{"id":"https://openalex.org/W4408588993","doi":"https://doi.org/10.1021/acs.jcim.4c02272","title":"Regulatory Interactions between APOBEC3B N- and C-Terminal Domains","display_name":"Regulatory Interactions between APOBEC3B N- and C-Terminal Domains","publication_year":2025,"publication_date":"2025-03-19","ids":{"openalex":"https://openalex.org/W4408588993","doi":"https://doi.org/10.1021/acs.jcim.4c02272","pmid":"https://pubmed.ncbi.nlm.nih.gov/40105360"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.4c02272","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c02272","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.4c02272?ref=article_openPDF","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.4c02272?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061855744","display_name":"Mac Kevin E. Braza","orcid":"https://orcid.org/0000-0002-6929-7397"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mac Kevin E. Braza","raw_affiliation_strings":["Department of Chemistry and Biochemistry","University of California, San Diego","Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry","institution_ids":[]},{"raw_affiliation_string":"University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015171885","display_name":"\u00d6zlem Demir","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"\u00d6zlem Demir","raw_affiliation_strings":["Department of Chemistry and Biochemistry","University of California, San Diego","Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry","institution_ids":[]},{"raw_affiliation_string":"University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064401041","display_name":"Surl-Hee Ahn","orcid":"https://orcid.org/0000-0002-3422-805X"},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Surl-Hee Ahn","raw_affiliation_strings":["Department of Chemical Engineering","University of California, Davis","Department of Chemical Engineering, University of California, Davis, Davis, California 95616, United States"],"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering","institution_ids":[]},{"raw_affiliation_string":"University of California, Davis","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of California, Davis, Davis, California 95616, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044490040","display_name":"Clare K. Morris","orcid":"https://orcid.org/0000-0002-4314-5387"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clare K. Morris","raw_affiliation_strings":["Department of Chemistry and Biochemistry","University of California, San Diego","Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry","institution_ids":[]},{"raw_affiliation_string":"University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070832401","display_name":"Carla Calv\u00f3\u2010Tusell","orcid":"https://orcid.org/0000-0003-2681-8460"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carla Calv\u00f3-Tusell","raw_affiliation_strings":["Department of Molecular Biology","University of California, San Diego","Department of Molecular Biology, University of California, San Diego, La Jolla, California 92093, United States"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Molecular Biology, University of California, San Diego, La Jolla, California 92093, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096365394","display_name":"Kelly L. McGuire","orcid":"https://orcid.org/0009-0005-7520-3675"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly L. McGuire","raw_affiliation_strings":["Department of Chemistry and Biochemistry","University of California, San Diego","Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry","institution_ids":[]},{"raw_affiliation_string":"University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004586332","display_name":"B\u00e1rbara de la Pe\u00f1a Avalos","orcid":"https://orcid.org/0000-0001-9796-8015"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B\u00e1rbara de la Pe\u00f1a Avalos","raw_affiliation_strings":["Department of Biochemistry and Structural Biology","University of Texas Health San Antonio","Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas 78229, United States"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Structural Biology","institution_ids":[]},{"raw_affiliation_string":"University of Texas Health San Antonio","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas 78229, United States","institution_ids":["https://openalex.org/I45438204","https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080092101","display_name":"Michael A. Carpenter","orcid":"https://orcid.org/0000-0001-9524-5323"},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Carpenter","raw_affiliation_strings":["Department of Biochemistry and Structural Biology","Howard Hughes Medical Institute","University of Texas Health San Antonio","Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, Texas 78229, United States","Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas 78229, United States"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Structural Biology","institution_ids":[]},{"raw_affiliation_string":"Howard Hughes Medical Institute","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"University of Texas Health San Antonio","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, Texas 78229, United States","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas 78229, United States","institution_ids":["https://openalex.org/I45438204","https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110584853","display_name":"Yanjun Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanjun Chen","raw_affiliation_strings":["Department of Biochemistry and Structural Biology","University of Texas Health San Antonio","Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas 78229, United States"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Structural Biology","institution_ids":[]},{"raw_affiliation_string":"University of Texas Health San Antonio","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas 78229, United States","institution_ids":["https://openalex.org/I45438204","https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025492881","display_name":"Lorenzo Casalino","orcid":"https://orcid.org/0000-0003-3581-1148"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorenzo Casalino","raw_affiliation_strings":["Department of Molecular Biology","University of California, San Diego","Department of Molecular Biology, University of California, San Diego, La Jolla, California 92093, United States"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Molecular Biology, University of California, San Diego, La Jolla, California 92093, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056554657","display_name":"Hideki Aihara","orcid":"https://orcid.org/0000-0001-7508-6230"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]},{"id":"https://openalex.org/I4210150971","display_name":"Institute of Molecular Biology and Biophysics","ror":"https://ror.org/051f11n17","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210150971"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Hideki Aihara","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology and Biophysics","University of Minnesota","Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, United States"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology and Biophysics","institution_ids":["https://openalex.org/I4210150971"]},{"raw_affiliation_string":"University of Minnesota","institution_ids":["https://openalex.org/I2800403580"]},{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063672303","display_name":"Mark A. Herzik","orcid":"https://orcid.org/0000-0001-6653-6682"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Herzik","raw_affiliation_strings":["Department of Chemistry and Biochemistry","University of California, San Diego","Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry","institution_ids":[]},{"raw_affiliation_string":"University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035901749","display_name":"Reuben S. Harris","orcid":"https://orcid.org/0000-0002-9034-9112"},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reuben S. Harris","raw_affiliation_strings":["Department of Biochemistry and Structural Biology","Howard Hughes Medical Institute","University of Texas Health San Antonio","Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, Texas 78229, United States","Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas 78229, United States"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Structural Biology","institution_ids":[]},{"raw_affiliation_string":"Howard Hughes Medical Institute","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"University of Texas Health San Antonio","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, Texas 78229, United States","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas 78229, United States","institution_ids":["https://openalex.org/I45438204","https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081468273","display_name":"Rommie E. Amaro","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rommie E. Amaro","raw_affiliation_strings":["Department of Molecular Biology","University of California, San Diego","Department of Molecular Biology, University of California, San Diego, La Jolla, California 92093, United States"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Molecular Biology, University of California, San Diego, La Jolla, California 92093, United States","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5081468273"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":1.1527,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.73402132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"65","issue":"7","first_page":"3593","last_page":"3604"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/terminal","display_name":"Terminal (telecommunication)","score":0.7806969881057739},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.43693289160728455},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3348999321460724},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.33019253611564636},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32986968755722046},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.13924208283424377}],"concepts":[{"id":"https://openalex.org/C2779664074","wikidata":"https://www.wikidata.org/wiki/Q3518405","display_name":"Terminal (telecommunication)","level":2,"score":0.7806969881057739},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43693289160728455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3348999321460724},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33019253611564636},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32986968755722046},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.13924208283424377}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jcim.4c02272","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c02272","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.4c02272?ref=article_openPDF","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:40105360","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40105360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12004528","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12004528","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acs.jcim.4c02272","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c02272","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.4c02272?ref=article_openPDF","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1088503213","display_name":null,"funder_award_id":"T32-CA009523","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3636431883","display_name":null,"funder_award_id":"P01-CA234228","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3857830346","display_name":null,"funder_award_id":"R35-GM118047","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332564","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408588993.pdf"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1178456644","https://openalex.org/W1990993204","https://openalex.org/W2001398410","https://openalex.org/W2029667189","https://openalex.org/W2042651904","https://openalex.org/W2044553096","https://openalex.org/W2056012861","https://openalex.org/W2060079863","https://openalex.org/W2067643341","https://openalex.org/W2075409576","https://openalex.org/W2076154818","https://openalex.org/W2078793281","https://openalex.org/W2106140689","https://openalex.org/W2126126169","https://openalex.org/W2129153475","https://openalex.org/W2131793664","https://openalex.org/W2155201844","https://openalex.org/W2177028599","https://openalex.org/W2313116527","https://openalex.org/W2332712348","https://openalex.org/W2334531949","https://openalex.org/W2404280981","https://openalex.org/W2527720111","https://openalex.org/W2556565974","https://openalex.org/W2567060579","https://openalex.org/W2572080171","https://openalex.org/W2587625522","https://openalex.org/W2620007692","https://openalex.org/W2731784911","https://openalex.org/W2770954695","https://openalex.org/W2772722150","https://openalex.org/W2804191505","https://openalex.org/W2804822363","https://openalex.org/W2888607272","https://openalex.org/W2919337517","https://openalex.org/W2949562137","https://openalex.org/W2974295206","https://openalex.org/W2991934759","https://openalex.org/W3004480399","https://openalex.org/W3122646881","https://openalex.org/W3125756628","https://openalex.org/W3128176044","https://openalex.org/W3134296933","https://openalex.org/W3154095608","https://openalex.org/W3173848215","https://openalex.org/W3177828909","https://openalex.org/W4210924529","https://openalex.org/W4226013321","https://openalex.org/W4286007893","https://openalex.org/W4294579788","https://openalex.org/W4319656581","https://openalex.org/W4320149430","https://openalex.org/W4385751161","https://openalex.org/W4386923834","https://openalex.org/W4387342933","https://openalex.org/W4389164778","https://openalex.org/W4392897360","https://openalex.org/W4392919113","https://openalex.org/W4398694779"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487"],"abstract_inverted_index":{"APOBEC3B":[0,47],"(A3B)":[1],"is":[2,51],"implicated":[3],"in":[4,54,164],"DNA":[5],"mutations":[6],"that":[7,91,119],"facilitate":[8],"tumor":[9],"evolution.":[10],"Although":[11],"structures":[12],"of":[13,39,66,86,92,129,145],"its":[14,40],"individual":[15],"N-":[16],"and":[17,21,42,56,73,97,142,153],"C-terminal":[18,48],"domains":[19],"(NTD":[20],"CTD)":[22],"have":[23],"been":[24],"resolved":[25],"through":[26],"X-ray":[27],"crystallography,":[28],"the":[29,46,84,87,93,112,122,126,130,139,151],"full-length":[30],"A3B":[31],"(fl-A3B)":[32],"structure":[33],"remains":[34],"elusive,":[35],"limiting":[36],"our":[37],"understanding":[38],"dynamics":[41,85,101,141],"mechanisms.":[43],"In":[44,58],"particular,":[45],"domain":[49],"(A3Bctd)":[50,89],"frequently":[52],"closed":[53],"models":[55,65],"structures.":[57],"this":[59],"study,":[60],"we":[61,105],"built":[62],"several":[63],"new":[64,159],"fl-A3B":[67,94,113,131],"using":[68],"integrative":[69],"structural":[70,140],"biology":[71],"methods":[72,109],"selected":[74],"a":[75],"top":[76],"model":[77],"for":[78,161],"further":[79],"dynamical":[80],"investigation.":[81],"We":[82],"compared":[83],"truncated":[88],"to":[90,110],"via":[95],"conventional":[96],"Gaussian":[98],"accelerated":[99],"molecular":[100],"(MD)":[102],"simulations.":[103],"Subsequently,":[104],"employed":[106],"weighted":[107],"ensemble":[108],"explore":[111],"active":[114,132,152],"site":[115],"opening":[116,127],"mechanism,":[117],"finding":[118],"interactions":[120],"at":[121],"NTD-CTD":[123],"interface":[124],"enhance":[125],"frequency":[128],"site.":[133],"Our":[134],"findings":[135],"shed":[136],"light":[137],"on":[138],"potential":[143],"druggability":[144],"fl-A3B,":[146],"including":[147],"observations":[148],"regarding":[149],"both":[150],"allosteric":[154],"sites,":[155],"which":[156],"may":[157],"offer":[158],"avenues":[160],"therapeutic":[162],"intervention":[163],"cancer.":[165]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
