Jena, Philosophenweg 14, D-07743 Jena, Germany","institution_ids":["https://openalex.org/I76198965"]},{"raw_affiliation_string":"Institute of Pharmacy/Pharmaceutical Chemistry and CMBI, University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]},{"raw_affiliation_string":"Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030967054","display_name":"Hermann Stuppner","orcid":"https://orcid.org/0000-0001-8862-0201"},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Hermann Stuppner","raw_affiliation_strings":["Institute\rof Pharmacy/Pharmacognosy and Center for\rMolecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute\rof Pharmacy/Pharmacognosy and Center for\rMolecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005983172"],"corresponding_institution_ids":["https://openalex.org/I190249584","https://openalex.org/I76198965"],"apc_list":null,"apc_paid":null,"fwci":3.929,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.9207112,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"56","issue":"4","first_page":"747","last_page":"762"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacophore","display_name":"Pharmacophore","score":0.957969069480896},{"id":"https://openalex.org/keywords/epoxide-hydrolase-2","display_name":"Epoxide hydrolase 2","score":0.9432828426361084},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.7559795379638672},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.6821245551109314},{"id":"https://openalex.org/keywords/ic50","display_name":"IC50","score":0.5635998845100403},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.4404509365558624},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.4013495445251465},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.2953319549560547},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.28725695610046387},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2441542148590088}],"concepts":[{"id":"https://openalex.org/C56173144","wikidata":"https://www.wikidata.org/wiki/Q1539893","display_name":"Pharmacophore","level":2,"score":0.957969069480896},{"id":"https://openalex.org/C18605011","wikidata":"https://www.wikidata.org/wiki/Q17916975","display_name":"Epoxide hydrolase 2","level":3,"score":0.9432828426361084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7559795379638672},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.6821245551109314},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5635998845100403},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4404509365558624},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4013495445251465},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2953319549560547},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.28725695610046387},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2441542148590088}],"mesh":[{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004851","descriptor_name":"Epoxide Hydrolases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D004851","descriptor_name":"Epoxide Hydrolases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D004851","descriptor_name":"Epoxide Hydrolases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D004851","descriptor_name":"Epoxide Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004851","descriptor_name":"Epoxide Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004851","descriptor_name":"Epoxide Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5b00592","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5b00592","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:26882208","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26882208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Clean water and sanitation","score":0.6200000047683716,"id":"https://metadata.un.org/sdg/6"}],"awards":[{"id":"https://openalex.org/G4919831301","display_name":null,"funder_award_id":"S10711","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G7937916653","display_name":null,"funder_award_id":"S10703","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"}],"funders":[{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"},{"id":"https://openalex.org/F4320326512","display_name":"Landes Tirols","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W1509967345","https://openalex.org/W1513508185","https://openalex.org/W1965392948","https://openalex.org/W1966228089","https://openalex.org/W1969307895","https://openalex.org/W1971129422","https://openalex.org/W1973834649","https://openalex.org/W1976921912","https://openalex.org/W1978229969","https://openalex.org/W1980978175","https://openalex.org/W1981594250","https://openalex.org/W1983225776","https://openalex.org/W1983798804","https://openalex.org/W1985767786","https://openalex.org/W1987859529","https://openalex.org/W1989552333","https://openalex.org/W1992303064","https://openalex.org/W1995454938","https://openalex.org/W2003402669","https://openalex.org/W2006634108","https://openalex.org/W2007187686","https://openalex.org/W2007239864","https://openalex.org/W2011144703","https://openalex.org/W2015296161","https://openalex.org/W2016639871","https://openalex.org/W2017005730","https://openalex.org/W2017132056","https://openalex.org/W2022124164","https://openalex.org/W2026085777","https://openalex.org/W2029898731","https://openalex.org/W2030460163","https://openalex.org/W2031853355","https://openalex.org/W2033342353","https://openalex.org/W2034063559","https://openalex.org/W2034628038","https://openalex.org/W2035608912","https://openalex.org/W2036353767","https://openalex.org/W2043509228","https://openalex.org/W2046855292","https://openalex.org/W2050456292","https://openalex.org/W2050676194","https://openalex.org/W2054781451","https://openalex.org/W2061457917","https://openalex.org/W2061608251","https://openalex.org/W2066580628","https://openalex.org/W2067549478","https://openalex.org/W2069651219","https://openalex.org/W2070579493","https://openalex.org/W2072185304","https://openalex.org/W2076019137","https://openalex.org/W2078374001","https://openalex.org/W2080809815","https://openalex.org/W2081452901","https://openalex.org/W2083428405","https://openalex.org/W2086328142","https://openalex.org/W2088883428","https://openalex.org/W2096857750","https://openalex.org/W2097927167","https://openalex.org/W2098905461","https://openalex.org/W2108772785","https://openalex.org/W2110573471","https://openalex.org/W2111204258","https://openalex.org/W2115197899","https://openalex.org/W2117356638","https://openalex.org/W2119391523","https://openalex.org/W2123758284","https://openalex.org/W2124496763","https://openalex.org/W2129077714","https://openalex.org/W2129591736","https://openalex.org/W2130479394","https://openalex.org/W2135910194","https://openalex.org/W2136184987","https://openalex.org/W2142219464","https://openalex.org/W2142310620","https://openalex.org/W2145630011","https://openalex.org/W2146083192","https://openalex.org/W2151324766","https://openalex.org/W2152007625","https://openalex.org/W2160712561","https://openalex.org/W2164797910","https://openalex.org/W2165828545","https://openalex.org/W2171522383","https://openalex.org/W2171696185","https://openalex.org/W2208203352","https://openalex.org/W2210622668","https://openalex.org/W2949387234"],"related_works":["https://openalex.org/W2000397010","https://openalex.org/W2115078847","https://openalex.org/W2062768126","https://openalex.org/W2969563261","https://openalex.org/W2061401330","https://openalex.org/W2055137136","https://openalex.org/W3041915240","https://openalex.org/W2077097504","https://openalex.org/W2586171341","https://openalex.org/W2167386965"],"abstract_inverted_index":{"There":[0],"is":[1],"an":[2,105],"increasing":[3],"interest":[4],"in":[5,89],"the":[6,16,51,90,115,122,141],"development":[7],"of":[8,18,28,54,60,80,83,117,143],"soluble":[9],"epoxide":[10],"hydrolase":[11],"(sEH)":[12],"inhibitors,":[13],"which":[14],"block":[15],"degradation":[17],"endogenous":[19],"anti-inflammatory":[20],"epoxyeicosatrienoic":[21],"acids.":[22],"Within":[23],"this":[24],"study,":[25],"a":[26,43,74,99,137],"set":[27,134],"pharmacophore":[29,132],"models":[30],"for":[31,50,140,145],"sEH":[32,45,66,103],"inhibitors":[33,67],"was":[34,39,48],"developed.":[35],"The":[36,94,110,130],"Specs":[37],"database":[38],"virtually":[40],"screened":[41],"and":[42],"cell-free":[44],"activity":[46],"assay":[47],"used":[49],"biological":[52,146],"investigation":[53],"virtual":[55],"hits.":[56],"In":[57],"total,":[58],"out":[59],"48":[61],"tested":[62],"compounds,":[63],"19":[64],"were":[65],"with":[68,104],"IC50":[69,87,106],"<":[70],"10":[71],"\u03bcM,":[72],"representing":[73],"prospective":[75],"true":[76],"positive":[77],"hit":[78],"rate":[79],"40%.":[81],"Six":[82],"these":[84],"compounds":[85,144],"displayed":[86],"values":[88],"low":[91],"nanomolar":[92],"range.":[93],"most":[95],"potent":[96],"compound":[97],"21,":[98],"urea":[100],"derivative,":[101],"inhibited":[102],"=":[107,127],"4.2":[108],"nM.":[109],"applied":[111],"approach":[112],"also":[113],"enabled":[114],"identification":[116],"diverse":[118],"chemical":[119],"scaffolds,":[120],"e.g.":[121],"pyrimidinone":[123],"derivative":[124],"29":[125],"(IC50":[126],"277":[128],"nM).":[129],"generated":[131],"model":[133],"therefore":[135],"represents":[136],"valuable":[138],"tool":[139],"selection":[142],"testing.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}