{"id":"https://openalex.org/W2290769847","doi":"https://doi.org/10.1021/acs.jcim.5b00501","title":"<i>LipidBuilder:</i> A Framework To Build Realistic Models for Biological Membranes","display_name":"<i>LipidBuilder:</i> A Framework To Build Realistic Models for Biological Membranes","publication_year":2015,"publication_date":"2015-11-25","ids":{"openalex":"https://openalex.org/W2290769847","doi":"https://doi.org/10.1021/acs.jcim.5b00501","mag":"2290769847"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5b00501","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5b00501","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://infoscience.epfl.ch/record/216493","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054797103","display_name":"Christophe Bovigny","orcid":null},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"funder","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Christophe Bovigny","raw_affiliation_strings":["Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland","Swiss Institute of Bioinformatics (SIB), CH-1015 Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics (SIB), CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007201502","display_name":"Giorgio E. Tam\u00f2","orcid":"https://orcid.org/0000-0003-1634-9357"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"funder","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Giorgio Tam\u00f2","raw_affiliation_strings":["Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland","Swiss Institute of Bioinformatics (SIB), CH-1015 Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics (SIB), CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069828726","display_name":"Thomas Lemmin","orcid":"https://orcid.org/0000-0001-5705-4964"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas Lemmin","raw_affiliation_strings":["Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053010520","display_name":"Nicolas Ma\u00efno","orcid":"https://orcid.org/0000-0002-1159-2318"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nicolas Ma\u00efno","raw_affiliation_strings":["Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065598178","display_name":"Matteo Dal Peraro","orcid":"https://orcid.org/0000-0002-2973-3975"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"funder","lineage":["https://openalex.org/I12708293"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matteo Dal Peraro","raw_affiliation_strings":["Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland","Swiss Institute of Bioinformatics (SIB), CH-1015 Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics (SIB), CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5054797103"],"corresponding_institution_ids":["https://openalex.org/I12708293","https://openalex.org/I5124864"],"apc_list":null,"apc_paid":null,"fwci":1.4587,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.82280034,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"55","issue":"12","first_page":"2491","last_page":"2499"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11177","display_name":"Spectroscopy and Quantum Chemical Studies","score":0.9886000156402588,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.82001793384552},{"id":"https://openalex.org/keywords/biological-membrane","display_name":"Biological membrane","score":0.6279574632644653},{"id":"https://openalex.org/keywords/lipid-bilayer","display_name":"Lipid bilayer","score":0.6271730661392212},{"id":"https://openalex.org/keywords/phospholipid","display_name":"Phospholipid","score":0.4779275059700012},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4577213525772095},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4570264518260956},{"id":"https://openalex.org/keywords/vesicle","display_name":"Vesicle","score":0.4210563600063324},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41383546590805054},{"id":"https://openalex.org/keywords/membrane-biology","display_name":"Membrane biology","score":0.4124354124069214},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38011136651039124},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.366058886051178},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2998262345790863}],"concepts":[{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.82001793384552},{"id":"https://openalex.org/C125501631","wikidata":"https://www.wikidata.org/wiki/Q1587185","display_name":"Biological membrane","level":3,"score":0.6279574632644653},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.6271730661392212},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.4779275059700012},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4577213525772095},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4570264518260956},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.4210563600063324},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41383546590805054},{"id":"https://openalex.org/C205365616","wikidata":"https://www.wikidata.org/wiki/Q16863771","display_name":"Membrane biology","level":3,"score":0.4124354124069214},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38011136651039124},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.366058886051178},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2998262345790863}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5b00501","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5b00501","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmh:oai:infoscience.epfl.ch:216493","is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/216493","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:infoscience.epfl.ch:216493","is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/216493","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.4399999976158142,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G2326710892","display_name":null,"funder_award_id":"148914","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G6989439113","display_name":null,"funder_award_id":"200020_157153","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G7105026502","display_name":null,"funder_award_id":"200021_135450","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1586357743","https://openalex.org/W1809199314","https://openalex.org/W1911958566","https://openalex.org/W1972778127","https://openalex.org/W1973044434","https://openalex.org/W1976499671","https://openalex.org/W1980387958","https://openalex.org/W1986276470","https://openalex.org/W2002948394","https://openalex.org/W2008081674","https://openalex.org/W2019521215","https://openalex.org/W2019670269","https://openalex.org/W2019922184","https://openalex.org/W2021341383","https://openalex.org/W2021490608","https://openalex.org/W2022540192","https://openalex.org/W2026867951","https://openalex.org/W2026885029","https://openalex.org/W2027578254","https://openalex.org/W2029667189","https://openalex.org/W2038758364","https://openalex.org/W2044077839","https://openalex.org/W2046674195","https://openalex.org/W2047796590","https://openalex.org/W2049286183","https://openalex.org/W2057653477","https://openalex.org/W2065335146","https://openalex.org/W2066414494","https://openalex.org/W2071740908","https://openalex.org/W2072167784","https://openalex.org/W2076322059","https://openalex.org/W2077684756","https://openalex.org/W2079462709","https://openalex.org/W2080042107","https://openalex.org/W2082960898","https://openalex.org/W2082966939","https://openalex.org/W2087496251","https://openalex.org/W2096769282","https://openalex.org/W2114958910","https://openalex.org/W2114991593","https://openalex.org/W2121936687","https://openalex.org/W2123768693","https://openalex.org/W2127522551","https://openalex.org/W2129365131","https://openalex.org/W2134762386","https://openalex.org/W2134983525","https://openalex.org/W2139357973","https://openalex.org/W2149628585","https://openalex.org/W2149761516","https://openalex.org/W2150981663","https://openalex.org/W2151156336","https://openalex.org/W2164405854","https://openalex.org/W2167690750","https://openalex.org/W2168269595","https://openalex.org/W2172084755","https://openalex.org/W2324912984","https://openalex.org/W2327174080","https://openalex.org/W2332709587","https://openalex.org/W3155828254","https://openalex.org/W4251044862"],"related_works":["https://openalex.org/W1625647566","https://openalex.org/W2039713723","https://openalex.org/W2084046036","https://openalex.org/W2153708143","https://openalex.org/W2793770089","https://openalex.org/W2405593726","https://openalex.org/W2370627827","https://openalex.org/W2227162213","https://openalex.org/W2085183163","https://openalex.org/W4236649164"],"abstract_inverted_index":{"The":[0,122],"physical":[1],"and":[2,23,28,56,77,109,186,230],"chemical":[3],"characterization":[4],"of":[5,9,17,44,80,88,96,111,124,136,149,158,160,227,244],"biological":[6,51,225,245],"membranes":[7,45,135,159,226],"is":[8,53,64],"fundamental":[10],"importance":[11],"for":[12,75,117,140],"understanding":[13],"the":[14,42,50,94,150,236,241],"functional":[15],"role":[16],"lipid":[18,138,152,209],"bilayers":[19,102],"in":[20,62,166],"shaping":[21],"cells":[22],"organelles,":[24],"steering":[25],"vesicle":[26],"trafficking":[27],"promoting":[29],"membrane-protein":[30],"signaling.":[31],"Molecular":[32],"dynamics":[33],"simulations":[34],"stand":[35],"as":[36,115,163,219,231],"a":[37,66,73,207,220,232],"powerful":[38],"tool":[39,222],"to":[40,126,223,235,239],"probe":[41],"properties":[43,243],"at":[46],"atomistic":[47],"level.":[48],"However,":[49],"membrane":[52,113,129,202,246],"highly":[54],"complex,":[55],"closely":[57],"mimicking":[58],"its":[59],"physiological":[60],"constitution":[61],"silico":[63],"not":[65],"straightforward":[67],"task.":[68],"Here,":[69],"we":[70,155],"present":[71],"LipidBuilder,":[72],"framework":[74],"creating":[76],"storing":[78],"models":[79,130,157,203],"biologically":[81],"relevant":[82],"phospholipid":[83],"species":[84],"with":[85],"acyl":[86],"tails":[87],"heterogeneous":[89,161],"composition.":[90],"LipidBuilder":[91,125,218],"also":[92],"enables":[93],"assembly":[95],"these":[97],"database-stored":[98],"lipids":[99],"into":[100],"realistic":[101,201],"featuring":[103],"asymmetric":[104],"distribution":[105],"on":[106],"layer":[107],"leaflets":[108],"concentration":[110],"given":[112],"constituents":[114],"defined,":[116],"example,":[118],"by":[119,133],"lipidomics":[120],"experiments.":[121,215],"ability":[123],"assemble":[127],"robust":[128,233],"was":[131],"validated":[132],"simulating":[134],"homogeneous":[137],"composition":[139,210],"which":[141],"experimental":[142],"data":[143],"are":[144],"available.":[145],"Furthermore,":[146],"taking":[147],"advantage":[148],"extensive":[151],"headgroup":[153],"repertoire,":[154],"assembled":[156],"nature":[162],"naturally":[164],"found":[165],"viral":[167],"(phage":[168],"PRD1),":[169],"bacterial":[170],"(Salmonella":[171],"enterica,":[172],"Laurinavicius,":[173],"S.;":[174],"Kakela,":[175],"R.;":[176],"Somerharju,":[177],"P.;":[178],"Bamford,":[179],"D.":[180],"H.;":[181],"Virology":[182],"2004,":[183],"322,":[184],"328\u2013336)":[185],"plant":[187],"(Chlorella":[188],"kessleri,":[189],"Rezanka,":[190],"T.;":[191],"Podojil,":[192],"M.;":[193],"J.":[194],"Chromatogr.":[195],"1989,":[196],"463,":[197],"397\u2013408)":[198],"organisms.":[199],"These":[200],"were":[204],"built":[205],"using":[206,247],"near-exact":[208],"revealed":[211],"from":[212],"analytical":[213],"chemistry":[214],"We":[216],"suggest":[217],"useful":[221],"model":[224],"near-biological":[228],"complexity,":[229],"complement":[234],"current":[237],"efforts":[238],"characterize":[240],"biophysical":[242],"molecular":[248],"simulation.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2016-06-24T00:00:00"}