{"id":"https://openalex.org/W4407016897","doi":"https://doi.org/10.1021/acs.jcim.4c02276","title":"Truncated Arctangent Rank Minimization and Double-Strategy Neighborhood Constraint Graph Inference for Drug\u2013Disease Association Prediction","display_name":"Truncated Arctangent Rank Minimization and Double-Strategy Neighborhood Constraint Graph Inference for Drug\u2013Disease Association Prediction","publication_year":2025,"publication_date":"2025-01-31","ids":{"openalex":"https://openalex.org/W4407016897","doi":"https://doi.org/10.1021/acs.jcim.4c02276","pmid":"https://pubmed.ncbi.nlm.nih.gov/39889248"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.4c02276","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c02276","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033342570","display_name":"Tiyao Liu","orcid":"https://orcid.org/0009-0004-9140-3653"},"institutions":[{"id":"https://openalex.org/I204553293","display_name":"China University of Petroleum, Beijing","ror":"https://ror.org/041qf4r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I204553293"]},{"id":"https://openalex.org/I4210112270","display_name":"Qingdao Academy of Intelligent Industries","ror":"https://ror.org/02a0rnh86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210112270"]},{"id":"https://openalex.org/I4210128818","display_name":"Institute of Software","ror":"https://ror.org/033dfsn42","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210128818"]},{"id":"https://openalex.org/I4210156066","display_name":"State Key Laboratory of Chemical Engineering","ror":"https://ror.org/05803vc71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210156066"]},{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tiyao Liu","raw_affiliation_strings":["China University of Petroleum","College of Computer Science and Technology, Qingdao Institute of Software","Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software","State Key Laboratory of Chemical Safety","Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software, Qingdao 266580, China","College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum, Qingdao 266580, China","State Key Laboratory of Chemical Safety, Qingdao 266580, China"],"raw_orcid":"https://orcid.org/0009-0004-9140-3653","affiliations":[{"raw_affiliation_string":"China University of Petroleum","institution_ids":["https://openalex.org/I204553293"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software","institution_ids":["https://openalex.org/I4210128818"]},{"raw_affiliation_string":"Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Chemical Safety","institution_ids":["https://openalex.org/I4210156066"]},{"raw_affiliation_string":"Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software, Qingdao 266580, China","institution_ids":["https://openalex.org/I4210112270"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum, Qingdao 266580, China","institution_ids":["https://openalex.org/I4210128818","https://openalex.org/I4210162190"]},{"raw_affiliation_string":"State Key Laboratory of Chemical Safety, Qingdao 266580, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111174523","display_name":"Shudong Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I204553293","display_name":"China University of Petroleum, Beijing","ror":"https://ror.org/041qf4r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I204553293"]},{"id":"https://openalex.org/I4210112270","display_name":"Qingdao Academy of Intelligent Industries","ror":"https://ror.org/02a0rnh86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210112270"]},{"id":"https://openalex.org/I4210128818","display_name":"Institute of Software","ror":"https://ror.org/033dfsn42","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210128818"]},{"id":"https://openalex.org/I4210156066","display_name":"State Key Laboratory of Chemical Engineering","ror":"https://ror.org/05803vc71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210156066"]},{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shudong Wang","raw_affiliation_strings":["China University of Petroleum","College of Computer Science and Technology, Qingdao Institute of Software","Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software","State Key Laboratory of Chemical Safety","Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software, Qingdao 266580, China","College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum, Qingdao 266580, China","State Key Laboratory of Chemical Safety, Qingdao 266580, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China University of Petroleum","institution_ids":["https://openalex.org/I204553293"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software","institution_ids":["https://openalex.org/I4210128818"]},{"raw_affiliation_string":"Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Chemical Safety","institution_ids":["https://openalex.org/I4210156066"]},{"raw_affiliation_string":"Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software, Qingdao 266580, China","institution_ids":["https://openalex.org/I4210112270"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum, Qingdao 266580, China","institution_ids":["https://openalex.org/I4210128818","https://openalex.org/I4210162190"]},{"raw_affiliation_string":"State Key Laboratory of Chemical Safety, Qingdao 266580, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067844688","display_name":"Shanchen Pang","orcid":"https://orcid.org/0009-0007-5620-0609"},"institutions":[{"id":"https://openalex.org/I204553293","display_name":"China University of Petroleum, Beijing","ror":"https://ror.org/041qf4r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I204553293"]},{"id":"https://openalex.org/I4210112270","display_name":"Qingdao Academy of Intelligent Industries","ror":"https://ror.org/02a0rnh86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210112270"]},{"id":"https://openalex.org/I4210128818","display_name":"Institute of Software","ror":"https://ror.org/033dfsn42","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210128818"]},{"id":"https://openalex.org/I4210156066","display_name":"State Key Laboratory of Chemical Engineering","ror":"https://ror.org/05803vc71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210156066"]},{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanchen Pang","raw_affiliation_strings":["China University of Petroleum","College of Computer Science and Technology, Qingdao Institute of Software","Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software","State Key Laboratory of Chemical Safety","College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum, Qingdao 266580, China","Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software, Qingdao 266580, China","State Key Laboratory of Chemical Safety, Qingdao 266580, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China University of Petroleum","institution_ids":["https://openalex.org/I204553293"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software","institution_ids":["https://openalex.org/I4210128818"]},{"raw_affiliation_string":"Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Chemical Safety","institution_ids":["https://openalex.org/I4210156066"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum, Qingdao 266580, China","institution_ids":["https://openalex.org/I4210128818","https://openalex.org/I4210162190"]},{"raw_affiliation_string":"Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software, Qingdao 266580, China","institution_ids":["https://openalex.org/I4210112270"]},{"raw_affiliation_string":"State Key Laboratory of Chemical Safety, Qingdao 266580, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049644698","display_name":"Xiaodong Tan","orcid":"https://orcid.org/0000-0002-0335-0909"},"institutions":[{"id":"https://openalex.org/I204553293","display_name":"China University of Petroleum, Beijing","ror":"https://ror.org/041qf4r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I204553293"]},{"id":"https://openalex.org/I4210112270","display_name":"Qingdao Academy of Intelligent Industries","ror":"https://ror.org/02a0rnh86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210112270"]},{"id":"https://openalex.org/I4210128818","display_name":"Institute of Software","ror":"https://ror.org/033dfsn42","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210128818"]},{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodong Tan","raw_affiliation_strings":["China University of Petroleum","College of Computer Science and Technology, Qingdao Institute of Software","Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software","Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software, Qingdao 266580, China","College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum, Qingdao 266580, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China University of Petroleum","institution_ids":["https://openalex.org/I204553293"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software","institution_ids":["https://openalex.org/I4210128818"]},{"raw_affiliation_string":"Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software","institution_ids":[]},{"raw_affiliation_string":"Shandong Key Laboratory of Intelligent Oil & Gas Industrial Software, Qingdao 266580, China","institution_ids":["https://openalex.org/I4210112270"]},{"raw_affiliation_string":"College of Computer Science and Technology, Qingdao Institute of Software, China University of Petroleum, Qingdao 266580, China","institution_ids":["https://openalex.org/I4210128818","https://openalex.org/I4210162190"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5111174523"],"corresponding_institution_ids":["https://openalex.org/I204553293","https://openalex.org/I4210112270","https://openalex.org/I4210128818","https://openalex.org/I4210156066","https://openalex.org/I4210162190"],"apc_list":null,"apc_paid":null,"fwci":6.1933,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.95925501,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"65","issue":"4","first_page":"2158","last_page":"2172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9695000052452087,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9628000259399414,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.7021452188491821},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.525384247303009},{"id":"https://openalex.org/keywords/minification","display_name":"Minification","score":0.47145137190818787},{"id":"https://openalex.org/keywords/constraint","display_name":"Constraint (computer-aided design)","score":0.4628865420818329},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4600808918476105},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43624016642570496},{"id":"https://openalex.org/keywords/rank","display_name":"Rank (graph theory)","score":0.43160852789878845},{"id":"https://openalex.org/keywords/inverse-trigonometric-functions","display_name":"Inverse trigonometric functions","score":0.42476871609687805},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.4245566725730896},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4185149669647217},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.391571581363678},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3437322974205017},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3029935359954834},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.2902994155883789},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19950059056282043},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.1255495548248291},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.10880494117736816}],"concepts":[{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.7021452188491821},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.525384247303009},{"id":"https://openalex.org/C147764199","wikidata":"https://www.wikidata.org/wiki/Q6865248","display_name":"Minification","level":2,"score":0.47145137190818787},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.4628865420818329},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4600808918476105},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43624016642570496},{"id":"https://openalex.org/C164226766","wikidata":"https://www.wikidata.org/wiki/Q7293202","display_name":"Rank (graph theory)","level":2,"score":0.43160852789878845},{"id":"https://openalex.org/C68827188","wikidata":"https://www.wikidata.org/wiki/Q674533","display_name":"Inverse trigonometric functions","level":2,"score":0.42476871609687805},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.4245566725730896},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4185149669647217},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.391571581363678},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3437322974205017},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3029935359954834},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.2902994155883789},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19950059056282043},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1255495548248291},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.10880494117736816},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.4c02276","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c02276","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:39889248","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39889248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5881903318","display_name":null,"funder_award_id":"2021YFA1000103","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7895523656","display_name":null,"funder_award_id":"2021YFA1000102","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W2128983843","https://openalex.org/W2259538443","https://openalex.org/W2322763599","https://openalex.org/W2473876819","https://openalex.org/W2529441728","https://openalex.org/W2559655401","https://openalex.org/W2771758625","https://openalex.org/W2790385355","https://openalex.org/W2790552352","https://openalex.org/W2803907380","https://openalex.org/W2888358121","https://openalex.org/W2896829849","https://openalex.org/W2912556930","https://openalex.org/W2915806464","https://openalex.org/W2922817064","https://openalex.org/W2946099214","https://openalex.org/W2946952196","https://openalex.org/W2960235084","https://openalex.org/W2960557205","https://openalex.org/W2969761002","https://openalex.org/W2997032704","https://openalex.org/W2997833976","https://openalex.org/W3000082418","https://openalex.org/W3003835206","https://openalex.org/W3012481772","https://openalex.org/W3020929333","https://openalex.org/W3024906290","https://openalex.org/W3045879648","https://openalex.org/W3082139797","https://openalex.org/W3093030756","https://openalex.org/W3097354806","https://openalex.org/W3113654230","https://openalex.org/W3145754360","https://openalex.org/W4223957045","https://openalex.org/W4309842604","https://openalex.org/W4313203574","https://openalex.org/W4313555682","https://openalex.org/W4317513368","https://openalex.org/W4363676248","https://openalex.org/W4367312557","https://openalex.org/W4382181479","https://openalex.org/W4388568061","https://openalex.org/W4390066222","https://openalex.org/W4391224391","https://openalex.org/W4391582532","https://openalex.org/W4391933417","https://openalex.org/W4402827768","https://openalex.org/W4403970827","https://openalex.org/W4404579419","https://openalex.org/W4404876522"],"related_works":["https://openalex.org/W3155892526","https://openalex.org/W2113914293","https://openalex.org/W4312625171","https://openalex.org/W2132350861","https://openalex.org/W2071613945","https://openalex.org/W2388395474","https://openalex.org/W2505844909","https://openalex.org/W1604705142","https://openalex.org/W2267250160","https://openalex.org/W2002606489"],"abstract_inverted_index":{"Accurately":[0],"identifying":[1],"new":[2,111],"therapeutic":[3],"uses":[4],"for":[5,82,95],"drugs":[6,97,171],"is":[7,229],"essential":[8],"to":[9,38,116,159,192],"advancing":[10],"pharmaceutical":[11],"research":[12],"and":[13,31,75,91,98,132,136,172,189,215,248],"development.":[14],"Graph":[15],"inference":[16,80,157],"techniques":[17],"have":[18],"shown":[19],"great":[20],"promise":[21],"in":[22,47,218,226],"predicting":[23],"drug-disease":[24,48,83,125,161,198,243],"associations,":[25],"offering":[26],"both":[27,96,187],"high":[28],"convergence":[29],"accuracy":[30],"efficiency.":[32],"However,":[33],"most":[34],"existing":[35,52],"methods":[36,53],"fail":[37],"sufficiently":[39],"address":[40],"the":[41,121,129,134,139,167,183,196,204,209,223,227],"issue":[42],"of":[43,124,138,141,170,203,212],"numerous":[44],"missing":[45],"information":[46,225],"association":[49,84],"networks.":[50],"Moreover,":[51],"are":[54,101],"often":[55],"constrained":[56,155],"by":[57,144],"local":[58],"or":[59],"single-directional":[60],"reasoning.":[61],"To":[62],"overcome":[63],"these":[64],"limitations,":[65],"we":[66,87,150],"propose":[67,151],"a":[68,110,152],"novel":[69],"approach,":[70],"truncated":[71,145],"arctangent":[72,146],"rank":[73,147],"minimization":[74],"double-strategy":[76,153],"neighborhood":[77,154],"constraint":[78],"graph":[79,156],"(TARMDNGI),":[81],"prediction.":[85],"First,":[86],"calculate":[88],"Gaussian":[89],"kernel":[90,93],"Laplace":[92],"similarities":[94],"diseases,":[99,173],"which":[100],"then":[102],"integrated":[103],"using":[104,195],"nonlinear":[105],"fusion":[106],"techniques.":[107],"We":[108],"introduce":[109],"matrix":[112,123,131],"completion":[113],"technique,":[114],"referred":[115],"as":[117,128],"TARM.":[118],"TARM":[119],"takes":[120],"adjacency":[122],"heterogeneous":[126,199,219],"networks":[127,143],"target":[130],"enhances":[133],"robustness":[135],"formability":[137],"edges":[140],"DDA":[142],"minimization.":[148],"Additionally,":[149],"method":[158,185],"predict":[160],"associations.":[162],"This":[163],"technique":[164],"focuses":[165],"on":[166],"neighboring":[168],"nodes":[169],"filtering":[174],"out":[175],"potential":[176],"noise":[177],"from":[178],"more":[179],"distant":[180],"nodes.":[181],"Furthermore,":[182],"DNGI":[184],"employs":[186],"top-down":[188],"bottom-up":[190],"strategies":[191,206],"infer":[193],"associations":[194,217],"entire":[197],"network.":[200],"The":[201],"synergy":[202],"dual":[205],"can":[207],"enhance":[208],"comprehensive":[210],"processing":[211],"complex":[213],"structures":[214],"cross-domain":[216],"graphs,":[220],"ensuring":[221],"that":[222,236],"rich":[224],"network":[228],"fully":[230],"utilized.":[231],"Experimental":[232],"results":[233],"consistently":[234],"demonstrate":[235],"TARMDNGI":[237],"outperforms":[238],"state-of-the-art":[239],"models":[240],"across":[241],"two":[242],"datasets,":[244],"one":[245,249],"lncRNA-disease":[246],"dataset,":[247],"microbe-disease":[250],"dataset.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-05-13T08:25:38.343686","created_date":"2025-10-10T00:00:00"}
