{"id":"https://openalex.org/W4403247788","doi":"https://doi.org/10.1021/acs.jcim.4c01471","title":"Deciphering the Morphological Difference of Amyloid-\u03b2 Fibrils in Familial and Sporadic Alzheimer\u2019s Diseases","display_name":"Deciphering the Morphological Difference of Amyloid-\u03b2 Fibrils in Familial and Sporadic Alzheimer\u2019s Diseases","publication_year":2024,"publication_date":"2024-10-09","ids":{"openalex":"https://openalex.org/W4403247788","doi":"https://doi.org/10.1021/acs.jcim.4c01471","pmid":"https://pubmed.ncbi.nlm.nih.gov/39382320"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.4c01471","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c01471","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11590496/pdf/nihms-2035002.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090617313","display_name":"Gangtong Huang","orcid":"https://orcid.org/0000-0001-8631-7014"},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gangtong Huang","raw_affiliation_strings":["Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089167632","display_name":"Zhiyuan Song","orcid":"https://orcid.org/0000-0003-3556-8205"},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiyuan Song","raw_affiliation_strings":["Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States"],"raw_orcid":"https://orcid.org/0000-0003-3556-8205","affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064661963","display_name":"Yun Xu","orcid":"https://orcid.org/0000-0001-5288-0319"},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun Xu","raw_affiliation_strings":["Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015199573","display_name":"Yunxiang Sun","orcid":"https://orcid.org/0000-0001-9799-7131"},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]},{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yunxiang Sun","raw_affiliation_strings":["Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States","School of Physical Science and Technology, Ningbo University, Ningbo 315211, China"],"raw_orcid":"https://orcid.org/0000-0001-9799-7131","affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States","institution_ids":["https://openalex.org/I8078737"]},{"raw_affiliation_string":"School of Physical Science and Technology, Ningbo University, Ningbo 315211, China","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100626869","display_name":"Feng Ding","orcid":null},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Feng Ding","raw_affiliation_strings":["Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States"],"raw_orcid":"https://orcid.org/0000-0003-1850-6336","affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States","institution_ids":["https://openalex.org/I8078737"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100626869"],"corresponding_institution_ids":["https://openalex.org/I8078737"],"apc_list":null,"apc_paid":null,"fwci":2.4356,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.89705215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"64","issue":"20","first_page":"8024","last_page":"8033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9757000207901001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-fibril","display_name":"Amyloid fibril","score":0.6849110126495361},{"id":"https://openalex.org/keywords/amyloid","display_name":"Amyloid (mycology)","score":0.6222168207168579},{"id":"https://openalex.org/keywords/alzheimers-disease","display_name":"Alzheimer's disease","score":0.5152978897094727},{"id":"https://openalex.org/keywords/amyloidosis","display_name":"Amyloidosis","score":0.4942662715911865},{"id":"https://openalex.org/keywords/amyloid-\u03b2","display_name":"Amyloid \u03b2","score":0.4813564419746399},{"id":"https://openalex.org/keywords/fibril","display_name":"Fibril","score":0.44812247157096863},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.4215083420276642},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4112277030944824},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3681463599205017},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3094250559806824},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.27592015266418457},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.16782113909721375}],"concepts":[{"id":"https://openalex.org/C2994168385","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid fibril","level":4,"score":0.6849110126495361},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.6222168207168579},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5152978897094727},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.4942662715911865},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.4813564419746399},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.44812247157096863},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4215083420276642},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4112277030944824},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3681463599205017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3094250559806824},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27592015266418457},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.16782113909721375}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.jcim.4c01471","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c01471","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:39382320","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39382320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11590496","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11590496/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11590496/pdf/nihms-2035002.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11361794","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11590496","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11590496","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11590496/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11590496/pdf/nihms-2035002.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6774060547","display_name":null,"funder_award_id":"R35GM145409","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G712052062","display_name":null,"funder_award_id":"R35GM145409","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7211802715","display_name":null,"funder_award_id":"P20GM121342","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7831941416","display_name":null,"funder_award_id":"P20GM121342","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309106","display_name":"Clemson University","ror":"https://ror.org/037s24f05"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4403247788.pdf"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1945463512","https://openalex.org/W1961186421","https://openalex.org/W1987134040","https://openalex.org/W1997167527","https://openalex.org/W2008708467","https://openalex.org/W2018207581","https://openalex.org/W2031880534","https://openalex.org/W2037312364","https://openalex.org/W2041155216","https://openalex.org/W2050673616","https://openalex.org/W2064331567","https://openalex.org/W2097758424","https://openalex.org/W2107696550","https://openalex.org/W2112154906","https://openalex.org/W2121779716","https://openalex.org/W2142184306","https://openalex.org/W2155201844","https://openalex.org/W2158089391","https://openalex.org/W2164765564","https://openalex.org/W2309071467","https://openalex.org/W2314944854","https://openalex.org/W2372745612","https://openalex.org/W2474799636","https://openalex.org/W2487730443","https://openalex.org/W2515309043","https://openalex.org/W2515706561","https://openalex.org/W2571390534","https://openalex.org/W2594071428","https://openalex.org/W2753860285","https://openalex.org/W2759411542","https://openalex.org/W2771052591","https://openalex.org/W2772785649","https://openalex.org/W2783923368","https://openalex.org/W2918608573","https://openalex.org/W3008583555","https://openalex.org/W3034648294","https://openalex.org/W3034727008","https://openalex.org/W3084854026","https://openalex.org/W3119202068","https://openalex.org/W3198578195","https://openalex.org/W3202815206","https://openalex.org/W4205765478","https://openalex.org/W4207035561","https://openalex.org/W4220673357","https://openalex.org/W4322767095","https://openalex.org/W4323656754","https://openalex.org/W4361190932","https://openalex.org/W4362661557","https://openalex.org/W4366362141","https://openalex.org/W4366985651","https://openalex.org/W4378640276","https://openalex.org/W4383315679","https://openalex.org/W4385851328","https://openalex.org/W4386316412","https://openalex.org/W4387267797","https://openalex.org/W4387736757","https://openalex.org/W4388153824","https://openalex.org/W4388901029","https://openalex.org/W4390063994","https://openalex.org/W4391022978","https://openalex.org/W4391218039","https://openalex.org/W4391435906"],"related_works":["https://openalex.org/W4390063994","https://openalex.org/W2341969299","https://openalex.org/W4240327756","https://openalex.org/W4394876284","https://openalex.org/W2334747311","https://openalex.org/W4211003773","https://openalex.org/W4294286266","https://openalex.org/W3168207341","https://openalex.org/W2409486739","https://openalex.org/W2023973572"],"abstract_inverted_index":{"The":[0,50,165],"aggregation":[1,152],"of":[2,13,23,28,58,137,160,187,197,228],"amyloid-\u03b2":[3],"(A\u03b2)":[4],"into":[5],"amyloid":[6,249],"fibrils":[7,18],"is":[8],"the":[9,25,81,89,100,118,124,135,138,161,173,177,194,198,214,242],"major":[10],"pathological":[11],"hallmark":[12],"Alzheimer\u2019s":[14],"disease":[15,72],"(AD).":[16],"A\u03b2":[17,65,151],"can":[19,77],"adopt":[20],"a":[21,104,113,183,225,237],"variety":[22],"morphologies,":[24],"relative":[26],"populations":[27],"which":[29],"are":[30],"recently":[31],"found":[32],"to":[33,80,149,156,172,224],"be":[34,78],"associated":[35],"with":[36,117,129,205],"different":[37],"AD":[38,45,52,243],"subtypes":[39,53,244],"such":[40],"as":[41,158],"familial":[42],"and":[43,47,63,85],"sporadic":[44,203],"(fAD":[46],"sAD,":[48],"respectively).":[49],"two":[51],"differ":[54],"in":[55,88,123,180,202,211],"their":[56],"ages":[57],"onset,":[59],"AD-related":[60],"genetic":[61],"predispositions,":[62],"dominant":[64,248],"fibril":[66,74,83,109,120,175,179,189,200,230,250],"morphologies.":[67,251],"We":[68],"postulate":[69],"that":[70,99,145],"these":[71],"subtype-dependent":[73],"morphology":[75,102,201],"differences":[76],"attributed":[79],"intrinsic":[82],"properties":[84],"interacting":[86],"molecules":[87],"environment.":[90],"Using":[91],"atomistic":[92],"discrete":[93],"molecular":[94],"dynamics":[95],"simulations,":[96],"we":[97,133],"demonstrated":[98],"fAD-dominant":[101,174,188],"exhibited":[103],"lower":[105,114],"free-energy":[106],"barrier":[107],"for":[108,240],"growth":[110],"but":[111],"also":[112],"stability":[115],"compared":[116],"sAD-dominant":[119,178,199],"morphology,":[121],"resulting":[122],"time-dependent":[125],"population":[126,196,227],"change":[127],"consistent":[128],"experimental":[130],"observations.":[131],"Additionally,":[132],"studied":[134],"effect":[136],"Bri2":[139,166,207,221],"BRICHOS":[140,167],"domain,":[141],"an":[142],"endogenous":[143],"protein":[144],"has":[146],"been":[147],"reported":[148],"inhibit":[150],"by":[153,246],"preferential":[154],"binding":[155,171],"fibrils,":[157],"one":[159],"possible":[162],"environmental":[163],"factors.":[164],"domain":[168],"showed":[169],"stronger":[170],"than":[176],"silico,":[181],"suggesting":[182],"more":[184],"effective":[185],"suppression":[186],"formation.":[190],"This":[191],"result":[192],"explains":[193],"high":[195,226],"cases":[204],"normal":[206],"functions.":[208],"Genetic":[209],"predisposition":[210],"fAD,":[212],"on":[213],"other":[215],"hand,":[216],"might":[217],"impair":[218],"or":[219],"overwhelm":[220],"functions,":[222],"leading":[223],"fAD-associated":[229],"morphology.":[231],"Together,":[232],"our":[233],"computational":[234],"findings":[235],"provide":[236],"theoretical":[238],"framework":[239],"elucidating":[241],"entailed":[245],"distinct":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-10-10T00:00:00"}
