{"id":"https://openalex.org/W4407887175","doi":"https://doi.org/10.1021/acs.jcim.4c01752","title":"ProCeSa: Contrast-Enhanced Structure-Aware Network for Thermostability Prediction with Protein Language Models","display_name":"ProCeSa: Contrast-Enhanced Structure-Aware Network for Thermostability Prediction with Protein Language Models","publication_year":2025,"publication_date":"2025-02-24","ids":{"openalex":"https://openalex.org/W4407887175","doi":"https://doi.org/10.1021/acs.jcim.4c01752","pmid":"https://pubmed.ncbi.nlm.nih.gov/39988825"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.4c01752","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c01752","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.4c01752?ref=article_openPDF","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.4c01752?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017474350","display_name":"Feixiang Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I4210108251","display_name":"Birmingham Research Park","ror":"https://ror.org/01ptjzx80","country_code":"GB","type":"archive","lineage":["https://openalex.org/I4210108251"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Feixiang Zhou","raw_affiliation_strings":["Readline Intelligence","Readline Intelligence, Birmingham B29 6SQ, U.K"],"affiliations":[{"raw_affiliation_string":"Readline Intelligence","institution_ids":[]},{"raw_affiliation_string":"Readline Intelligence, Birmingham B29 6SQ, U.K","institution_ids":["https://openalex.org/I4210108251"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shuo Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shuo Zhang","raw_affiliation_strings":["School of Computer Science","University of Birmingham","School of Computer Science, University of Birmingham, Birmingham B15 2TT, U.K"],"affiliations":[{"raw_affiliation_string":"School of Computer Science","institution_ids":[]},{"raw_affiliation_string":"University of Birmingham","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"School of Computer Science, University of Birmingham, Birmingham B15 2TT, U.K","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108048500","display_name":"Huifeng Zhang","orcid":"https://orcid.org/0000-0002-3764-6791"},"institutions":[{"id":"https://openalex.org/I4210108251","display_name":"Birmingham Research Park","ror":"https://ror.org/01ptjzx80","country_code":"GB","type":"archive","lineage":["https://openalex.org/I4210108251"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Huifeng Zhang","raw_affiliation_strings":["Readline Intelligence","Readline Intelligence, Birmingham B29 6SQ, U.K"],"affiliations":[{"raw_affiliation_string":"Readline Intelligence","institution_ids":[]},{"raw_affiliation_string":"Readline Intelligence, Birmingham B29 6SQ, U.K","institution_ids":["https://openalex.org/I4210108251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001710920","display_name":"Jian K. Liu","orcid":"https://orcid.org/0000-0002-5391-7213"},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jian K. Liu","raw_affiliation_strings":["School of Computer Science","University of Birmingham","School of Computer Science, University of Birmingham, Birmingham B15 2TT, U.K"],"affiliations":[{"raw_affiliation_string":"School of Computer Science","institution_ids":[]},{"raw_affiliation_string":"University of Birmingham","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"School of Computer Science, University of Birmingham, Birmingham B15 2TT, U.K","institution_ids":["https://openalex.org/I79619799"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001710920","https://openalex.org/A5108048500"],"corresponding_institution_ids":["https://openalex.org/I4210108251","https://openalex.org/I79619799"],"apc_list":null,"apc_paid":null,"fwci":5.2489,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.95370959,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"65","issue":"5","first_page":"2304","last_page":"2313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thermostability","display_name":"Thermostability","score":0.9770130515098572},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6283476948738098},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"Protein structure prediction","score":0.5524894595146179},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5330568552017212},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.4540480077266693},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4530562460422516},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.39755165576934814},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.3921251893043518},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23282793164253235},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1111503541469574}],"concepts":[{"id":"https://openalex.org/C2781216036","wikidata":"https://www.wikidata.org/wiki/Q902494","display_name":"Thermostability","level":3,"score":0.9770130515098572},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6283476948738098},{"id":"https://openalex.org/C18051474","wikidata":"https://www.wikidata.org/wiki/Q899656","display_name":"Protein structure prediction","level":3,"score":0.5524894595146179},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5330568552017212},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.4540480077266693},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4530562460422516},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39755165576934814},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.3921251893043518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23282793164253235},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1111503541469574},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.jcim.4c01752","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c01752","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.4c01752?ref=article_openPDF","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:39988825","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39988825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11898056","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11898056","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/1239ac51-e7ac-41a9-bc7e-0efee2b5bece","is_oa":true,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/1239ac51-e7ac-41a9-bc7e-0efee2b5bece","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zhou, F, Zhang, S, Zhang, H & Liu, J K 2025, 'ProCeSa : Contrast-Enhanced Structure-Aware Network for Thermostability Prediction with Protein Language Models', Journal of Chemical Information and Modeling, vol. 65, no. 5, pp. 2304-2313. https://doi.org/10.1021/acs.jcim.4c01752","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1021/acs.jcim.4c01752","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c01752","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.4c01752?ref=article_openPDF","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4407887175.pdf"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1974572084","https://openalex.org/W1999341492","https://openalex.org/W2031328428","https://openalex.org/W2047444359","https://openalex.org/W2063272004","https://openalex.org/W2081893178","https://openalex.org/W2085861012","https://openalex.org/W2092387745","https://openalex.org/W2096733369","https://openalex.org/W2098639665","https://openalex.org/W2141062474","https://openalex.org/W2153457180","https://openalex.org/W2158780885","https://openalex.org/W2167052843","https://openalex.org/W2171610577","https://openalex.org/W2473135273","https://openalex.org/W2608356044","https://openalex.org/W2648949596","https://openalex.org/W2785250581","https://openalex.org/W2912783011","https://openalex.org/W2914757825","https://openalex.org/W2964015378","https://openalex.org/W2981180678","https://openalex.org/W3015921770","https://openalex.org/W3035524453","https://openalex.org/W3113826677","https://openalex.org/W3129073614","https://openalex.org/W3146944767","https://openalex.org/W3164046276","https://openalex.org/W3177500196","https://openalex.org/W3177828909","https://openalex.org/W3186179742","https://openalex.org/W3199148273","https://openalex.org/W3201942032","https://openalex.org/W3213545574","https://openalex.org/W4212965593","https://openalex.org/W4223581484","https://openalex.org/W4283588627","https://openalex.org/W4292829079","https://openalex.org/W4296354070","https://openalex.org/W4306873876","https://openalex.org/W4309506674","https://openalex.org/W4317931114","https://openalex.org/W4327550249","https://openalex.org/W4362471278","https://openalex.org/W4366392978","https://openalex.org/W4379932151","https://openalex.org/W4382198799","https://openalex.org/W4385622695","https://openalex.org/W4389486963","https://openalex.org/W4390521376","https://openalex.org/W4392544734","https://openalex.org/W4394892342","https://openalex.org/W4396721167","https://openalex.org/W4399285138","https://openalex.org/W4400358823","https://openalex.org/W4401900858","https://openalex.org/W4405173137","https://openalex.org/W4405702281"],"related_works":["https://openalex.org/W2946599741","https://openalex.org/W2593264178","https://openalex.org/W2136856901","https://openalex.org/W2368468053","https://openalex.org/W2058542300","https://openalex.org/W2043066834","https://openalex.org/W1564749278","https://openalex.org/W2294851134","https://openalex.org/W3215498386","https://openalex.org/W2902589384"],"abstract_inverted_index":{"Proteins":[0],"play":[1],"a":[2,90,115],"fundamental":[3],"role":[4],"in":[5,30,34,44,154],"biology,":[6],"and":[7,84,102,157],"their":[8,13],"thermostability":[9,20,46,110,172],"is":[10,21],"essential":[11],"for":[12],"proper":[14],"functionality.":[15],"The":[16],"precise":[17],"measurement":[18],"of":[19,123,147,169],"crucial,":[22],"traditionally":[23],"relying":[24],"on":[25,71,139],"resource-intensive":[26],"experiments.":[27],"Recent":[28],"advances":[29],"deep":[31,55],"learning,":[32],"particularly":[33],"protein":[35,45,63,79,134,171],"language":[36],"models":[37,49],"(PLMs),":[38],"have":[39],"significantly":[40],"accelerated":[41],"the":[42,62,72,121,145,166],"progress":[43],"prediction.":[47,111],"These":[48],"utilize":[50],"various":[51],"biological":[52],"characteristics":[53],"or":[54],"representations":[56],"generated":[57],"by":[58,120,173],"PLMs":[59,107],"to":[60,108,129,181],"represent":[61],"sequences.":[64,135],"However,":[65],"effectively":[66],"incorporating":[67],"structural":[68,103,183],"information,":[69],"based":[70],"PLM":[73],"embeddings,":[74,177],"while":[75],"not":[76],"considering":[77],"atomic":[78,182],"structures,":[80],"remains":[81],"an":[82],"open":[83],"formidable":[85],"challenge.":[86],"Here,":[87],"we":[88],"propose":[89],"novel":[91],"Protein":[92],"Contrast-enhanced":[93],"Structure-Aware":[94],"(ProCeSa)":[95],"model":[96,113],"that":[97,163],"seamlessly":[98],"integrates":[99],"both":[100,155],"sequence":[101,176],"information":[104],"extracted":[105],"from":[106],"enhance":[109],"Our":[112,160],"employs":[114],"contrastive":[116],"learning":[117],"scheme":[118],"guided":[119],"categories":[122],"amino":[124],"acid":[125],"residues,":[126],"allowing":[127],"it":[128],"discern":[130],"intricate":[131],"patterns":[132],"within":[133],"Rigorous":[136],"experiments":[137],"conducted":[138],"publicly":[140],"available":[141],"data":[142],"sets":[143],"establish":[144],"superiority":[146],"our":[148],"method":[149],"over":[150],"state-of-the-art":[151],"approaches,":[152],"excelling":[153],"classification":[156],"regression":[158],"tasks.":[159],"results":[161],"demonstrate":[162],"ProCeSa":[164],"addresses":[165],"complex":[167],"challenge":[168],"predicting":[170],"utilizing":[174],"PLM-derived":[175],"without":[178],"requiring":[179],"access":[180],"data.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3}],"updated_date":"2026-04-14T08:04:32.555800","created_date":"2025-10-10T00:00:00"}
