{"id":"https://openalex.org/W2406124857","doi":"https://doi.org/10.1021/acs.jcim.5b00130","title":"Rule-Based Prediction Models of Cytochrome P450 Inhibition","display_name":"Rule-Based Prediction Models of Cytochrome P450 Inhibition","publication_year":2015,"publication_date":"2015-06-25","ids":{"openalex":"https://openalex.org/W2406124857","doi":"https://doi.org/10.1021/acs.jcim.5b00130","mag":"2406124857","pmid":"https://pubmed.ncbi.nlm.nih.gov/26108525"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.5b00130","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5b00130","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002510581","display_name":"Bo\u2010Han Su","orcid":null},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Bo-Han Su","raw_affiliation_strings":["Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106"],"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102820899","display_name":"Yi-Shu Tu","orcid":"https://orcid.org/0000-0003-0210-3778"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-shu Tu","raw_affiliation_strings":["Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106"],"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102074668","display_name":"Chieh Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chieh Lin","raw_affiliation_strings":["Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106"],"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009668054","display_name":"Chi-Yu Shao","orcid":null},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chi-Yu Shao","raw_affiliation_strings":["Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106"],"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083648905","display_name":"Olivia A. Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Olivia A. Lin","raw_affiliation_strings":["Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106"],"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021255582","display_name":"Yufeng Jane Tseng","orcid":"https://orcid.org/0000-0002-8461-6181"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yufeng J. Tseng","raw_affiliation_strings":["Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106"],"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106","institution_ids":["https://openalex.org/I16733864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5002510581"],"corresponding_institution_ids":["https://openalex.org/I16733864"],"apc_list":null,"apc_paid":null,"fwci":3.1546,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.92457493,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"55","issue":"7","first_page":"1426","last_page":"1434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9778000116348267,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9670000076293945,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"Cytochrome P450","score":0.5653369426727295},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4330451190471649},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41547891497612},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34026211500167847},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.26010268926620483},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.21712848544120789},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.10201635956764221}],"concepts":[{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.5653369426727295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4330451190471649},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41547891497612},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34026211500167847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26010268926620483},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21712848544120789},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10201635956764221}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D065607","descriptor_name":"Cytochrome P-450 Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D065607","descriptor_name":"Cytochrome P-450 Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D065607","descriptor_name":"Cytochrome P-450 Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D065607","descriptor_name":"Cytochrome P-450 Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D065607","descriptor_name":"Cytochrome P-450 Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D065607","descriptor_name":"Cytochrome P-450 Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.5b00130","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.5b00130","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:26108525","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26108525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"awards":[{"id":"https://openalex.org/G6301042052","display_name":null,"funder_award_id":"103-2325-B-400-005","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W84368778","https://openalex.org/W1565972757","https://openalex.org/W1972156862","https://openalex.org/W1975448236","https://openalex.org/W1987323764","https://openalex.org/W1995875735","https://openalex.org/W2003998164","https://openalex.org/W2010546664","https://openalex.org/W2016347738","https://openalex.org/W2017398555","https://openalex.org/W2020847930","https://openalex.org/W2026330543","https://openalex.org/W2031216614","https://openalex.org/W2045776044","https://openalex.org/W2052796126","https://openalex.org/W2059329439","https://openalex.org/W2060862064","https://openalex.org/W2066273100","https://openalex.org/W2077736710","https://openalex.org/W2085859386","https://openalex.org/W2091450245","https://openalex.org/W2096705340","https://openalex.org/W2103503682","https://openalex.org/W2107450474","https://openalex.org/W2123676318","https://openalex.org/W2125055259","https://openalex.org/W2126810594","https://openalex.org/W2134356816","https://openalex.org/W2138794713","https://openalex.org/W2145621051","https://openalex.org/W2145812409","https://openalex.org/W2148603752","https://openalex.org/W2150641509","https://openalex.org/W2156909104","https://openalex.org/W2159887157","https://openalex.org/W2161471267","https://openalex.org/W2978725006","https://openalex.org/W3152434232","https://openalex.org/W4211162396"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487","https://openalex.org/W1986764834"],"abstract_inverted_index":{"Hepatotoxicity,":[0],"drug-induced":[1],"liver":[2],"injury,":[3],"and":[4,75,92,202],"competitive":[5],"Cytochrome":[6],"P-450":[7],"(CYP)":[8],"isozyme":[9],"binding":[10],"are":[11],"serious":[12],"problems":[13],"associated":[14],"with":[15,69,231],"drug":[16,98],"use.":[17],"It":[18],"would":[19],"be":[20,153,221],"favorable":[21],"to":[22,25,78,119,166,182,215,223],"avoid":[23],"or":[24,41,55,100],"understand":[26],"potential":[27],"CYP":[28,38,58,87,125,186,194,200,213,232,241],"inhibition":[29,81,195],"at":[30],"the":[31,110,115,121,136,143,148,183,211,238,252],"developmental":[32],"stages.":[33],"However,":[34],"current":[35],"in":[36,114],"silico":[37],"prediction":[39,44,82,126,173,242],"models":[40,83,130,138,150,174,219],"available":[42,145],"public":[43],"servers":[45],"can":[46,151,175,220],"provide":[47,176],"only":[48],"yes/no":[49],"classification":[50],"results":[51],"for":[52,84,95,109,155,178,193,198,208],"just":[53],"one":[54],"a":[56,65,105,160,249],"few":[57],"enzymes.":[59,187],"In":[60],"this":[61],"study,":[62],"we":[63],"utilized":[64],"rule-based":[66,80,172,218],"C5.0":[67],"algorithm":[68,108],"different":[70],"descriptors,":[71],"including":[72],"PaDEL,":[73],"Mold(2),":[74],"PubChem":[76],"fingerprints,":[77],"construct":[79],"five":[85,184,189,212],"major":[86,185],"enzymes-CYP1A2,":[88],"CYP2C9,":[89],"CYP2C19,":[90],"CYP2D6":[91],"CYP3A4-that":[93],"account":[94],"90%":[96],"of":[97,112,123,142,159,163,210,237,251],"oxidation":[99],"hydrolysis.":[101],"We":[102],"also":[103,152],"developed":[104],"rational":[106],"sampling":[107],"selection":[111],"compounds":[113,164],"training":[116],"data":[117],"set,":[118],"enhance":[120],"performance":[122],"these":[124],"models.":[127,146],"The":[128,188],"optimized":[129],"include":[131],"several":[132],"improved":[133],"features.":[134],"First,":[135],"final":[137,149],"significantly":[139],"outperformed":[140],"all":[141],"currently":[144],"Second,":[147],"used":[154,222],"rapid":[156],"virtual":[157],"screening":[158],"large":[161],"set":[162],"due":[165],"their":[167],"ruleset-based":[168],"nature.":[169],"Moreover,":[170],"such":[171],"rulesets":[177],"structural":[179,227],"features":[180,228],"related":[181],"most":[190],"significant":[191],"rules":[192],"were":[196],"identified":[197],"each":[199,209],"enzymes":[201,214],"discussed.":[203],"An":[204],"example":[205],"was":[206],"chosen":[207],"demonstrate":[216],"how":[217],"gain":[224],"insights":[225],"into":[226],"that":[229],"correspond":[230],"inhibitions.":[233],"A":[234],"newer":[235],"version":[236],"freely":[239],"accessible":[240],"server,":[243],"CypRules,":[244],"is":[245],"presented":[246],"here":[247],"as":[248],"result":[250],"aforementioned":[253],"improvements.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}