{"id":"https://openalex.org/W4413008664","doi":"https://doi.org/10.1021/acs.jcim.4c02269","title":"Energy Landscapes and Structural Plasticity of Intrinsically Disordered Histones","display_name":"Energy Landscapes and Structural Plasticity of Intrinsically Disordered Histones","publication_year":2025,"publication_date":"2025-08-06","ids":{"openalex":"https://openalex.org/W4413008664","doi":"https://doi.org/10.1021/acs.jcim.4c02269","pmid":"https://pubmed.ncbi.nlm.nih.gov/40768165"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.4c02269","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c02269","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.jcim.4c02269","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069085599","display_name":"Rafael Giordano Viegas","orcid":"https://orcid.org/0000-0002-6102-3375"},"institutions":[{"id":"https://openalex.org/I107371206","display_name":"Federal Institute of S\u00e3o Paulo","ror":"https://ror.org/005pn5z34","country_code":"BR","type":"education","lineage":["https://openalex.org/I107371206"]},{"id":"https://openalex.org/I4210107917","display_name":"Exact Sciences (United States)","ror":"https://ror.org/01kc31v38","country_code":"US","type":"company","lineage":["https://openalex.org/I4210107917"]},{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Rafael G. Viegas","raw_affiliation_strings":["Department of Physics, Institute of Biosciences, Humanities and Exact Sciences","Federal Institute of Education, Science and Technology of S\u00e3o Paulo (IFSP)","S\u00e3o Paulo State University (UNESP)"],"raw_orcid":"https://orcid.org/0000-0002-6102-3375","affiliations":[{"raw_affiliation_string":"Department of Physics, Institute of Biosciences, Humanities and Exact Sciences","institution_ids":["https://openalex.org/I4210107917"]},{"raw_affiliation_string":"Federal Institute of Education, Science and Technology of S\u00e3o Paulo (IFSP)","institution_ids":["https://openalex.org/I107371206"]},{"raw_affiliation_string":"S\u00e3o Paulo State University (UNESP)","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007728924","display_name":"Wu Hao","orcid":"https://orcid.org/0000-0001-7748-737X"},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Wu","raw_affiliation_strings":["Oncology Chemistry, AstraZeneca, 35 Gatehouse Dr, Waltham, Massachusetts 02451, United States"],"raw_orcid":"https://orcid.org/0000-0001-7748-737X","affiliations":[{"raw_affiliation_string":"Oncology Chemistry, AstraZeneca, 35 Gatehouse Dr, Waltham, Massachusetts 02451, United States","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065236542","display_name":"Murilo N. Sanches","orcid":"https://orcid.org/0000-0001-9650-7989"},"institutions":[{"id":"https://openalex.org/I4210107917","display_name":"Exact Sciences (United States)","ror":"https://ror.org/01kc31v38","country_code":"US","type":"company","lineage":["https://openalex.org/I4210107917"]},{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Murilo N. Sanches","raw_affiliation_strings":["Department of Physics, Institute of Biosciences, Humanities and Exact Sciences","S\u00e3o Paulo State University (UNESP)"],"raw_orcid":"https://orcid.org/0000-0001-9650-7989","affiliations":[{"raw_affiliation_string":"Department of Physics, Institute of Biosciences, Humanities and Exact Sciences","institution_ids":["https://openalex.org/I4210107917"]},{"raw_affiliation_string":"S\u00e3o Paulo State University (UNESP)","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008042705","display_name":"Garegin A. Papoian","orcid":null},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garegin A. Papoian","raw_affiliation_strings":["Biophysics Program, Institute for Physical Science and Technology","Department of Chemistry and Biochemistry","University of Maryland"],"raw_orcid":"https://orcid.org/0000-0001-8580-3790","affiliations":[{"raw_affiliation_string":"Biophysics Program, Institute for Physical Science and Technology","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry","institution_ids":[]},{"raw_affiliation_string":"University of Maryland","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024994552","display_name":"Vitor B. P. Leite","orcid":"https://orcid.org/0000-0003-0008-9079"},"institutions":[{"id":"https://openalex.org/I4210107917","display_name":"Exact Sciences (United States)","ror":"https://ror.org/01kc31v38","country_code":"US","type":"company","lineage":["https://openalex.org/I4210107917"]},{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR","US"],"is_corresponding":true,"raw_author_name":"Vitor B.P. Leite","raw_affiliation_strings":["Department of Physics, Institute of Biosciences, Humanities and Exact Sciences","S\u00e3o Paulo State University (UNESP)"],"raw_orcid":"https://orcid.org/0000-0003-0008-9079","affiliations":[{"raw_affiliation_string":"Department of Physics, Institute of Biosciences, Humanities and Exact Sciences","institution_ids":["https://openalex.org/I4210107917"]},{"raw_affiliation_string":"S\u00e3o Paulo State University (UNESP)","institution_ids":["https://openalex.org/I879563668"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5024994552"],"corresponding_institution_ids":["https://openalex.org/I4210107917","https://openalex.org/I879563668"],"apc_list":null,"apc_paid":null,"fwci":0.7114,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.72687214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"65","issue":"16","first_page":"8679","last_page":"8687"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasticity","display_name":"Plasticity","score":0.724280059337616},{"id":"https://openalex.org/keywords/histone","display_name":"Histone","score":0.5942357778549194},{"id":"https://openalex.org/keywords/structural-plasticity","display_name":"Structural plasticity","score":0.5602131485939026},{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"Intrinsically disordered proteins","score":0.4532907009124756},{"id":"https://openalex.org/keywords/energy","display_name":"Energy (signal processing)","score":0.4516427516937256},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35095083713531494},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.3443428874015808},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3226516842842102},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.29561325907707214},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.2945624589920044},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.243915855884552},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.23725998401641846},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18345341086387634},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.11922222375869751}],"concepts":[{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.724280059337616},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5942357778549194},{"id":"https://openalex.org/C2993191138","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Structural plasticity","level":2,"score":0.5602131485939026},{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.4532907009124756},{"id":"https://openalex.org/C186370098","wikidata":"https://www.wikidata.org/wiki/Q442787","display_name":"Energy (signal processing)","level":2,"score":0.4516427516937256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35095083713531494},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3443428874015808},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3226516842842102},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.29561325907707214},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2945624589920044},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.243915855884552},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.23725998401641846},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18345341086387634},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.11922222375869751},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jcim.4c02269","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c02269","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:40768165","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40768165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:europepmc.org:11190316","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12381848","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acs.jcim.4c02269","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c02269","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4300000071525574,"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7"}],"awards":[{"id":"https://openalex.org/G174316680","display_name":null,"funder_award_id":"2022/ 07231-7","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G1983319002","display_name":null,"funder_award_id":"2023/02219-1","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G2909686496","display_name":null,"funder_award_id":"2021/15028-4","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G8833116012","display_name":null,"funder_award_id":"310017/2020-3","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1607931568","https://openalex.org/W1773400868","https://openalex.org/W1912412578","https://openalex.org/W1976499671","https://openalex.org/W1992898397","https://openalex.org/W2007765298","https://openalex.org/W2008890975","https://openalex.org/W2015115860","https://openalex.org/W2016170088","https://openalex.org/W2016267980","https://openalex.org/W2023921624","https://openalex.org/W2029667189","https://openalex.org/W2037249548","https://openalex.org/W2037794607","https://openalex.org/W2040809566","https://openalex.org/W2041119019","https://openalex.org/W2045533286","https://openalex.org/W2059324308","https://openalex.org/W2078520459","https://openalex.org/W2096125044","https://openalex.org/W2102701612","https://openalex.org/W2104939587","https://openalex.org/W2121586455","https://openalex.org/W2122199548","https://openalex.org/W2125022522","https://openalex.org/W2132720084","https://openalex.org/W2132747517","https://openalex.org/W2137129298","https://openalex.org/W2138645972","https://openalex.org/W2140565568","https://openalex.org/W2147988069","https://openalex.org/W2234142868","https://openalex.org/W2266595811","https://openalex.org/W2325642794","https://openalex.org/W2329092529","https://openalex.org/W2414650303","https://openalex.org/W2560656057","https://openalex.org/W2610586915","https://openalex.org/W2770625402","https://openalex.org/W2809650930","https://openalex.org/W2885610180","https://openalex.org/W2911536414","https://openalex.org/W2912126500","https://openalex.org/W2921876744","https://openalex.org/W2925138603","https://openalex.org/W2953016572","https://openalex.org/W2975605169","https://openalex.org/W2981180356","https://openalex.org/W2982547327","https://openalex.org/W3093693693","https://openalex.org/W3130608459","https://openalex.org/W3131565789","https://openalex.org/W3135014513","https://openalex.org/W3155107084","https://openalex.org/W3159156584","https://openalex.org/W3177858566","https://openalex.org/W3192889434","https://openalex.org/W3202742435","https://openalex.org/W3217259878","https://openalex.org/W3217611742","https://openalex.org/W4210588499","https://openalex.org/W4210968583","https://openalex.org/W4211196614","https://openalex.org/W4212940766","https://openalex.org/W4213050306","https://openalex.org/W4226224711","https://openalex.org/W4283080252","https://openalex.org/W4307338130","https://openalex.org/W4381309750","https://openalex.org/W4392987333","https://openalex.org/W4396707145"],"related_works":["https://openalex.org/W2071046912","https://openalex.org/W3217731247","https://openalex.org/W2771501339","https://openalex.org/W578172782","https://openalex.org/W2091112217","https://openalex.org/W4210804497","https://openalex.org/W2281384865","https://openalex.org/W2540773970","https://openalex.org/W3217011804","https://openalex.org/W2416893245"],"abstract_inverted_index":{"Intrinsically":[0],"disordered":[1],"proteins":[2],"(IDPs)":[3],"are":[4],"characterized":[5],"by":[6,109,137],"their":[7,81,163],"lack":[8],"of":[9,32,48,67,73,96,123,147,156,162],"a":[10],"stable":[11],"3D":[12],"structure,":[13],"enabling":[14],"them":[15],"to":[16,165],"adopt":[17],"multiple":[18],"conformations":[19],"and":[20,39,70,84,100,150,168],"participate":[21],"in":[22,152],"various":[23],"cellular":[24,169],"processes.":[25],"This":[26,87,141],"study":[27],"investigates":[28],"the":[29,36,40,46,56,64,74,93,97,104,120,124,144,154],"conformational":[30,65,94,105,121,148],"dynamics":[31,167],"histone":[33,42,126],"tails,":[34],"specifically":[35],"H4":[37,75,98],"tail":[38,99],"linker":[41,125],"H1,":[43],"focusing":[44],"on":[45],"effects":[47],"post-translational":[49],"modifications":[50],"(PTMs)":[51],"such":[52],"as":[53],"acetylation.":[54],"Utilizing":[55],"energy":[57],"landscape":[58],"visualization":[59],"method":[60],"(ELViM),":[61],"we":[62],"projected":[63],"space":[66,106,122],"wild":[68],"type":[69],"acetylated":[71],"forms":[72],"tail,":[76],"revealing":[77],"significant":[78],"insights":[79],"into":[80],"structural":[82,133],"heterogeneity":[83,95,134],"preferential":[85],"ensembles.":[86],"approach":[88],"demonstrated":[89],"that":[90],"acetylation":[91],"reduces":[92],"introduces":[101],"regions":[102],"within":[103],"uniquely":[107],"occupied":[108],"each":[110],"form,":[111],"which":[112],"may":[113],"correlate":[114],"with":[115],"specific":[116],"biological":[117],"functions.":[118],"Furthermore,":[119],"H1":[127],"was":[128],"analyzed,":[129],"illustrating":[130],"how":[131],"its":[132],"is":[135],"influenced":[136],"nucleosome":[138],"binding":[139],"modes.":[140],"work":[142],"highlights":[143],"critical":[145],"role":[146],"plasticity":[149],"PTMs":[151],"regulating":[153],"multifunctionality":[155],"IDPs,":[157],"thereby":[158],"enhancing":[159],"our":[160],"understanding":[161],"contributions":[164],"chromatin":[166],"regulation.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
