{"id":"https://openalex.org/W4405492798","doi":"https://doi.org/10.1021/acs.jcim.4c01966","title":"AI-Driven Drug Discovery for Rare Diseases","display_name":"AI-Driven Drug Discovery for Rare Diseases","publication_year":2024,"publication_date":"2024-12-17","ids":{"openalex":"https://openalex.org/W4405492798","doi":"https://doi.org/10.1021/acs.jcim.4c01966","pmid":"https://pubmed.ncbi.nlm.nih.gov/39689164"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.4c01966","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c01966","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089489436","display_name":"Amit Gangwal","orcid":null},"institutions":[{"id":"https://openalex.org/I4210132590","display_name":"Shri Vile Parle Kelavani Mandal","ror":"https://ror.org/03ddhrn22","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210132590","https://openalex.org/I4405260087"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amit Gangwal","raw_affiliation_strings":["Department of Natural Product Chemistry","Shri Vile Parle Kelavani Mandal\u2019s Institute of Pharmacy","Department of Natural Product Chemistry, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule 424001, Maharashtra, India"],"affiliations":[{"raw_affiliation_string":"Department of Natural Product Chemistry","institution_ids":[]},{"raw_affiliation_string":"Shri Vile Parle Kelavani Mandal\u2019s Institute of Pharmacy","institution_ids":["https://openalex.org/I4210132590"]},{"raw_affiliation_string":"Department of Natural Product Chemistry, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule 424001, Maharashtra, India","institution_ids":["https://openalex.org/I4210132590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083327774","display_name":"Antonio Lavecchia","orcid":"https://orcid.org/0000-0002-2181-8026"},"institutions":[{"id":"https://openalex.org/I4210137452","display_name":"Drug Discovery Laboratory (Norway)","ror":"https://ror.org/04nybae35","country_code":"NO","type":"company","lineage":["https://openalex.org/I4210137452"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT","NO"],"is_corresponding":true,"raw_author_name":"Antonio Lavecchia","raw_affiliation_strings":["University of Naples Federico II","\u201cDrug Discovery\u201d Laboratory, Department of Pharmacy","\"Drug Discovery\" Laboratory, Department of Pharmacy, University of Naples Federico II, I-80131 Naples, Italy"],"affiliations":[{"raw_affiliation_string":"University of Naples Federico II","institution_ids":["https://openalex.org/I71267560"]},{"raw_affiliation_string":"\u201cDrug Discovery\u201d Laboratory, Department of Pharmacy","institution_ids":["https://openalex.org/I4210137452"]},{"raw_affiliation_string":"\"Drug Discovery\" Laboratory, Department of Pharmacy, University of Naples Federico II, I-80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083327774"],"corresponding_institution_ids":["https://openalex.org/I4210137452","https://openalex.org/I71267560"],"apc_list":null,"apc_paid":null,"fwci":13.7833,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.99170381,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"65","issue":"5","first_page":"2214","last_page":"2231"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9829999804496765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.7600768804550171},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.6925351619720459},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.5886145830154419},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.5685350894927979},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5674853324890137},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.5311763286590576},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.46691158413887024},{"id":"https://openalex.org/keywords/orphan-drug","display_name":"Orphan drug","score":0.43209803104400635},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"Biomarker discovery","score":0.41612082719802856},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3928585350513458},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.3791956305503845},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.3335155248641968},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32353854179382324},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32075774669647217},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.21421891450881958},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.21156644821166992},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.2027662992477417},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.117520272731781}],"concepts":[{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.7600768804550171},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6925351619720459},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.5886145830154419},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.5685350894927979},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5674853324890137},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.5311763286590576},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46691158413887024},{"id":"https://openalex.org/C75480439","wikidata":"https://www.wikidata.org/wiki/Q1367466","display_name":"Orphan drug","level":2,"score":0.43209803104400635},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.41612082719802856},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3928585350513458},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3791956305503845},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3335155248641968},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32353854179382324},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32075774669647217},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.21421891450881958},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21156644821166992},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2027662992477417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.117520272731781},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.0},{"id":"https://openalex.org/C548081761","wikidata":"https://www.wikidata.org/wiki/Q180388","display_name":"Waste management","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035583","descriptor_name":"Rare Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D035583","descriptor_name":"Rare Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D035583","descriptor_name":"Rare Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D035583","descriptor_name":"Rare Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D035583","descriptor_name":"Rare Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035583","descriptor_name":"Rare Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035583","descriptor_name":"Rare Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.4c01966","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c01966","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:39689164","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39689164","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G853743651","display_name":null,"funder_award_id":"2022P5LPHS","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"}],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W1988782368","https://openalex.org/W2026672686","https://openalex.org/W2045791858","https://openalex.org/W2053717624","https://openalex.org/W2101982893","https://openalex.org/W2263865604","https://openalex.org/W2295208775","https://openalex.org/W2316649978","https://openalex.org/W2328111136","https://openalex.org/W2333772288","https://openalex.org/W2444690946","https://openalex.org/W2737639704","https://openalex.org/W2738402542","https://openalex.org/W2766021430","https://openalex.org/W2766834118","https://openalex.org/W2783464703","https://openalex.org/W2889450541","https://openalex.org/W2892378636","https://openalex.org/W2896002881","https://openalex.org/W2899057363","https://openalex.org/W2909472027","https://openalex.org/W2913195599","https://openalex.org/W2922939447","https://openalex.org/W2934326527","https://openalex.org/W2939321522","https://openalex.org/W2947996805","https://openalex.org/W2955318914","https://openalex.org/W2959938226","https://openalex.org/W2962398326","https://openalex.org/W2963515495","https://openalex.org/W2964677890","https://openalex.org/W2973267506","https://openalex.org/W2992899796","https://openalex.org/W2995381955","https://openalex.org/W2996021891","https://openalex.org/W2998922495","https://openalex.org/W3029577894","https://openalex.org/W3030464560","https://openalex.org/W3030978062","https://openalex.org/W3038072559","https://openalex.org/W3044852492","https://openalex.org/W3049197809","https://openalex.org/W3087156149","https://openalex.org/W3088014546","https://openalex.org/W3093687066","https://openalex.org/W3125935675","https://openalex.org/W3129597087","https://openalex.org/W3143491409","https://openalex.org/W3147439045","https://openalex.org/W3152642460","https://openalex.org/W3155106196","https://openalex.org/W3158891634","https://openalex.org/W3199131848","https://openalex.org/W3207534753","https://openalex.org/W3207997298","https://openalex.org/W3212055541","https://openalex.org/W4200013470","https://openalex.org/W4200300989","https://openalex.org/W4206508717","https://openalex.org/W4210852924","https://openalex.org/W4253171146","https://openalex.org/W4282557619","https://openalex.org/W4283587267","https://openalex.org/W4283650099","https://openalex.org/W4287373263","https://openalex.org/W4300960771","https://openalex.org/W4304166000","https://openalex.org/W4313880353","https://openalex.org/W4324150178","https://openalex.org/W4363652204","https://openalex.org/W4366835631","https://openalex.org/W4367049264","https://openalex.org/W4379016428","https://openalex.org/W4383912288","https://openalex.org/W4384831976","https://openalex.org/W4385374442","https://openalex.org/W4386758157","https://openalex.org/W4386847634","https://openalex.org/W4387381575","https://openalex.org/W4387472633","https://openalex.org/W4388042006","https://openalex.org/W4388499117","https://openalex.org/W4390006825","https://openalex.org/W4392163954","https://openalex.org/W4392458883","https://openalex.org/W4392468778","https://openalex.org/W4395053803","https://openalex.org/W4396521393","https://openalex.org/W4396530953","https://openalex.org/W4398133351","https://openalex.org/W4399677534","https://openalex.org/W4399954566","https://openalex.org/W4400084330","https://openalex.org/W4400518765","https://openalex.org/W4400735202","https://openalex.org/W4401281117","https://openalex.org/W4401322211","https://openalex.org/W4402000573","https://openalex.org/W4402827768"],"related_works":["https://openalex.org/W2899096130","https://openalex.org/W3190782215","https://openalex.org/W2902729297","https://openalex.org/W3110500039","https://openalex.org/W4255531208","https://openalex.org/W4396858017","https://openalex.org/W4400165188","https://openalex.org/W4206422705","https://openalex.org/W4320009247","https://openalex.org/W3186872001"],"abstract_inverted_index":{"Rare":[0],"diseases":[1],"(RDs),":[2],"affecting":[3],"300":[4],"million":[5],"people":[6],"globally,":[7],"present":[8],"a":[9,154],"daunting":[10],"public":[11],"health":[12],"challenge":[13],"characterized":[14],"by":[15,47,98],"complexity,":[16],"limited":[17],"treatment":[18],"options,":[19],"and":[20,51,80,120,129,170,174],"diagnostic":[21],"hurdles.":[22],"Despite":[23],"legislative":[24],"efforts,":[25],"such":[26,106],"as":[27,107],"the":[28,58,70,158],"1983":[29],"US":[30],"Orphan":[31],"Drug":[32],"Act,":[33],"more":[34],"than":[35],"90%":[36],"of":[37,61,72,162,181],"RDs":[38,97],"lack":[39],"effective":[40],"therapies.":[41],"Traditional":[42],"drug":[43,94,108,122],"discovery":[44,95],"models,":[45],"marked":[46],"lengthy":[48],"development":[49,143,175],"cycles":[50],"high":[52],"failure":[53],"rates,":[54],"struggle":[55],"to":[56,92],"meet":[57],"unique":[59],"demands":[60],"RDs,":[62,145],"often":[63],"yielding":[64],"poor":[65],"returns":[66],"on":[67],"investment.":[68],"However,":[69],"advent":[71],"artificial":[73],"intelligence":[74],"(AI),":[75],"encompassing":[76],"machine":[77],"learning":[78,82],"(ML)":[79],"deep":[81],"(DL),":[83],"offers":[84],"groundbreaking":[85],"solutions.":[86],"This":[87,150],"review":[88,133],"explores":[89],"AI's":[90,163],"potential":[91],"revolutionize":[93],"for":[96,144],"overcoming":[99],"these":[100],"challenges.":[101],"It":[102],"discusses":[103],"AI-driven":[104],"advancements,":[105],"repurposing,":[109],"biomarker":[110],"discovery,":[111],"personalized":[112],"medicine,":[113],"genetics,":[114],"clinical":[115],"trial":[116],"optimization,":[117],"corporate":[118],"innovations,":[119],"novel":[121],"target":[123],"identification.":[124],"By":[125],"synthesizing":[126],"current":[127],"knowledge":[128],"recent":[130],"breakthroughs,":[131],"this":[132,178],"provides":[134],"crucial":[135],"insights":[136],"into":[137],"how":[138],"AI":[139],"can":[140],"accelerate":[141],"therapeutic":[142],"ultimately":[146],"improving":[147],"patient":[148],"outcomes.":[149],"comprehensive":[151],"analysis":[152],"fills":[153],"critical":[155],"gap":[156],"in":[157,166,177],"literature,":[159],"enhancing":[160],"understanding":[161],"pivotal":[164],"role":[165],"transforming":[167],"RD":[168],"research":[169,173],"guiding":[171],"future":[172],"efforts":[176],"vital":[179],"area":[180],"medicine.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":18}],"updated_date":"2026-03-28T08:17:26.163206","created_date":"2025-10-10T00:00:00"}