{"id":"https://openalex.org/W4404585832","doi":"https://doi.org/10.1021/acs.jcim.4c01554","title":"ReduMixDTI: Prediction of Drug\u2013Target Interaction with Feature Redundancy Reduction and Interpretable Attention Mechanism","display_name":"ReduMixDTI: Prediction of Drug\u2013Target Interaction with Feature Redundancy Reduction and Interpretable Attention Mechanism","publication_year":2024,"publication_date":"2024-11-21","ids":{"openalex":"https://openalex.org/W4404585832","doi":"https://doi.org/10.1021/acs.jcim.4c01554","pmid":"https://pubmed.ncbi.nlm.nih.gov/39570771"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.4c01554","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c01554","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Mingqing Liu","orcid":"https://orcid.org/0009-0007-7314-6472"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingqing Liu","raw_affiliation_strings":["Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China MoE Key Laboratory of Brain-inspired Intelligent Perception and Cognition, University of Science and Technology of China, Hefei 230026, Anhui, China","National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Hefei 230026, Anhui, China"],"raw_orcid":"https://orcid.org/0009-0007-7314-6472","affiliations":[{"raw_affiliation_string":"Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China MoE Key Laboratory of Brain-inspired Intelligent Perception and Cognition, University of Science and Technology of China, Hefei 230026, Anhui, China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Hefei 230026, Anhui, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044536284","display_name":"Xuechun Meng","orcid":"https://orcid.org/0009-0009-3180-9527"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuechun Meng","raw_affiliation_strings":["Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China MoE Key Laboratory of Brain-inspired Intelligent Perception and Cognition, University of Science and Technology of China, Hefei 230026, Anhui, China","National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Hefei 230026, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China MoE Key Laboratory of Brain-inspired Intelligent Perception and Cognition, University of Science and Technology of China, Hefei 230026, Anhui, China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Hefei 230026, Anhui, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043278912","display_name":"Yiyang Mao","orcid":null},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiyang Mao","raw_affiliation_strings":["Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China MoE Key Laboratory of Brain-inspired Intelligent Perception and Cognition, University of Science and Technology of China, Hefei 230026, Anhui, China","National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Hefei 230026, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China MoE Key Laboratory of Brain-inspired Intelligent Perception and Cognition, University of Science and Technology of China, Hefei 230026, Anhui, China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Hefei 230026, Anhui, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067065399","display_name":"Hongqi Li","orcid":"https://orcid.org/0000-0003-4898-4857"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongqi Li","raw_affiliation_strings":["Department of Geriatrics, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230026, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230026, Anhui, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100396318","display_name":"Ji Liu","orcid":"https://orcid.org/0000-0002-0240-8881"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ji Liu","raw_affiliation_strings":["Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China MoE Key Laboratory of Brain-inspired Intelligent Perception and Cognition, University of Science and Technology of China, Hefei 230026, Anhui, China","Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei 230026, Anhui, China","MoE Key Laboratory of Brain-inspired Intelligent Perception and Cognition, University of Science and Technology of China, Hefei 230026, Anhui, China","National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Hefei 230026, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China MoE Key Laboratory of Brain-inspired Intelligent Perception and Cognition, University of Science and Technology of China, Hefei 230026, Anhui, China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei 230026, Anhui, China","institution_ids":[]},{"raw_affiliation_string":"MoE Key Laboratory of Brain-inspired Intelligent Perception and Cognition, University of Science and Technology of China, Hefei 230026, Anhui, China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Hefei 230026, Anhui, China","institution_ids":["https://openalex.org/I126520041"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5067065399","https://openalex.org/A5100396318"],"corresponding_institution_ids":["https://openalex.org/I126520041"],"apc_list":null,"apc_paid":null,"fwci":4.8398,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.95842784,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"64","issue":"23","first_page":"8952","last_page":"8962"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11948","display_name":"Machine Learning in Materials Science","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9866999983787537,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.8779391050338745},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6978763937950134},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6399347186088562},{"id":"https://openalex.org/keywords/redundancy","display_name":"Redundancy (engineering)","score":0.6122558116912842},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5273504853248596},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.46665215492248535},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.42727887630462646},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3720024824142456},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.15107181668281555}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.8779391050338745},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6978763937950134},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6399347186088562},{"id":"https://openalex.org/C152124472","wikidata":"https://www.wikidata.org/wiki/Q1204361","display_name":"Redundancy (engineering)","level":2,"score":0.6122558116912842},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5273504853248596},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.46665215492248535},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.42727887630462646},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3720024824142456},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.15107181668281555},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.4c01554","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c01554","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:39570771","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39570771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4184568980","display_name":null,"funder_award_id":"31970950","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5726886742","display_name":null,"funder_award_id":"2308085MH239","funder_id":"https://openalex.org/F4320334897","funder_display_name":"Natural Science Foundation of Anhui Province"},{"id":"https://openalex.org/G5880739035","display_name":null,"funder_award_id":"91957112","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334897","display_name":"Natural Science Foundation of Anhui Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1975147762","https://openalex.org/W1976262446","https://openalex.org/W1981276685","https://openalex.org/W2009313526","https://openalex.org/W2054253103","https://openalex.org/W2105668062","https://openalex.org/W2121175754","https://openalex.org/W2135209350","https://openalex.org/W2148145769","https://openalex.org/W2151357092","https://openalex.org/W2166550586","https://openalex.org/W2612329522","https://openalex.org/W2744129621","https://openalex.org/W2767891136","https://openalex.org/W2785947426","https://openalex.org/W2860192827","https://openalex.org/W2896002881","https://openalex.org/W2896829849","https://openalex.org/W2935632020","https://openalex.org/W3018980093","https://openalex.org/W3023126697","https://openalex.org/W3028589594","https://openalex.org/W3029836473","https://openalex.org/W3044334750","https://openalex.org/W3096561213","https://openalex.org/W3126516421","https://openalex.org/W3134958209","https://openalex.org/W3164853136","https://openalex.org/W3202227570","https://openalex.org/W3206585172","https://openalex.org/W4205328831","https://openalex.org/W4309452766","https://openalex.org/W4318981550","https://openalex.org/W4322745247","https://openalex.org/W4372347372","https://openalex.org/W4386071462","https://openalex.org/W4386898749","https://openalex.org/W4388006581","https://openalex.org/W4388007339","https://openalex.org/W4389918314","https://openalex.org/W4391967369","https://openalex.org/W4392111029","https://openalex.org/W4392693790","https://openalex.org/W4396721167","https://openalex.org/W4400142953","https://openalex.org/W4401532898","https://openalex.org/W4403681696"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W2888392564","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W4390569940","https://openalex.org/W4361193272","https://openalex.org/W2963326959","https://openalex.org/W4388685194","https://openalex.org/W4312407344","https://openalex.org/W1986582023"],"abstract_inverted_index":{"Identifying":[0],"drug-target":[1],"interactions":[2,82,125],"(DTIs)":[3],"is":[4],"essential":[5],"for":[6,83,188],"drug":[7,89,127],"discovery":[8],"and":[9,26,34,65,77,90,100,111,128,154,167,185],"development.":[10],"Existing":[11],"deep":[12],"learning":[13],"approaches":[14],"to":[15,23,114,172,193],"DTI":[16,45,84,196],"prediction":[17],"often":[18],"employ":[19],"powerful":[20],"feature":[21,75,190],"encoders":[22],"represent":[24],"drugs":[25],"targets":[27],"holistically,":[28],"which":[29,59],"usually":[30],"cause":[31],"significant":[32],"redundancy":[33,76],"noise":[35],"by":[36,95],"neglecting":[37],"the":[38,50,116,132,174],"restricted":[39],"binding":[40,57,136],"regions.":[41],"Furthermore,":[42],"many":[43],"previous":[44],"networks":[46,99],"ignore":[47],"or":[48],"simplify":[49],"complex":[51,80],"intermolecular":[52],"interaction":[53],"process":[54],"involving":[55],"diverse":[56],"types,":[58],"significantly":[60],"limits":[61],"both":[62],"predictive":[63],"ability":[64],"interpretability.":[66,175],"We":[67],"propose":[68],"ReduMixDTI,":[69],"an":[70],"end-to-end":[71],"model":[72,187],"that":[73,179],"addresses":[74],"explicitly":[78,122],"captures":[79],"local":[81],"prediction.":[85,197],"In":[86,138],"this":[87],"study,":[88],"target":[91,129],"features":[92,106],"are":[93,107],"encoded":[94],"using":[96],"graph":[97],"neural":[98,102],"convolutional":[101],"networks,":[103],"respectively.":[104],"These":[105],"refined":[108],"from":[109],"channel":[110],"spatial":[112],"perspectives":[113],"enhance":[115,173],"representations.":[117],"The":[118,176],"proposed":[119],"attention":[120,170],"mechanism":[121],"models":[123],"pairwise":[124],"between":[126],"substructures,":[130],"improving":[131],"model's":[133],"understanding":[134],"of":[135],"processes.":[137],"extensive":[139],"comparisons":[140],"with":[141],"seven":[142],"state-of-the-art":[143],"methods,":[144],"ReduMixDTI":[145,180],"demonstrates":[146],"superior":[147],"performance":[148],"across":[149],"three":[150],"benchmark":[151],"data":[152],"sets":[153,157],"external":[155],"test":[156],"reflecting":[158],"real-world":[159],"scenarios.":[160],"Additionally,":[161],"we":[162],"perform":[163],"comprehensive":[164],"ablation":[165],"studies":[166],"visualize":[168],"protein":[169],"weights":[171],"results":[177],"confirm":[178],"serves":[181],"as":[182],"a":[183],"robust":[184],"interpretable":[186],"reducing":[189],"redundancy,":[191],"contributing":[192],"advances":[194],"in":[195]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}