{"id":"https://openalex.org/W1944636897","doi":"https://doi.org/10.1021/acs.jcim.5b00181","title":"Discovery of Novel CXCR2 Inhibitors Using Ligand-Based Pharmacophore Models","display_name":"Discovery of Novel CXCR2 Inhibitors Using Ligand-Based Pharmacophore Models","publication_year":2015,"publication_date":"2015-07-08","ids":{"openalex":"https://openalex.org/W1944636897","doi":"https://doi.org/10.1021/acs.jcim.5b00181","mag":"1944636897","pmid":"https://pubmed.ncbi.nlm.nih.gov/26153616"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5b00181","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5b00181","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054387845","display_name":"Helen Ha","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen Ha","raw_affiliation_strings":["Department\rof Pharmacology and Pharmaceutical Sciences, University of Southern California School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90033, United States","Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Pharmacology and Pharmaceutical Sciences, University of Southern California School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90033, United States","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90033, United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102946678","display_name":"Bikash Debnath","orcid":"https://orcid.org/0000-0001-9698-0012"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bikash Debnath","raw_affiliation_strings":["Department\rof Medicinal Chemistry, College of Pharmacy, and Translational Oncology\rProgram, University of Michigan, North Campus Research Complex, 2800\rPlymouth Road, Ann Arbor, Michigan 48109, United States","Department of Medicinal Chemistry, College of Pharmacy, and Translational Oncology Program, University of Michigan , North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, Michigan 48109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Medicinal Chemistry, College of Pharmacy, and Translational Oncology\rProgram, University of Michigan, North Campus Research Complex, 2800\rPlymouth Road, Ann Arbor, Michigan 48109, United States","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210117557"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, College of Pharmacy, and Translational Oncology Program, University of Michigan , North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, Michigan 48109, United States","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210117557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015636325","display_name":"Srinivas Odde","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srinivas Odde","raw_affiliation_strings":["Department\rof Pharmacology and Pharmaceutical Sciences, University of Southern California School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90033, United States","Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Pharmacology and Pharmaceutical Sciences, University of Southern California School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90033, United States","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90033, United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055588228","display_name":"Tim Bensman","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tim Bensman","raw_affiliation_strings":["Department\rof Clinical Pharmacy, University of Southern California School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90033, United States","Department of Clinical Pharmacy, University of Southern California School of Pharmacy , 1985 Zonal Avenue, Los Angeles, California 90033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Clinical Pharmacy, University of Southern California School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90033, United States","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Clinical Pharmacy, University of Southern California School of Pharmacy , 1985 Zonal Avenue, Los Angeles, California 90033, United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061782270","display_name":"Henry C. Ho","orcid":"https://orcid.org/0000-0002-2916-6245"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry Ho","raw_affiliation_strings":["Department\rof Clinical Pharmacy, University of Southern California School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90033, United States","Department of Clinical Pharmacy, University of Southern California School of Pharmacy , 1985 Zonal Avenue, Los Angeles, California 90033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Clinical Pharmacy, University of Southern California School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90033, United States","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Clinical Pharmacy, University of Southern California School of Pharmacy , 1985 Zonal Avenue, Los Angeles, California 90033, United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048749857","display_name":"Paul M. Beringer","orcid":"https://orcid.org/0000-0002-3744-3310"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M. Beringer","raw_affiliation_strings":["Department\rof Clinical Pharmacy, University of Southern California School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90033, United States","Department of Clinical Pharmacy, University of Southern California School of Pharmacy , 1985 Zonal Avenue, Los Angeles, California 90033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Clinical Pharmacy, University of Southern California School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90033, United States","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Clinical Pharmacy, University of Southern California School of Pharmacy , 1985 Zonal Avenue, Los Angeles, California 90033, United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023220693","display_name":"Nouri Neamati","orcid":"https://orcid.org/0000-0003-3291-7131"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nouri Neamati","raw_affiliation_strings":["Department\rof Medicinal Chemistry, College of Pharmacy, and Translational Oncology\rProgram, University of Michigan, North Campus Research Complex, 2800\rPlymouth Road, Ann Arbor, Michigan 48109, United States","Department of Medicinal Chemistry, College of Pharmacy, and Translational Oncology Program, University of Michigan , North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, Michigan 48109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Medicinal Chemistry, College of Pharmacy, and Translational Oncology\rProgram, University of Michigan, North Campus Research Complex, 2800\rPlymouth Road, Ann Arbor, Michigan 48109, United States","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210117557"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, College of Pharmacy, and Translational Oncology Program, University of Michigan , North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, Michigan 48109, United States","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210117557"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023220693"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210117557"],"apc_list":null,"apc_paid":null,"fwci":1.8366,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.86967335,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"55","issue":"8","first_page":"1720","last_page":"1738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacophore","display_name":"Pharmacophore","score":0.8966450691223145},{"id":"https://openalex.org/keywords/cxc-chemokine-receptors","display_name":"CXC chemokine receptors","score":0.7120802998542786},{"id":"https://openalex.org/keywords/inflammation","display_name":"Inflammation","score":0.6201816201210022},{"id":"https://openalex.org/keywords/chemokine","display_name":"Chemokine","score":0.46721211075782776},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.44177767634391785},{"id":"https://openalex.org/keywords/chemokine-receptor","display_name":"Chemokine receptor","score":0.4412570297718048},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.43945249915122986},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3913714289665222},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3503762483596802},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3303612470626831},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.16121920943260193}],"concepts":[{"id":"https://openalex.org/C56173144","wikidata":"https://www.wikidata.org/wiki/Q1539893","display_name":"Pharmacophore","level":2,"score":0.8966450691223145},{"id":"https://openalex.org/C84913492","wikidata":"https://www.wikidata.org/wiki/Q5014892","display_name":"CXC chemokine receptors","level":5,"score":0.7120802998542786},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6201816201210022},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.46721211075782776},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44177767634391785},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.4412570297718048},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43945249915122986},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3913714289665222},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3503762483596802},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3303612470626831},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16121920943260193}],"mesh":[{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071560","descriptor_name":"beta-Arrestin 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071560","descriptor_name":"beta-Arrestin 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071560","descriptor_name":"beta-Arrestin 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019390","descriptor_name":"Arrestins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019390","descriptor_name":"Arrestins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019390","descriptor_name":"Arrestins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5b00181","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5b00181","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:26153616","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26153616","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7200000286102295}],"awards":[{"id":"https://openalex.org/G8739262295","display_name":null,"funder_award_id":"LC090363","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1495127214","https://openalex.org/W1546015235","https://openalex.org/W1550129999","https://openalex.org/W1557239654","https://openalex.org/W1753762092","https://openalex.org/W1780460389","https://openalex.org/W1874438500","https://openalex.org/W1916800927","https://openalex.org/W1961326234","https://openalex.org/W1965067898","https://openalex.org/W1967373130","https://openalex.org/W1968712031","https://openalex.org/W1973033965","https://openalex.org/W1973191530","https://openalex.org/W1976219459","https://openalex.org/W1980271166","https://openalex.org/W1984023133","https://openalex.org/W1987838637","https://openalex.org/W1989769800","https://openalex.org/W1990057891","https://openalex.org/W1990893819","https://openalex.org/W2004161673","https://openalex.org/W2008218015","https://openalex.org/W2010239869","https://openalex.org/W2012315119","https://openalex.org/W2013067643","https://openalex.org/W2017497185","https://openalex.org/W2018114151","https://openalex.org/W2026983932","https://openalex.org/W2027065525","https://openalex.org/W2028126678","https://openalex.org/W2028799636","https://openalex.org/W2032021351","https://openalex.org/W2034459290","https://openalex.org/W2035567578","https://openalex.org/W2046618178","https://openalex.org/W2046638583","https://openalex.org/W2049069390","https://openalex.org/W2050456292","https://openalex.org/W2058902088","https://openalex.org/W2066880035","https://openalex.org/W2068951489","https://openalex.org/W2070422848","https://openalex.org/W2072955764","https://openalex.org/W2077541257","https://openalex.org/W2077885301","https://openalex.org/W2078374001","https://openalex.org/W2080698860","https://openalex.org/W2088069551","https://openalex.org/W2094958614","https://openalex.org/W2097026573","https://openalex.org/W2097546936","https://openalex.org/W2101840637","https://openalex.org/W2103397308","https://openalex.org/W2110567472","https://openalex.org/W2115567169","https://openalex.org/W2115620743","https://openalex.org/W2134055933","https://openalex.org/W2134878826","https://openalex.org/W2140927361","https://openalex.org/W2153146450","https://openalex.org/W2161634702","https://openalex.org/W2174655783","https://openalex.org/W2328737044","https://openalex.org/W2949417238","https://openalex.org/W4230049581","https://openalex.org/W4296792904","https://openalex.org/W4296816736"],"related_works":["https://openalex.org/W1967767097","https://openalex.org/W2289050973","https://openalex.org/W2098873911","https://openalex.org/W2913403903","https://openalex.org/W1969454135","https://openalex.org/W2155139562","https://openalex.org/W2959910393","https://openalex.org/W2162826889","https://openalex.org/W1523507291","https://openalex.org/W2019143025"],"abstract_inverted_index":{"The":[0],"chemokine":[1],"receptor":[2],"CXCR2":[3,31,80,89,163],"is":[4,11],"expressed":[5],"on":[6,86],"various":[7],"immune":[8],"cells":[9],"and":[10,16,22,32,52,121,128,146,151,177,209,211,230,234],"essential":[12],"for":[13,110,227],"neutrophil":[14,175],"recruitment":[15,119],"angiogenesis":[17],"at":[18],"sites":[19],"of":[20,41,57,97,156,167,193,199],"acute":[21,212],"chronic":[23,46],"inflammation":[24,132,180,213],"caused":[25],"by":[26,67],"tissue":[27],"injury":[28],"or":[29],"infection.":[30],"its":[33],"ligand,":[34],"CXCL8,":[35],"are":[36,75,224],"implicated":[37],"in":[38,111,114,124,134,181,214],"a":[39,95,115,184,190,196],"number":[40],"inflammation-mediated":[42],"diseases":[43],"such":[44],"as":[45,61,232],"obstructive":[47],"pulmonary":[48],"disease,":[49],"cystic":[50],"fibrosis,":[51],"cancer.":[53],"Though":[54],"the":[55,71,105],"development":[56,231],"CXCR2-specific":[58],"small-molecule":[59],"inhibitors":[60],"anti-inflammatory":[62,233],"agents":[63],"has":[64],"been":[65],"pursued":[66],"pharmaceutical":[68],"companies":[69],"within":[70],"past":[72],"decade,":[73],"there":[74],"currently":[76],"no":[77],"clinically":[78],"approved":[79],"inhibitors.":[81],"A":[82],"pharmacophore":[83,106,140,186,222],"model":[84],"based":[85],"previously":[87],"reported":[88],"antagonists":[90],"was":[91],"developed":[92],"to":[93],"screen":[94],"database":[96],"commercially":[98],"available":[99],"compounds.":[100],"Small-molecule":[101],"compounds":[102,137,203,218],"identified":[103,138,189,219],"from":[104,139,195,220],"screening":[107,113],"were":[108],"selected":[109],"vitro":[112],"cell-based":[116,126],"CXCR2-mediated":[117],"\u03b2-arrestin-2":[118],"assay":[120],"further":[122,228],"characterized":[123],"several":[125],"assays":[127],"lipopolysaccharide":[129],"(LPS)-induced":[130],"lung":[131,145,179],"studies":[133,155],"mice.":[135,182],"CX":[136,217],"modeling":[141],"inhibited":[142],"cell":[143,149,207],"migration,":[144],"colon":[147],"cancer":[148],"proliferation,":[150,210],"colony":[152],"formation.":[153],"Mechanistic":[154],"CX4152":[157,171],"showed":[158],"that":[159],"this":[160],"compound":[161],"inhibits":[162,173],"signaling":[164],"through":[165],"downregulation":[166],"surface":[168],"CXCR2.":[169],"Additionally,":[170],"significantly":[172],"CXCL8-mediated":[174],"migration":[176,208],"LPS-induced":[178],"Using":[183],"CXCR2-inhibitor-based":[185],"model,":[187],"we":[188],"novel":[191],"set":[192],"sulfonamides":[194],"diverse":[197],"library":[198],"small":[200],"molecules.":[201],"These":[202],"inhibit":[204],"CXCR2/\u03b2-arrestin-2":[205],"association,":[206],"mouse":[215],"models.":[216],"our":[221],"models":[223],"potential":[225],"leads":[226],"optimization":[229],"anticancer":[235],"agents.":[236]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}